阅读说明：本技术 在连续流动体系中保持窄停留时间分布的机械方法 (Mechanical method for maintaining narrow residence time distribution in continuous flow systems ) 是由 R.图切利 J.考尔马雷 L.梅西尔 M.荷尔斯泰因 C.吉莱斯皮 R.希尔 于 2018-04-18 设计创作，主要内容包括：在连续流动体系中维持窄停留时间分布的方法,其特别适用于病毒灭活,如在蛋白纯化过程期间。将流体样品引入轴向流动通道,并使其以离散包或区域在其中流动以使停留时间分布和轴向分散最小化。本文所述的实施方案避免或最小化了在蛋白纯化过程期间使用大罐或储器进行病毒灭活的需要；减少了病毒灭活所需的总时间,和/或减少了在蛋白纯化过程期间进行病毒灭活操作所需的总物理空间,这继而减少了纯化过程的总占地面积。(A method for maintaining a narrow residence time distribution in a continuous flow system is particularly useful for viral inactivation, such as during a protein purification process. A fluid sample is introduced into the axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. The embodiments described herein avoid or minimize the need for large tanks or reservoirs for virus inactivation during the protein purification process; the overall time required for virus inactivation is reduced, and/or the overall physical space required for performing virus inactivation operations during the protein purification process is reduced, which in turn reduces the overall footprint of the purification process.)