阅读说明：本技术 环amp反应元件结合蛋白(cbp)和/或300kda腺病毒e1a结合蛋白(p300)降解化合物和使用方法 (Cyclic AMP response element binding protein (CBP) and/or 300KDA adenovirus E1A binding protein (P300) degradation compounds and methods of use ) 是由 刘京 迈克尔·布鲁诺·普勒韦 王佳亮 韩笑然 陈立群 于 2020-02-25 设计创作，主要内容包括：二价化合物组合物包含一种或多种二价化合物。二价化合物包含结合至降解标签的环AMP反应元件结合蛋白(CBP)和/或300kDa腺病毒EIA结合蛋白(P300)配体(CBP/P300配体)。使用二价化合物的方法是治疗有需要的受试者的某些疾病。本发明公开了鉴定此类二价化合物的方法。(The divalent compound composition comprises one or more divalent compounds. The divalent compound comprises a cyclic AMP response element binding protein (CBP) and/or a 300kDa adenovirus EIA binding protein (P300) ligand (CBP/P300 ligand) bound to a degradation tag. Methods of using the divalent compounds are to treat certain diseases in a subject in need thereof. Methods of identifying such divalent compounds are disclosed.)