Kill harmful organism activity Cvclopropvlmethvl amide derivatives
阅读说明：本技术 杀有害生物活性环丙基甲基酰胺衍生物 (Kill harmful organism activity Cvclopropvlmethvl amide derivatives ) 是由 J·Y·卡萨耶尔 M·艾尔卡瑟米 T·皮特纳 A·斯托勒 于 2018-03-22 设计创作，主要内容包括：本发明涉及具有式(I)的化合物,其中取代基是如在权利要求1中所定义的,以及那些化合物的农用化学上可接受的盐、立体异构体、对映异构体、互变异构体和N-氧化物；涉及用于制备具有式(I)的化合物的中间体,涉及包含它们的组合物并且涉及使用它们来对抗并且控制昆虫、螨、线虫和软体动物有害生物的方法。<Image he="312" wi="700" file="DDA0002195148050000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The present invention relates to the compounds with formula (I), and wherein substituent group is such as acceptable salt, stereoisomer, enantiomter, tautomer and N- oxide in claimed in claim 1 and those compounds agrochemicals；It is related to being used to prepare the intermediate of the compound with formula (I), be related to comprising their compositions and is related to the method for making to be used to fight and control insect, mite, nematode and mollusk pests.)
1. one kind has the compound of formula (I),
Wherein
A1、A2、A3And A4It is C-H, C-R independently of one another5Or nitrogen；
R1It is hydrogen, C1-C8Alkyl, C1-C8Alkyl-carbonyl-, C3-C6Naphthene base carbonyl, C1-C8Alkoxy, C1-C8Alkoxy -C1-C8 Alkyl, C1-C8Alkoxy carbonyl, C1-C8Alkyl carbonyl epoxide C1-C8Alkyl, C1-C8Alkoxy carbonyl sulfanyl C1-C8Alkyl ammonia Base carbonyl oxygroup C1-C8Alkyl, C1-C8Dialkyl amino carbonyl oxy C1-C8Alkyl, C1-C8Alkyl amino-carbonyl C1-C8Alkyl, C1-C8Dialkyl amino carbonyl C1-C8Alkyl or C1-C8Alkoxy carbonyl C1-C8Alkyl amino C1-C8Alkyl, wherein each alkyl Or alkoxy base can optionally replace by the halogen atom from one to three or by cyano group；
R2It is cyano, C (S) NH2Or C (O) NH2；
R3It is C1-C8Halogenated alkyl；
R4It is aryl, by one to three R7Substituted aryl, heteroaryl or by one to three R7Substituted heteroaryl；
R5It is independently halogen, cyano, nitro, C1-C8Alkyl, C3-C8Naphthenic base, C1-C8Halogenated alkyl, C2-C8Alkenyl, C2-C8 Halogenated alkenyl, C2-C8Alkynyl, C2-C8Halo alkynyl, C1-C8Alkoxy, C1-C8Halogenated alkoxy or C1-C8Alkoxy carbonyl-, Or two R on adjacent carbon atom5It is formed together-CH=CH-CH=CH- bridge ,-CH2-CH2-CH2Bridge ,-CH (OH)- CH2-CH2Bridge ,-C (O)-CH2-CH2Bridge or-N=CH-CH=CH- bridge；
R6It is hydrogen or C1-C8Alkyl；And
R7It is independently halogen, cyano, nitro, C1-C8Alkyl, C1-C8Halogenated alkyl, C1-C8Alkoxy, C1-C8Haloalkoxy Base；
And acceptable salt, stereoisomer, enantiomter, tautomer and N- in the agrochemicals of those compounds Oxide.
2. the compound according to claim 1 with formula (I), wherein R1It is hydrogen, C1-C8Alkyl, C1-C8Alkyl-carbonyl- Or C1-C8Alkoxy carbonyl.
3. the compound according to claim 1 with formula (I), wherein R1It is C1-C8Alkyl, C1-C8Alkyl-carbonyl-, C3- C6Naphthene base carbonyl, C1-C8Alkoxy, C1-C8Alkoxy -C1-C8Alkyl, C1-C8Alkoxy carbonyl, C1-C8Alkyl carbonyl epoxide C1-C8Alkyl, C1-C8Alkoxy carbonyl sulfanyl C1-C8Alkyl amino carbonyl oxy C1-C8Alkyl, C1-C8Dialkyl amido carbonyl Base oxygroup C1-C8Alkyl, C1-C8Alkyl amino-carbonyl C1-C8Alkyl, C1-C8Dialkyl amino carbonyl C1-C8Alkyl or C1-C8Alkane Epoxide carbonyl C1-C8Alkyl amino C1-C8Alkyl, wherein each alkyl or alkoxy base can be optionally by from one to three A halogen atom substituent replaces.
4. the compound according to claim 3 with formula (I), wherein R1It is C1-C8Cyanoalkyl, C1-C8Alkoxy- C1-C8Alkyl, C1-C8Alkoxy carbonyl or C1-C8Alkyl carbonyl epoxide C1-C8Alkyl.
5. the compound according to claim 4 with formula (I), wherein R1It is methoxy, ethoxyl methyl, methoxy Base carbonyl, ethoxy carbonyl, methyl carbonyloxymethyl, 1- Methylethyl carbonyloxymethyl or 1,1- dimethyl ethyl carbonyl Oxygroup methyl.
6. the compound according to any one of claim 1 to 5 with formula (I), wherein R2It is cyano.
7. the compound according to any one of claim 1 to 5 with formula (I), wherein R2It is C (S) NH2Or C (O) NH2。
8. the compound according to any one of claim 1 to 7 with formula (I), wherein R3It is C1-C4Halogenated alkyl.
9. the compound according to any one of claim 1 to 8 with formula (I), wherein R4It is aryl, by one to three A R7Substituted aryl, 5 yuan of -6 unit's heteroaryl or by one to three R75 yuan of -6 unit's heteroaryl replaced.
10. the compound according to any one of claim 1 to 9 with formula (I), wherein R5It is independently halogen, cyanogen Base, nitro, C1-C8Alkyl, C3-C8Naphthenic base, C1-C8Halogenated alkyl or C2-C8Alkenyl.
11. the compound according to any one of claim 1 to 10 with formula (I), wherein R7It is independently halogen, cyanogen Base, C1-C4Alkyl, C1-C4Halogenated alkyl, C1-C4Alkoxy or C1-C4Halogenated alkoxy.
12. the compound according to any one of claim 1 to 11 with formula (I), wherein R6It is hydrogen.
13. one kind has the compound of formula (Int-I),
Wherein A1、A2、A3、A4、R1And R6It is and the X as defined under formula (I) in claim 1BBe halogen, cyano, Formoxyl, CH=N-OH or acetyl group；R2It is cyano, C (S) NH2, C (O) OH or C (O) NH2；And the change with formula (Int-I) Close the salt or N- oxide of object.
14. one kind has the compound of formula (Int-II),
Wherein A1、A2、A3、A4、R1And R6It is as defined under formula (I) in claim 1；R2It is cyano, C (S) NH2、C (O) OH or C (O) NH2；XCIt is CH2Halogen, CH=C (R3)R4Or CH2C(OH)(R3)R4, wherein R3And R4It is such as in claim It is defined under formula (I) in 1；And the salt or N- oxide of the compound with formula (Int-II).
15. one kind has the compound of formula (Int-III),
Wherein A1、A2、A3、A4、R1、R3、R4And R6It is as defined in the compound with formula (I)；And there is formula (Int-III) salt or N- oxide of compound.
16. one kind kills pest composition, it includes at least one according to claim 1 in 12 that this, which kills pest composition, Described in any item compounds with formula (I) or it is appropriate when its tautomer helped as active constituent and at least one Agent, the compound are available salt form in free form or agrochemicals in all cases.
17. a kind of method for controlling harmful organism, this method includes applying composition according to claim 16 In these harmful organisms or its environment, be used to handle the method for human or animal body except through operation or therapy and in people or Except the diagnostic method implemented on animal body.
18. a kind of method for protecting seed to attack from harmful organism, this method includes using according to claim 1 described in 6 These seeds of compositions-treated or the place planted of these seeds.
Embodiment E1:
In a preferred embodiment of the present invention, R1It is hydrogen, C1-C8Alkyl, C1-C8Alkyl-carbonyl-or C1-C8Alkoxy carbonyl Base；More preferably hydrogen, methyl, ethyl, methyl carbonyl-or methoxycarbonyl；Most preferably hydrogen, methyl or ethyl；Especially It is hydrogen or methyl；More particularly hydrogen.
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