阅读说明：本技术 一种组合物及其制备和应用 (Composition and preparation and application thereof ) 是由 沈鸣 巴福生 田亚平 杨广明 于 2020-06-04 设计创作，主要内容包括：本发明公开一种组合物及其制备和应用。使用本发明所提供组合物制备的消毒溶液为含有0.2g/L的多聚赖氨酸、0.8-1.0g/L的N-乙酰神经氨酸、1.0g/L的溶菌酶和10g/L海藻糖,pH为6.8的磷酸盐缓冲液。该消毒溶液可以用于制备防护无纺布,进而用于制备口罩等微生物防护用品。防护效果好而且稳定性好,保存期长。(The invention discloses a composition, and a preparation method and application thereof. The disinfectant solution prepared by using the composition provided by the invention is a phosphate buffer solution with pH of 6.8 and containing 0.2g/L of polylysine, 0.8-1.0g/L of N-acetylneuraminic acid, 1.0g/L of lysozyme and 10g/L of trehalose. The disinfectant solution can be used for preparing protective non-woven fabrics and further used for preparing microbial protective articles such as masks and the like. Good protection effect, good stability and long storage life.)

1. The composition is characterized by comprising 1 part of polylysine, 4-5 parts of N-acetylneuraminic acid, 10 parts of lysozyme and a proper amount of trehalose.

2. The composition of claim 1, wherein the composition comprises 1 part polylysine, 5 parts N-acetylneuraminic acid, 10 parts lysozyme, and appropriate amounts of trehalose.

3. A disinfecting solution comprising 0.2g/L polylysine, 0.8-1.0g/L N-acetylneuraminic acid, 1.0g/L lysozyme and 10g/L trehalose in a phosphate buffer at a pH of 6.8.

4. The protective non-woven fabric is characterized in that the protective non-woven fabric simultaneously bears polylysine, N-acetylneuraminic acid, lysozyme and trehalose.

5. The nonwoven fabric of claim 4, wherein 1.6mg of polylysine, 6.4-8.0mg of N-acetylneuraminic acid, 8.0mg of lysozyme and 80mg of trehalose are loaded per square meter of nonwoven fabric.

6. The method for preparing the non-woven fabric for protection of any one of claims 4 or 5, which comprises diluting the disinfectant solution prepared in claim 3 with 15% alcohol by 2 times, uniformly spraying the solution at room temperature in a total amount of 8mL per square meter of the non-woven fabric, and drying the solution at 60 ℃.

7. A microbial protective product comprising at least one layer of the protective nonwoven fabric of claim 4 or 5.

8. Use of the composition of claim 1 for the preparation of a disinfecting solution.

9. Use of the antiseptic solution of claim 3 in the preparation of a non-woven protective fabric.

10. Use of a repellent nonwoven fabric according to claim 4 or 5 for the preparation of a microbial protective product.

Technical Field

The invention relates to a composition, and a preparation method and application thereof.

Background

The new crown pneumonia epidemic situation makes human body more aware of the severity of threat of microorganisms such as virus and bacteria to human body. The conventional sterilization and disinfection in daily life and the supply and effectiveness of protective equipment under special conditions become hot points of attention of people, the improvement of the effectiveness of conventional sterilization and disinfection products for daily life becomes an urgent need of people, and the timely and effective supply and the improvement of the effectiveness of protection of protective equipment such as masks, medical protective clothing and the like also become urgent needs and key factors for epidemic prevention and control.

Disclosure of Invention

The invention aims to provide a composition, and preparation and application thereof, so as to at least partially improve the effectiveness of sterilization and disinfection products, improve the antibacterial and virus adsorption capacity of microbial protective products such as masks and the like, and improve the effective supply capacity of the microbial protective products such as masks and the like by prolonging the shelf life of the products.

The present invention relates to at least the following technical solutions.

The embodiment of the invention relates to a composition, which comprises 1 part of polylysine, 4-5 parts of N-acetylneuraminic acid, 10 parts of lysozyme and a proper amount of trehalose. Preferably, the composition comprises 1 part of polylysine, 5 parts of N-acetylneuraminic acid, 10 parts of lysozyme and a proper amount of trehalose.

The embodiment of the invention relates to a disinfection solution which is a phosphate buffer solution containing 0.2g/L of polylysine, 0.8-1.0g/L of N-acetylneuraminic acid, 1.0g/L of lysozyme and 10g/L of trehalose and having the pH value of 6.8. The disinfecting solution may be prepared using the aforementioned composition.

The embodiment of the invention relates to a protective non-woven fabric which simultaneously bears a proper amount of polylysine, N-acetylneuraminic acid, lysozyme and trehalose. Specifically, it may be such that 1.6mg of polylysine, 6.4 to 8.0mg of N-acetylneuraminic acid, 8.0mg of lysozyme and 80mg of trehalose are carried per square meter of nonwoven fabric.

The embodiment of the invention also provides a method for preparing the protective non-woven fabric, which comprises the steps of diluting the disinfection solution by 2 times with 15% alcohol, uniformly spraying the disinfection solution according to the total amount of 8mL per square meter of non-woven fabric at normal temperature, and drying at 60 ℃.

The embodiment of the invention also relates to a microbial protection product which comprises at least one layer of the protection non-woven fabric. The microbial protective product refers to a protective product which can be worn or worn by people to prevent microbial infection such as virus and bacteria, and comprises a mask, a medical protective garment and the like.

The invention also relates to the use of the aforementioned composition for the preparation of a disinfecting solution.

The invention also relates to the application of the disinfection solution in preparing the protective non-woven fabric.

The invention also relates to application of the protective non-woven fabric in preparation of microbial protective articles such as masks and the like.

The antibacterial and disinfectant composition provided by the invention has obviously improved antibacterial and disinfectant capabilities compared with the existing like products, and has long storage life. The antibacterial sterilizing composition is sprayed on non-woven fabrics to manufacture the mask, has obvious advantages in antibacterial capability and virus adsorption capability compared with the prior similar products, has longer retention period, and is more guaranteed in the supply capability of responding to emergencies.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.

The percentage content of the invention is volume ratio content under the condition that the solvent and the solute are both liquid, and weight volume ratio content under the condition that the solute is solid solvent.

First group