阅读说明：本技术 安全的牛肝素、制备方法和应用 (Safe bovine heparin, preparation method and application ) 是由 R·S·D·阿奎诺 P·A·D·S·穆拉渺 L·N·D·梅德利诺斯 E·P·维拉诺瓦 A·M 于 2019-02-11 设计创作，主要内容包括：本发明涉及用于放大规模生产安全的牛肝素的制备方法,及其生产方法和应用,所述安全的牛肝素由不同选择的未分级的牛肝素聚合物组成,其具有低6-O-脱硫酸化的葡糖胺含量和猪样抗凝血活性以及鱼精蛋白中和。这种安全的牛肝素(SB肝素)具有与猪肝素(临床使用参考)可比的结构和功能,作为安全的药学产品可预防临床使用障碍,允许其作为可互换的药物使用。(The present invention relates to a process for the preparation of safe bovine heparin consisting of differently selected unfractionated polymers of bovine heparin with a low 6-O-desulphated glucosamine content and porcine-like anticoagulant activity and protamine neutralization for large scale production, as well as to a process for its production and use. The safe bovine heparin (SB heparin) has a structure and a function comparable to those of porcine heparin (clinical use reference), and can prevent clinical use disorder as a safe pharmaceutical product, allowing it to be used as an interchangeable drug.)