阅读说明：本技术 多聚体t细胞调节多肽及其使用方法 (Multimeric T cell modulating polypeptides and methods of use thereof ) 是由 罗纳德·D·赛德尔三世 鲁道夫·J·查帕罗 于 2019-01-08 设计创作，主要内容包括：本公开提供T细胞调节多聚体多肽,其包含免疫调节多肽,该免疫调节多肽表现出降低的与同源共免疫调节多肽的结合亲和力。T细胞调节多聚体多肽可用于调节T细胞的活性,并用于调节个体的免疫反应。(The present disclosure provides T cell modulating multimeric polypeptides comprising immunomodulatory polypeptides that exhibit reduced binding affinity to a homologous co-immunomodulatory polypeptide. T cell modulating multimeric polypeptides are useful for modulating the activity of T cells and for modulating an immune response in an individual.)

具体实施方式

加以描述，但熟习此项技术者应了解的是可在不脱离本发明的真实精神及范畴下进行各种变化且可用等效物进行替代。此外，可进行许多修改以使特定情况、材料、物质组成、方法、一或多个方法步骤适合于本发明的目标、精神及范畴。所有这些修改皆意欲在随附于此的申请专利范围的范畴内。

序列表

<110> 罗纳德·D·赛德尔三世

鲁道夫·J·查帕罗

库尔生物制药有限公司

<120> 多聚体T细胞调节多肽及其使用方法

<130> CUEB-112WO

<150> 62/615,225

<151> 2018-01-09

<150> 62/615,253

<151> 2018-01-09

<150> 62/713,408

<151> 2018-08-01

<150> 62/782,109

<151> 2018-12-19

<150> 62/782,214

<151> 2018-12-19

<160> 406

<170> PatentIn版本3.5

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Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu

1 5 10 15

Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr

20 25 30

Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu

35 40 45

Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile

50 55 60

Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser

65 70 75 80

Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn

85 90 95

Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr

100 105 110

Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val

115 120 125

Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val

130 135 140

Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr

145 150 155 160

Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser

165 170 175

Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn

180 185 190

Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr

195 200 205

Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu

210 215 220

Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr

225 230 235 240

Leu Ser Pro Ser Thr

245

<210> 2

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Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser

1 5 10 15

Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu

20 25 30

Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln

35 40 45

Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg

50 55 60

Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala

65 70 75 80

Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys

85 90 95

Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val

100 105 110

Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro

115 120 125

Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys

130 135 140

Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys

145 150 155 160

Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr

165 170 175

Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr

180 185 190

Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile

195 200 205

Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile

210 215

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Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr

1 5 10 15

Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe

20 25 30

Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr

35 40 45

Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu

50 55 60

Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu

65 70 75 80

Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn

85 90 95

Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala

100 105 110

Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg

115 120 125

Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly

130 135 140

Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser

145 150 155 160

Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala

165 170 175

Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp

180 185 190

Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe

195 200 205

Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu

210 215 220

Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser

225 230 235 240

Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro

245 250 255

Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu

260 265

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Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

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Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val

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Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr

20 25 30

Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser

35 40 45

Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu

50 55 60

Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser

65 70 75 80

Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr

85 90 95

Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys

100 105 110

Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser

115 120 125

Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro

130 135 140

Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly

145 150 155 160

Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile

165 170 175

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met

180 185 190

Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro

195 200 205

Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser

210 215 220

<210> 6

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Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val

1 5 10 15

Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr

20 25 30

Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu

35 40 45

Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly

50 55 60

Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe

65 70 75 80

Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn

85 90 95

Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr

100 105 110

Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser

115 120

<210> 7

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<212> PRT

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Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val

1 5 10 15

Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys

20 25 30

Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser

35 40 45

Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg

50 55 60

Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro

65 70 75 80

Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe

85 90 95

Ala Ala Tyr Arg Ser

100

<210> 8

<211> 224

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<400> 8

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 9

<211> 110

<212> PRT

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Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 10

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<212> PRT

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Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro

1 5 10 15

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val

20 25 30

Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe

35 40 45

Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser

50 55 60

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp

65 70 75 80

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

85 90 95

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

100 105 110

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

115 120 125

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

130 135 140

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

145 150 155 160

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

165 170 175

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

180 185 190

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

195 200 205

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

210 215 220

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

225 230 235 240

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

245 250

<210> 11

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<212> PRT

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Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 12

<211> 175

<212> PRT

<213> 智人

<400> 12

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu

1 5 10 15

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser

20 25 30

Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys

35 40 45

Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val

50 55 60

Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly

65 70 75 80

Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly

85 90 95

Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu

100 105 110

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser

115 120 125

Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg

130 135 140

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg

145 150 155 160

Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170 175

<210> 13

<211> 167

<212> PRT

<213> 智人

<400> 13

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu

1 5 10 15

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser

20 25 30

Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys

35 40 45

Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val

50 55 60

Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly

65 70 75 80

Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly

85 90 95

Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu

100 105 110

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser

115 120 125

Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg

130 135 140

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg

145 150 155 160

Val Thr Pro Glu Ile Pro Ala

165

<210> 14

<211> 255

<212> PRT

<213> 智人

<400> 14

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu

1 5 10 15

Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro

20 25 30

Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys

35 40 45

Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile

50 55 60

Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser

65 70 75 80

Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly

85 90 95

Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu

100 105 110

Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln

115 120 125

Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys

130 135 140

Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro

145 150 155 160

Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala

165 170 175

Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu

180 185 190

Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu

195 200 205

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe

210 215 220

Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly

225 230 235 240

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu

245 250 255

<210> 15

<211> 133

<212> PRT

<213> 智人

<400> 15

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 16

<211> 251

<212> PRT

<213> 智人

<400> 16

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys

1 5 10 15

Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg

20 25 30

Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly

35 40 45

Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser

50 55 60

Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln

65 70 75 80

Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp

85 90 95

Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn

100 105 110

Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr

115 120 125

Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu

130 135 140

Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln

145 150 155 160

Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu

165 170 175

Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys

180 185 190

Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr

195 200 205

Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly

210 215 220

Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp

225 230 235 240

Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile

245 250

<210> 17

<211> 524

<212> PRT

<213> 智人

<400> 17

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn

1 5 10 15

Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys

20 25 30

Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu

35 40 45

Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly

50 55 60

Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg

65 70 75 80

Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp

85 90 95

Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln

100 105 110

Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser

115 120 125

Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr

130 135 140

Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys

145 150 155 160

Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln

165 170 175

Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr

180 185 190

Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala

195 200 205

Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu

210 215 220

Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys

225 230 235 240

Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro

245 250 255

Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp

260 265 270

Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro

275 280 285

Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp

290 295 300

Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala

305 310 315 320

Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly

325 330 335

Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln

340 345 350

Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly

355 360 365

Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu

370 375 380

Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu

385 390 395 400

Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr

405 410 415

Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu

420 425 430

Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro

435 440 445

Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu

450 455 460

Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu

465 470 475 480

Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg

485 490 495

Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu

500 505 510

Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val

515 520

<210> 18

<211> 347

<212> PRT

<213> 智人

<400> 18

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala

1 5 10 15

Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr

20 25 30

Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met

35 40 45

Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr

50 55 60

Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys

65 70 75 80

Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln

85 90 95

Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp

100 105 110

Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn

115 120 125

Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser

130 135 140

Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys

145 150 155 160

Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr

165 170 175

Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp

180 185 190

Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu

195 200 205

Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp

210 215 220

Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala

225 230 235 240

Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys

245 250 255

Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys

260 265 270

Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp

275 280 285

Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser

290 295 300

Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu

305 310 315 320

Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp

325 330 335

Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr

340 345

<210> 19

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<400> 19

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 20

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<400> 20

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 21

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (15)..(15)

<223> 除谷氨酸外的任何氨基酸

<400> 21

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Xaa His

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 22

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<400> 22

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 23

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除酪氨酸外的任何氨基酸

<400> 23

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Xaa Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 24

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 除谷氨酰胺外的任何氨基酸

<400> 24

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Xaa Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 25

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<400> 25

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 26

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<400> 26

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 27

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (15)..(15)

<223> 除谷氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<400> 27

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Xaa His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 28

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<400> 28

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 29

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 除谷氨酰胺外的任何氨基酸

<400> 29

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Xaa Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 30

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除酪氨酸外的任何氨基酸

<400> 30

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Xaa Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 31

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除酪氨酸外的任何氨基酸

<400> 31

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Xaa Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 32

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除酪氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 除谷氨酰胺外的任何氨基酸

<400> 32

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Xaa Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Xaa Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 33

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除酪氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 除谷氨酰胺外的任何氨基酸

<400> 33

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Xaa Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Xaa Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 34

<211> 133

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除组氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除苯丙氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 除谷氨酰胺外的任何氨基酸

<400> 34

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Xaa Ser Ile

115 120 125

Ile Ser Thr Leu Thr

130

<210> 35

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 35

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala

1 5

<210> 36

<211> 8

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 36

Asp Tyr Lys Asp Asp Asp Asp Lys

1 5

<210> 37

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 37

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu

1 5 10

<210> 38

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 38

His His His His His

1 5

<210> 39

<211> 6

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 39

His His His His His His

1 5

<210> 40

<211> 8

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 40

Trp Ser His Pro Gln Phe Glu Lys

1 5

<210> 41

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 41

Arg Tyr Ile Arg Ser

1 5

<210> 42

<211> 4

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 42

Phe His His Thr

1

<210> 43

<211> 17

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 43

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg

1 5 10 15

Ala

<210> 44

<211> 8

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 44

Leu Glu Val Leu Phe Gln Gly Pro

1 5

<210> 45

<211> 7

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 45

Glu Asn Leu Tyr Thr Gln Ser

1 5

<210> 46

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 46

Asp Asp Asp Asp Lys

1 5

<210> 47

<211> 4

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 47

Leu Val Pro Arg

1

<210> 48

<211> 22

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 48

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val

1 5 10 15

Glu Glu Asn Pro Gly Pro

20

<210> 49

<211> 119

<212> PRT

<213> 智人

<400> 49

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg

20 25 30

His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser

35 40 45

Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu

50 55 60

Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp

65 70 75 80

Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp

85 90 95

Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile

100 105 110

Val Lys Trp Asp Arg Asp Met

115

<210> 50

<211> 119

<212> PRT

<213> Macaca mulatta

<400> 50

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg

20 25 30

His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser

35 40 45

Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu

50 55 60

Lys Met Gly Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp

65 70 75 80

Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Asn Glu Lys Asp

85 90 95

Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gly Pro Arg Thr

100 105 110

Val Lys Trp Asp Arg Asp Met

115

<210> 51

<211> 118

<212> PRT

<213> Bos taurus

<400> 51

Met Ala Arg Phe Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Asp Ala Ile Gln Arg Pro Pro Lys Ile Gln Val Tyr Ser Arg

20 25 30

His Pro Pro Glu Asp Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Tyr

35 40 45

Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu

50 55 60

Lys Ile Lys Ser Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser

65 70 75 80

Phe Tyr Leu Leu Ser His Ala Glu Phe Thr Pro Asn Ser Lys Asp Gln

85 90 95

Tyr Ser Cys Arg Val Lys His Val Thr Leu Glu Gln Pro Arg Ile Val

100 105 110

Lys Trp Asp Arg Asp Leu

115

<210> 52

<211> 119

<212> PRT

<213> Mus musculus

<400> 52

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr

1 5 10 15

Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg

20 25 30

His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr

35 40 45

Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys

50 55 60

Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp

65 70 75 80

Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp

85 90 95

Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr

100 105 110

Val Tyr Trp Asp Arg Asp Met

115

<210> 53

<211> 276

<212> PRT

<213> 智人

<400> 53

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 54

<211> 274

<212> PRT

<213> Mus musculus

<400> 54

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg

35 40 45

Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr

50 55 60

Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr

65 70 75 80

Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln

85 90 95

Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly

100 105 110

Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg

130 135 140

Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn

165 170 175

Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His

180 185 190

Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu

210 215 220

Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn

245 250 255

Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp

<210> 55

<211> 99

<212> PRT

<213> 智人

<400> 55

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu

1 5 10 15

Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro

20 25 30

Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys

35 40 45

Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu

50 55 60

Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys

65 70 75 80

Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp

85 90 95

Arg Asp Met

<210> 56

<211> 99

<212> PRT

<213> 智人

<400> 56

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu

1 5 10 15

Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro

20 25 30

Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys

35 40 45

Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu

50 55 60

Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys

65 70 75 80

Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp

85 90 95

Arg Asp Met

<210> 57

<211> 276

<212> PRT

<213> 智人

<400> 57

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 58

<211> 275

<212> PRT

<213> 智人

<400> 58

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 59

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (4)..(4)

<223> 除脯氨酸外的任何氨基酸

<400> 59

Val Pro Gly Xaa Gly

1 5

<210> 60

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 60

Gly Ser Gly Gly Ser

1 5

<210> 61

<211> 4

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 61

Gly Gly Gly Ser

1

<210> 62

<211> 4

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 62

Gly Gly Ser Gly

1

<210> 63

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 63

Gly Gly Ser Gly Gly

1 5

<210> 64

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 64

Gly Ser Gly Ser Gly

1 5

<210> 65

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 65

Gly Ser Gly Gly Gly

1 5

<210> 66

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 66

Gly Gly Gly Ser Gly

1 5

<210> 67

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 67

Gly Ser Ser Ser Gly

1 5

<210> 68

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 68

Gly Ser Ser Ser Ser

1 5

<210> 69

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 69

Gly Gly Gly Gly Ser

1 5

<210> 70

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 70

Ala Ala Ala Gly Gly

1 5

<210> 71

<211> 15

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 71

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

1 5 10 15

<210> 72

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 72

Leu Leu Met Gly Thr Leu Gly Ile Val

1 5

<210> 73

<211> 8

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 73

Thr Leu Gly Ile Val Cys Pro Ile

1 5

<210> 74

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 74

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr

1 5 10

<210> 75

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 75

Tyr Met Leu Asp Leu Gln Pro Glu Thr

1 5

<210> 76

<211> 219

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (8)..(8)

<223> 除天冬氨酸外的任何氨基酸

<400> 76

Phe Thr Val Thr Val Pro Lys Xaa Leu Tyr Val Val Glu Tyr Gly Ser

1 5 10 15

Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu

20 25 30

Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln

35 40 45

Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg

50 55 60

Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala

65 70 75 80

Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys

85 90 95

Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val

100 105 110

Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro

115 120 125

Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys

130 135 140

Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys

145 150 155 160

Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr

165 170 175

Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr

180 185 190

Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile

195 200 205

Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile

210 215

<210> 77

<211> 219

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (36)..(36)

<223> 除异亮氨酸外的任何氨基酸

<400> 77

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser

1 5 10 15

Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu

20 25 30

Ala Ala Leu Xaa Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln

35 40 45

Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg

50 55 60

Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala

65 70 75 80

Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys

85 90 95

Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val

100 105 110

Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro

115 120 125

Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys

130 135 140

Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys

145 150 155 160

Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr

165 170 175

Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr

180 185 190

Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile

195 200 205

Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile

210 215

<210> 78

<211> 219

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (54)..(54)

<223> 除谷氨酰胺外的任何氨基酸

<400> 78

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser

1 5 10 15

Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu

20 25 30

Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln

35 40 45

Phe Val His Gly Glu Xaa Asp Leu Lys Val Gln His Ser Ser Tyr Arg

50 55 60

Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala

65 70 75 80

Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys

85 90 95

Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val

100 105 110

Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro

115 120 125

Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys

130 135 140

Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys

145 150 155 160

Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr

165 170 175

Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr

180 185 190

Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile

195 200 205

Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile

210 215

<210> 79

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (19)..(19)

<223> 除天冬酰胺外的任何氨基酸

<400> 79

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Xaa Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 80

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (63)..(63)

<223> 除天冬酰胺外的任何氨基酸

<400> 80

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Xaa Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 81

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (67)..(67)

<223> 除异亮氨酸外的任何氨基酸

<400> 81

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Xaa Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 82

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (86)..(86)

<223> 除赖氨酸外的任何氨基酸

<400> 82

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Xaa Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 83

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (157)..(157)

<223> 除谷氨酰胺外的任何氨基酸

<400> 83

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Xaa Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 84

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (158)..(158)

<223> 除天冬氨酸外的任何氨基酸

<400> 84

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Xaa Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 85

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (25)..(25)

<223> 除亮氨酸外的任何氨基酸

<400> 85

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Xaa Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 86

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (31)..(31)

<223> 除酪氨酸外的任何氨基酸

<400> 86

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Xaa Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 87

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (33)..(33)

<223> 除谷氨酰胺外的任何氨基酸

<400> 87

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Xaa Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 88

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (38)..(38)

<223> 除甲硫氨酸外的任何氨基酸

<400> 88

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Xaa Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 89

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (39)..(39)

<223> 除缬氨酸外的任何氨基酸

<400> 89

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Xaa Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 90

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (49)..(49)

<223> 除异亮氨酸外的任何氨基酸

<400> 90

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Xaa Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 91

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (53)..(53)

<223> 除酪氨酸外的任何氨基酸

<400> 91

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Xaa Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 92

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (60)..(60)

<223> 除天冬氨酸外的任何氨基酸

<400> 92

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Xaa Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 93

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (108)..(108)

<223> 除苯丙氨酸外的任何氨基酸

<400> 93

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Xaa Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 94

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (156)..(156)

<223> 除丝氨酸外的任何氨基酸

<400> 94

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Xaa Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 95

<211> 208

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (111)..(111)

<223> 除脯氨酸外的任何氨基酸

<400> 95

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Xaa Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

<210> 96

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<400> 96

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 97

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除天冬氨酸外的任何氨基酸

<400> 97

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 98

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (70)..(70)

<223> 除色氨酸外的任何氨基酸

<400> 98

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Xaa Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 99

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 99

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 100

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<400> 100

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 101

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除天冬氨酸外的任何氨基酸

<400> 101

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 102

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (70)..(70)

<223> 除色氨酸外的任何氨基酸

<400> 102

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Xaa Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 103

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 103

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 104

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (41)..(41)

<223> 除缬氨酸外的任何氨基酸

<400> 104

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Xaa Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 105

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (41)..(41)

<223> 除缬氨酸外的任何氨基酸

<400> 105

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Xaa Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 106

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (35)..(35)

<223> 除谷氨酰胺外的任何氨基酸

<400> 106

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Xaa Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 107

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (35)..(35)

<223> 除谷氨酰胺外的任何氨基酸

<400> 107

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Xaa Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 108

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (33)..(33)

<223> 除苯丙氨酸外的任何氨基酸

<400> 108

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Xaa Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 109

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (33)..(33)

<223> 除苯丙氨酸外的任何氨基酸

<400> 109

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Xaa Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 110

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (72)..(72)

<223> 除亮氨酸外的任何氨基酸

<400> 110

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Xaa Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 111

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (72)..(72)

<223> 除亮氨酸外的任何氨基酸

<400> 111

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Xaa Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 112

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (59)..(59)

<223> 除酪氨酸外的任何氨基酸

<400> 112

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Xaa Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 113

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (59)..(59)

<223> 除酪氨酸外的任何氨基酸

<400> 113

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Xaa Met Asn Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 114

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 114

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 115

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 115

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 116

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 116

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 117

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (17)..(17)

<223> 除天冬酰胺外的任何氨基酸

<220>

<221> misc_特征

<222> (66)..(66)

<223> Xaa可以是除His外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 117

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Asn Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 118

<211> 224

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 118

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn

100 105 110

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val

115 120 125

Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys

130 135 140

Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp

145 150 155 160

Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val

165 170 175

Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr

180 185 190

Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro

195 200 205

Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro

210 215 220

<210> 119

<211> 110

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (61)..(61)

<223> 除天冬酰胺外的任何氨基酸

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除天冬氨酸外的任何氨基酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> 除组氨酸外的任何氨基酸

<400> 119

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro

1 5 10 15

Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val

20 25 30

Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly

35 40 45

Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Xaa Arg Thr Ser

50 55 60

Phe Xaa Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys

65 70 75 80

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His Xaa Lys Lys Pro Thr Gly

85 90 95

Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu

100 105 110

<210> 120

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (47)..(47)

<223> 除赖氨酸外的任何氨基酸

<400> 120

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Xaa Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 121

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (147)..(147)

<223> 除谷氨酰胺外的任何氨基酸

<400> 121

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Xaa Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 122

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (11)..(11)

<223> 除甲硫氨酸外的任何氨基酸

<400> 122

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Xaa Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 123

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (12)..(12)

<223> 除苯丙氨酸外的任何氨基酸

<400> 123

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Xaa Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 124

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (14)..(14)

<223> 除谷氨酰胺外的任何氨基酸

<400> 124

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Xaa Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 125

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (15)..(15)

<223> 除亮氨酸外的任何氨基酸

<400> 125

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Xaa Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 126

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (16)..(16)

<223> 除缬氨酸外的任何氨基酸

<400> 126

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Xaa

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 127

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (18)..(18)

<223> 除谷氨酰胺外的任何氨基酸

<400> 127

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Xaa Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 128

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (19)..(19)

<223> 除天冬酰胺外的任何氨基酸

<400> 128

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Xaa Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 129

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (20)..(20)

<223> 除缬氨酸外的任何氨基酸

<400> 129

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Xaa Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 130

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (21)..(21)

<223> 除亮氨酸外的任何氨基酸

<400> 130

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Xaa Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 131

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (22)..(22)

<223> 除亮氨酸外的任何氨基酸

<400> 131

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Xaa Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 132

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (23)..(23)

<223> 除异亮氨酸外的任何氨基酸

<400> 132

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Xaa Asp Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 133

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (24)..(24)

<223> 除天冬氨酸外的任何氨基酸

<400> 133

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Xaa Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 134

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (25)..(25)

<223> 除甘氨酸外的任何氨基酸

<400> 134

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Asp Xaa Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 135

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (26)..(26)

<223> 除脯氨酸外的任何氨基酸

<400> 135

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Xaa Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 136

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (27)..(27)

<223> 除亮氨酸外的任何氨基酸

<400> 136

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Xaa Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 137

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (28)..(28)

<223> 除丝氨酸外的任何氨基酸

<400> 137

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Xaa Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 138

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (29)..(29)

<223> 除色氨酸外的任何氨基酸

<400> 138

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Xaa Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 139

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (30)..(30)

<223> 除酪氨酸外的任何氨基酸

<400> 139

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Xaa Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 140

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (31)..(31)

<223> 除丝氨酸外的任何氨基酸

<400> 140

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Xaa Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 141

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (32)..(32)

<223> 除天冬氨酸外的任何氨基酸

<400> 141

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Xaa

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 142

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (33)..(33)

<223> 除脯氨酸外的任何氨基酸

<400> 142

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Xaa Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 143

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (34)..(34)

<223> 除甘氨酸外的任何氨基酸

<400> 143

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Xaa Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 144

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (35)..(35)

<223> 除亮氨酸外的任何氨基酸

<400> 144

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Xaa Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 145

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (37)..(37)

<223> 除甘氨酸外的任何氨基酸

<400> 145

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Xaa Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 146

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (38)..(38)

<223> 除缬氨酸外的任何氨基酸

<400> 146

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Xaa Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 147

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (39)..(39)

<223> 除丝氨酸外的任何氨基酸

<400> 147

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Xaa Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 148

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (40)..(40)

<223> 除亮氨酸外的任何氨基酸

<400> 148

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Xaa Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 149

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (41)..(41)

<223> 除苏氨酸外的任何氨基酸

<400> 149

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Xaa Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 150

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (42)..(42)

<223> 除甘氨酸外的任何氨基酸

<400> 150

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Xaa Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 151

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (43)..(43)

<223> 除甘氨酸外的任何氨基酸

<400> 151

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Xaa Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 152

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (44)..(44)

<223> 除亮氨酸外的任何氨基酸

<400> 152

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Xaa Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 153

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (45)..(45)

<223> 除丝氨酸外的任何氨基酸

<400> 153

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Xaa Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 154

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (46)..(46)

<223> 除酪氨酸外的任何氨基酸

<400> 154

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Xaa Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 155

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (48)..(48)

<223> 除谷氨酸外的任何氨基酸

<400> 155

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Xaa

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 156

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (49)..(49)

<223> 除天冬氨酸外的任何氨基酸

<400> 156

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Xaa Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 157

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (50)..(50)

<223> 除苏氨酸外的任何氨基酸

<400> 157

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Xaa Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 158

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (51)..(51)

<223> 除赖氨酸外的任何氨基酸

<400> 158

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Xaa Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 159

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (52)..(52)

<223> 除谷氨酸外的任何氨基酸

<400> 159

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Xaa Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 160

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (64)..(64)

<223> 除苯丙氨酸外的任何氨基酸

<400> 160

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Xaa

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 161

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (65)..(65)

<223> 除苯丙氨酸外的任何氨基酸

<400> 161

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Xaa Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 162

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (66)..(66)

<223> 除谷氨酰胺外的任何氨基酸

<400> 162

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Xaa Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 163

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (67)..(67)

<223> 除亮氨酸外的任何氨基酸

<400> 163

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Xaa Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 164

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (68)..(68)

<223> 除谷氨酸外的任何氨基酸

<400> 164

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Xaa Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 165

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (69)..(69)

<223> 除亮氨酸外的任何氨基酸

<400> 165

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Xaa Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 166

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (70)..(70)

<223> 除精氨酸外的任何氨基酸

<400> 166

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Xaa Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 167

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (71)..(71)

<223> 除精氨酸外的任何氨基酸

<400> 167

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Xaa Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 168

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (72)..(72)

<223> 除缬氨酸外的任何氨基酸

<400> 168

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Xaa Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 169

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (73)..(73)

<223> 除缬氨酸外的任何氨基酸

<400> 169

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Xaa Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 170

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (75)..(75)

<223> 除甘氨酸外的任何氨基酸

<400> 170

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Xaa Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 171

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (76)..(76)

<223> 除谷氨酸外的任何氨基酸

<400> 171

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Xaa Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 172

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (77)..(77)

<223> 除甘氨酸外的任何氨基酸

<400> 172

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Xaa Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 173

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (78)..(78)

<223> 除丝氨酸外的任何氨基酸

<400> 173

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Xaa Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 174

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (104)..(104)

<223> 除天冬氨酸外的任何氨基酸

<400> 174

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Xaa Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 175

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (105)..(105)

<223> 除亮氨酸外的任何氨基酸

<400> 175

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Xaa Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 176

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (106)..(106)

<223> 除脯氨酸外的任何氨基酸

<400> 176

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Xaa Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 177

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (109)..(109)

<223> 除丝氨酸外的任何氨基酸

<400> 177

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Xaa Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 178

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (110)..(110)

<223> 除丝氨酸外的任何氨基酸

<400> 178

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Xaa Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 179

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (111)..(111)

<223> 除谷氨酸外的任何氨基酸

<400> 179

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Xaa Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 180

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (113)..(113)

<223> 除精氨酸外的任何氨基酸

<400> 180

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Xaa Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 181

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (114)..(114)

<223> 除天冬酰胺外的任何氨基酸

<400> 181

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Xaa Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 182

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (115)..(115)

<223> 除丝氨酸外的任何氨基酸

<400> 182

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Xaa Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 183

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (117)..(117)

<223> 除苯丙氨酸外的任何氨基酸

<400> 183

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Xaa Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 184

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (130)..(130)

<223> 除谷氨酰胺外的任何氨基酸

<400> 184

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Xaa Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 185

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (131)..(131)

<223> 除精氨酸外的任何氨基酸

<400> 185

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Xaa Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 186

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (132)..(132)

<223> 除亮氨酸外的任何氨基酸

<400> 186

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Xaa Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 187

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (133)..(133)

<223> 除甘氨酸外的任何氨基酸

<400> 187

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Xaa Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 188

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (134)..(134)

<223> 除缬氨酸外的任何氨基酸

<400> 188

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Xaa His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 189

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (135)..(135)

<223> 除组氨酸外的任何氨基酸

<400> 189

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val Xaa Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 190

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (136)..(136)

<223> 除亮氨酸外的任何氨基酸

<400> 190

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Xaa His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 191

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (137)..(137)

<223> 除组氨酸外的任何氨基酸

<400> 191

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu Xaa Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 192

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (138)..(138)

<223> 除苏氨酸外的任何氨基酸

<400> 192

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Xaa Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 193

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (139)..(139)

<223> 除谷氨酸外的任何氨基酸

<400> 193

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Xaa Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 194

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (141)..(141)

<223> 除精氨酸外的任何氨基酸

<400> 194

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Xaa Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 195

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (143)..(143)

<223> 除精氨酸外的任何氨基酸

<400> 195

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Xaa His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 196

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (144)..(144)

<223> 除组氨酸外的任何氨基酸

<400> 196

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg Xaa

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 197

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (146)..(146)

<223> 除色氨酸外的任何氨基酸

<400> 197

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Xaa Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 198

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (148)..(148)

<223> 除亮氨酸外的任何氨基酸

<400> 198

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Xaa Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 199

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (149)..(149)

<223> 除苏氨酸外的任何氨基酸

<400> 199

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Xaa Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 200

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (150)..(150)

<223> 除谷氨酰胺外的任何氨基酸

<400> 200

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Xaa Gly Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 201

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (151)..(151)

<223> 除甘氨酸外的任何氨基酸

<400> 201

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Xaa Ala Thr Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 202

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (153)..(153)

<223> 除苏氨酸外的任何氨基酸

<400> 202

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Xaa Val Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 203

<211> 174

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (154)..(154)

<223> 除缬氨酸外的任何氨基酸

<400> 203

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

1 5 10 15

Ala Gln Asn Val Leu Leu Ile Gly Gly Pro Leu Ser Trp Tyr Ser Asp

20 25 30

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

35 40 45

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

50 55 60

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser

65 70 75 80

Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala

85 90 95

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala

100 105 110

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala

115 120 125

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His

130 135 140

Ala Trp Gln Leu Thr Gln Gly Ala Thr Xaa Leu Gly Leu Phe Arg Val

145 150 155 160

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu

165 170

<210> 204

<211> 227

<212> PRT

<213> 智人

<400> 204

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly

1 5 10 15

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

20 25 30

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

35 40 45

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

50 55 60

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

65 70 75 80

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

85 90 95

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

100 105 110

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

115 120 125

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

130 135 140

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

145 150 155 160

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

165 170 175

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

180 185 190

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

195 200 205

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

210 215 220

Pro Gly Lys

225

<210> 205

<211> 325

<212> PRT

<213> 智人

<400> 205

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser

1 5 10 15

Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

20 25 30

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

35 40 45

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

50 55 60

Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr

65 70 75 80

Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr

85 90 95

Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro

100 105 110

Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr

115 120 125

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val

130 135 140

Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val

145 150 155 160

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser

165 170 175

Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu

180 185 190

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala

195 200 205

Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro

210 215 220

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln

225 230 235 240

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala

245 250 255

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr

260 265 270

Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu

275 280 285

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser

290 295 300

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser

305 310 315 320

Leu Ser Pro Gly Lys

325

<210> 206

<211> 246

<212> PRT

<213> 智人

<400> 206

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr

1 5 10 15

Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu

20 25 30

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp

35 40 45

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp

50 55 60

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly

65 70 75 80

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn

85 90 95

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp

100 105 110

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro

115 120 125

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu

130 135 140

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn

145 150 155 160

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile

165 170 175

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr

180 185 190

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys

195 200 205

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys

210 215 220

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu

225 230 235 240

Ser Leu Ser Pro Gly Lys

245

<210> 207

<211> 383

<212> PRT

<213> 智人

<400> 207

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His

1 5 10 15

Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr

20 25 30

His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln

35 40 45

Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met

50 55 60

Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu

65 70 75 80

Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile

85 90 95

Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr

100 105 110

Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro

115 120 125

Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu

130 135 140

Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys

145 150 155 160

Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val

165 170 175

Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val

180 185 190

Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys

195 200 205

Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn

210 215 220

Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp

225 230 235 240

Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro

245 250 255

Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val

260 265 270

Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala

275 280 285

Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu

290 295 300

Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala

305 310 315 320

Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp

325 330 335

Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr

340 345 350

Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser

355 360 365

Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys

370 375 380

<210> 208

<211> 276

<212> PRT

<213> 智人

<400> 208

Val Thr Ser Thr Leu Thr Ile Lys Glx Ser Asp Trp Leu Gly Glu Ser

1 5 10 15

Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn

20 25 30

Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe

35 40 45

Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys

50 55 60

Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asx Ser Val Thr Ile

65 70 75 80

Ser Trp Thr Arg Glu Glu Asn Gly Ala Val Lys Thr His Thr Asn Ile

85 90 95

Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser

100 105 110

Ile Cys Glu Asp Asx Asp Trp Ser Gly Glu Arg Phe Thr Cys Thr Val

115 120 125

Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro

130 135 140

Lys Gly Val Ala Leu His Arg Pro Asx Val Tyr Leu Leu Pro Pro Ala

145 150 155 160

Arg Glx Glx Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val

165 170 175

Thr Gly Phe Ser Pro Ala Asp Val Phe Val Glu Trp Met Gln Arg Gly

180 185 190

Glu Pro Leu Ser Pro Gln Lys Tyr Val Thr Ser Ala Pro Met Pro Glu

195 200 205

Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser

210 215 220

Glu Glu Glu Trp Asn Thr Gly Gly Thr Tyr Thr Cys Val Val Ala His

225 230 235 240

Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr

245 250 255

Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala

260 265 270

Gly Thr Cys Tyr

275

<210> 209

<211> 353

<212> PRT

<213> 智人

<400> 209

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr

1 5 10 15

Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe

20 25 30

Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val

35 40 45

Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr

50 55 60

Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly

65 70 75 80

Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp

85 90 95

Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro

100 105 110

Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser

115 120 125

Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn

130 135 140

Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe

145 150 155 160

Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu

165 170 175

Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys

180 185 190

Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr

195 200 205

Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn

210 215 220

Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu

225 230 235 240

Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser

245 250 255

Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro

260 265 270

Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly

275 280 285

Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp

290 295 300

Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu

305 310 315 320

Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro

325 330 335

Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys

340 345 350

Tyr

<210> 210

<211> 222

<212> PRT

<213> 智人

<400> 210

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser

1 5 10 15

Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr

20 25 30

Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr

35 40 45

Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu

50 55 60

Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val

65 70 75 80

Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr

85 90 95

His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser

100 105 110

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp

115 120 125

Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe

130 135 140

Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu

145 150 155 160

Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser

165 170 175

Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu

180 185 190

Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro

195 200 205

Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys

210 215 220

<210> 211

<211> 327

<212> PRT

<213> 智人

<400> 211

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg

1 5 10 15

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr

20 25 30

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser

35 40 45

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser

50 55 60

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr

65 70 75 80

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys

85 90 95

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro

100 105 110

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

115 120 125

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

130 135 140

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp

145 150 155 160

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe

165 170 175

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

180 185 190

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu

195 200 205

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

210 215 220

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys

225 230 235 240

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

245 250 255

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

260 265 270

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

275 280 285

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser

290 295 300

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

305 310 315 320

Leu Ser Leu Ser Leu Gly Lys

325

<210> 212

<211> 227

<212> PRT

<213> 智人

<400> 212

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly

1 5 10 15

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

20 25 30

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

35 40 45

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

50 55 60

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

65 70 75 80

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

85 90 95

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

100 105 110

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

115 120 125

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser

130 135 140

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

145 150 155 160

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

165 170 175

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

180 185 190

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

195 200 205

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

210 215 220

Pro Gly Lys

225

<210> 213

<211> 227

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 213

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly

1 5 10 15

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

20 25 30

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

35 40 45

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

50 55 60

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

65 70 75 80

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

85 90 95

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile

100 105 110

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

115 120 125

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser

130 135 140

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

145 150 155 160

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

165 170 175

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

180 185 190

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

195 200 205

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

210 215 220

Pro Gly Lys

225

<210> 214

<211> 227

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 214

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly

1 5 10 15

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

20 25 30

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

35 40 45

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

50 55 60

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

65 70 75 80

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

85 90 95

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

100 105 110

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

115 120 125

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser

130 135 140

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

145 150 155 160

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

165 170 175

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

180 185 190

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

195 200 205

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

210 215 220

Pro Gly Lys

225

<210> 215

<211> 227

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 215

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

1 5 10 15

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

20 25 30

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

35 40 45

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

50 55 60

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

65 70 75 80

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

85 90 95

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

100 105 110

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

115 120 125

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser

130 135 140

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

145 150 155 160

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

165 170 175

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

180 185 190

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

195 200 205

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

210 215 220

Pro Gly Lys

225

<210> 216

<211> 365

<212> PRT

<213> 智人

<400> 216

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala

1 5 10 15

Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln

85 90 95

Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly

115 120 125

Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala

165 170 175

Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro

195 200 205

Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro

290 295 300

Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala

305 310 315 320

Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser

325 330 335

Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val

355 360 365

<210> 217

<211> 362

<212> PRT

<213> 智人

<400> 217

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala

1 5 10 15

Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln

85 90 95

Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly

115 120 125

Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu

165 170 175

Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro

195 200 205

Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser

290 295 300

Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val

305 310 315 320

Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser

325 330 335

Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Val Ser Leu Thr Ala

355 360

<210> 218

<211> 366

<212> PRT

<213> 智人

<400> 218

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly

1 5 10 15

Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe

20 25 30

Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln

85 90 95

Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly

115 120 125

Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala

165 170 175

Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro

195 200 205

Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu

275 280 285

Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro

290 295 300

Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val

305 310 315 320

Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys

325 330 335

Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn

340 345 350

Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala

355 360 365

<210> 219

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 219

Gly Thr Leu Arg Gly

1 5

<210> 220

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 220

Tyr Asn Gln Ser Glu

1 5

<210> 221

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 221

Thr Ala Ala Asp Met

1 5

<210> 222

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 222

Ala Gln Thr Thr Lys

1 5

<210> 223

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 223

Val Glu Thr Arg Pro

1 5

<210> 224

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 224

Gly Asp Gly Thr Phe

1 5

<210> 225

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 225

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 226

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 226

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 227

<211> 275

<212> PRT

<213> 智人

<400> 227

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 228

<211> 275

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 228

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 229

<211> 276

<212> PRT

<213> 智人

<400> 229

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 230

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 230

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 231

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 231

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Cys Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 232

<211> 276

<212> PRT

<213> 智人

<400> 232

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu Pro

275

<210> 233

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 233

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu Pro

275

<210> 234

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 234

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Cys Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu Pro

275

<210> 235

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 235

Gly Cys Gly Gly Ser

1 5

<210> 236

<211> 20

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 236

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

1 5 10 15

Gly Gly Gly Ser

20

<210> 237

<211> 15

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 237

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

1 5 10 15

<210> 238

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 238

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val

1 5 10

<210> 239

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 239

Gly Leu Ser Arg Tyr Val Ala Arg Leu Gly

1 5 10

<210> 240

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 240

Lys Leu His Leu Tyr Ser His Pro Ile

1 5

<210> 241

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 241

Phe Leu Leu Ser Leu Gly Ile His Leu

1 5

<210> 242

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 242

Ala Leu Met Pro Leu Tyr Ala Cys Ile

1 5

<210> 243

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 243

Ser Leu Tyr Ala Asp Ser Pro Ser Val

1 5

<210> 244

<211> 1587

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 244

atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60

ggctctcact ccatgaggta tttcttcaca tccgtgtccc ggcccggccg cggggagccc 120

cgcttcatcg cagtgggcta cgtggacgac acgcagttcg tgcggttcga cagcgacgcc 180

gcgagccaga ggatggagcc gcgggcgccg tggatagagc aggagggtcc ggagtattgg 240

gacggggaga cacggaaagt gaaggcccac tcacagactc accgagtgga cctggggacc 300

ctgcgcggcg cctacaacca gagcgaggcc ggttctcaca ccgtccagag gatgtatggc 360

tgcgacgtgg ggtcggactg gcgcttcctc cgcgggtacc accagtacgc ctacgacggc 420

aaggattaca tcgccctgaa agaggacctg cgctcttgga ccgcggcgga catggcagct 480

cagaccacca agcacaagtg ggaggcggcc catgtggcgg agcagttgag agcctacctg 540

gagggcacgt gcgtggagtg gctccgcaga tacctggaga acgggaagga gacgctgcag 600

cgcacggacg cccccaaaac gcatatgact caccacgctg tctctgacca tgaagccacc 660

ctgaggtgct gggccctgag cttctaccct gcggagatca cactgacctg gcagcgggat 720

ggggaggacc agacccagga cacggagctc gtggagacca ggccttgcgg ggatggaacc 780

ttccagaagt gggcggctgt ggtggtgcct tctggacagg agcagagata cacctgccat 840

gtgcagcatg agggtttgcc caagcccctc accctgagat gggaggcagc tgcgggtggc 900

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgccggggg accgtcagtc 960

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1020

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1080

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1140

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1200

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1260

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 1320

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1380

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1440

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcagatg gcagcagggg 1500

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagtcc 1560

ctctccctgt ctccgggtaa atagtga 1587

<210> 245

<211> 507

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 245

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro

275 280 285

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

290 295 300

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

305 310 315 320

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

325 330 335

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

340 345 350

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

355 360 365

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser

370 375 380

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

385 390 395 400

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu

405 410 415

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe

420 425 430

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

435 440 445

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

450 455 460

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

465 470 475 480

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

485 490 495

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

500 505

<210> 246

<211> 1587

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 246

atgtatcgca tgcaactgct gagctgcatt gcactctctc tggcactcgt caccaattcc 60

ggctctcact ccatgaggta tttcttcaca tccgtgtccc ggcccggccg cggggagccc 120

cgcttcatcg cagtgggcta cgtggacgac acgcagttcg tgcggttcga cagcgacgcc 180

gcgagccaga ggatggagcc gcgggcgccg tggatagagc aggagggtcc ggagtattgg 240

gacggggaga cacggaaagt gaaggcccac tcacagactc accgagtgga cctggggacc 300

ctgcgcggct gctacaacca gagcgaggcc ggttctcaca ccgtccagag gatgtatggc 360

tgcgacgtgg ggtcggactg gcgcttcctc cgcgggtacc accagtacgc ctacgacggc 420

aaggattaca tcgccctgaa agaggacctg cgctcttgga ccgcggcgga catggcagct 480

cagaccacca agcacaagtg ggaggcggcc catgtggcgg agcagttgag agcctacctg 540

gagggcacgt gcgtggagtg gctccgcaga tacctggaga acgggaagga gacgctgcag 600

cgcacggacg cccccaaaac gcatatgact caccacgctg tctctgacca tgaagccacc 660

ctgaggtgct gggccctgag cttctaccct gcggagatca cactgacctg gcagcgggat 720

ggggaggacc agacccagga cacggagctc gtggagacca ggccttgcgg ggatggaacc 780

ttccagaagt gggcggctgt ggtggtgcct tctggacagg agcagagata cacctgccat 840

gtgcagcatg agggtttgcc caagcccctc accctgagat gggaggcagc tgcgggtggc 900

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgccggggg accgtcagtc 960

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1020

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1080

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1140

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1200

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1260

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 1320

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1380

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1440

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcagatg gcagcagggg 1500

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagtcc 1560

ctctccctgt ctccgggtaa atagtga 1587

<210> 247

<211> 507

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 247

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro

275 280 285

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

290 295 300

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

305 310 315 320

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

325 330 335

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

340 345 350

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

355 360 365

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser

370 375 380

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

385 390 395 400

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu

405 410 415

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe

420 425 430

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

435 440 445

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

450 455 460

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

465 470 475 480

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

485 490 495

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

500 505

<210> 248

<211> 438

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 248

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgccct ccgacttctt cccctccgtg ggtggaggtg gttctggagg aggcggttcg 120

ggcggaggtg gtagtatcca gcgtactcca aagattcagg tttactcatg ccatccagca 180

gagaatggaa agtcaaattt cctgaattgc tatgtgtctg ggtttcatcc atccgacatt 240

gaagttgact tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct 300

ttcagcaagg actggtcttt ctatctcttg tattatactg aattcacccc cactgaaaaa 360

gatgagtatg cctgccgtgt gaaccacgtg actttgtcac agcccaagat agttaagtgg 420

gatcgagaca tgtagtga 438

<210> 249

<211> 124

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 249

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Gly Gly Gly Gly Ser Gly

1 5 10 15

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile

20 25 30

Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu

35 40 45

Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu

50 55 60

Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser

65 70 75 80

Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr

85 90 95

Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu

100 105 110

Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 250

<211> 438

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 250

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgccct ccgacttctt cccctccgtg ggttgcggtg gttctggagg aggcggttcg 120

ggcggaggtg gtagtatcca gcgtactcca aagattcagg tttactcatg ccatccagca 180

gagaatggaa agtcaaattt cctgaattgc tatgtgtctg ggtttcatcc atccgacatt 240

gaagttgact tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct 300

ttcagcaagg actggtcttt ctatctcttg tattatactg aattcacccc cactgaaaaa 360

gatgagtatg cctgccgtgt gaaccacgtg actttgtcac agcccaagat agttaagtgg 420

gatcgagaca tgtagtga 438

<210> 251

<211> 124

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 251

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Gly Cys Gly Gly Ser Gly

1 5 10 15

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile

20 25 30

Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu

35 40 45

Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu

50 55 60

Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser

65 70 75 80

Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr

85 90 95

Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu

100 105 110

Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 252

<211> 2505

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 252

atgtatcgca tgcaactgct gagctgcatt gcactctctc tggcactcgt caccaattcc 60

gcccctactt ccagctccac caagaagacg cagcttcagc tggaagcact gctgctcgat 120

ctgcagatga tactgaatgg cattaacaac tacaaaaacc ccaagctcac tcgcatgctg 180

accgctaaat tctacatgcc caagaaggct acggaactga agcacctgca gtgccttgag 240

gaggaactca agccactcga ggaggtgctg aacctggcac agtcaaagaa ctttcacctg 300

cggccaagag acctgatttc gaacatcaac gtgattgtgc tggaattgaa gggctcagaa 360

actacgttca tgtgcgagta cgccgacgaa actgctacta tcgtggagtt cttgaaccgc 420

tggatcacgt tctgccagag cattatttca actcttaccg gtggaggtgg ttctggaggt 480

ggtggatcag gaggaggtgg ctccgggggt ggaggtagcg ctcccacgtc atcctccact 540

aaaaagaccc agctgcaact cgaggcactg ttgctggacc tccagatgat tctgaacgga 600

atcaacaact ataagaaccc gaagctgact agaatgttga ctgccaaatt ttatatgcca 660

aagaaggcaa ctgagttgaa gcatctgcaa tgcctggaag aggagctgaa gccactggaa 720

gaggtgctta acctcgctca gtccaagaac ttccatctgc gcccacggga ccttatctcc 780

aacattaacg tgatcgtgct ggaactgaag ggatccgaaa ccacttttat gtgcgaatac 840

gctgacgaaa ccgccactat cgtcgagttc ctgaacaggt ggatcacctt ctgccagtcc 900

attatctcca ccctcaccgg aggaggagga tccggtggtg gaggctcggg tggaggaggc 960

tcaggaggag gcggaagcgg ctctcactcc atgaggtatt tcttcacatc cgtgtcccgg 1020

cccggccgcg gggagccccg cttcatcgca gtgggctacg tggacgacac gcagttcgtg 1080

cggttcgaca gcgacgccgc gagccagagg atggagccgc gggcgccgtg gatagagcag 1140

gagggtccgg agtattggga cggggagaca cggaaagtga aggcccactc acagactcac 1200

cgagtggacc tggggaccct gcgcggcgcc tacaaccaga gcgaggccgg ttctcacacc 1260

gtccagagga tgtatggctg cgacgtgggg tcggactggc gcttcctccg cgggtaccac 1320

cagtacgcct acgacggcaa ggattacatc gccctgaaag aggacctgcg ctcttggacc 1380

gcggcggaca tggcagctca gaccaccaag cacaagtggg aggcggccca tgtggcggag 1440

cagttgagag cctacctgga gggcacgtgc gtggagtggc tccgcagata cctggagaac 1500

gggaaggaga cgctgcagcg cacggacgcc cccaaaacgc atatgactca ccacgctgtc 1560

tctgaccatg aagccaccct gaggtgctgg gccctgagct tctaccctgc ggagatcaca 1620

ctgacctggc agcgggatgg ggaggaccag acccaggaca cggagctcgt ggagaccagg 1680

ccttgcgggg atggaacctt ccagaagtgg gcggctgtgg tggtgccttc tggacaggag 1740

cagagataca cctgccatgt gcagcatgag ggtttgccca agcccctcac cctgagatgg 1800

gaggcagctg cgggtggcga caaaactcac acatgcccac cgtgcccagc acctgaagcc 1860

gccgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 1920

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 1980

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 2040

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 2100

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa 2160

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 2220

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 2280

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 2340

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 2400

agcagatggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac 2460

cactacacgc agaagtccct ctccctgtct ccgggtaaat agtga 2505

<210> 253

<211> 813

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 253

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

130 135 140

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr

145 150 155 160

Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met

165 170 175

Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met

180 185 190

Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His

195 200 205

Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn

210 215 220

Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser

225 230 235 240

Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe

245 250 255

Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn

260 265 270

Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly

275 280 285

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

290 295 300

Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg

305 310 315 320

Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp

325 330 335

Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu

340 345 350

Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly

355 360 365

Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu

370 375 380

Gly Thr Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr

385 390 395 400

Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu

405 410 415

Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu

420 425 430

Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr

435 440 445

Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala

450 455 460

Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn

465 470 475 480

Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr

485 490 495

His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu

500 505 510

Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu

515 520 525

Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp

530 535 540

Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu

545 550 555 560

Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu

565 570 575

Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys

580 585 590

Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu

595 600 605

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu

610 615 620

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys

625 630 635 640

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys

645 650 655

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu

660 665 670

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys

675 680 685

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys

690 695 700

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser

705 710 715 720

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys

725 730 735

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln

740 745 750

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly

755 760 765

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln

770 775 780

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn

785 790 795 800

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

805 810

<210> 254

<211> 2505

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 254

atgtatcgca tgcaactgct gagctgcatt gcactctctc tggcactcgt caccaattcc 60

gcccctactt ccagctccac caagaagacg cagcttcagc tggaagcact gctgctcgat 120

ctgcagatga tactgaatgg cattaacaac tacaaaaacc ccaagctcac tcgcatgctg 180

accgctaaat tctacatgcc caagaaggct acggaactga agcacctgca gtgccttgag 240

gaggaactca agccactcga ggaggtgctg aacctggcac agtcaaagaa ctttcacctg 300

cggccaagag acctgatttc gaacatcaac gtgattgtgc tggaattgaa gggctcagaa 360

actacgttca tgtgcgagta cgccgacgaa actgctacta tcgtggagtt cttgaaccgc 420

tggatcacgt tctgccagag cattatttca actcttaccg gtggaggtgg ttctggaggt 480

ggtggatcag gaggaggtgg ctccgggggt ggaggtagcg ctcccacgtc atcctccact 540

aaaaagaccc agctgcaact cgaggcactg ttgctggacc tccagatgat tctgaacgga 600

atcaacaact ataagaaccc gaagctgact agaatgttga ctgccaaatt ttatatgcca 660

aagaaggcaa ctgagttgaa gcatctgcaa tgcctggaag aggagctgaa gccactggaa 720

gaggtgctta acctcgctca gtccaagaac ttccatctgc gcccacggga ccttatctcc 780

aacattaacg tgatcgtgct ggaactgaag ggatccgaaa ccacttttat gtgcgaatac 840

gctgacgaaa ccgccactat cgtcgagttc ctgaacaggt ggatcacctt ctgccagtcc 900

attatctcca ccctcaccgg aggaggagga tccggtggtg gaggctcggg tggaggaggc 960

tcaggaggag gcggaagcgg ctctcactcc atgaggtatt tcttcacatc cgtgtcccgg 1020

cccggccgcg gggagccccg cttcatcgca gtgggctacg tggacgacac gcagttcgtg 1080

cggttcgaca gcgacgccgc gagccagagg atggagccgc gggcgccgtg gatagagcag 1140

gagggtccgg agtattggga cggggagaca cggaaagtga aggcccactc acagactcac 1200

cgagtggacc tggggaccct gcgcggctgc tacaaccaga gcgaggccgg ttctcacacc 1260

gtccagagga tgtatggctg cgacgtgggg tcggactggc gcttcctccg cgggtaccac 1320

cagtacgcct acgacggcaa ggattacatc gccctgaaag aggacctgcg ctcttggacc 1380

gcggcggaca tggcagctca gaccaccaag cacaagtggg aggcggccca tgtggcggag 1440

cagttgagag cctacctgga gggcacgtgc gtggagtggc tccgcagata cctggagaac 1500

gggaaggaga cgctgcagcg cacggacgcc cccaaaacgc atatgactca ccacgctgtc 1560

tctgaccatg aagccaccct gaggtgctgg gccctgagct tctaccctgc ggagatcaca 1620

ctgacctggc agcgggatgg ggaggaccag acccaggaca cggagctcgt ggagaccagg 1680

ccttgcgggg atggaacctt ccagaagtgg gcggctgtgg tggtgccttc tggacaggag 1740

cagagataca cctgccatgt gcagcatgag ggtttgccca agcccctcac cctgagatgg 1800

gaggcagctg cgggtggcga caaaactcac acatgcccac cgtgcccagc acctgaagcc 1860

gccgggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 1920

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 1980

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 2040

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 2100

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa 2160

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 2220

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 2280

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 2340

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 2400

agcagatggc agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac 2460

cactacacgc agaagtccct ctccctgtct ccgggtaaat agtga 2505

<210> 255

<211> 813

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 255

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala

1 5 10 15

Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys

20 25 30

Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys

35 40 45

Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys

50 55 60

Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu

65 70 75 80

Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu

85 90 95

Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala

100 105 110

Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile

115 120 125

Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

130 135 140

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr

145 150 155 160

Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met

165 170 175

Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met

180 185 190

Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His

195 200 205

Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn

210 215 220

Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser

225 230 235 240

Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe

245 250 255

Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn

260 265 270

Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly

275 280 285

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

290 295 300

Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg

305 310 315 320

Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp

325 330 335

Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu

340 345 350

Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly

355 360 365

Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu

370 375 380

Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr

385 390 395 400

Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu

405 410 415

Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu

420 425 430

Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr

435 440 445

Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala

450 455 460

Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn

465 470 475 480

Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr

485 490 495

His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu

500 505 510

Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu

515 520 525

Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp

530 535 540

Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu

545 550 555 560

Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu

565 570 575

Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys

580 585 590

Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu

595 600 605

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu

610 615 620

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys

625 630 635 640

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys

645 650 655

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu

660 665 670

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys

675 680 685

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys

690 695 700

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser

705 710 715 720

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys

725 730 735

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln

740 745 750

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly

755 760 765

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln

770 775 780

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn

785 790 795 800

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

805 810

<210> 256

<211> 2271

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 256

atgtatcgca tgcaactgct gagctgcatt gcactctctc tggcactcgt caccaattcc 60

gttatccacg tgaccaagga agtgaaagaa gtggcaacgc tgtcctgtgg tcacaatgtt 120

tctgttgaag agctggcaca aactcgcatc tactggcaaa aggagaagaa aatggtgctg 180

actatgatgt ctggggacat gaatatatgg cccgagtaca agaaccggac catctttgat 240

atcactaata acctctccat tgtgatcctg gctctgcgcc catctgacga gggcacatac 300

gagtgtgttg ttctggccta tgaaaaagac gctttcaagc gggaacacct ggctgaagtg 360

acgttatcag tcaaagctga cttccctaca cctagtatat ctgactttga aattccaact 420

tctaatatta gaaggataat ttgctcaacc tctggaggtt ttccagagcc tcacctctcc 480

tggttggaaa atggagaaga attaaatgcc atcaacacaa cagtttccca agatcctgaa 540

actgagctct atgctgttag cagcaaactg gatttcaata tgacaaccaa ccacagcttc 600

atgtgtctca tcaagtatgg acatttaaga gtgaatcaga ccttcaactg gaatacaacc 660

aagcaagagc attttcctga taacggagga ggaggatccg gtggtggagg ctcgggtgga 720

ggaggctcag gaggaggcgg aagcggctct cactccatga ggtatttctt cacatccgtg 780

tcccggcccg gccgcgggga gccccgcttc atcgcagtgg gctacgtgga cgacacgcag 840

ttcgtgcggt tcgacagcga cgccgcgagc cagaggatgg agccgcgggc gccgtggata 900

gagcaggagg gtccggagta ttgggacggg gagacacgga aagtgaaggc ccactcacag 960

actcaccgag tggacctggg gaccctgcgc ggcgcctaca accagagcga ggccggttct 1020

cacaccgtcc agaggatgta tggctgcgac gtggggtcgg actggcgctt cctccgcggg 1080

taccaccagt acgcctacga cggcaaggat tacatcgccc tgaaagagga cctgcgctct 1140

tggaccgcgg cggacatggc agctcagacc accaagcaca agtgggaggc ggcccatgtg 1200

gcggagcagt tgagagccta cctggagggc acgtgcgtgg agtggctccg cagatacctg 1260

gagaacggga aggagacgct gcagcgcacg gacgccccca aaacgcatat gactcaccac 1320

gctgtctctg accatgaagc caccctgagg tgctgggccc tgagcttcta ccctgcggag 1380

atcacactga cctggcagcg ggatggggag gaccagaccc aggacacgga gctcgtggag 1440

accaggcctt gcggggatgg aaccttccag aagtgggcgg ctgtggtggt gccttctgga 1500

caggagcaga gatacacctg ccatgtgcag catgagggtt tgcccaagcc cctcaccctg 1560

agatgggagg cagctgcggg tggcgacaaa actcacacat gcccaccgtg cccagcacct 1620

gaagccgccg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 1680

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 1740

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 1800

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1860

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 1920

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1980

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 2040

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 2100

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 2160

gacaagagca gatggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg 2220

cacaaccact acacgcagaa gtccctctcc ctgtctccgg gtaaatagtg a 2271

<210> 257

<211> 735

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 257

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

210 215 220

Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val

225 230 235 240

Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val

245 250 255

Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg

260 265 270

Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp

275 280 285

Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val

290 295 300

Asp Leu Gly Thr Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser

305 310 315 320

His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg

325 330 335

Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile

340 345 350

Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala

355 360 365

Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu

370 375 380

Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu

385 390 395 400

Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His

405 410 415

Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp

420 425 430

Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp

435 440 445

Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys

450 455 460

Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly

465 470 475 480

Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys

485 490 495

Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His

500 505 510

Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val

515 520 525

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr

530 535 540

Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu

545 550 555 560

Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys

565 570 575

Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser

580 585 590

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys

595 600 605

Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile

610 615 620

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro

625 630 635 640

Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu

645 650 655

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn

660 665 670

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser

675 680 685

Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg

690 695 700

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu

705 710 715 720

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

725 730 735

<210> 258

<211> 2271

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 258

atgtatcgca tgcaactgct gagctgcatt gcactctctc tggcactcgt caccaattcc 60

gttatccacg tgaccaagga agtgaaagaa gtggcaacgc tgtcctgtgg tcacaatgtt 120

tctgttgaag agctggcaca aactcgcatc tactggcaaa aggagaagaa aatggtgctg 180

actatgatgt ctggggacat gaatatatgg cccgagtaca agaaccggac catctttgat 240

atcactaata acctctccat tgtgatcctg gctctgcgcc catctgacga gggcacatac 300

gagtgtgttg ttctggccta tgaaaaagac gctttcaagc gggaacacct ggctgaagtg 360

acgttatcag tcaaagctga cttccctaca cctagtatat ctgactttga aattccaact 420

tctaatatta gaaggataat ttgctcaacc tctggaggtt ttccagagcc tcacctctcc 480

tggttggaaa atggagaaga attaaatgcc atcaacacaa cagtttccca agatcctgaa 540

actgagctct atgctgttag cagcaaactg gatttcaata tgacaaccaa ccacagcttc 600

atgtgtctca tcaagtatgg acatttaaga gtgaatcaga ccttcaactg gaatacaacc 660

aagcaagagc attttcctga taacggagga ggaggatccg gtggtggagg ctcgggtgga 720

ggaggctcag gaggaggcgg aagcggctct cactccatga ggtatttctt cacatccgtg 780

tcccggcccg gccgcgggga gccccgcttc atcgcagtgg gctacgtgga cgacacgcag 840

ttcgtgcggt tcgacagcga cgccgcgagc cagaggatgg agccgcgggc gccgtggata 900

gagcaggagg gtccggagta ttgggacggg gagacacgga aagtgaaggc ccactcacag 960

actcaccgag tggacctggg gaccctgcgc ggctgctaca accagagcga ggccggttct 1020

cacaccgtcc agaggatgta tggctgcgac gtggggtcgg actggcgctt cctccgcggg 1080

taccaccagt acgcctacga cggcaaggat tacatcgccc tgaaagagga cctgcgctct 1140

tggaccgcgg cggacatggc agctcagacc accaagcaca agtgggaggc ggcccatgtg 1200

gcggagcagt tgagagccta cctggagggc acgtgcgtgg agtggctccg cagatacctg 1260

gagaacggga aggagacgct gcagcgcacg gacgccccca aaacgcatat gactcaccac 1320

gctgtctctg accatgaagc caccctgagg tgctgggccc tgagcttcta ccctgcggag 1380

atcacactga cctggcagcg ggatggggag gaccagaccc aggacacgga gctcgtggag 1440

accaggcctt gcggggatgg aaccttccag aagtgggcgg ctgtggtggt gccttctgga 1500

caggagcaga gatacacctg ccatgtgcag catgagggtt tgcccaagcc cctcaccctg 1560

agatgggagg cagctgcggg tggcgacaaa actcacacat gcccaccgtg cccagcacct 1620

gaagccgccg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 1680

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 1740

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 1800

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1860

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 1920

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1980

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 2040

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 2100

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 2160

gacaagagca gatggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg 2220

cacaaccact acacgcagaa gtccctctcc ctgtctccgg gtaaatagtg a 2271

<210> 259

<211> 735

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 259

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys

1 5 10 15

Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp

20 25 30

Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn

35 40 45

Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn

50 55 60

Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr

65 70 75 80

Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe Lys Arg Glu His

85 90 95

Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser

100 105 110

Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys

115 120 125

Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn

130 135 140

Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu

145 150 155 160

Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr

165 170 175

Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn

180 185 190

Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn

195 200 205

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

210 215 220

Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val

225 230 235 240

Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val

245 250 255

Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg

260 265 270

Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp

275 280 285

Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val

290 295 300

Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser

305 310 315 320

His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg

325 330 335

Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile

340 345 350

Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala

355 360 365

Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu

370 375 380

Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu

385 390 395 400

Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His

405 410 415

Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp

420 425 430

Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp

435 440 445

Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys

450 455 460

Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly

465 470 475 480

Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys

485 490 495

Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His

500 505 510

Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val

515 520 525

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr

530 535 540

Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu

545 550 555 560

Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys

565 570 575

Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser

580 585 590

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys

595 600 605

Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile

610 615 620

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro

625 630 635 640

Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu

645 650 655

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn

660 665 670

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser

675 680 685

Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg

690 695 700

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu

705 710 715 720

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

725 730 735

<210> 260

<211> 2169

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 260

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgccct ccgacttctt cccctccgtg ggtggaggtg gttctggagg aggcggttcg 120

ggcggaggtg gtagtatcca gcgtactcca aagattcagg tttactcatg ccatccagca 180

gagaatggaa agtcaaattt cctgaattgc tatgtgtctg ggtttcatcc atccgacatt 240

gaagttgact tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct 300

ttcagcaagg actggtcttt ctatctcttg tattatactg aattcacccc cactgaaaaa 360

gatgagtatg cctgccgtgt gaaccacgtg actttgtcac agcccaagat agttaagtgg 420

gatcgagaca tgggtggcgg ggggtccgga ggaggtggat ccggcggagg gggatctggc 480

ggaggcggat caggaggtgg cggctctgac cctgcaggcc tgctggatct gcggcagggc 540

atgttcgcac aactcgtggc ccagaacgtg ctgctgatcg atggaccgct gtcctggtac 600

tccgacccgg gacttgccgg agtgtcactg actggaggat tgtcctacgc cgaagatacg 660

aaggagctcg tcgtggcgaa ggccggagtg tactatgtgt tcttccagct cgaactccgg 720

agagtcgtgg ccggggaagg ctccggctcc gtgtcacttg ccctgcacct ccagccactt 780

cggtcggccg ctggagccgc cgcactggcc ctgaccgtcg acctccctcc tgcgtcctcc 840

gaggctcgca actcggcctt cggattccaa gggcgccttc tgcacctgtc cgcgggacag 900

aggctggggg tgcatctgca tactgaagcg cgggcacggc atgcttggca gctgactcag 960

ggagcaactg tcctgggtct gttccgcgtg actccggaaa tccccgccgg tggaggtggc 1020

tcaggaggcg gcggcagcgg tggaggaggg agcggaggag gcggatccgg tggaggcgga 1080

agcgaccctg ccggactcct ggatctgcgg cagggcatgt tcgcccagtt ggtggcgcag 1140

aacgtcctgc tcattgacgg gccgctgtcg tggtacagcg atccgggctt ggccggagtc 1200

tcgctgaccg gaggactcag ctacgccgaa gataccaagg agctggtcgt ggccaaggcc 1260

ggagtgtact acgtgttctt ccaactggaa ctgcgccggg tggtggctgg cgaaggatcc 1320

gggtcggtgt ccctggccct gcatctgcag cctctgcgct cagccgcagg agcagccgcc 1380

ttggcgctca ccgtggacct tccgcccgcc tcctcggaag cccggaacag cgccttcggc 1440

ttccaaggca gactcctgca cttgagcgcg ggccagagac tgggagtgca cctccacacc 1500

gaagcgcgcg caaggcacgc ctggcagctc acccagggag ccaccgtgct gggcttgttt 1560

cgagtcaccc ccgagatccc agccggcgga ggaggttccg gtggcggtgg atcaggcggt 1620

ggaggctcgg gtggaggggg tagcggaggg ggtggttccg accccgcagg actgctggac 1680

ctccggcagg ggatgttcgc gcaactggtg gctcagaatg tcctgctgat tgacggcccc 1740

ctgtcgtggt actcggaccc tggccttgcc ggcgtgtcct tgactggagg gctgtcgtac 1800

gccgaggaca ctaaggagct ggtcgtggcc aaagccggcg tgtactacgt gttctttcag 1860

ctggaactga ggagagtggt ggcgggagaa ggcagcggct cagtgtccct cgccctgcac 1920

cttcaaccac tccgctctgc cgctggtgca gctgcgctcg ccctcactgt ggatcttcca 1980

ccggcaagct ccgaggccag aaactccgcc ttcgggttcc aggggaggct gctgcatctc 2040

tccgccggcc agagactggg cgtgcacttg cacactgagg ctagggctcg ccatgcctgg 2100

cagctgaccc agggcgccac tgtgctggga ctgttccggg tgaccccaga aatcccggcc 2160

tcctagtga 2169

<210> 261

<211> 701

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 261

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Gly Gly Gly Gly Ser Gly

1 5 10 15

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile

20 25 30

Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu

35 40 45

Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu

50 55 60

Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser

65 70 75 80

Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr

85 90 95

Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu

100 105 110

Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

130 135 140

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

145 150 155 160

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

165 170 175

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

180 185 190

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

195 200 205

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

210 215 220

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

225 230 235 240

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

245 250 255

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

260 265 270

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

275 280 285

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

290 295 300

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly Gly

305 310 315 320

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

325 330 335

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

340 345 350

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

355 360 365

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

370 375 380

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

385 390 395 400

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

405 410 415

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

420 425 430

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

435 440 445

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

450 455 460

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

465 470 475 480

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

485 490 495

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly Gly

500 505 510

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

515 520 525

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

530 535 540

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

545 550 555 560

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

565 570 575

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

580 585 590

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

595 600 605

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

610 615 620

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

625 630 635 640

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

645 650 655

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

660 665 670

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

675 680 685

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser

690 695 700

<210> 262

<211> 2169

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 262

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgccct ccgacttctt cccctccgtg ggttgcggtg gttctggagg aggcggttcg 120

ggcggaggtg gtagtatcca gcgtactcca aagattcagg tttactcatg ccatccagca 180

gagaatggaa agtcaaattt cctgaattgc tatgtgtctg ggtttcatcc atccgacatt 240

gaagttgact tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct 300

ttcagcaagg actggtcttt ctatctcttg tattatactg aattcacccc cactgaaaaa 360

gatgagtatg cctgccgtgt gaaccacgtg actttgtcac agcccaagat agttaagtgg 420

gatcgagaca tgggtggcgg ggggtccgga ggaggtggat ccggcggagg gggatctggc 480

ggaggcggat caggaggtgg cggctctgac cctgcaggcc tgctggatct gcggcagggc 540

atgttcgcac aactcgtggc ccagaacgtg ctgctgatcg atggaccgct gtcctggtac 600

tccgacccgg gacttgccgg agtgtcactg actggaggat tgtcctacgc cgaagatacg 660

aaggagctcg tcgtggcgaa ggccggagtg tactatgtgt tcttccagct cgaactccgg 720

agagtcgtgg ccggggaagg ctccggctcc gtgtcacttg ccctgcacct ccagccactt 780

cggtcggccg ctggagccgc cgcactggcc ctgaccgtcg acctccctcc tgcgtcctcc 840

gaggctcgca actcggcctt cggattccaa gggcgccttc tgcacctgtc cgcgggacag 900

aggctggggg tgcatctgca tactgaagcg cgggcacggc atgcttggca gctgactcag 960

ggagcaactg tcctgggtct gttccgcgtg actccggaaa tccccgccgg tggaggtggc 1020

tcaggaggcg gcggcagcgg tggaggaggg agcggaggag gcggatccgg tggaggcgga 1080

agcgaccctg ccggactcct ggatctgcgg cagggcatgt tcgcccagtt ggtggcgcag 1140

aacgtcctgc tcattgacgg gccgctgtcg tggtacagcg atccgggctt ggccggagtc 1200

tcgctgaccg gaggactcag ctacgccgaa gataccaagg agctggtcgt ggccaaggcc 1260

ggagtgtact acgtgttctt ccaactggaa ctgcgccggg tggtggctgg cgaaggatcc 1320

gggtcggtgt ccctggccct gcatctgcag cctctgcgct cagccgcagg agcagccgcc 1380

ttggcgctca ccgtggacct tccgcccgcc tcctcggaag cccggaacag cgccttcggc 1440

ttccaaggca gactcctgca cttgagcgcg ggccagagac tgggagtgca cctccacacc 1500

gaagcgcgcg caaggcacgc ctggcagctc acccagggag ccaccgtgct gggcttgttt 1560

cgagtcaccc ccgagatccc agccggcgga ggaggttccg gtggcggtgg atcaggcggt 1620

ggaggctcgg gtggaggggg tagcggaggg ggtggttccg accccgcagg actgctggac 1680

ctccggcagg ggatgttcgc gcaactggtg gctcagaatg tcctgctgat tgacggcccc 1740

ctgtcgtggt actcggaccc tggccttgcc ggcgtgtcct tgactggagg gctgtcgtac 1800

gccgaggaca ctaaggagct ggtcgtggcc aaagccggcg tgtactacgt gttctttcag 1860

ctggaactga ggagagtggt ggcgggagaa ggcagcggct cagtgtccct cgccctgcac 1920

cttcaaccac tccgctctgc cgctggtgca gctgcgctcg ccctcactgt ggatcttcca 1980

ccggcaagct ccgaggccag aaactccgcc ttcgggttcc aggggaggct gctgcatctc 2040

tccgccggcc agagactggg cgtgcacttg cacactgagg ctagggctcg ccatgcctgg 2100

cagctgaccc agggcgccac tgtgctggga ctgttccggg tgaccccaga aatcccggcc 2160

tcctagtga 2169

<210> 263

<211> 701

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 263

Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Gly Cys Gly Gly Ser Gly

1 5 10 15

Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile

20 25 30

Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu

35 40 45

Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu

50 55 60

Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser

65 70 75 80

Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr

85 90 95

Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu

100 105 110

Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

130 135 140

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

145 150 155 160

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

165 170 175

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

180 185 190

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

195 200 205

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

210 215 220

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

225 230 235 240

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

245 250 255

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

260 265 270

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

275 280 285

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

290 295 300

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly Gly

305 310 315 320

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

325 330 335

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

340 345 350

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

355 360 365

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

370 375 380

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

385 390 395 400

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

405 410 415

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

420 425 430

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

435 440 445

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

450 455 460

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

465 470 475 480

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

485 490 495

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly Gly

500 505 510

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

515 520 525

Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly

530 535 540

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

545 550 555 560

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly

565 570 575

Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala

580 585 590

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala

595 600 605

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu

610 615 620

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro

625 630 635 640

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg

645 650 655

Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr

660 665 670

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

675 680 685

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser

690 695 700

<210> 264

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 264

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

aacctggtgc cgatggtggc gaccgtgggg ggaggagcct caggaggagg aggatccggg 120

ggtggaggta gcatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt gatag 435

<210> 265

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 265

Asn Leu Val Pro Met Val Ala Thr Val Gly Gly Gly Ala Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 266

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 266

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

aacctggtgc cgatggtggc gaccgtgggg tgcggaggct caggaggagg aggatccggg 120

ggtggaggta gcatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt gatag 435

<210> 267

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 267

Asn Leu Val Pro Met Val Ala Thr Val Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 268

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 268

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ggcctgtccc ggtacgtggc ccggctgggt ggaggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 269

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 269

Gly Leu Ser Arg Tyr Val Ala Arg Leu Gly Gly Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 270

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 270

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ggcctgtccc ggtacgtggc ccggctgggt tgcggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 271

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 271

Gly Leu Ser Arg Tyr Val Ala Arg Leu Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 272

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 272

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

aagctgcacc tgtactccca ccccatcggt ggaggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 273

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 273

Lys Leu His Leu Tyr Ser His Pro Ile Gly Gly Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 274

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 274

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

aagctgcacc tgtactccca ccccatcggt tgcggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 275

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 275

Lys Leu His Leu Tyr Ser His Pro Ile Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 276

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 276

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgctgt ccctgggcat ccacctgggt ggaggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 277

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 277

Phe Leu Leu Ser Leu Gly Ile His Leu Gly Gly Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 278

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 278

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

ttcctgctgt ccctgggcat ccacctgggt tgcggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 279

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 279

Phe Leu Leu Ser Leu Gly Ile His Leu Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 280

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 280

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

gccctgatgc ccctgtacgc ctgcatcggt ggaggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 281

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 281

Ala Leu Met Pro Leu Tyr Ala Cys Ile Gly Gly Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 282

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 282

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

gccctgatgc ccctgtacgc ctgcatcggt tgcggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 283

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 283

Ala Leu Met Pro Leu Tyr Ala Cys Ile Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 284

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 284

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

tccctgtacg ccgactcccc ctccgtgggt ggaggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 285

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 285

Ser Leu Tyr Ala Asp Ser Pro Ser Val Gly Gly Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 286

<211> 435

<212> DNA

<213> 人工序列

<220>

<223> 合成序列

<400> 286

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc 60

tccctgtacg ccgactcccc ctccgtgggt tgcggtggtt ctggaggagg cggttcgggc 120

ggaggtggta gtatccagcg tactccaaag attcaggttt actcatgcca tccagcagag 180

aatggaaagt caaatttcct gaattgctat gtgtctgggt ttcatccatc cgacattgaa 240

gttgacttac tgaagaatgg agagagaatt gaaaaagtgg agcattcaga cttgtctttc 300

agcaaggact ggtctttcta tctcttgtat tatactgaat tcacccccac tgaaaaagat 360

gagtatgcct gccgtgtgaa ccacgtgact ttgtcacagc ccaagatagt taagtgggat 420

cgagacatgt agtga 435

<210> 287

<211> 123

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 287

Ser Leu Tyr Ala Asp Ser Pro Ser Val Gly Cys Gly Gly Ser Gly Gly

1 5 10 15

Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln

20 25 30

Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn

35 40 45

Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu

50 55 60

Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe

65 70 75 80

Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro

85 90 95

Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser

100 105 110

Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

115 120

<210> 288

<211> 275

<212> PRT

<213> 智人

<400> 288

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu

145 150 155 160

Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 289

<211> 275

<212> PRT

<213> 智人

<400> 289

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 290

<211> 275

<212> PRT

<213> 智人

<400> 290

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu

275

<210> 291

<211> 275

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 291

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 292

<211> 254

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 292

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Ala Gly

65 70 75 80

Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp

85 90 95

Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr

100 105 110

Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp His Lys Trp Glu Ala Ala

115 120 125

His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu

130 135 140

Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr

145 150 155 160

Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu

165 170 175

Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr

180 185 190

Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu

195 200 205

Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala

210 215 220

Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln

225 230 235 240

His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro

245 250

<210> 293

<211> 243

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 293

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Ala Gly

65 70 75 80

Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp

85 90 95

Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr

100 105 110

Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp His Lys Trp Glu Ala Ala

115 120 125

His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu

130 135 140

Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr

145 150 155 160

Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu

165 170 175

Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr

180 185 190

Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu

195 200 205

Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr

210 215 220

Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg

225 230 235 240

Trp Glu Pro

<210> 294

<211> 365

<212> PRT

<213> 智人

<400> 294

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala

1 5 10 15

Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln

85 90 95

Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly

115 120 125

Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala

165 170 175

Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Arg Cys Val Glu Trp Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro

195 200 205

Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro

290 295 300

Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala

305 310 315 320

Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser

325 330 335

Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val

355 360 365

<210> 295

<211> 365

<212> PRT

<213> 智人

<400> 295

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala

1 5 10 15

Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Ser Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys Ala His Ser Gln

85 90 95

Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser

100 105 110

Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly

115 120 125

Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Val

165 170 175

Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Asp Gly Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro

195 200 205

Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro

290 295 300

Thr Val Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala

305 310 315 320

Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Asn Ser

325 330 335

Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val

355 360 365

<210> 296

<211> 365

<212> PRT

<213> 智人

<400> 296

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala

1 5 10 15

Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Thr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala His Ser Gln

85 90 95

Ile Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Ala Gly Ser His Thr Ile Gln Met Met Tyr Gly Cys Asp Val Gly

115 120 125

Ser Asp Gly Arg Phe Leu Arg Gly Tyr Gln Gln Asp Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Met Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val

165 170 175

Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro

195 200 205

Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val

260 265 270

Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro

290 295 300

Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala

305 310 315 320

Val Phe Ala Gly Ala Val Val Ala Ala Val Arg Trp Arg Arg Lys Ser

325 330 335

Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Met Ser Leu Thr Ala Cys Lys Val

355 360 365

<210> 297

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 297

Arg Asn Leu Arg Gly

1 5

<210> 298

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 298

Thr Ala Ala Asp Thr

1 5

<210> 299

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 299

Ala Gln Ile Thr Gln

1 5

<210> 300

<211> 5

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<400> 300

Gly Asp Arg Thr Phe

1 5

<210> 301

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (9)..(9)

<223> X是苯丙氨酸, 酪氨酸, 丝氨酸,或苏氨酸

<220>

<221> Misc_特征

<222> (44)..(44)

<223> X是赖氨酸或精氨酸

<220>

<221> Misc_特征

<222> (62)..(62)

<223> X是谷氨酰胺, 甘氨酸, 谷氨酸,或精氨酸

<220>

<221> Misc_特征

<222> (63)..(63)

<223> X是天冬酰胺或谷氨酸

<220>

<221> Misc_特征

<222> (65)..(65)

<223> X是精氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (66)..(66)

<223> X是天冬酰胺或赖氨酸

<220>

<221> Misc_特征

<222> (67)..(67)

<223> X是甲硫氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (70)..(70)

<223> X是组氨酸或谷氨酰胺

<220>

<221> Misc_特征

<222> (73)..(73)

<223> X是苏氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (74)..(74)

<223> X是天冬氨酸或组氨酸

<220>

<221> Misc_特征

<222> (76)..(76)

<223> X是丙氨酸, 缬氨酸,或谷氨酸

<220>

<221> Misc_特征

<222> (77)..(77)

<223> X是天冬酰胺或天冬氨酸

<220>

<221> Misc_特征

<222> (79)..(79)

<223> X是甘氨酸或精氨酸

<220>

<221> Misc_特征

<222> (80)..(80)

<223> X是苏氨酸或精氨酸

<220>

<221> Misc_特征

<222> (81)..(81)

<223> X是亮氨酸或丙氨酸

<220>

<221> Misc_特征

<222> (82)..(82)

<223> X是精氨酸或亮氨酸

<220>

<221> Misc_特征

<222> (83)..(83)

<223> X是甘氨酸或精氨酸

<220>

<221> Misc_特征

<222> (90)..(90)

<223> X是丙氨酸或天冬氨酸

<220>

<221> Misc_特征

<222> (95)..(95)

<223> X是异亮氨酸, 亮氨酸,或缬氨酸

<220>

<221> Misc_特征

<222> (97)..(97)

<223> X是异亮氨酸, 精氨酸,或甲硫氨酸

<220>

<221> Misc_特征

<222> (99)..(99)

<223> X是苯丙氨酸或酪氨酸

<220>

<221> Misc_特征

<222> (105)..(105)

<223> X是丝氨酸或脯氨酸

<220>

<221> Misc_特征

<222> (107)..(107)

<223> X是色氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (114)..(114)

<223> X是精氨酸, 组氨酸,或谷氨酰胺

<220>

<221> Misc_特征

<222> (116)..(116)

<223> X是天冬氨酸或酪氨酸

<220>

<221> Misc_特征

<222> (127)..(127)

<223> X是天冬酰胺或赖氨酸

<220>

<221> Misc_特征

<222> (142)..(142)

<223> X是苏氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (144)..(144)

<223> X是赖氨酸或谷氨酰胺

<220>

<221> Misc_特征

<222> (145)..(145)

<223> X是精氨酸或组氨酸

<220>

<221> Misc_特征

<222> (149)..(149)

<223> X是丙氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (150)..(150)

<223> X是丙氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (151)..(151)

<223> X是组氨酸或精氨酸

<220>

<221> Misc_特征

<222> (156)..(156)

<223> X是精氨酸, 亮氨酸, 谷氨酰胺,或色氨酸

<220>

<221> Misc_特征

<222> (158)..(158)

<223> X是缬氨酸或丙氨酸

<220>

<221> Misc_特征

<222> (161)..(161)

<223> X是天冬氨酸或谷氨酸

<220>

<221> Misc_特征

<222> (163)..(163)

<223> X是精氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (166)..(166)

<223> X是天冬氨酸或谷氨酸

<220>

<221> Misc_特征

<222> (167)..(167)

<223> X是色氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (184)..(184)

<223> X是脯氨酸或丙氨酸

<220>

<221> Misc_特征

<222> (193)..(193)

<223> X是脯氨酸或丙氨酸

<220>

<221> Misc_特征

<222> (194)..(194)

<223> X是缬氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (207)..(207)

<223> X是丝氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (246)..(246)

<223> X是丙氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (253)..(253)

<223> X是谷氨酰胺或谷氨酸

<220>

<221> Misc_特征

<222> (276)..(276)

<223> X是脯氨酸或亮氨酸

<400> 301

Gly Ser His Ser Met Arg Tyr Phe Xaa Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Xaa Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Xaa Xaa Thr

50 55 60

Xaa Xaa Xaa Lys Ala Xaa Ser Gln Xaa Xaa Arg Xaa Xaa Leu Xaa Xaa

65 70 75 80

Xaa Xaa Xaa Tyr Tyr Asn Gln Ser Glu Xaa Gly Ser His Thr Xaa Gln

85 90 95

Xaa Met Xaa Gly Cys Asp Val Gly Xaa Asp Xaa Arg Phe Leu Arg Gly

100 105 110

Tyr Xaa Gln Xaa Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Xaa Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Xaa Thr Xaa

130 135 140

Xaa Lys Trp Glu Xaa Xaa Xaa Glu Ala Glu Gln Xaa Arg Xaa Tyr Leu

145 150 155 160

Xaa Gly Xaa Cys Val Xaa Xaa Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Xaa Pro Lys Thr His Met Thr His His

180 185 190

Xaa Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Xaa Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Xaa Val Val Val Pro Ser Gly Xaa Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Xaa

275

<210> 302

<211> 275

<212> PRT

<213> 智人

<400> 302

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 303

<211> 276

<212> PRT

<213> 智人

<400> 303

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 304

<211> 275

<212> PRT

<213> 智人

<400> 304

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 305

<211> 276

<212> PRT

<213> 智人

<400> 305

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 306

<211> 341

<212> PRT

<213> 智人

<400> 306

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr

50 55 60

Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro Ser Ser Gln Pro Thr Val Pro Ile Val Gly Ile Ile

275 280 285

Ala Gly Leu Val Leu Leu Gly Ala Val Ile Thr Gly Ala Val Val Ala

290 295 300

Ala Val Met Trp Arg Arg Asn Ser Ser Asp Arg Lys Gly Gly Ser Tyr

305 310 315 320

Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu

325 330 335

Thr Ala Cys Lys Val

340

<210> 307

<211> 341

<212> PRT

<213> 智人

<400> 307

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Arg Asn Val Lys Ala His Ser Gln Ile Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln

85 90 95

Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile

275 280 285

Ala Gly Leu Val Leu Phe Gly Ala Val Phe Ala Gly Ala Val Val Ala

290 295 300

Ala Val Arg Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr

305 310 315 320

Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Met Ser Leu

325 330 335

Thr Ala Cys Lys Val

340

<210> 308

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (9)..(9)

<223> X是组氨酸，酪氨酸,或天冬氨酸

<220>

<221> Misc_特征

<222> (11)..(11)

<223> X是丙氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (12)..(12)

<223> X是甲硫氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (24)..(24)

<223> X是丙氨酸, 丝氨酸,或苏氨酸

<220>

<221> Misc_特征

<222> (32)..(32)

<223> X是谷氨酰胺或亮氨酸

<220>

<221> Misc_特征

<222> (41)..(41)

<223> X是丙氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (45)..(45)

<223> X是谷氨酸, 甲硫氨酸, 赖氨酸,或苏氨酸

<220>

<221> Misc_特征

<222> (46)..(46)

<223> X是丙氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (63)..(63)

<223> X是谷氨酸或天冬酰胺

<220>

<221> Misc_特征

<222> (66)..(66)

<223> X是异亮氨酸或赖氨酸

<220>

<221> Misc_特征

<222> (67)..(67)

<223> X是酪氨酸, 苯丙氨酸, 丝氨酸,或胱氨酸

<220>

<221> Misc_特征

<222> (70)..(70)

<223> X是天冬酰胺或谷氨酰胺

<220>

<221> Misc_特征

<222> (71)..(71)

<223> X是丙氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (74)..(74)

<223> X是天冬氨酸或酪氨酸

<220>

<221> Misc_特征

<222> (76)..(76)

<223> X是谷氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (77)..(77)

<223> X是丝氨酸或天冬酰胺

<220>

<221> Misc_特征

<222> (80)..(80)

<223> X是苏氨酸, 天冬酰胺,或异亮氨酸

<220>

<221> Misc_特征

<222> (81)..(81)

<223> X是丙氨酸或亮氨酸

<220>

<221> Misc_特征

<222> (82)..(82)

<223> X是亮氨酸或精氨酸

<220>

<221> Misc_特征

<222> (83)..(83)

<223> X是精氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (94)..(94)

<223> X是苏氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (95)..(95)

<223> X是亮氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (97)..(97)

<223> X是精氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (131)..(131)

<223> X是精氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (143)..(143)

<223> X是S或T

<220>

<221> Misc_特征

<222> (147)..(147)

<223> X是L或W

<220>

<221> misc_特征

<222> (152)..(152)

<223> Xaa是E或V

<220>

<221> misc_特征

<222> (156)..(156)

<223> Xaa是R, D, L

<220>

<221> misc_特征

<222> (158)..(158)

<223> Xaa A或T

<220>

<221> Misc_特征

<222> (163)..(163)

<223> X是亮氨酸, 谷氨酸,或苏氨酸

<220>

<221> Misc_特征

<222> (177)..(177)

<223> X是谷氨酸或天冬氨酸

<220>

<221> Misc_特征

<222> (178)..(178)

<223> X是赖氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (180)..(180)

<223> X是谷氨酸或谷氨酰胺

<220>

<221> Misc_特征

<222> (194)..(194)

<223> X是异亮氨酸或缬氨酸

<400> 308

Gly Ser His Ser Met Arg Tyr Phe Xaa Thr Xaa Xaa Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Xaa Val Gly Tyr Val Asp Asp Thr Xaa

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Xaa Ser Pro Arg Xaa Xaa Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Xaa Thr

50 55 60

Gln Xaa Xaa Lys Thr Xaa Xaa Thr Gln Xaa Tyr Xaa Xaa Asn Leu Xaa

65 70 75 80

Xaa Xaa Xaa Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Xaa Xaa Gln

85 90 95

Xaa Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Xaa Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Xaa Gln

130 135 140

Arg Lys Xaa Glu Ala Ala Arg Xaa Ala Glu Gln Xaa Arg Xaa Tyr Leu

145 150 155 160

Glu Gly Xaa Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Xaa Xaa Leu Xaa Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 309

<211> 362

<212> PRT

<213> 智人

<400> 309

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala

1 5 10 15

Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe

20 25 30

Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser

35 40 45

Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala

50 55 60

Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly

65 70 75 80

Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln

85 90 95

Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser

100 105 110

Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly

115 120 125

Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly

130 135 140

Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala

145 150 155 160

Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu

165 170 175

Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu

180 185 190

Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro

195 200 205

Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr

210 215 220

Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr

225 230 235 240

Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu

245 250 255

Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val

260 265 270

Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

275 280 285

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser

290 295 300

Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val

305 310 315 320

Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser

325 330 335

Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser

340 345 350

Ala Gln Gly Ser Asp Val Ser Leu Thr Ala

355 360

<210> 310

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (1)..(1)

<223> X是半胱氨酸或甘氨酸

<220>

<221> Misc_特征

<222> (6)..(6)

<223> X是精氨酸或赖氨酸

<220>

<221> Misc_特征

<222> (9)..(9)

<223> X是苯丙氨酸, 酪氨酸, 丝氨酸,或天冬氨酸

<220>

<221> Misc_特征

<222> (14)..(14)

<223> X是精氨酸或色氨酸

<220>

<221> Misc_特征

<222> (21)..(21)

<223> X是组氨酸或精氨酸

<220>

<221> Misc_特征

<222> (24)..(24)

<223> X是丙氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (35)..(35)

<223> X是谷氨酰胺或精氨酸

<220>

<221> Misc_特征

<222> (49)..(49)

<223> X是丙氨酸或精氨酸

<220>

<221> Misc_特征

<222> (66)..(66)

<223> X是天冬酰胺,或赖氨酸

<220>

<221> Misc_特征

<222> (73)..(73)

<223> X是苏氨酸或丙氨酸

<220>

<221> Misc_特征

<222> (77)..(77)

<223> X是丝氨酸或天冬酰胺

<220>

<221> Misc_特征

<222> (80)..(80)

<223> X是天冬酰胺或赖氨酸

<220>

<221> Misc_特征

<222> (90)..(90)

<223> X是丙氨酸或天冬氨酸

<220>

<221> Misc_特征

<222> (91)..(91)

<223> X是甘氨酸或精氨酸

<220>

<221> Misc_特征

<222> (94)..(94)

<223> X是苏氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (95)..(95)

<223> X是亮氨酸或异亮氨酸

<220>

<221> Misc_特征

<222> (97)..(97)

<223> X是色氨酸或精氨酸

<220>

<221> Misc_特征

<222> (99)..(99)

<223> X是半胱氨酸, 酪氨酸, 苯丙氨酸,或丝氨酸

<220>

<221> Misc_特征

<222> (103)..(103)

<223> X是亮氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (113)..(113)

<223> X是酪氨酸或组氨酸

<220>

<221> Misc_特征

<222> (114)..(114)

<223> X是天冬氨酸或天冬酰胺

<220>

<221> Misc_特征

<222> (116)..(116)

<223> X是酪氨酸, 苯丙氨酸, 丝氨酸,或亮氨酸

<220>

<221> Misc_特征

<222> (147)..(147)

<223> X是亮氨酸或色氨酸

<220>

<221> Misc_特征

<222> (152)..(152)

<223> X是谷氨酸, 丙氨酸,或苏氨酸

<220>

<221> Misc_特征

<222> (156)..(156)

<223> X是精氨酸, 亮氨酸,或色氨酸

<220>

<221> Misc_特征

<222> (163)..(163)

<223> X是亮氨酸或苏氨酸

<220>

<221> Misc_特征

<222> (173)..(173)

<223> X是谷氨酸或赖氨酸

<220>

<221> Misc_特征

<222> (177)..(177)

<223> X是谷氨酸或赖氨酸

<220>

<221> Misc_特征

<222> (184)..(184)

<223> X是组氨酸或脯氨酸

<220>

<221> Misc_特征

<222> (194)..(194)

<223> X是精氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (219)..(219)

<223> X是色氨酸或精氨酸

<220>

<221> Misc_特征

<222> (248)..(248)

<223> X是缬氨酸或甲硫氨酸

<220>

<221> Misc_特征

<222> (253)..(253)

<223> X是谷氨酸或赖氨酸

<220>

<221> Misc_特征

<222> (261)..(261)

<223> X是甲硫氨酸或缬氨酸

<220>

<221> Misc_特征

<222> (267)..(267)

<223> X是脯氨酸或谷氨酰胺

<220>

<221> Misc_特征

<222> (273)..(273)

<223> X是精氨酸或丝氨酸

<220>

<221> Misc_特征

<222> (275)..(275)

<223> X是脯氨酸或甘氨酸

<400> 310

Xaa Ser His Ser Met Xaa Tyr Phe Xaa Thr Ala Val Ser Xaa Pro Gly

1 5 10 15

Arg Gly Glu Pro Xaa Phe Ile Xaa Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Xaa Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Xaa Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Xaa Tyr Lys Arg Gln Ala Gln Xaa Asp Arg Val Xaa Leu Arg Xaa

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Xaa Xaa Ser His Xaa Xaa Gln

85 90 95

Xaa Met Xaa Gly Cys Asp Xaa Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Xaa Xaa Gln Xaa Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Xaa Glu Ala Ala Arg Xaa Ala Glu Gln Xaa Arg Ala Tyr Leu

145 150 155 160

Glu Gly Xaa Cys Val Glu Trp Leu Arg Arg Tyr Leu Xaa Asn Gly Lys

165 170 175

Xaa Thr Leu Gln Arg Ala Glu Xaa Pro Lys Thr His Val Thr His His

180 185 190

Pro Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Xaa Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Xaa Val Pro Ser Gly Xaa Glu Gln Arg

245 250 255

Tyr Thr Cys His Xaa Gln His Glu Gly Leu Xaa Glu Pro Leu Thr Leu

260 265 270

Xaa Trp Xaa Pro

275

<210> 311

<211> 274

<212> PRT

<213> 智人

<400> 311

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg

35 40 45

Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr

50 55 60

Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr

65 70 75 80

Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln

85 90 95

Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly

100 105 110

Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg

130 135 140

Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn

165 170 175

Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His

180 185 190

Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu

210 215 220

Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn

245 250 255

Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp

<210> 312

<211> 223

<212> PRT

<213> 智人

<400> 312

Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser

1 5 10 15

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

20 25 30

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro

35 40 45

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

50 55 60

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val

65 70 75 80

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

85 90 95

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr

100 105 110

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

115 120 125

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys

130 135 140

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

145 150 155 160

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

165 170 175

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser

180 185 190

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

195 200 205

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

210 215 220

<210> 313

<211> 252

<212> PRT

<213> 人工序列

<220>

<223> 合成多肽

<220>

<221> Misc_特征

<222> (79)..(79)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<220>

<221> Misc_特征

<222> (81)..(81)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<220>

<221> Misc_特征

<222> (126)..(126)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<220>

<221> Misc_特征

<222> (128)..(128)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<220>

<221> Misc_特征

<222> (215)..(215)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<220>

<221> Misc_特征

<222> (217)..(217)

<223> 独立地选自1-5个天然氨基酸的氨基酸群组,或除脯氨酸或甘氨酸外的任何天然氨基酸

<400> 313

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Xaa Cys

65 70 75 80

Xaa Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly

85 90 95

Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly

100 105 110

Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Xaa Cys Xaa

115 120 125

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

130 135 140

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

145 150 155 160

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

165 170 175

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

180 185 190

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

195 200 205

Thr Gln Asp Thr Glu Leu Xaa Cys Xaa Gln Lys Trp Ala Ala Val Val

210 215 220

Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu

225 230 235 240

Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro

245 250

<210> 314

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 314

Ser Thr Leu Pro Glu Thr Thr Val Val

1 5

<210> 315

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 315

Leu Ile Met Pro Ala Arg Phe Tyr Pro Lys

1 5 10

<210> 316

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 316

Ala Ile Met Pro Ala Arg Phe Tyr Pro Lys

1 5 10

<210> 317

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 317

Tyr Val Asn Val Asn Met Gly Leu Lys

1 5

<210> 318

<211> 8

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 318

Pro Leu Gly Phe Phe Pro Asp His

1 5

<210> 319

<211> 15

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 319

Met Gln Trp Asn Ser Thr Ala Leu His Gln Ala Leu Gln Asp Pro

1 5 10 15

<210> 320

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 320

Leu Leu Asp Pro Arg Val Arg Gly Leu

1 5

<210> 321

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 321

Ser Ile Leu Ser Lys Thr Gly Asp Pro Val

1 5 10

<210> 322

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 322

Val Leu Gln Ala Gly Phe Phe Leu Leu

1 5

<210> 323

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 323

Phe Leu Leu Thr Arg Ile Leu Thr Ile

1 5

<210> 324

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 324

Phe Leu Gly Gly Thr Pro Val Cys Leu

1 5

<210> 325

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 325

Leu Leu Cys Leu Ile Phe Leu Leu Val

1 5

<210> 326

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 326

Leu Val Leu Leu Asp Tyr Gln Gly Met Leu

1 5 10

<210> 327

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 327

Leu Leu Asp Tyr Gln Gly Met Leu Pro Val

1 5 10

<210> 328

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 328

Ile Pro Ile Pro Ser Ser Trp Ala Phe

1 5

<210> 329

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 329

Trp Leu Ser Leu Leu Val Pro Phe Val

1 5

<210> 330

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 330

Gly Leu Ser Pro Thr Val Trp Leu Ser Val

1 5 10

<210> 331

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 331

Ser Ile Val Ser Pro Phe Ile Pro Leu Leu

1 5 10

<210> 332

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 332

Ile Leu Ser Pro Phe Leu Pro Leu Leu

1 5

<210> 333

<211> 17

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 333

Ala Thr Val Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser

1 5 10 15

Val

<210> 334

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 334

Leu Pro Ser Asp Phe Phe Pro Ser Val

1 5

<210> 335

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 335

Cys Leu Thr Phe Gly Arg Glu Thr Val

1 5

<210> 336

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 336

Val Leu Glu Tyr Leu Val Ser Phe Gly Val

1 5 10

<210> 337

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 337

Glu Tyr Leu Val Ser Phe Gly Val Trp

1 5

<210> 338

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 338

Ile Leu Ser Thr Leu Pro Glu Thr Thr Val

1 5 10

<210> 339

<211> 11

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 339

Ser Thr Leu Pro Glu Thr Thr Val Val Arg Arg

1 5 10

<210> 340

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 340

Asn Val Ser Ile Pro Trp Thr His Lys

1 5

<210> 341

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 341

Lys Val Gly Asn Phe Thr Gly Leu Tyr

1 5

<210> 342

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 342

Gly Leu Tyr Ser Ser Thr Val Pro Val

1 5

<210> 343

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 343

Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys

1 5 10

<210> 344

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 344

Thr Pro Ala Arg Val Thr Gly Gly Val Phe

1 5 10

<210> 345

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 345

Leu Val Val Asp Phe Ser Gln Phe Ser Arg

1 5 10

<210> 346

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 346

Gly Leu Ser Arg Tyr Val Ala Arg Leu

1 5

<210> 347

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 347

Ser Ile Ala Cys Ser Val Val Arg Arg

1 5

<210> 348

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 348

Tyr Met Asp Asp Val Val Leu Gly Ala

1 5

<210> 349

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 349

Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys

1 5 10

<210> 350

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 350

Lys Tyr Thr Ser Phe Pro Trp Leu Leu

1 5

<210> 351

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 351

Ile Leu Arg Gly Thr Ser Phe Val Tyr Val

1 5 10

<210> 352

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 352

His Leu Ser Leu Arg Gly Leu Phe Val

1 5

<210> 353

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 353

Val Leu His Lys Arg Thr Leu Gly Leu

1 5

<210> 354

<211> 10

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 354

Gly Leu Ser Ala Met Ser Thr Thr Asp Leu

1 5 10

<210> 355

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 355

Cys Leu Phe Lys Asp Trp Glu Glu Leu

1 5

<210> 356

<211> 9

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 356

Val Leu Gly Gly Cys Arg His Lys Leu

1 5

<210> 357

<211> 20

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 357

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu

1 5 10 15

Val Thr Asn Ser

20

<210> 358

<211> 20

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 358

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala

20

<210> 359

<211> 833

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 359

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu

1 5 10 15

Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu

20 25 30

Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile

35 40 45

Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe

50 55 60

Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu

65 70 75 80

Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys

85 90 95

Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile

100 105 110

Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala

115 120 125

Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe

130 135 140

Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly

145 150 155 160

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr

165 170 175

Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu

180 185 190

Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys

195 200 205

Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr

210 215 220

Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu

225 230 235 240

Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg

245 250 255

Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser

260 265 270

Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val

275 280 285

Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr

290 295 300

Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

305 310 315 320

Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr

325 330 335

Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly

340 345 350

Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser

355 360 365

Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu

370 375 380

Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp

385 390 395 400

Arg Val Asp Leu Gly Thr Leu Arg Gly Ala Tyr Asn Gln Ser Glu Asp

405 410 415

Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp

420 425 430

Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp

435 440 445

Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met

450 455 460

Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu

465 470 475 480

Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg

485 490 495

Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys

500 505 510

Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg

515 520 525

Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln

530 535 540

Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg

545 550 555 560

Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro

565 570 575

Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu

580 585 590

Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys

595 600 605

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

610 615 620

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

625 630 635 640

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

645 650 655

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

660 665 670

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

675 680 685

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

690 695 700

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

705 710 715 720

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

725 730 735

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr

740 745 750

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

755 760 765

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

770 775 780

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

785 790 795 800

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

805 810 815

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

820 825 830

Lys

<210> 360

<211> 858

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 360

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu

1 5 10 15

Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu

20 25 30

Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile

35 40 45

Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe

50 55 60

Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu

65 70 75 80

Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys

85 90 95

Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile

100 105 110

Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala

115 120 125

Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe

130 135 140

Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly

145 150 155 160

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr

165 170 175

Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu

180 185 190

Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys

195 200 205

Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr

210 215 220

Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu

225 230 235 240

Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg

245 250 255

Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser

260 265 270

Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val

275 280 285

Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr

290 295 300

Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

305 310 315 320

Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Tyr Thr

325 330 335

Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly

340 345 350

Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser

355 360 365

Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu

370 375 380

Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln Thr Asp

385 390 395 400

Arg Val Asp Leu Gly Thr Leu Arg Gly Ala Tyr Asn Gln Ser Glu Asp

405 410 415

Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly Pro Asp

420 425 430

Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp

435 440 445

Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met

450 455 460

Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala Ala Glu

465 470 475 480

Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg

485 490 495

Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys

500 505 510

Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg

515 520 525

Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln

530 535 540

Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg

545 550 555 560

Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro

565 570 575

Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu

580 585 590

Pro Lys Pro Leu Thr Leu Arg Trp Glu Gly Gly Gly Gly Ser Gly Gly

595 600 605

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

610 615 620

Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys

625 630 635 640

Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro

645 650 655

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys

660 665 670

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp

675 680 685

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu

690 695 700

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu

705 710 715 720

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn

725 730 735

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly

740 745 750

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu

755 760 765

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr

770 775 780

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn

785 790 795 800

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe

805 810 815

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn

820 825 830

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr

835 840 845

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

850 855

<210> 361

<211> 144

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 361

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Leu Ile Met Pro Ala Arg Phe Tyr Pro Lys Gly Gly

20 25 30

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg

35 40 45

Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys

50 55 60

Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile

65 70 75 80

Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His

85 90 95

Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr

100 105 110

Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn

115 120 125

His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

130 135 140

<210> 362

<211> 144

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 362

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Ala Ile Met Pro Ala Arg Phe Tyr Pro Lys Gly Gly

20 25 30

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg

35 40 45

Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys

50 55 60

Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile

65 70 75 80

Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His

85 90 95

Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr

100 105 110

Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn

115 120 125

His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

130 135 140

<210> 363

<211> 143

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 363

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Tyr Val Asn Val Asn Met Gly Leu Lys Gly Gly Gly

20 25 30

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr

35 40 45

Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser

50 55 60

Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu

65 70 75 80

Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser

85 90 95

Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr

100 105 110

Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His

115 120 125

Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

130 135 140

<210> 364

<211> 144

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 364

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Gly Gly

20 25 30

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg

35 40 45

Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys

50 55 60

Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile

65 70 75 80

Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His

85 90 95

Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr

100 105 110

Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn

115 120 125

His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

130 135 140

<210> 365

<211> 143

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 365

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser

1 5 10 15

Gly Leu Glu Ala Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Gly

20 25 30

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr

35 40 45

Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser

50 55 60

Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu

65 70 75 80

Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser

85 90 95

Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr

100 105 110

Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His

115 120 125

Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met

130 135 140

<210> 366

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 366

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu

145 150 155 160

Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Leu

275

<210> 367

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 367

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 368

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 368

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Glu Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Asp Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Leu

275

<210> 369

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 369

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Leu

275

<210> 370

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 370

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr

50 55 60

Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 371

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 371

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr

50 55 60

Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 372

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 372

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr

50 55 60

Gly Lys Val Lys Ala Gln Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 373

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 373

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Arg Asn Val Lys Ala His Ser Gln Ile Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln

85 90 95

Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 374

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 374

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Arg Lys Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 375

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 375

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 376

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 376

Gly Ser His Ser Met Arg Tyr Phe Asp Thr Ala Met Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Phe Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Thr Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 377

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 377

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 378

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 378

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Cys Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Thr

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Thr Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 379

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 379

Gly Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 380

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 380

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Trp Arg Ala Tyr Leu

145 150 155 160

Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 381

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 381

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile

65 70 75 80

Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 382

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 382

Cys Ser His Ser Met Lys Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Trp Met Cys Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Met Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 383

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 383

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Arg Ser His Ile Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 384

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 384

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 385

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 385

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Trp Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Glu Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Asn Leu Arg Lys

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Phe Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Lys Pro

275

<210> 386

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 386

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Asn Leu Arg Lys

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Trp Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Trp Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 387

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 387

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu Pro

275

<210> 388

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 388

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Ser Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu Pro

275

<210> 389

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 389

Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Gln Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Thr Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Lys Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Gly Pro

275

<210> 390

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 390

Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Asn Leu Arg Lys

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His

180 185 190

Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 391

<211> 275

<212> PRT

<213> 智人

<400> 391

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr

50 55 60

Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln

85 90 95

Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly

100 105 110

Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys

130 135 140

Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu

145 150 155 160

Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 392

<211> 275

<212> PRT

<213> 智人

<400> 392

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr

50 55 60

Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu

145 150 155 160

Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 393

<211> 275

<212> PRT

<213> 智人

<400> 393

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln

85 90 95

Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

130 135 140

Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu

260 265 270

Ser Trp Glu

275

<210> 394

<211> 275

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 394

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 395

<211> 275

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 395

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu

275

<210> 396

<211> 276

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<400> 396

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr

50 55 60

Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr

65 70 75 80

Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln

85 90 95

Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly

100 105 110

Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys

130 135 140

His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His

180 185 190

Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu

260 265 270

Arg Trp Glu Pro

275

<210> 397

<211> 284

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<220>

<221> misc_特征

<222> (89)..(89)

<223> Xaa是K或E

<220>

<221> misc_特征

<222> (107)..(107)

<223> Xaa是R或G

<220>

<221> misc_特征

<222> (157)..(157)

<223> Xaa是R或G

<220>

<221> misc_特征

<222> (158)..(158)

<223> Xaa是A或V

<220>

<221> misc_特征

<222> (255)..(255)

<223> Xaa是Q或P

<220>

<221> misc_特征

<222> (267)..(267)

<223> Xaa是P或S

<400> 397

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln

20 25 30

Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg

35 40 45

Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr

50 55 60

Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr

65 70 75 80

Leu Arg Gly Tyr Tyr Asn Gln Ser Xaa Ala Gly Ser His Thr Leu Gln

85 90 95

Trp Met His Gly Cys Glu Leu Gly Pro Asp Xaa Arg Phe Leu Arg Gly

100 105 110

Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu

130 135 140

Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Xaa Xaa Tyr Leu

145 150 155 160

Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys

165 170 175

Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Xaa Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Xaa Glu Pro Val Thr Leu

260 265 270

Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile

275 280

<210> 398

<211> 284

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<220>

<221> misc_特征

<222> (7)..(7)

<223> Xaa是Y或F

<220>

<221> misc_特征

<222> (50)..(50)

<223> Xaa是P或Q

<220>

<221> misc_特征

<222> (251)..(251)

<223> Xaa是S或P

<220>

<221> misc_特征

<222> (278)..(278)

<223> Xaa是P或L

<400> 398

Gly Ser His Ser Leu Arg Xaa Phe Ser Thr Ala Val Ser Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr Val Asp Asp Thr Gln

20 25 30

Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro Arg Met Glu Pro Arg

35 40 45

Glu Xaa Trp Val Glu Gln Glu Gly Pro Gln Tyr Trp Glu Trp Thr Thr

50 55 60

Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg Val Ala Leu Arg Asn

65 70 75 80

Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln

85 90 95

Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly Arg Leu Leu Arg Gly

100 105 110

Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr Ile Ser Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val Ala Gln Ile Thr Gln

130 135 140

Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu Phe Arg Thr Tyr Leu

145 150 155 160

Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr Leu Glu Asn Gly Lys

165 170 175

Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala His Val Ala His His

180 185 190

Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Glu Gln

210 215 220

Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Xaa Gly Glu Glu Gln Arg

245 250 255

Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Gln Pro Leu Ile Leu

260 265 270

Arg Trp Glu Gln Ser Xaa Gln Pro Thr Ile Pro Ile

275 280

<210> 399

<211> 284

<212> PRT

<213> 人工序列

<220>

<223> 合成序列

<220>

<221> misc_特征

<222> (13)..(13)

<223> Xaa是S或F

<220>

<221> misc_特征

<222> (27)..(27)

<223> Xaa是Y或H

<220>

<221> misc_特征

<222> (31)..(31)

<223> Xaa是T, S,或M

<220>

<221> misc_特征

<222> (34)..(34)

<223> Xaa是L或V

<220>

<221> misc_特征

<222> (54)..(54)

<223> Xaa是Q或R

<220>

<221> misc_特征

<222> (81)..(81)

<223> Xaa是P或L

<220>

<221> misc_特征

<222> (100)..(100)

<223> Xaa是G或D

<220>

<221> misc_特征

<222> (104)..(104)

<223> Xaa是G或V

<220>

<221> misc_特征

<222> (105)..(105)

<223> Xaa是S或C

<220>

<221> misc_特征

<222> (110)..(110)

<223> Xaa是L或I

<220>

<221> misc_特征

<222> (159)..(159)

<223> Xaa是Y或H

<220>

<221> misc_特征

<222> (169)..(169)

<223> Xaa是H或R

<220>

<221> misc_特征

<222> (171)..(171)

<223> Xaa是Y或H

<220>

<221> misc_特征

<222> (178)..(178)

<223> Xaa是M或T

<220>

<221> misc_特征

<222> (185)..(185)

<223> Xaa是P或A

<220>

<221> misc_特征

<222> (219)..(219)

<223> Xaa是R, W,或Q

<220>

<221> misc_特征

<222> (258)..(258)

<223> Xaa是T或M

<220>

<221> misc_特征

<222> (275)..(275)

<223> Xaa是K或E

<400> 399

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Xaa Arg Pro Gly

1 5 10 15

Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Xaa Val Asp Asp Xaa Gln

20 25 30

Phe Xaa Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg

35 40 45

Ala Pro Trp Val Glu Xaa Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr

50 55 60

Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr

65 70 75 80

Xaa Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln

85 90 95

Trp Met Ile Xaa Cys Asp Leu Xaa Xaa Asp Gly Arg Leu Xaa Arg Gly

100 105 110

Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu

115 120 125

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys

130 135 140

Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Xaa Leu

145 150 155 160

Glu Gly Thr Cys Val Glu Trp Leu Xaa Arg Xaa Leu Glu Asn Gly Lys

165 170 175

Glu Xaa Leu Gln Arg Ala Asp Pro Xaa Lys Thr His Val Thr His His

180 185 190

Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe

195 200 205

Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Xaa Asp Gly Glu Asp Gln

210 215 220

Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr

225 230 235 240

Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg

245 250 255

Tyr Xaa Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu

260 265 270

Arg Trp Xaa Gln Ser Ser Leu Pro Thr Ile Pro Ile

275 280

<210> 400

<211> 445

<212> PRT

<213> 乙型肝炎病毒

<400> 400

Met Trp Leu Ile Ile Thr Ser Arg Arg Asp Ile Ile Tyr Thr Leu Phe

1 5 10 15

Gly Arg Arg Val Ser Tyr Ile Lys Glu Ser Pro His Val Ala Pro His

20 25 30

Phe Ala Gly His His Ile Leu Gly Asn Lys Ile Tyr Ser Met Gly Gly

35 40 45

Trp Ser Ser Lys Pro Arg Lys Gly Met Gly Thr Asn Leu Ser Val Pro

50 55 60

Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Lys

65 70 75 80

Ala Asn Ser Asp Asn Pro Asp Trp Asp Leu Asn Pro His Lys Asp Asn

85 90 95

Trp Pro Asp Ala Asn Lys Val Gly Val Gly Ala Phe Gly Pro Gly Phe

100 105 110

Ile Pro Ser His Gly Gly Leu Leu Gly Trp Ser Pro Lys Ala Gln Gly

115 120 125

Ile Leu Thr Thr Val Pro Ala Ala Ser Leu Leu Ala Ser Thr Ile Gly

130 135 140

Lys Ser Gly Arg Gln Pro Thr Pro Leu Ser Pro Pro Leu Arg Asp Thr

145 150 155 160

His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln Thr Leu

165 170 175

Gln Asp Pro Arg Val Arg Ala Leu Tyr Phe Pro Ala Gly Gly Ser Ser

180 185 190

Ser Gly Thr Val Ser Pro Ala Gln Asn Thr Val Ser Ala Ile Ser Ser

195 200 205

Ile Leu Ser Lys Thr Gly Asp Pro Val Pro Asn Met Glu Asn Ile Ala

210 215 220

Ser Gly Leu Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu

225 230 235 240

Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr

245 250 255

Ser Leu Asn Phe Leu Gly Gly Thr Pro Val Cys Leu Gly Gln Asn Ser

260 265 270

Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys Cys Pro Pro Ile Cys

275 280 285

Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Cys

290 295 300

Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln

305 310 315 320

Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser

325 330 335

Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser Met

340 345 350

Phe Thr Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys

355 360 365

Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp

370 375 380

Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln

385 390 395 400

Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met

405 410 415

Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser Pro Phe Met

420 425 430

Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile

435 440 445

<210> 401

<211> 281

<212> PRT

<213> 乙型肝炎病毒

<400> 401

Met Gln Trp Asn Ser Ser Thr Phe His Gln Ala Leu Leu Asp Pro Arg

1 5 10 15

Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val

20 25 30

Asn Pro Val Pro Thr Thr Ala Ser Pro Ile Ser Ser Ile Phe Ser Arg

35 40 45

Thr Gly Asp Pro Ala Pro Asn Met Glu Ser Thr Thr Ser Gly Phe Leu

50 55 60

Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile

65 70 75 80

Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe

85 90 95

Leu Gly Gly Ala Pro Thr Cys Pro Gly Gln Asn Leu Gln Ser Pro Thr

100 105 110

Ser Asn His Ser Gln Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg

115 120 125

Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu

130 135 140

Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro

145 150 155 160

Val Cys Pro Leu Leu Pro Gly Thr Ser Thr Thr Ser Thr Gly Pro Cys

165 170 175

Lys Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser Met Phe Pro Ser Cys

180 185 190

Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro

195 200 205

Ser Ser Trp Ala Phe Ala Arg Phe Leu Trp Glu Trp Ala Ser Val Arg

210 215 220

Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly

225 230 235 240

Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp

245 250 255

Gly Pro Ser Leu Tyr Asn Ile Leu Asn Pro Phe Leu Pro Leu Leu Pro

260 265 270

Ile Phe Phe Cys Leu Trp Val Tyr Ile

275 280

<210> 402

<211> 226

<212> PRT

<213> 乙型肝炎病毒

<400> 402

Met Glu Ser Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln

1 5 10 15

Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu

20 25 30

Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr Cys

35 40 45

Pro Gly Gln Asn Leu Gln Ser Pro Thr Ser Asn His Ser Gln Thr Ser

50 55 60

Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe

65 70 75 80

Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val

85 90 95

Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly

100 105 110

Thr Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala

115 120 125

Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp

130 135 140

Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg

145 150 155 160

Phe Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu

165 170 175

Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu

180 185 190

Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile

195 200 205

Leu Asn Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val

210 215 220

Tyr Ile

225

<210> 403

<211> 843

<212> PRT

<213> 乙型肝炎病毒

<400> 403

Met Pro Leu Ser Tyr Gln His Phe Arg Lys Leu Leu Leu Leu Asp Glu

1 5 10 15

Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly

20 25 30

Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val

35 40 45

Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser

50 55 60

Ser Thr Val Pro Cys Phe Asn Pro Lys Trp Gln Thr Pro Ser Phe Pro

65 70 75 80

Asp Ile His Leu Gln Glu Asp Ile Val Asp Arg Cys Lys Gln Phe Val

85 90 95

Gly Pro Leu Thr Val Asn Glu Asn Arg Arg Leu Lys Leu Ile Met Pro

100 105 110

Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly

115 120 125

Ile Lys Pro Tyr Tyr Pro Glu His Val Val Asn His Tyr Phe Gln Thr

130 135 140

Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg

145 150 155 160

Glu Ser Thr Arg Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu

165 170 175

Gln Asp Leu Gln His Gly Arg Leu Val Phe Lys Thr Ser Lys Arg His

180 185 190

Gly Asp Lys Ser Phe Cys Pro Gln Ser Pro Gly Ile Leu Pro Arg Ser

195 200 205

Ser Val Gly Pro Cys Ile Gln Ser Gln Leu Arg Lys Ser Arg Leu Gly

210 215 220

Pro Gln Pro Ala Gln Gly Gln Leu Ala Gly Arg Gln Gln Gly Gly Ser

225 230 235 240

Gly Ser Ile Arg Ala Arg Val His Pro Ser Pro Trp Gly Thr Val Gly

245 250 255

Val Glu Pro Ser Gly Ser Gly His Thr His Asn Cys Ala Ser Ser Ser

260 265 270

Ser Ser Cys Leu His Gln Ser Ala Val Arg Lys Ala Ala Tyr Ser Leu

275 280 285

Ile Ser Thr Ser Lys Gly His Ser Ser Ser Gly His Ala Val Glu Leu

290 295 300

His His Phe Pro Pro Asn Ser Ser Arg Ser Gln Ser Gln Gly Pro Val

305 310 315 320

Leu Ser Cys Trp Trp Leu Gln Phe Arg Asn Ser Glu Pro Cys Ser Glu

325 330 335

Tyr Cys Leu Cys His Ile Val Asn Leu Ile Glu Asp Trp Gly Pro Cys

340 345 350

Thr Glu His Gly Glu His Arg Ile Arg Thr Pro Arg Thr Pro Ala Arg

355 360 365

Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn Pro His Asn Thr Thr

370 375 380

Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe Ser Arg Gly Asp Thr

385 390 395 400

Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn Leu Gln Ser Leu Thr

405 410 415

Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser Leu Asp Val Ser Ala

420 425 430

Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala Met Pro His Leu Leu

435 440 445

Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala Arg Leu Ser Ser Asn

450 455 460

Ser Arg Ile Ile Asn Asn Gln His Arg Thr Met Gln Asn Leu His Asn

465 470 475 480

Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Met Leu Leu Tyr Lys Thr

485 490 495

Tyr Gly Arg Lys Leu His Leu Tyr Ser His Pro Ile Ile Leu Gly Phe

500 505 510

Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro Phe Leu Leu Ala Gln

515 520 525

Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg Ala Phe Pro His Cys

530 535 540

Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu Gly Ala Lys Ser Val

545 550 555 560

Gln His Leu Glu Ser Leu Tyr Ala Ala Val Thr Asn Phe Leu Leu Ser

565 570 575

Leu Gly Ile His Leu Asn Pro His Lys Thr Lys Arg Trp Gly Tyr Ser

580 585 590

Leu Asn Phe Met Gly Tyr Val Ile Gly Cys Trp Gly Thr Met Pro Gln

595 600 605

Glu His Ile Val Gln Lys Ile Lys Met Cys Phe Arg Lys Leu Pro Val

610 615 620

Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu

625 630 635 640

Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met Pro

645 650 655

Leu Tyr Ala Cys Ile Gln Ala Lys Gln Ala Phe Thr Phe Ser Pro Thr

660 665 670

Tyr Lys Ala Phe Leu Ser Lys Gln Tyr Leu Asn Leu Tyr Pro Val Ala

675 680 685

Arg Gln Arg Ser Gly Leu Cys Gln Val Phe Ala Asp Ala Thr Pro Thr

690 695 700

Gly Trp Gly Leu Ala Ile Gly His Gln Arg Met Arg Gly Thr Phe Val

705 710 715 720

Ser Pro Leu Pro Ile His Thr Ala Glu Leu Leu Ala Ala Cys Phe Ala

725 730 735

Arg Ser Arg Ser Gly Ala Lys Leu Ile Gly Thr Asp Asn Ser Val Val

740 745 750

Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala

755 760 765

Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Val Pro Ser Ala Leu

770 775 780

Asn Pro Ala Asp Asp Pro Ser Arg Gly Arg Leu Gly Leu Tyr Arg Pro

785 790 795 800

Leu Leu Arg Leu Leu Tyr Arg Pro Thr Thr Gly Arg Thr Ser Leu Tyr

805 810 815

Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro Asp Arg Val His Phe

820 825 830

Ala Ser Pro Leu His Val Ala Trp Arg Pro Pro

835 840

<210> 404

<211> 185

<212> PRT

<213> 乙型肝炎病毒

<400> 404

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Ser Ala Glu Leu Leu

1 5 10 15

Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp

20 25 30

Thr Ala Lys Ala Leu Phe Gln Glu Ala Leu Glu Ser Pro Glu His Cys

35 40 45

Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Asp

50 55 60

Leu Met Thr Leu Ala Thr Trp Val Gly Ala Asn Leu Glu Asp Pro Ala

65 70 75 80

Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Thr Ala Gly Leu Lys

85 90 95

Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg

100 105 110

Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr

115 120 125

Pro Pro Pro Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro

130 135 140

Glu Thr Thr Val Val Arg Tyr Arg Asp Arg Gly Arg Ser Thr Arg Arg

145 150 155 160

Arg Thr Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg

165 170 175

Arg Ser Gln Ser Arg Glu Ser Gln Cys

180 185

<210> 405

<211> 212

<212> PRT

<213> 乙型肝炎病毒

<400> 405

Met Gln Leu Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro Thr

1 5 10 15

Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile

20 25 30

Asp Pro Tyr Lys Glu Phe Gly Ala Ser Ala Glu Leu Leu Ser Phe Leu

35 40 45

Pro Ser Asp Phe Phe Pro Ser Ile Arg Asp Leu Leu Asp Thr Ala Ser

50 55 60

Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His

65 70 75 80

His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Asn

85 90 95

Leu Ala Thr Trp Val Gly Ser Asn Leu Glu Asp Pro Ala Ser Arg Glu

100 105 110

Leu Val Val Ser Tyr Val Asn Val Asn Met Gly Leu Lys Ile Arg Gln

115 120 125

Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val

130 135 140

Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala

145 150 155 160

Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr

165 170 175

Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro

180 185 190

Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg

195 200 205

Gly Ser Gln Cys

210

<210> 406

<211> 154

<212> PRT

<213> 乙型肝炎病毒

<400> 406

Met Ala Ala Arg Leu Cys Cys Gln Leu Asp Pro Ala Arg Asp Val Leu

1 5 10 15

Cys Leu Arg Pro Val Gly Ala Glu Ser Cys Gly Arg Pro Phe Ser Gly

20 25 30

Ser Leu Gly Thr Leu Ser Ser Pro Ser Pro Ser Ala Val Pro Thr Asp

35 40 45

His Gly Ala His Leu Ser Leu Arg Gly Leu Pro Val Cys Ala Phe Ser

50 55 60

Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg Arg Met Glu

65 70 75 80

Thr Thr Val Asn Ala His Gln Ile Leu Pro Lys Val Leu His Lys Arg

85 90 95

Thr Leu Gly Leu Ser Ala Met Ser Thr Thr Asp Leu Glu Ala Tyr Phe

100 105 110

Lys Asp Cys Leu Phe Lys Asp Trp Glu Glu Leu Gly Glu Glu Ile Arg

115 120 125

Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val Cys Ala

130 135 140

Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala

145 150