阅读说明：本技术 用于通过电子显微术或关联显微术表征生物样品的造影溶液 (Contrast solution for characterizing biological samples by electron microscopy or correlated microscopy ) 是由 瓦伦蒂娜·凯佩罗 乔瓦尼·西尼奥雷 塞巴斯蒂亚诺·迪皮耶特罗 梅丽莎·桑蒂 奥尔多·莫斯卡帝 于 2020-01-24 设计创作，主要内容包括：本发明涉及一种溶液,其包含：在由水/有机溶剂混合物或有机溶剂组成的溶剂中的杂多酸和镧系元素盐。任选地,该溶液还可以包含具有包括在4-6的区间内的pH的有机缓冲液或无机缓冲液,或强碱或强酸。本发明的目的还包括所述溶液及其组分之间的反应的任何产物作为用于生物样品的造影介质的用途,以及用于制备生物样品的方法,该方法在至少一个步骤中使用所述溶液用于通过关联显微术(CLEM)和电子显微术(EM)进行分析。(The present invention relates to a solution comprising: heteropolyacids and lanthanide salts in a solvent consisting of a water/organic solvent mixture or an organic solvent. Optionally, the solution may also comprise an organic or inorganic buffer, or a strong base or acid, having a pH comprised in the interval 4-6. The object of the invention also includes the use of any product of the reaction between said solution and its components as a contrast medium for biological samples, as well as a method for preparing biological samples using said solution in at least one step for analysis by correlation microscopy (CLEM) and Electron Microscopy (EM).)