阅读说明：本技术 用于制备富含对映异构体和非对映异构体的环丁烷胺和环丁烷酰胺的方法 (Process for preparing enantiomerically and diastereomerically enriched cyclobutaneamines and cyclobutaneamides ) 是由 R·杜梅尼尔 T·斯梅杰卡尔 B·P·米施拉 V·R·格帕尔萨慕斯拉姆 E·戈迪诺 A·C 于 2018-11-14 设计创作，主要内容包括：本发明涉及一种用于制备富含对映异构体和非对映异构体的环丁烷胺和环丁烷酰胺的方法,所述方法通过使(a)环丙基腈反应成环丙基醛,(b)进一步反应成环丁酮,或(d’)进一步反应成烯胺,(c)进一步反应成富含对映异构体和非对映异构体的环丁烷胺或(d)进一步反应成烯胺和(e)富含对映异构体和非对映异构体的环丁基酰胺以获得(f)富含对映异构体和非对映异构体的环丁烷胺,并且(g)进一步反应成富含对映异构体和非对映异构体的环丁烷酰胺。(The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutaneamines and cyclobutaneamides by reacting (a) cyclopropanecarbonitrile to cyclopropylaldehyde, (b) further to cyclobutanone, or (d') further to enamine, (c) further to enantiomerically and diastereomerically enriched cyclobutaneamine or (d) further to enamine and (e) enantiomerically and diastereomerically enriched cyclobutyl amide to obtain (f) enantiomerically and diastereomerically enriched cyclobutaneamine and (g) further to enantiomerically and diastereomerically enriched cyclobutaneamide.)