阅读说明：本技术 一种利用微粉技术生产抗抑郁症药物的方法 (Method for producing anti-depression medicine by using micro powder technology ) 是由 张贵民 杜丙源 徐燕 于 2020-06-24 设计创作，主要内容包括：本发明属于中药技术领域,具体涉及一种利用微粉技术生产抗抑郁症药物的方法。本发明提供了一种利用微粉技术生产抗抑郁症药物的方法。利用微粉技术不仅使得制剂工艺更加合理可行,而且显著提高药物对抑郁症的治疗效果,更好的发挥中药茯苓的抗抑郁作用。动物实验研究结果表明：茯苓微粉可显著改善抑郁症模型大鼠旷野实验的抑郁行为,缩短抑郁症大鼠的强迫游泳不动时间,效果显著好于茯苓细粉,用微粉技术制备的茯苓微粉胶囊剂用于抑郁症治疗时,效果显著,与现有抗抑郁药物氟西汀的抗抑郁效果相当。(The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a method for producing an anti-depression drug by using a micro-powder technology. The invention provides a method for producing an anti-depression drug by using a micro powder technology. By utilizing the micro-powder technology, the preparation process is more reasonable and feasible, the treatment effect of the medicament on depression is obviously improved, and the anti-depression effect of the traditional Chinese medicine poria cocos is better exerted. The results of animal experiments show that: the poria cocos micropowder capsule can obviously improve the depressive behavior of a rat in a depression model in a field experiment, shortens the immobility time of forced swimming of a rat in depression, has an obvious effect better than that of the poria cocos micropowder, and has an obvious effect when used for treating depression, and the effect is equivalent to the antidepressant effect of fluoxetine serving as the existing antidepressant drug.)

1. A method for producing traditional Chinese medicine by utilizing micro powder technology is characterized by comprising the following steps:

(1) cleaning traditional Chinese medicinal materials, drying in an oven, pulverizing in a high-speed pulverizer, sieving to obtain coarse powder of the traditional Chinese medicinal materials, and pulverizing the coarse powder in an airflow pulverizer to obtain micro powder of the traditional Chinese medicinal materials;

(2) sterilizing the micro powder obtained in the step (1), cooling, and preparing into clinically acceptable dosage forms with pharmaceutically acceptable auxiliary materials.

2. The method of claim 1, wherein the Chinese herbal materials of step (1) are selected from the group consisting of Poria, fructus Tritici Levis, semen Ziziphi Spinosae, cortex et radix Polygalae, rhizoma Cyperi, bupleuri radix, radix Curcumae, citron bark, radix Glycyrrhizae Preparata, fructus Jujubae, bupleuri radix, radix Paeoniae alba, flos Albizziae, radix Curcumae, rhizoma Ligustici Chuanxiong, fructus Gardeniae, rhizoma Cyperi, semen Sojae Preparatum, pericarpium Citri Reticulatae viride; more preferably, the traditional Chinese medicine is selected from poria cocos.

3. The method of claim 1, wherein the dosage form of step (2) is any one of a capsule, a tablet or a granule.

4. The method of claim 1, wherein the pharmaceutically acceptable excipient in step (2) is one or more selected from starch, dextrin, sucrose, microcrystalline cellulose, sodium carboxymethyl starch, lactose and corn starch.

5. The method of claim 1, consisting essentially of

(1) Washing Poria with water, drying at 40-60 deg.C in oven, pulverizing in high speed pulverizer, sieving with 80 mesh sieve to obtain Poria coarse powder, and pulverizing under the conditions of compressed air pressure of 0.4-0.6Kpa and feeding speed of 0.5-10kg/h with airflow pulverizer to obtain Poria micropowder;

(2) analyzing the particle size distribution of the poria cocos micro powder obtained in the step (1) by using a laser particle size distribution instrument, sterilizing the obtained poria cocos micro powder at the temperature of 115 ℃ and 125 ℃ for 10-30 minutes, cooling, and preparing the obtained poria cocos micro powder into capsules, tablets or granules.

6. The method of claim 1, characterized in that it essentially comprises the steps of:

(1) washing Poria with water, drying in oven at 40 deg.C, pulverizing in high speed pulverizer, sieving with 80 mesh sieve to obtain Poria coarse powder, and pulverizing with air flow pulverizer under compressed air pressure of 0.4Kpa and feeding speed of 0.5kg/h to obtain Poria micropowder;

(2) analyzing the particle size distribution of the poria cocos micro powder obtained in the step (1) by using a laser particle size distribution instrument, sterilizing the obtained poria cocos micro powder at the temperature of 115 ℃ and 125 ℃ for 10-30 minutes, cooling, and preparing the obtained poria cocos micro powder into capsules, tablets or granules.

7. The method of claim 1, characterized in that it essentially comprises the steps of:

(1) washing Poria with water, drying in oven at 60 deg.C, pulverizing in high speed pulverizer, sieving with 80 mesh sieve to obtain Poria coarse powder, and pulverizing with airflow pulverizer under compressed air pressure of 0.5Kpa and feeding speed of 2kg/h to obtain Poria micropowder;

(2) analyzing the particle size distribution of the poria cocos micro powder obtained in the step (1) by using a laser particle size distribution instrument, sterilizing the obtained poria cocos micro powder for 30 minutes at 115 ℃, cooling, and preparing the obtained poria cocos micro powder into capsules, tablets or granules.

8. The method of claim 1, characterized in that it essentially comprises the steps of:

(1) washing Poria with water, drying in oven at 50 deg.C, pulverizing in high speed pulverizer, sieving with 80 mesh sieve to obtain Poria coarse powder, and pulverizing with airflow pulverizer under compressed air pressure of 0.6Kpa and feeding speed of 10kg/h to obtain Poria micropowder;

(2) analyzing the particle size distribution of the poria cocos micro powder obtained in the step (1) by using a laser particle size distribution instrument, sterilizing the obtained poria cocos micro powder at the temperature of 115 ℃ and 125 ℃ for 10-30 minutes, cooling, and preparing the obtained poria cocos micro powder into capsules, tablets or granules.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a method for producing an anti-depression drug by using a micro-powder technology.

Background

The traditional Chinese medicine tuckahoe which is one of four monarch eight delicacies has been eaten in China for more than 2000 years, and has the effects of clearing damp and promoting diuresis, strengthening spleen, calming heart and the like. The search of databases such as PubMed and Scifinder shows that the poria cocos mainly contains chemical components such as polysaccharides, triterpenes, sterols and the like, and has various biological activities of resisting tumors, regulating immunity, resisting inflammation, resisting oxidation, resisting aging, improving memory, regulating the urinary system, reducing blood sugar, reducing blood fat, calming, hypnotizing, protecting liver and the like.

Poria cocos, as one of effective components of the classic famous prescription Kaixin powder, is proved to have an anti-depression effect, but the application of the poria cocos in anti-depression medicines is limited due to the defects of the traditional Chinese medicines.

Disclosure of Invention

The invention provides a method for producing an antidepressant by using a micro powder technology, which aims to better apply the traditional Chinese medicine tuckahoe to the treatment of depression patients.

The invention aims to be realized by the following technical scheme:

a method for producing traditional Chinese medicine by using micropowder technology comprises the following steps:

(1) cleaning traditional Chinese medicinal materials, drying in an oven, pulverizing in a high-speed pulverizer, sieving to obtain coarse powder of the traditional Chinese medicinal materials, and pulverizing the coarse powder in an airflow pulverizer to obtain micro powder of the traditional Chinese medicinal materials;

(2) sterilizing the micro powder obtained in the step (1), cooling, and preparing into clinically acceptable dosage forms with pharmaceutically acceptable auxiliary materials.

The traditional Chinese medicinal materials in the step (1) are selected from poria cocos, blighted wheat, spina date seed, polygala tenuifolia, rhizoma cyperi, radix bupleuri, radix curcumae, citron bark, honey-fried licorice root, Chinese date, radix bupleuri, radix paeoniae alba, flos albiziae, radix curcumae, ligusticum wallichii, gardenia, rhizoma cyperi, lobster sauce and pericarpium citri reticulatae viride; more preferably, the traditional Chinese medicine is selected from poria cocos.

The dosage form in the step (2) is any one of capsules, tablets or granules.

The pharmaceutically acceptable auxiliary materials in the step (2) are one or a combination of more of starch, dextrin, sucrose, microcrystalline cellulose, sodium carboxymethyl starch, lactose and corn starch.

Further, (1) washing Poria with water, drying in oven at 40-60 deg.C, pulverizing in high speed pulverizer, sieving with 80 mesh sieve to obtain Poria coarse powder, and pulverizing with air jet at compressed air pressure of 0.4-0.6Kpa to obtain Poria micropowder.

(2) Analyzing the particle size distribution of the poria cocos micro powder obtained in the step (1) by using a laser particle size distribution instrument, sterilizing the obtained poria cocos micro powder at the temperature of 115 ℃ and 125 ℃ for 10-30 minutes, cooling, and preparing the micro powder into capsules, tablets or granules.

The drying temperature of the washed poria cocos blocks can be any one temperature of 40-60 ℃, so long as the aim of drying can be achieved.

The required Poria micropowder can be obtained by using jet mill at a compressed air pressure of 0.4-0.6Kpa and a feeding speed of 0.5-10kg/h, and the particle size distribution of Poria micropowder is analyzed by laser particle size distribution instrument, with D90<20 um.

The sterilization temperature of the tuckahoe micro powder can be any one of 115 ℃ and 125 ℃; the sterilization time corresponding to the temperature is a time for achieving the sterilization effect, and both are preferably 115 ℃ and 30 minutes.

The poria cocos micropowder obtained by the method is used for carrying out anti-depression effect research on depression model rats, and test results show that: the poria cocos micropowder can obviously improve the depressive behavior of a rat in depression in a field test, and the poria cocos micropowder has no obvious improvement effect; both the poria cocos micropowder and the poria cocos fine powder can shorten the immobility time of forced swimming of a rat with depression, but compared with the poria cocos fine powder, the improvement effect of the poria cocos micropowder is more obvious, and the two groups of powder have statistical difference.

The prepared tuckahoe micro powder capsule is used for treating depression patients, and has obvious treatment effect which is equivalent to that of the existing depression treatment drug fluoxetine.

The method for preparing the anti-depression drug by using the micro-powder technology provided by the invention enables the effective components in the traditional Chinese medicine to be more easily dissolved out without extracting, separating and purifying the effective components of the traditional Chinese medicine, improves the bioavailability, and further improves the treatment effect of the drug on diseases.

Drawings

FIG. 1 is a distribution diagram of the particle size of Poria cocos micropowder in embodiment 2

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

The present invention is further illustrated by the following specific examples, but it should be understood by those skilled in the art that the examples provided in the present invention are not intended to limit the present invention in any way, and any type of technical solution that can be obtained without inventive step is within the scope of the present invention.