阅读说明：本技术 一种含有唾液酸和dha的微胶囊及其制备方法 (Microcapsule containing sialic acid and DHA and preparation method thereof ) 是由 程彦 邓颖妍 于 2020-05-26 设计创作，主要内容包括：本发明属于食品加工技术领域,具体涉及一种含有唾液酸和DHA的微胶囊及其制备方法。本发明提供的含有唾液酸和DHA的微胶囊包含如下组分及其重量百分数：唾液酸15～25％,DHA 15～25％,芬多精精油0.3～0.5％,乳酸钙0.5～0.8％,乳化剂1～2％,复合壁材46.7～68.2％。本发明提供的含有唾液酸和DHA的微胶囊,采用的均为天然化合物,对人体刺激作用小,可以快速被吸收,且无残留,还具有一定的杀菌功效。(The invention belongs to the technical field of food processing, and particularly relates to a microcapsule containing sialic acid and DHA and a preparation method thereof. The microcapsule containing sialic acid and DHA provided by the invention comprises the following components in percentage by weight: 15-25% of sialic acid, 15-25% of DHA (docosahexaenoic acid), 0.3-0.5% of fendorin essential oil, 0.5-0.8% of calcium lactate, 1-2% of emulsifier and 46.7-68.2% of composite wall material. The microcapsule containing sialic acid and DHA provided by the invention adopts natural compounds, has small stimulation to human bodies, can be quickly absorbed, has no residue, and also has a certain sterilization effect.)

1. A microcapsule containing sialic acid and DHA is characterized by comprising the following components in percentage by weight: 15-25% of sialic acid, 15-25% of DHA (docosahexaenoic acid), 0.3-0.5% of fendorin essential oil, 0.5-0.8% of calcium lactate, 1-2% of emulsifier and 46.7-68.2% of composite wall material.

2. A microcapsule containing sialic acid and DHA according to claim 1, consisting of the following components and their percentages by weight: 20% of sialic acid, 20% of DHA, 0.4% of fendorin essential oil, 0.7% of calcium lactate, 1.5% of emulsifier and 52.4% of composite wall material.

3. A microcapsule containing sialic acid and DHA according to claim 1 or 2, wherein the emulsifier is selected from the group consisting of elsinan, guaiac and phosphorylcholine in a weight ratio of 7-9: 3-5: 6-8.

4. A microcapsule according to claim 3 containing sialic acid and DHA, wherein the emulsifier is selected from the group consisting of elsinan, guaiac and phosphorylcholine in a weight ratio of 8: 4: 7.

5. The microcapsule containing sialic acid and DHA as claimed in claim 1 or 2, wherein the composite wall material is prepared from zein and rosin in a weight ratio of (8-10): 1 to 3.

6. A microcapsule containing sialic acid and DHA according to claim 5, wherein the composite wall material is prepared from zein and rosin in a weight ratio of 9: 2.

7. A process for the preparation of microcapsules containing sialic acid and DHA, according to any one of claims 1 to 6, comprising the following steps:

s1, adding sialic acid and calcium lactate into water, heating to 35-45 ℃, and stirring to dissolve to obtain a mixture I;

s2, adding the composite wall material and the fendorin essential oil into the mixture I obtained in the step S1, heating to 45-50 ℃, and uniformly stirring to obtain a mixture II;

s3, adding an emulsifier and DHA into the mixture II obtained in the step S2, cooling to 25-30 ℃, magnetically stirring and emulsifying uniformly, and then placing under the pressure of 30-40 MPa, and homogenizing for 20-30 min for the second time to obtain a uniformly mixed emulsion;

s4, spray drying the evenly mixed emulsion obtained in the step S3 to obtain the emulsion.

8. The method for preparing a microcapsule containing sialic acid and DHA as claimed in claim 7, wherein the stirring and dissolving conditions in the step S1 are 300 to 500rpm for 40 to 50 min.

9. The method for preparing microcapsules containing sialic acid and DHA as claimed in claim 7, wherein the stirring in step S2 is performed at a speed of 600-800 rpm for 30-40 min.

10. The method for preparing microcapsules containing sialic acid and DHA according to claim 7, wherein the spray drying in step S4 is performed by: and (3) atomizing the emulsion in a drying chamber for 25-30 min to quickly vaporize the water.

Technical Field

The invention belongs to the technical field of food processing, and particularly relates to a microcapsule containing sialic acid and DHA and a preparation method thereof

Background

Sialic acid (Sialic acid) Sialic acid is a derivative of a 9-carbon monosaccharide. The name is from greek text σ ι α λ σ (sialos) 'saliva', a negatively charged ion that produces a smooth feel to saliva. It not only has the function of inducing invasive pathogenic bacteria, but also is currently recognized as a transmitter of ganglioside and is a component of the brain. Sialic acid can prevent pathogen invasion. Sialic acid is also a receptor for influenza virus, a binding site for influenza virus to bind in mucus cells.

DHA (docosahexaenoic acid, DHA) and docosahexaenoic acid, commonly known as NAOHUANGJIN, are unsaturated fatty acids which are very important for human body, and DHA is a main component for the growth and maintenance of nervous system cells, is an important constituent of brain and retina, has a content of 20% in cerebral cortex of human body and a proportion of about 50% in retina of eyes, and is of great importance for the intelligence development of infants. As an essential fatty acid, the compound has more remarkable effects of enhancing memory and thinking ability, improving intelligence and the like. The research on the epidemiology of the population discovers that the people with high DHA content in the body have stronger psychological bearing capacity and high intelligence development index.

DHA has important influence on the development of fetal brain and also has important effect on the maturation of retinal photoreceptor cells. The pregnant woman can increase the content of alpha-linolenic acid by taking food rich in alpha-linolenic acid during pregnancy, and DHA is synthesized by using the alpha-linolenic acid in maternal blood and then delivered to the brain and retina of the fetus, so that the maturity of nerve cells in the fetus is increased.

Research shows that the content of sialic acid and the content of DHA have obvious correlation, which indicates that the sialic acid and the DHA are both related to brain structure and brain function development and are beneficial to the early development of the infant brain. The sialic acid and DHA content status in infants depends on the content of sialic acid and DHA in the exogenous diet. Therefore, pregnant women should pay attention to the intake of more sialic acid and DHA during pregnancy to promote fetal brain development.

However, the stability of sialic acid is easily affected by other substances, and DHA is easily oxidized due to the active subunit, so that the influence on human health is caused.

Based on the above, Chinese patent CN104041827B discloses a microcapsule containing sialic acid and DHA and a preparation method thereof, wherein the microcapsule contains 10-30% of sialic acid; 10-30% of DHA; 50% -80% of carbohydrate; 0.5 to 3 percent of emulsifier; the microcapsule has the advantage of strong stability, however, the microcapsule is easy to be remained in the body due to incomplete absorption, has stimulation effect on the human body, has high cost and is only suitable for the field of food.

In conclusion, the defects of high cost, wide application range, easy stimulation to human bodies, poor stability and the like generally exist in the prior art.

Disclosure of Invention

The purpose of the application is to provide a microcapsule containing sialic acid and DHA and a preparation method thereof aiming at the defects generally existing in the prior art. The microcapsule containing sialic acid and DHA provided by the invention is simple in preparation process and low in cost, can be completely absorbed by a human body, has no residue, and cannot generate stimulation to the human body.

In order to achieve the purpose, the invention adopts the technical scheme that:

a microcapsule containing sialic acid and DHA comprises the following components in percentage by weight: 15-25% of sialic acid, 15-25% of DHA (docosahexaenoic acid), 0.3-0.5% of fendorin essential oil, 0.5-0.8% of calcium lactate, 1-2% of emulsifier and 46.7-68.2% of composite wall material.

Preferably, the microcapsule containing sialic acid and DHA consists of the following components in percentage by weight: 20% of sialic acid, 20% of DHA, 0.4% of fendorin essential oil, 0.7% of calcium lactate, 1.5% of emulsifier and 52.4% of composite wall material.

Preferably, the emulsifier is prepared from elsholtzia bodinieri, guaiac and phosphorylcholine according to the weight ratio of 7-9: 3-5: 6-8.

Preferably, the emulsifier is prepared from elsholtzia bodinieri, guaiac and phosphorylcholine according to a weight ratio of 8: 4: 7.

Preferably, the composite wall material is prepared from zein and turpentine according to a weight ratio of (8-10): 1 to 3.

Preferably, the composite wall material is prepared from zein and turpentine in a weight ratio of 9: 2.

The invention also provides a preparation method of the microcapsule containing sialic acid and DHA, which comprises the following steps:

s1, adding sialic acid and calcium lactate into water, heating to 35-45 ℃, and stirring to dissolve to obtain a mixture I;

s2, adding the composite wall material and the fendorin essential oil into the mixture I obtained in the step S1, heating to 45-50 ℃, and uniformly stirring to obtain a mixture II;

s3, adding an emulsifier and DHA into the mixture II obtained in the step S2, cooling to 25-30 ℃, magnetically stirring and emulsifying uniformly, and then placing under the pressure of 30-40 MPa, and homogenizing for 20-30 min for the second time to obtain a uniformly mixed emulsion;

s4, spray drying the evenly mixed emulsion obtained in the step S3 to obtain the emulsion.

Preferably, the stirring and dissolving conditions in step S1 are stirring at a speed of 300-500 rpm for 40-50 min.

Preferably, the stirring in step S2 is performed at a speed of 600-800 rpm for 30-40 min.

Preferably, the specific operation of spray drying in step S4 is: and (3) atomizing the emulsion in a drying chamber for 25-30 min to quickly vaporize the water.

According to the invention, sialic acid and DHA are added simultaneously according to a certain proportion, which is beneficial to improving the content of sialic acid and DHA in a human body, promoting the improvement of human intelligence development index and the maturation of retina light-sensitive cells, and is also beneficial to promoting the growth and development of a fetus when taken by a pregnant woman.

Meanwhile, the composite wall material formed by zein and rosin which are mixed according to a certain proportion is added, a membrane structure is provided for the microcapsule, the membrane structure is non-toxic, the irritation reaction of the microcapsule to skin is reduced, the stability is extremely high, and the stability of the microcapsule can be improved. Moreover, the applicant unexpectedly finds that the fendorin essential oil and the calcium lactate are added into the microcapsule, so that the digestion and absorption of the microcapsule can be promoted, the residue of the fendorin essential oil and the calcium lactate can be prevented from producing irritation reaction on a human body, and the calcium element can be supplemented for the human body to improve the immunity of the human body.

Compared with the prior art, the microcapsule containing sialic acid and DHA provided by the invention has the following advantages:

(1) according to the microcapsule containing sialic acid and DHA, a mixed wall material is added, so that a nontoxic membrane structure is formed, the irritation reaction of the microcapsule to skin is reduced, and the stability of the microcapsule is improved;

(2) according to the microcapsule containing sialic acid and DHA, the fendorin essential oil and the calcium lactate are mixed for use, so that calcium can be provided for a human body, the digestion and absorption capacity of the human body to the microcapsule is obviously improved, and the stimulation reaction of residues to the human body is avoided;

(3) the microcapsule containing sialic acid and DHA provided by the invention is simple in preparation process and low in cost, can be suitable for preparing medicines, foods and the like, and improves the application range of the microcapsule.

Detailed Description

The present invention is further explained with reference to the following specific examples, but it should be noted that the following examples are only illustrative of the present invention and should not be construed as limiting the present invention, and all technical solutions similar or equivalent to the present invention are within the scope of the present invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are commercially available products.

Wherein, the reagents used in the invention are all common reagents and can be purchased from common reagent production and sale companies.