阅读说明：本技术 一种预防佝偻病、促进钙磷吸收的滴剂饮料 (Drop beverage for preventing rickets and promoting calcium and phosphorus absorption ) 是由 蔚晨歌 华力 于 2019-11-27 设计创作，主要内容包括：本发明公开了一种预防佝偻病、促进钙磷吸收的滴剂饮料,由如下质量份的各组分组成：0.105%维生素D3和99.985%MCT；每个剂量单位中含有400国际单位(IU)的维生素D3。通过以下制备工艺获得：准确称取MCT油投入混料罐,同时开动罐上的搅拌器,加热,温度达到65-70°C后,保持10-15分钟；将该液体冷却至室温(20-25°C),按比例加入维生素D3继续搅拌15分钟至均匀,然后分瓶灌装。本发明预防佝偻病,促进钙,磷吸收,运用滴剂饮料,儿童效果更乐于服用,大大提高了临床使用的顺应性。本发明的制备工艺简单,使用常用辅料,成本较低廉,具有良好的市场前景。(The invention discloses a drop beverage for preventing rickets and promoting calcium and phosphorus absorption, which comprises the following components in parts by mass: 0.105% vitamin D3 and 99.985% MCT; each dosage unit contained 400 International Units (IU) of vitamin D3. The preparation method comprises the following steps: accurately weighing MCT oil, putting into a mixing tank, starting a stirrer on the tank, heating, keeping the temperature for 10-15 minutes after the temperature reaches 65-70 ℃; cooling the liquid to room temperature (20-25 deg.C), adding vitamin D3 at a certain ratio, stirring for 15 min, and bottling. The invention can prevent rickets, promote the absorption of calcium and phosphorus, and has better effect for children by applying the drop beverage, thereby greatly improving the compliance of clinical use. The invention has simple preparation process, uses common auxiliary materials, has low cost and good market prospect.)

1. A drop beverage for preventing rickets and promoting calcium and phosphorus absorption is characterized in that: including vitamin D3 and MCT.

2. A drop beverage for preventing rickets and promoting calcium and phosphorus absorption as claimed in claim 1, wherein: the vitamin D drops comprise the following components in parts by mass: 0.105% vitamin D3 and 99.985% MCT.

3. A drop beverage for preventing rickets and promoting calcium and phosphorus absorption as claimed in claim 1, wherein: the vitamin D drops contain 400 International Units (IU) of vitamin D3 per dosage unit.

4. A drop beverage for preventing rickets and promoting calcium phosphorus absorption as claimed in claims 1 to 3 wherein: the preparation process comprises the following steps:

(1) mixing liquid ingredients: accurately weighing MCT oil according to the production capacity of equipment, putting the MCT oil into a mixing tank, starting a stirrer on the mixing tank, heating the MCT oil until the temperature reaches 65-70 ℃, and keeping the MCT oil for 10-15 minutes; cooling the liquid to room temperature (20-25 ℃), proportionally adding vitamin D3, and continuously stirring for 15 minutes until the liquid is uniform;

(2) bottle distribution and filling: transferring the completely and uniformly mixed liquid to a filling machine for filling; adjusting the filling machine according to the filling amount; filling bottles and covers are prepared according to requirements; the filling quantity was measured hourly after the filling was started.

5. A drop beverage for preventing rickets and promoting calcium and phosphorus absorption as claimed in claim 4, wherein: in the step (2), 12ml of vitamin D drops are subpackaged in each filling bottle.

Technical Field

The invention belongs to the technical field of health-care drinks, and particularly relates to a drop beverage for preventing rickets and promoting calcium and phosphorus absorption.

Background

The discovery of vitamin D is the result of people struggling with rickets. As early as 1824, cod liver oil has been found to play an important role in treating rickets. In 1918, Meilandi Jazz of UK confirmed rickets as a nutritional deficiency. He mistakenly believes that he is a deficiency in vitamin a. Professor a.windaus at the university of Gottingen in 1930 first determined the chemical structure of vitamin D, and the chemical properties of vitamin D2 obtained in 1932 by ultraviolet irradiation of ergosterol were elucidated. The chemical properties of vitamin D3 were not determined until 1936. In 1913, scientists Elmer McCollum and Marguerite Davis found a substance in cod liver oil, named "vitamin A", later, UK doctor Edwards Melllanby found that dogs fed cod liver oil did not get rickets, and concluded that vitamin A or its cofactors prevented rickets. In 1921, the Elmer McCollum used the same experiment of destroying vitamin A in cod liver oil, and the result is the same, which indicates that the rickets resistance is not the vitamin A. He named vitamin D, the fourth vitamin, but this was unknown to people at the time, something that is different from other vitamins because, as long as there was uv light, people could synthesize it by themselves (contrary to the definition of vitamins).

At present, vitamin D drops are a medicament for preventing and treating rickets in children. Through a large number of evidence-based medical researches and basic researches, the vitamin D drops have certain curative effects on the treatment of cancer, hypertension, diabetes, tuberculosis and immunologic dysfunction.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a drop beverage for preventing rickets and promoting calcium and phosphorus absorption.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a drop beverage for preventing rickets and promoting calcium and phosphorus absorption comprises vitamin D3 and MCT.

Further, the vitamin D drops comprise the following components in parts by mass: 0.105% vitamin D3 and 99.985% MCT.

Further, the vitamin D drops contain 400 International Units (IU) of vitamin D3 per dosage unit.

The invention also provides a preparation process of the drop beverage for preventing rickets and promoting calcium and phosphorus absorption, which comprises the following steps:

(1) mixing liquid ingredients: accurately weighing MCT oil according to the production capacity of equipment, putting the MCT oil into a mixing tank, starting a stirrer on the mixing tank, heating the MCT oil until the temperature reaches 65-70 ℃, and keeping the MCT oil for 10-15 minutes; cooling the liquid to room temperature (20-25 deg.C), adding vitamin D3 at a certain ratio, and stirring for 15 min;

(2) filling: transferring the completely and uniformly mixed liquid to a filling machine for filling; adjusting the filling machine according to the filling amount; filling bottles and covers are prepared according to requirements; the filling quantity was measured hourly after the filling was started.

Further, in the step (2), 12ml of vitamin D drops are subpackaged in each filling bottle.

The vitamin D drops of the present invention are administered orally. The dosage to be administered can be readily determined by one skilled in the art based on the actual circumstances. E.g., 0.4ml, i.e., one drop, per day, containing 400 International Units (IU) of vitamin D3; because vitamin D3 has 1IU of 0.025ug, 400IU of 10ug, which meets the national standard of 2-15ug, and is suitable for children of 1-3 years old.

The raw materials of the invention are as follows:

(1) vitamin D3: also known as nicotinamide, cholecalciferol. The absorption of calcium and phosphorus by the body is improved, and the levels of plasma calcium and plasma phosphorus reach saturation; promoting growth and skeleton calcification, and promoting tooth health; increased phosphorus absorption through the intestinal wall and increased phosphorus reabsorption through the renal tubules; maintaining normal levels of citrate in the blood; preventing amino acid loss through the kidney. Can be used for preventing and treating rickets, osteomalacia, tetany and finger tetany of infants, rickets with dental caries;

(2) and MCT: is short for Medium Chain Triglycerides (Medium Chain Triglycerides) and is a triglyceride composed of saturated and Medium Chain fatty acids with a carbon Chain length of 6-12. The compound is commonly used as a solvent, a carrier and an emulsifier in the pharmaceutical industry, can also be used as a solvent of essence, pigment and vitamin in the food industry, and has the characteristics of difficult decomposition by gastric acid and easy hydrolysis in intestinal tracts. Naturally occurring in foods such as palm kernel oil, coconut oil, and breast milk, are one of the sources of dietary fat. As a food additive, medium chain triglycerides are composed of only saturated fatty acids, have a low freezing point, are liquid at room temperature, and have a low viscosity. Compared with soybean oil, the liquid is completely odorless and colorless transparent liquid. Compared with common oil and hydrogenated oil, the medium chain triglyceride has very low unsaturated fatty acid content, high oxidation stability, iodine value not higher than 0.5, and MCT stability at high temperature and low temperature.

Has the advantages that: the invention can prevent rickets, promote the absorption of calcium and phosphorus, and has better effect for children by applying the drop beverage, thereby greatly improving the compliance of clinical use. The invention has simple preparation process, uses common auxiliary materials, has low cost and good market prospect.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

A drop beverage for preventing rickets and promoting calcium and phosphorus absorption comprises the following components in parts by mass: 0.105% vitamin D3 and 99.985% MCT. Each dosage unit contained 400 International Units (IU) of vitamin D3. The preparation process comprises the following steps:

(1) mixing liquid ingredients: accurately weighing MCT oil according to the production capacity of equipment, putting the MCT oil into a mixing tank, starting a stirrer on the mixing tank, heating the MCT oil until the temperature reaches 65-70 ℃, and keeping the MCT oil for 10-15 minutes; cooling the liquid to room temperature (20-25 deg.C), adding vitamin D3 at a certain ratio, and stirring for 15 min; transferring the completely and uniformly mixed liquid to a filling machine for filling;

(2) filling: adjusting the filling machine according to the filling amount; filling bottles and covers are prepared according to requirements; and detecting the filling amount every hour after the filling is started, and subpackaging 12ml of vitamin D drops in each filling bottle.

Performance testing of vitamin D drops

The vitamin D drops prepared in example 1 were each subjected to performance evaluation, and the evaluation items and results are shown in tables 1 to 4 below.

Sensory index and evaluation of vitamin D drops in Table 1

Item	Index (I)	Examples
			Color and luster	Light yellow to yellow	Meet the index
Taste and smell	Has no peculiar smell	Meet the index
			Status of state	Clear oily liquid and no foreign body visible with normal vision	Meet the index

Physicochemical indices and evaluation of vitamin D drops in Table 2

Item	Index (I)	Inspection method	Examples
				Lead (in terms of Pb), mg/kg	≤0.02	GB5009.12	Not detected out
Total arsenic (As), mg/kg	≤0.3	GB5009.11	Not detected out
				Total mercury (in Hg), mg/kg	≤0.02	GB5009.17	Not detected out
Acid value, mg/g	≤4	GB5009.229	0.36
				Peroxide number, g/100g	≤0.25	GB5009.227	0.022

Vitamin D drop microbiological indicators and evaluations in the examples of Table 3

Item	Index (I)	Inspection method	Examples
				Total number of colonies, CFU/g	≤1000	GB 4789.2	＜10
Coliform group, mpn/g	≤0.43	GB 4789.3	＜0.3
				Mold and Yeast, CFU/g	≤50	GB 4789.15	＜10
Staphylococcus aureus	≤0/25g	GB 4789.10	Not detected out
				Salmonella	≤0/25g	GB 4789.4	Not detected out

Vitamin D drops were tested for their marker components by GB 5009.82: each bottle contained vitamin D (index 288-.