阅读说明：本技术 靶向治疗学 (Targeted therapeutics ) 是由 D.U.基马纳马达 英伟文 于 2013-04-16 设计创作，主要内容包括：本发明涉及靶向治疗学。本发明提供包括缀合(conjugated)到结合部分上的效应物部分的药理学化合物,所述结合部分将所述效应物部分导向目标生物靶点。本发明还提供包括所述化合物的组合物、试剂盒和方法(例如治疗、诊断和成像)。所述化合物可被描述为蛋白质相互作用结合部分-药物缀合物(SDC-TRAP)化合物,其包括蛋白质相互作用结合部分和效应物部分。例如,在涉及治疗癌症的某些实施方案中,该SDC-TRAP可包括缀合到作为效应物部分的细胞毒性剂上的Hsp90抑制剂。(The present invention relates to targeted therapeutics. The present invention provides pharmacological compounds comprising an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. The invention also provides compositions, kits and methods (e.g., therapy, diagnosis and imaging) comprising the compounds. The compounds may be described as protein interaction binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interaction binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can comprise an Hsp90 inhibitor conjugated to a cytotoxic agent as an effector moiety.)