阅读说明：本技术 使用不透明框架的调节性人工晶状体装置、系统、以及方法 (Accommodating intraocular lens devices, systems, and methods using opaque frames ) 是由 C·E·库拉图 J·A·卡皮恩 N·J·伍德尔 L·迪亚茨-桑塔那 R·斯泰拉 R·D·林 于 2018-04-30 设计创作，主要内容包括：本文中披露了一种用于插入患者眼睛中的植入式调节性IOL系统(300),所述系统(300)包括：光学元件(305)和包括不透明框架(310)的壳体(306)。所述光学元件(305)包括具有可变光焦度的光学晶状体,并且所述不透明框架(305)周向地设置为围绕所述光学元件(305)的周边。(an implantable accommodating IOL system (300) for insertion in an eye of a patient, the system (300) comprising an optical element (305) and a housing (306) comprising an opaque frame (310), the optical element (305) comprising an optical lens having a variable optical power, and the opaque frame (305) being circumferentially disposed about a periphery of the optical element (305).)

1, an implantable accommodating intraocular lens, IOL, system for insertion into an eye of a patient, the system comprising:

an optical element comprising an optical lens having a variable optical power; and

a housing comprising an opaque frame circumferentially disposed about a perimeter of the optical element.

2. The accommodating IOL system of claim 1, wherein the housing comprises a transparent anterior window and a transparent posterior window.

3. The accommodating IOL system of claim 2, wherein the opaque frame circumferentially surrounds the transparent anterior window and the transparent posterior window.

4. The accommodating IOL system of claim 3, wherein the optical element is positioned between the transparent anterior window and the transparent posterior window.

5. The accommodating IOL system of claim 1, further comprising an electronic component coupled to the optical element.

6. The accommodating IOL system of claim 5, wherein the electronic component comprises a power source.

7. The accommodating IOL system of claim 1, wherein the optical element comprises an electrically responsive active element having an th thickness and a th refractive index.

8. The accommodating IOL system of claim 7, wherein the optical element comprises an adjustable optical technology.

9. The accommodating IOL system of claim 7, wherein the optical element further comprises a passive element having a second thickness and a second index of refraction, wherein a light beam passing through the active element has a phase difference with the light beam passing through the passive element.

10. The accommodating IOL system of claim 9, wherein the second index of refraction is different than the th index of refraction.

11. The accommodating IOL system of claim 9, wherein the second thickness is different than the th thickness.

12. The accommodating IOL system of claim 1, wherein the opaque frame is shaped and configured to follow a peripheral contour of the optical element.

13. The accommodating IOL system of claim 5, further comprising at least peripheral housings shaped and configured to house the electronic components coupled to the optical element.

14. The accommodating IOL system of claim 13, further comprising at least support legs shaped and configured to receive electrical connections extending between the electronic components and the optical element in the peripheral housing.

15. The accommodating IOL system of claim 14, wherein the at least support legs comprise a hollow tubular structure extending between the peripheral housing and the opaque frame.

Technical Field

The present disclosure relates generally to the field of ophthalmic lenses, and more particularly to electrically active ophthalmic lenses.

Background

The human eye provides vision by transmitting light through a clear outer portion called the cornea, and focusing the image through the crystalline lens onto the retina. The quality of the focused image depends on many factors, including the size and shape of the eye, and the transparency of the cornea and lens. When aging or disease causes the lens to become less transparent, vision deteriorates because of the diminished light that can be transmitted to the retina. This deficiency of the lens of the eye is medically known as a cataract. At present, cataracts are treated by surgically removing the affected lens and replacing it with an artificial intraocular lens ("IOL"). Cataract extraction is the most common operation performed worldwide.

In the natural lens, distance and near vision are provided by a mechanism known as accommodation. The natural lens is contained within the capsular bag and is soft early in life. The capsular bag is suspended from the ciliary muscle by the zonules. Relaxation of the ciliary muscle tensions these zonules and stretches the capsular bag. As a result, the natural lens tends to flatten. The tension of the ciliary muscle relaxes the tension on the zonules, allowing the capsular bag and the natural lens to assume a more rounded shape. In this way, the natural lens can alternately focus on near objects and distant objects.

As the lens ages, it becomes stiffer and less able to change its shape in response to the tightening of the ciliary muscle. In addition, the ciliary muscle loses flexibility and range of motion. This makes it more difficult for the lens to focus on near objects, a medical condition known as presbyopia. Presbyopia affects almost all adults between the ages of 45 and 50.

The improvement to monofocal IOLs is accommodative IOLs, which actually change focus by movement (physical deformation and/or translation within the orbit) when the muscular ciliary body reacts to accommodative stimuli from the brain, similar to the way the natural crystalline lens focuses.

However, the different components of an electrically active or electrically actuated IOL often result in an undesirably large implant that is difficult to implant into an eye through a small incision. Large incisions may lead to surgical complications, such as loss of vision secondary to scarring or trauma to ocular tissue. In addition, electrically active IOLs require a power source to function properly, thereby making the patient susceptible to poor visual quality when the IOL is powered or fails to function due to a system failure.

The apparatus, systems, and methods disclosed herein overcome or more of the deficiencies in the prior art.

Disclosure of Invention

In exemplary aspects, the present disclosure is directed to implantable accommodating intraocular lens (IOL) systems for insertion in a patient's eye, the system comprising an optical element and an opaque frame in aspects, the optical element comprises an optical lens having a variable optical power, and the housing comprises an opaque frame circumferentially disposed about a periphery of the optical element.

In aspects, the housing includes a transparent front window and a transparent rear window, the opaque frame circumferentially surrounds the transparent front window and the transparent rear window, and the optical element is positioned between the transparent front window and the transparent rear window.

In aspects, the optical element includes an electrically reactive active element having a th thickness and a th index of refraction.

In , the optical element comprises a tunable optical technology.

In an aspect , the opaque frame is shaped and configured to follow the perimeter profile of the optical element.

In aspects, the device includes at least peripheral housings shaped and configured to house electronic components and connections to the optical elements.

In aspects, the apparatus includes at least support legs shaped and configured to accommodate electrical connections extending between the electronic component in the housing and the optical element, in aspects, the at least support legs include a hollow tubular structure extending between the housing and the opaque frame, in aspects, the at least support legs are shaped as linear supports extending between the opaque frame and the housing, in aspects, the at least support legs are shaped as curved supports extending between the opaque frame and the housing, in aspects, the at least support legs are optically transparent.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory in nature and are intended to provide an understanding of the present disclosure, rather than to limit the scope of the disclosure. In this regard, additional aspects, features and advantages of the present disclosure will be apparent to those skilled in the art from the following detailed description.

Drawings

The drawings illustrate embodiments of the apparatus and methods disclosed herein and together with the description serve to explain the principles of the disclosure.

Fig. 1 is a diagrammatic view of a cross-sectional side view of an eye.

Fig. 2 illustrates a front view of an exemplary accommodating IOL device in accordance with embodiments consistent with the principles of the present disclosure.

Fig. 3A illustrates a cross-sectional view of another embodiments of an exemplary accommodating IOL device consistent with the principles of the present disclosure.

Fig. 3B illustrates a cross-sectional view of the exemplary accommodating IOL device shown in fig. 3A positioned in an eye in a manner consistent with the principles of the present disclosure.

Fig. 4 illustrates a perspective view of an exemplary accommodating IOL device, according to an embodiment of the present disclosure.

Fig. 5 illustrates a cross-sectional view of the exemplary accommodating IOL device shown in fig. 4 implanted into an eye in accordance with embodiments of the present disclosure.

Fig. 6A and 6B illustrate exemplary accommodating IOL devices according to another embodiments consistent with the principles of the present disclosure fig. 6A illustrates a front view and fig. 6B illustrates a perspective view of the exemplary accommodating IOL device.

Fig. 7-14 illustrate front views of different exemplary accommodating IOL devices according to different embodiments consistent with the principles of the present disclosure.

Detailed Description

For the purposes of promoting an understanding of the principles of the disclosure, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same.

Embodiments of the present disclosure include accommodating IOL devices configured to correct far and/or near vision and provide good image quality and extended depth of focus ("EDOF") capability even in the event of a system failure, in embodiments, the accommodating IOL devices described herein provide good visual quality by maintaining monofocal visual quality and providing extended depth of focus even without power.

In embodiments, the accommodating IOL devices described herein include electrically active and passive optical components that are separable and distinct portions of the device in contrast to conventional monolithic electrically active accommodating implants, such embodiments may facilitate implantation through a small incision in cases, the accommodating IOL devices described herein may be implanted into the eye to replace a diseased lens (e.g., an opacified natural lens of a cataractous patient) in other cases, the accommodating IOL devices described herein may be implanted in the sulcus 32 (shown in fig. 1) anterior to the natural lens in embodiments, the accommodating IOL devices described herein include a plurality of optical components that may be configured to complement and cooperate with one another when implanted in different regions of the eye to enhance the vision of the patient.

FIG. 1 is a diagram of an eye 10 showing anatomical structures associated with surgical cataract removal and IOL implantation, the eye 10 including an opacified lens 12, an optically clear cornea 14, and an iris 16, a lens capsule or capsular bag 18 located posterior to the iris 16 of the eye 10 containing the opacified lens 12 which is seated between an anterior capsule segment or capsule 20 and a posterior capsule segment or capsule 22, the anterior capsule 20 and the posterior capsule 22 meeting at an equatorial region 23 of the lens capsule 18, the eye 10 further including an anterior chamber 24 located anterior to the iris 16 and a posterior chamber 26 located between the iris 16 and the lens capsule 18.

A common technique for cataract surgery is extracapsular cataract extraction ("ECCE") which involves creating an incision near the outer edge of the cornea 14 and an opening in the anterior capsule 20 (i.e., an anterior capsulotomy) through which the opacified lens 12 is removed. The lens 12 may be removed by various known methods, including phacoemulsification, in which ultrasonic energy is applied to the lens to fragment it into small pieces that are aspirated out of the lens capsule 18 in a timely manner. Thus, the lens capsule 18 remains substantially intact throughout the ECCE process except for the portion of the anterior capsule 20 removed to access the lens 12. The intact posterior capsule 22 provides support for the IOL and acts as a barrier to vitreous humor within the vitreous cavity. After removal of the opacified lens 12, an IOL may be implanted into the lens capsule 18 through an opening in the anterior capsule 20 to restore clarity and refractive function to a healthy lens. Zonule forces exerted by the ciliary body 28 and attached zonules 30 around the periphery of the lens capsule 18 may act on the IOL. The ciliary body 28 and zonules 30 anchor the lens capsule 18 in place and assist in accommodation, which is the process by which the eye 10 changes optical power as the distance of the images changes to maintain a clear focus on the images.

FIG. 2 illustrates a front view of an exemplary accommodating IOL device 100 according to embodiments consistent with the principles of the present disclosure the accommodating IOL device described herein is configured to provide clear vision and accommodation using electrically active or active components in addition to passive components in the exemplary embodiments disclosed herein, the accommodating IOL device 100 comprises a circular and at least partially flexible disk configured to be implanted in the lens capsule 18 or in the sulcus 32. As shown in FIGS. 2 and 3, the accommodating IOL device 100 is shaped as a generally circular disk comprising an active area 105 and a passive area 110. in embodiments, the active area 105 and the passive area 110 comprise a single lens.

In the depicted embodiment, the active region 105 occupies a central region of the IOL device 100, while the inactive region 110 extends to a peripheral region of the IOL device 100. the active region 105 is shaped and configured as a substantially circular component in other embodiments, the active region 105 may have any of a variety of shapes, including, for example, rectangular, oval, elliptical, and square, in embodiments, the active region 105 includes an index of refraction that is different than the index of refraction of the inactive region 110.

Active region 105 may comprise any of a variety of materials that have optical properties that may be changed by electrical control, active region 105 comprises an electrically active element that may provide variable optical power through any adjustable optical technology, including (by way of non-limiting example) a moving lens, liquid crystals, and/or electrowetting, although these variable properties described herein typically include refractive index and optical power, embodiments of the invention may comprise materials having other variable properties such as prismatic power, coloration, and other variable properties.

In embodiments, the inactive region 110 is shaped and configured as a circular ring surrounding the active region 105. in other embodiments, as shown in fig. 3A, the inactive region 110 is shaped and configured as a separate disk adjacent to the active region 105. the inactive region 110 may include a different index of refraction than the index of refraction of the active region 105. the inactive 110 and active 105 regions are formed of any of a variety of biocompatible materials . in contrast to the active region 105, the inactive region 110 is formed of a relatively more flexible material. in embodiments, as shown in fig. 4, the active region 105 may be associated with several other features designed to power and control the active region.although in the depicted embodiment the outer diameter D1a of the active region 105 is shown to be significantly smaller than the outer diameter D2 of the inactive region 110, in other embodiments, the outer diameter D1a of the active region 105 may be sized to be larger relative to the outer diameter D2 of the inactive region 110. in the depicted embodiment, the outer diameter D1 of the active region 105 may be sized to be substantially smaller than the outer diameter D2 of the inactive region 105, however in the exemplary embodiments the active region may be as equal to the outer diameter of the active region 105, in the range of 3637 mm, from the range of the inactive region 11 mm, 366 mm, 3637 mm, and the active region 15 mm, 7 mm, 8mm, 7 mm, 8mm, 7 mm, 8mm, 7.

Accommodating IOL device 100 is designed and optimized such that both active area 105 and inactive area 110 have matching focal points (or matching focal points) to provide a focused image of distant objects on retina 11 for all pupil sizes. When an object is near the eye 10, the optical power of the active region 105 may be adjusted in response to an input signal (e.g., an electrical input signal) to focus the image on the retina 11. This provides accommodation to the patient in a manner similar to a healthy natural lens.

In embodiments, as shown in FIG. 4, the active region 105 may be associated with several other components designed to power and control the active region, by way of non-limiting example, if the active region 105 cannot be powered due to a system failure or a dead battery, the active region 105 is shaped and configured to combine with the passive region 110 to function like a passive or monofocal lens . in an exemplary embodiment, the unpowered active region 105 has the same optical power as the passive region 110. however, due to the thickness and refractive index differences between the two regions, the active region 105 may behave as a passive lens having a different optical power than the passive region 110.

FIG. 3A illustrates a cross-sectional view of an exemplary accommodating IOL device 150 according to another embodiments consistent with the principles of the present disclosure accommodating IOL device 150 is configured to provide clear vision and accommodation using electrically active or active components in addition to passive components like accommodating IOL device 100 described above, accommodating IOL device 150 may be used to replace an opacified natural lens 12 of a cataract patient and provide clear vision and enhanced accommodation for the patient.

As shown in FIGS. 3A and 3B, accommodating IOL device 150 includes an electrically active or active element 155 and a passive element 160. except for the following differences, active element 155 may have substantially similar characteristics to active region 105 described above with reference to FIGS. 2 and 3. except for the differences described above, passive element 160 may have substantially similar characteristics to passive region 110 described above with reference to FIGS. 2 and 3. unlike in accommodating IOL device 100 where active region 105 and passive region 110 are part of a single, unitary optic, active element 155 and passive element 160 of accommodating IOL device 150 include two separate and separable optical components.

As shown in FIGS. 3A and 3B, the active element 155 and the passive element 160 form separate optical components or regions that are formed and configured to function as . in the depicted embodiment, both the active element 155 and the passive element 160 are shaped and configured as generally circular optical components that allow the light beam to pass through the accommodating IOL device 150 toward the retina 11. in other embodiments, the active element 155 may have any of a variety of shapes, including, for example, rectangular, oval, elliptical, and square.in embodiments, as shown in FIG. 7, the active element 155 may be associated with several other components designed to power and control the active element.A thickness T86523 included with the active element 155 may range from 0.2mm to 2 mm. for example, in exemplary embodiments, a thickness T1 of the active element 155 may be 0.6 mm. in embodiments, a thickness T1 of the active element 155 may range from a center of the active region 155 to 168 of the active region 155, a thickness T635 of the active element may be 0.6 mm. in embodiments, a thickness T1 of the active element 155 may be greater than a thickness T168 of the active element 155 may be smaller than a thickness of the active element 155, although the active element may be of the active element 155 may be of the active element or passive element may be of the peripheral area 155 may be of the same size as shown in embodiments, and may be smaller than the active element 160 in other embodiments, although the active element may be shown by the active element may be of the active element 155, the active element may be of the same size.

Peripheral edge 170 comprises the outermost circumferential region of passive element 160 in cases, as shown in FIG. 3A, peripheral edge 170 comprises the outermost circumferential edge of accommodating IOL device 150 in embodiments, accommodating IOL device 150 may taper toward peripheral edge 170 to help stabilize accommodating IOL device 100 within lens capsule 18 and/or sulcus 32 which may allow accommodating IOL device 150 to self-stabilize and self-hold in eye 10 (i.e., without the use of sutures, adhesives, or manually operated instruments). in embodiments, the angle of taper from passive element 160 to peripheral edge 170 is selected to substantially match the angle of equatorial region 23 in lens capsule 18, thereby helping to self-stabilize accommodating IOL device 150 in eye 10.

FIG. 3B illustrates a cross-sectional view of the exemplary accommodating IOL device 150 shown in FIG. 3A positioned in an eye in a manner consistent with the principles of the present disclosure in the depicted embodiment, accommodating IOL device 150 includes an at least partially flexible device configured to be implanted in the lens capsule 18 or sulcus 32 (i.e., the region between the iris 16 and the lens capsule 18). passive element 160 is relatively more flexible than active element 155. in embodiments, passive element 160 is a large diameter, foldable, relatively soft lens and active element 155 is a relatively stiff device having a smaller diameter than passive element 160.

As shown in the embodiment depicted in FIGS. 3A and 3B, active element 155 is positioned behind passive element 160 in lens capsule 18 of eye 10 in other embodiments, accommodating IOL device 150 may be positioned in the eye such that active element 155 is positioned in front of passive element 160 in eye 10 (i.e., closer to anterior chamber 24 of eye 10). in both cases, active element 155 and passive element 160 are positioned in alignment along a central axis CA that extends vertically through central region 165 of device 150. in embodiments, active element 155 and passive element 160 may be positioned in separate regions of eye 10.

Active component 155 and passive component 160 may not be required to be implanted simultaneously in eye 10 active component 155 and passive component 160 may be implanted sequentially in eye 10 in the same ophthalmic surgery or may be implanted in eye 10 in separate surgeries performed at different times in in some cases active element 155 may be implanted in an eye 10 that already contains a passive lens (i.e., a non-accommodating IOL), thereby providing the potential for presbyopia correction in a patient with an artificial lens.

In embodiments, accommodating IOL device 150 includes a substantially circular device configured to self-stabilize in eye 10 (e.g., in lens capsule 18 or sulcus 32) with its enlargement in embodiments, accommodating IOL device 150 includes a substantially circular device configured to self-stabilize in eye 10 (e.g., in lens capsule 18 or sulcus 32) with a haptic support 220 (as described below with respect to FIG. 4).

Passive element 160 and/or active element 155 may be shaped and configured to maintain the natural circular profile of lens capsule 18 when accommodating IOL device 150 is positioned in eye 10 and to stabilize lens capsule 18 in the event of compromised zonule integrity, in embodiments passive element 160 comprises a generally circular disk having a generally circular shape configured to match the generally circular cross-sectional shape of lens capsule 18 as lens capsule 18 is divided across equatorial region 23 on the coronal plane, in embodiments device 150 (i.e., active element 155 and/or passive element 160) may taper from central region 165 of device 150 toward peripheral edge 170, peripheral edge 170 comprises the outermost circumferential region of accommodating IOL device 150. in embodiments , accommodating IOL device 150 may taper toward its peripheral edge 170 to help stabilize accommodating IOL device 100 within lens capsule 18 and/or sulcus 32. this may allow accommodating IOL device 150 to be self-stabilizing and self-retaining in eye 10 (i.e., from the point of use of the accommodating IOL device , the eye capsule 18 is self-adhering to the eye capsule 18, thus stabilizing the accommodating IOL device 150 in embodiments from the equatorial region .

Fig. 4 illustrates a perspective view of an exemplary accommodating IOL device 200 according to embodiments of the present disclosure fig. 5 illustrates a cross-sectional view of the exemplary accommodating IOL device 200 shown in fig. 4 implanted into an eye 10 according to embodiments of the present disclosure.

The exemplary accommodating IOL device 200 shown in figures 4 and 5 is substantially the same as the accommodating IOL device 150 shown in figures 3A and 3B, except for the differences noted below. Similar to accommodating IOL device 150, accommodating IOL device 200 comprises a two-element IOL including an active component 205 and a passive component 210. The active component 205 is substantially the same as the active element 155 described above. In the pictured embodiment shown in fig. 4, accommodating IOL device 200 includes additional components 215 (e.g., power supply, circuitry, control module, antenna, etc.) related to the operation of electrically active element 155. Several additional components 215 are shown, together with the active element 205, grouped in a housing 218. The passive components 210 are substantially the same as the passive components 160 described above, except for the differences described herein.

In cases, the two-element accommodating IOL device 200 (and IOL device 150) may enhance device stability and improve protection of structures of the eye 10 over conventional IOL devices.A passive element 210 may act as an anchor structure for the active element 205 in embodiments, as shown in figures 4 and 5, for example, and, if positioned posterior or posterior to the active element 205, the softer passive element 210 may act as a buffer during implantation procedures for the active element 205 as well as during other procedures, such as laser posterior capsulotomy.

In the depicted embodiment, accommodating IOL device 200 comprises a substantially circular device comprising haptic support 220, shown in fig. 4, configured to self-stabilize in the lens capsule 18 (or sulcus 32) of eye 10, as shown in fig. 5. The haptic support 220 comprises a substantially flexible, curved elongate member extending outwardly from the accommodating IOL device 200. In the depicted embodiment, the loop support 220 extends radially from the passive element 210. In other embodiments, the loop support 220 may extend from the active element 205. Haptic support 220 is shaped and configured to expand into lens capsule 18 and/or sulcus 32 in order to stabilize and anchor IOL device 200 in eye 10. The haptic support 220 may be shaped and configured to maintain the natural circular contour of the lens capsule 18 when the accommodating IOL device 200 is positioned in the eye 10 and to stabilize the lens capsule 18 in the event of impaired zonular integrity. In the depicted embodiment, IOL device 200 includes a centering member 206 shaped and configured to stabilize and center IOL device 200 in lens capsule 18 (or sulcus 32) of eye 10. Other embodiments do not have centering members 206.

Fig. 6A and 6B illustrate an exemplary accommodating IOL system 300 according to another embodiments consistent with the principles of the present disclosure the system 300 provides high image quality for patients of all pupil sizes and object positions, and acceptable distance vision in the event of a power failure, in cases the system 300 may be used to replace a cataract patient's cloudy natural lens and may provide clear vision and accommodation to these patients the accommodating IOL system 300 includes an optical element 305 positioned in a housing 306. in the pictured embodiment, the optical element 305 is hermetically sealed in the housing 306. the housing 306 includes a transparent front window 307, a transparent back window 308, and an opaque frame 310. in the pictured embodiment, the optical element 305 is sandwiched between the transparent front window 307 and the transparent back window 308, and is circumferentially surrounded by the opaque frame 310. the opaque frame 310 may be continuous with the transparent windows 307, 308. in the pictured embodiment, the system 300 includes four support legs 315a, 315B, 315c, and 315d extending between the opaque frame 310 and two peripheral housings 320a, 320B.

For example, in embodiments, as shown in FIGS. 6A and 6B, optical element 305 may be substantially identical to active element 155 described above with respect to FIG. 3A. in such embodiments, as shown in FIG. 6B, accommodative IOL system 300 may include a passive element or passive component positioned outside housing 306. the embodiment shown in FIG. 6B features a passive component 311 that includes a haptic support 312 that is substantially similar to passive component 210 and haptic support 220, respectively, described above with respect to FIG. 4. in FIGS. 7-14, although passive component 311 is not shown, it is to be understood that accommodative IOL systems 300a-300h may include passive component 311 shown in FIGS. 6A and 6B.

In other embodiments, optical element 305 may comprise a two-element accommodating lens substantially the same as accommodating IOL device 100 described above with respect to FIG. 2 if passive element 160 is smaller than or equal in size to active element 155, both active element 155 and passive element 160 may be housed in housing 306. these embodiments may appear substantially similar to the embodiments depicted in FIGS. 7-14 (where passive element 160 is positioned in housing 106, either in front of or behind active element 155). accordingly, optical element 305 may provide variable optical power by any of the available adjustable optical techniques including, but not limited to, moving the lens, liquid crystals, and electrowetting). In cases, optical element 305 provides variable optical power for primarily correcting presbyopia.

In cases, when implanted in eye 10, optical element 305 may be held in place centered on the optical path of the eye by housing 306 opaque frame 310 may reduce optical effects caused by phase changes and stray light caused by the edges of optical element 305 (more specifically, caused by the edges of active element 155 of optical element 305). opaque frame 310 may reduce optical aberrations in regions outside of optical element 305.

The opaque frame 310 and the transparent front window 307 and transparent rear window 308 completely enclose the optical element 305 the front window 307 and rear window 308 are transparent to allow light to pass through the optical element 305 the opaque frame 310 comprises an opaque ring shaped and sized to fixedly surround or frame the perimeter of the optical element 305 in the depicted embodiment the opaque frame 310 is shaped as a ring or circle sized and shaped to follow the circular shape of the optical element 305 in other embodiments the opaque frame 310 may be any shape that closely surrounds the circumferential perimeter of the optical element 305 therefore the opaque frame 310 may conform to the shape or perimeter profile of the optical element 305 the opaque frame 310 may be constructed of any of various biocompatible materials including but not limited to titanium, ceramic, sapphire, quartz, and glass the opaque frame 310 comprises an inner diameter D5. that measures slightly larger than the outer diameter of the optical element (for example, in the case of , the outer diameter D3 of the active element shown in fig. 3A) in embodiments D5., the inner diameter of the active element shown in fig. 3A , the outer diameter D3525, measured in the example of 356 mm, the thickness of the example, 734, measured in the example of 3535 mm, 3mm, measured in the example, 3mm, 3, in the example embodiment of the thickness of the example, measured at 3535 mm, measured at mm, measured at 734 mm, measured in the example, measured at the thickness of the example, measured at 734 mm, measured at the thickness.

In the pictured embodiment, as described above, system 300 includes four support legs 315a, 315B, 315c, and 315D extending between opaque frame 310 and two peripheral housings 320a, 320B, support legs 315a-D include relatively thin supports for opaque frame 310 that extend radially outward from the opaque frame to peripheral housings 320a, 320B, support legs 315a-D include hollow tubular structures extending between opaque frame 310 and peripheral housings 320a, 320B, in the case of , support legs 315a-D are formed of the same material as opaque frame 310, in the other cases, support legs 315a-D are formed of a biocompatible material different from opaque frame 310. in the case of , support legs 315a-D may be opaque in other embodiments, support legs 315a-D may be optically transparent. in the other embodiments, regions marked with letters A represent peripheral housings (320a, 320B), regions marked with letters B (315a and 315B) between support legs (315a and 315B) and opaque frame 310, and regions marked with letters B, in the case where the outer diameter of the support legs 320a, 320B, the outer diameter of the lens housing 300 mm, the outer diameter of the lens housing 300a, 315B, and the outer diameter of the lens housing 300 mm in the other embodiments, 368 mm, 3626 mm, 3618 mm, 367 mm, 3mm, and 368 mm, and 368 mm.

In embodiments, the exemplary accommodating IOL system 300 includes a power source and control electronics housed in peripheral housings 320a, 320 b. support legs 315a-d may house electrical connectors and contacts that couple the active components of the optical element 310 with such peripheral electronics.the optical element 305 and opaque frame 310 may be connected to the power source and control electronics by electrical connectors and contacts housed in support legs 315 a-d. the length L1 of support leg 315a may range from 0.5mm to 5mm in examples, measuring a width L1 of 1mm in the depicted embodiment, the length L1 of each of the support legs 315a-d is the same.

In the illustrated embodiment, the support legs 315a-d are substantially linear and straight in other embodiments or more of the support legs 315a-d may be curved or bent along their length as shown in FIGS. 11-14, the size, profile, number, thickness, and arrangement of the support legs may vary between different embodiments.

FIGS. 11-14 illustrate different exemplary accommodating IOL systems 300a-300h, including an optical element 305, according to different embodiments consistent with the principles of the present disclosure, the configuration of accommodating IOL systems 300a-h (including the shape and size of opaque frame 310, the shape, size, and number of peripheral housing 320, and the shape, size, and number of support legs 315) may be different in each of the following embodiments as shown in FIGS. 11-14, although accommodating IOL systems 300a-h are different in structure from system 300 shown in FIG. 6, the opaque frames, housings, and support legs in systems 300a-h are substantially similar in use and function to opaque frame 310, peripheral housing 320, and support legs 315a-d in FIGS. 11-14.

The number, size, and arrangement of the support legs 315 ' and peripheral shells 320 ' may be selected, among other factors, to take into account the type of condition to be treated, the particular anatomy of the patient, or the type of optical element 305 to be placed in the opaque frames 310 ', the spaces between the opaque frames 310 ', support legs 315 ', and shells reduce the overall volume of the accommodating IOL system 300a-h and maintain the ability of the healthcare practitioner to perform a fundus examination, in embodiments these spaces increase the flexibility, collapsibility, and expandability of the accommodating IOL device 300 a-h.

Figure 7 illustrates an exemplary accommodating IOL 300a that includes two peripheral housings 320 ' attached to an opaque frame 310 ' by four support legs 315 '. The two perimeter housings 320 'are positioned adjacent to each other along the perimeter of the opaque frame 310' rather than being disposed opposite (i.e., approximately 180 apart) from each other as in the embodiment shown in fig. 6. For example, the perimeter housings 320' may be positioned approximately 135 ° apart.

FIG. 8 illustrates an exemplary accommodating IOL 300b that includes two peripheral housings 320 ' attached to an opaque frame 310 ' by three support legs 315 ' the two peripheral housings 320 ' are positioned at approximately right angles to each other relative to the opaque frame 310 ' rather than being disposed opposite each other as in the embodiment shown in FIG. 6. in the depicted embodiment, the central support leg 315 ' is shaped to be thinner than the other two support legs 315 '.

FIG. 9 illustrates an exemplary accommodating IOL 300c that includes peripheral shells 320 'attached to an opaque frame 310' by a single elongated support leg 315 'extending tangentially from the frame 310' to the outer edge of the peripheral shells 320 'in the pictured embodiment, the peripheral shells 320' are larger in size and have larger arcs of curvature than the peripheral shells 320 shown in FIG. 6.

FIG. 10 illustrates an exemplary accommodating IOL 300d that includes two peripheral housings 320 'attached to an opaque frame 310' by two support legs 315 'extending tangentially from the perimeter of the optical element 305', wherein each support leg 315 'is coupled to an outer edge of the respective peripheral housing 320'.

FIG. 11 illustrates an exemplary accommodating IOL 300e comprising two peripheral housings 320 ' attached to an opaque frame 310 ' by two support legs 315 ' in the pictured embodiment, each of the two support legs 315 ' extend from a midline of the opaque frame 310 ' and connect to a central region of each peripheral housing 320 ', each of the two support legs 315 ' extend along a common linear axis LA that extends through the center of the optical element 305.

Figure 12 illustrates an exemplary accommodating IOL 300f that includes two peripheral shells 320 ' attached to an opaque frame 310 ' by four elongated support legs 315 '. The support legs 315 ' are tangentially attached to the perimeter of the opaque frame 310 ' and extend to the outer edge of the respective perimeter housing 320 '.

Figure 13 illustrates an exemplary accommodating IOL 300g that includes two peripheral shells 320 ' attached to an opaque frame 310 ' by two elongated curved support legs 315 '.

FIG. 14 illustrates an exemplary accommodating IOL 300h that includes two peripheral housings 320 'attached to an opaque frame 310' by four elongated curved support legs 315 'in the pictured embodiment, each of the four support legs 315' extend from the peripheral perimeter of the opaque frame 310 'so as to connect to the sides of the peripheral housings 320'.

The accommodating IOL devices and systems described herein may be formed of any of a variety of biocompatible materials having the optical properties required to perform adequate vision correction as well as the necessary elastic, flexible, distensible, and conformable properties for intraocular surgery in embodiments individual components of the accommodating IOL devices described herein may be formed of different biocompatible materials of different degrees of compliance for example in embodiments inactive region 110 and passive elements 160 and 210 may be formed of more flexible and compliant materials than active region 105 and active elements 155 and 205 in order to minimize contact damage or trauma to the intraocular structures.

In this regard, while illustrative embodiments have been shown and described, a wide variety of modifications, changes, and substitutions are contemplated in the foregoing disclosure and, it is therefore, to be understood that such modifications may be made without departing from the scope of the present disclosure, it is intended that appended claim be interpreted as broadly and in a manner consistent with the present disclosure.