阅读说明：本技术 一种芳基环丙烷化合物制备方法 (Preparation method of aryl cyclopropane compound ) 是由 郭记松 马力 周勇 于 2021-09-30 设计创作，主要内容包括：本发明公开了一种芳基环丙烷化合物制备方法,以1.0eq苯乙腈类和1.1eq的1-溴-2-氯乙烷为起始原料,N,N-二甲基乙酰胺为溶剂,溶剂用量10V,加2.5eq氢化钠,反应体系用惰性气体保护并且在加料时控制温度在-15±5℃,室温反应5到16小时,所得粗产品过柱分离纯化。本发明芳基环丙烷化合物制备方法可以方便地得到芳基环丙烷化合物,且该反应的投料操作简便,适用范围较传统的合成方法更广,反应条件温和,为后续衍生物的合成也提供了比较方便的路线。(The invention discloses a preparation method of aryl cyclopropane compound, which takes 1.0eq of phenylacetonitrile and 1.1eq of 1-bromo-2-chloroethane as initial raw materials, N, N-dimethylacetamide as solvent, the dosage of the solvent is 10V, 2.5eq of sodium hydride is added, a reaction system is protected by inert gas, the temperature is controlled at minus or plus 5 ℃ during feeding, the reaction is carried out for 5 to 16 hours at room temperature, and the obtained crude product is separated and purified by a column. The preparation method of the aryl cyclopropane compound can conveniently obtain the aryl cyclopropane compound, the feeding operation of the reaction is simple and convenient, the application range is wider than that of the traditional synthetic method, the reaction condition is mild, and a more convenient route is provided for the synthesis of the subsequent derivatives.)

1. A process for preparing arylcyclopropane compounds, which comprises using 1.0eq of cyanobenzonitrile and 1.1eq of 1-bromo-2-chloroethane as starting materials, using N, N-dimethylacetamide as solvent, adding 2.5eq of sodium hydride, reacting at room temperature for 5 to 16 hours while controlling the temperature at-15 + -5 ℃ under the protection of inert gas.

2. The process for producing an arylcyclopropane compound according to claim 1, wherein the concentration of sodium hydride is 60%.

3. The process for producing arylcyclopropane compound according to claim 1, wherein a crude product obtained by the reaction is subjected to column separation and purification.

4. The process for producing an arylcyclopropane compound according to claim 1, wherein the amount of the solvent used is 10V.

5. A process for the preparation of arylcyclopropane compounds, as claimed in claim 1, wherein the temperature is controlled at-15 ℃ during the addition.

6. The method for producing an arylcyclopropane compound according to claim 1, wherein the arylcyclopropane compound comprises:

Technical Field

The invention belongs to the field of organic compounds, and particularly relates to a preparation method of an aryl cyclopropane compound.

Background

The aryl cyclopropane and the derivatives thereof are not only basic structures of some natural products, but also important organic synthesis intermediates. It is widely found in many microorganisms and non-natural biologically active molecules. Because of the special geometric structure of cyclopropane, the cyclopropane has strong tension and is relatively unstable, and is easy to carry out ring-opening reaction to generate stable ring-opening compounds or generate ring-expanding reaction to obtain corresponding four-membered ring, five-membered ring or six-membered ring compounds and the like. As a three-carbon synthon widely applied in modern organic chemistry, aryl cyclopropane and derivatives thereof have been paid attention to by people. Simons-Smith reaction, which is the most widely used for synthesizing cyclopropane in recent years; the specific reaction is as follows:

although having the following advantages:

1) various olefins may participate in the reaction: simple olefins, alpha, beta-unsaturated aldehyde ketones, electron rich olefins (enol ethers, enamines, etc.);

2) the zinc-copper couple can improve the yield and the reaction speed;

3) the results for diethylzinc and diiodomethane are very reproducible;

4) the cyclopropanation of electron rich olefins is faster due to the electrophilic nature of the reagents, etc.

However, olefins with more substituents also slow down the reaction due to greater steric hindrance, and there are also some cases where the substrate reaction is incomplete during synthesis of the molecule. Therefore, it is necessary to develop a synthetic method with simple operation and wider applicability.

Disclosure of Invention

The invention aims to solve the problems, and provides a preparation method of an arylcyclopropane compound, which can conveniently obtain a target compound, has simple and convenient feeding operation of the reaction, wider application range than the traditional synthesis method and mild reaction conditions, and provides a more convenient route for the synthesis of subsequent derivatives.

The purpose of the invention is realized as follows:

the preparation method of the aryl cyclopropane compound takes 1.0eq of phenylacetonitrile and 1.1eq of 1-bromo-2-chloroethane as initial raw materials, N, N-dimethylacetamide as a solvent, 2.5eq of sodium hydride is added, a reaction system is protected by inert gas, the temperature is controlled to be minus or plus 5 ℃ when the materials are added, and the reaction lasts for 5 to 16 hours at room temperature.

The concentration of sodium hydride in the above-mentioned process for producing an arylcyclopropane compound was 60%.

And (3) passing the crude product obtained by the reaction in the preparation method of the aryl cyclopropane compound through a column for separation and purification.

The solvent dosage in the preparation method of the aryl cyclopropane compound is 10V.

In the preparation method of the aryl cyclopropane compound, the temperature is controlled to be-15 ℃ when materials are added.

The arylcyclopropane compound in the above-mentioned process for producing arylcyclopropane compound comprises:

the preparation method of the aryl cyclopropane compound can conveniently obtain the aryl cyclopropane compound, the feeding operation of the reaction is simple and convenient, the application range is wider than that of the traditional synthetic method, the reaction condition is mild, and a more convenient route is provided for the synthesis of the subsequent derivatives.

Detailed Description

The present invention will be further described with reference to the following examples.

The invention discloses a preparation method of aryl cyclopropane compound, which takes 1.0eq of phenylacetonitrile and 1.1eq of 1-bromo-2-chloroethane as initial raw materials, 10V of N, N-dimethylacetamide as solvent, 2.5eq of sodium hydride is added, the reaction system is protected by inert gas, the temperature is controlled at-15 ℃ during feeding, the reaction is carried out for 5 to 16 hours at room temperature, and the crude product is separated and purified by a column.

Examples 1 to 1

-15 ℃ and N₂Under protection, 2.5eq of 60% sodium hydride (9.25g,231.25mmol) was added to 120ml of dimethylacetamide, 1.0eq of phenylacetonitrile was dissolved in 60ml of dimethylacetamide, and slowly added dropwise to the system while controlling the temperature not to exceed-10 ℃, and then stirred at-15 ℃ for 15 minutes. 1.1eq of 1-bromo-2-chloroethane (14.59g,101.75mmol) was dissolved in 60ml of dimethylacetamide and slowly added dropwise to the system while controlling the temperature to not more than-10 ℃. After the addition, the temperature is naturally raised to room temperature and the mixture is stirred for 1 hour. After the reaction was complete, quench with water and add ethyl acetate: extracting with petroleum ether at a ratio of 1:10, combining organic phases, drying with anhydrous sodium sulfate, concentrating, and purifying the crude product by silica gel column chromatography, wherein the eluent is ethyl acetate: and (3) concentrating the solvent to obtain the target aryl cyclopropane compound, wherein the petroleum ether is 1: 10.

In this example, when phenylacetonitrile was 3-fluorophenylacetonitrile, the method of example 1-1 was employed to obtain 1- (3-fluorophenyl) cyclopropane-1-carbonitrile (14.46g), which was 97% in yield and had the following structural formula:

LC-MS(ESI)m/z 162.2(M+H)+

¹H NMR(400MHz,CDCl₃)δ7.32(dd,J＝14.2,7.3Hz,1H),7.10(d,J＝7.6Hz,1H),6.98(t,J＝8.7Hz,2H),1.77(d,J＝7.3Hz,2H),1.41(t,J＝6.3Hz,2H).

examples 1 to 2

In this example, the phenylacetonitrile compound was 2-fluorophenylacetonitrile, and the method of example 1-1 was employed to obtain 1- (2-fluorophenyl) cyclopropane-1-carbonitrile (13.7g), which was 94.5% in yield and had the following structural formula:

LC-MS(ESI)m/z 162.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.37–7.24(m,2H),7.15–7.03(m,2H),1.67(t,J＝6.2Hz,2H),1.38(t,J＝6.2Hz,2H).

examples 1 to 3

In this example, when phenylacetonitrile was 4-fluorophenylacetonitrile, the procedure of example 1-1 was employed to obtain 1- (4-fluorophenyl) cyclopropane-1-carbonitrile (12.152g), which was 81.5% in yield and had the following structural formula:

LC-MS(ESI)m/z 162.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.37–7.24(m,2H),7.15–7.03(m,2H),1.67(t,J＝6.2Hz,2H),1.38(t,J＝6.2Hz,2H).

examples 1 to 4

In this example, when the phenylacetonitrile was 2, 4-difluorophenylacetonitrile, the compound 1- (2, 4-difluorophenyl) cyclopropane-1-carbonitrile (10.982g) was obtained in a yield of 75.1% by the method of example 1-1, and the structural formula was as follows:

LC-MS(ESI)m/z 180.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.36–7.23(m,1H),6.90–6.78(m,2H),1.73–1.61(m,2H),1.41–1.28(m,2H).

examples 1 to 5

In the present example, when the phenylacetonitrile was 2, 6-difluorophenylacetonitrile, the compound 1- (2, 6-difluorophenyl) cyclopropane-1-carbonitrile (14.6g) was obtained in 99% yield by the method of example 1-1, and the structural formula was as follows:

LC-MS(ESI)m/z 180.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.38–7.27(m,1H),6.91(t,J＝8.1Hz,2H),1.82–1.72(m,2H),1.38(t,J＝6.5Hz,2H).

examples 1 to 6

In this example, when the phenylacetonitrile was 3, 5-difluorophenylacetonitrile, the compound 1- (3, 5-difluorophenyl) cyclopropane-1-carbonitrile (12.3g) was obtained in 84.1% yield by the method of example 1-1, and the structural formula was as follows:

LC-MS(ESI)m/z 180.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ6.81(d,J＝6.4Hz,2H),6.74(t,J＝8.7Hz,1H),1.83–1.76(m,2H),1.46–1.38(m,2H).

examples 1 to 7

In this example, when the phenylacetonitrile was 3, 4-difluorophenylacetonitrile, the compound 1- (3, 4-difluorophenyl) cyclopropane-1-carbonitrile (12.253g) was obtained in 83.8% yield by the method of example 1-1, and the structural formula was as follows:

LC-MS(ESI)m/z 180.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.12(dt,J＝9.6,6.0Hz,2H),7.05(d,J＝11.0Hz,1H),1.74(q,J＝5.6Hz,2H),1.36(q,J＝5.6Hz,2H).

examples 1 to 8

The method of example 1-1 was used to obtain 1- (2-chlorophenyl) cyclopropane-1-carbonitrile (12.88g) in 87.2% yield from phenylacetonitrile to 2-chlorobenzonitrile in the present example, the structural formula was as follows:

LC-MS(ESI)m/z 178.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.45–7.40(m,1H),7.36–7.32(m,1H),7.32–7.27(m,1H),7.27–7.22(m,1H),1.77–1.71(m,2H),1.37–1.31(m,2H).

examples 1 to 9

In this example, when phenylacetonitrile was 4-chloro-2-fluorophenylacetonitrile, the method of example 1-1 was employed to obtain 1- (4-chloro-2-fluorophenyl) cyclopropane-1-carbonitrile (12.07g), which was 83.7% in yield and was represented by the following structural formula:

LC-MS(ESI)m/z 196.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.27(t,J＝8.0Hz,1H),7.12(d,J＝8.5Hz,2H),1.68(dd,J＝7.3,5.3Hz,2H),1.36(q,J＝5.4Hz,2H).

examples 1 to 10

In the present example, the procedure of example 1-1 was used to obtain 1- (3-fluoro-4-methoxyphenyl) cyclopropane-1-carbonitrile (10.378g) as a compound from phenylacetonitrile as 3-fluoro-4-methoxybenzonitrile in a yield of 72%, which had the following structural formula:

LC-MS(ESI)m/z 192.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.07(d,J＝8.4Hz,1H),7.01–6.88(m,2H),3.88(s,3H),1.69(d,J＝7.4Hz,2H),1.36–1.29(m,2H).

examples 1 to 11

In the present example, the procedure of example 1-1 was followed to obtain 1- (3-bromophenyl) cyclopropane-1-carbonitrile (9g) from phenylacetonitrile as 3-bromophenylacetonitrile in a yield of 63.6%, which had the following structural formula:

LC-MS(ESI)m/z 222.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.40(t,J＝5.5Hz,2H),7.25–7.17(m,2H),1.77–1.69(m,2H),1.44–1.36(m,2H).

examples 1 to 12

In the present example, the method of example 1-1 was used to obtain 1- (4-bromophenyl) cyclopropane-1-carbonitrile (10.575g) in 74.7% yield, which is a compound of phenylacetonitrile represented by the following structural formula:

LC-MS(ESI)m/z 222.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.48(d,J＝8.1Hz,2H),7.17(d,J＝8.1Hz,2H),1.75(d,J＝7.4Hz,2H),1.42–1.34(m,2H).

examples 1 to 13

In this example, the procedure of example 1-1 was used to obtain 1- (3, 5-dimethylphenyl) cyclopropane-1-carbonitrile (9.58g) as a compound of phenylacetonitrile as 3, 5-dimethylbenzylacetonitrile in a yield of 65.03%, which had the following structural formula:

LC-MS(ESI)m/z 172.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ6.92(s,3H),2.32(s,6H),1.68(s,2H),1.38(s,2H).

example 2-1

Compound 1- (3-fluorophenyl) cyclopropane-1-carbonitrile (6.85g,42.5mmol) was dissolved in 34ml ethanol, an aqueous solution (34ml) of potassium hydroxide (7.154g,127.5mmol) was added, the mixture was heated to reflux for 24 hours, after completion of the reaction, the solvent was concentrated to dryness, the residue was dissolved in 15ml water, and PH was adjusted to 3-4 with hydrochloric acid solution, a white solid was precipitated, and the filter cake was filtered and washed with water, dried to give compound 1- (3-fluorophenyl) cyclopropane-1-carboxylic acid (7.18g), yield 93.7%, structural formula:

LC-MS(ESI)m/z 181.2(M+H)⁺

¹H NMR(400MHz,CDCl₃)δ7.31–7.22(m,2H),7.12(d,J＝7.6Hz,1H),7.05(d,J＝9.7Hz,1H),6.96(t,J＝8.4Hz,1H),1.74–1.62(m,2H),1.26(s,2H).

examples 2 to 2

In this example, when phenylacetonitrile was 1- (2-fluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (2-fluorophenyl) cyclopropane-1-carboxylic acid (5.98g) was obtained in a yield of 78.1% by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 181.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.25(d,J＝7.8Hz,2H),7.11–6.98(m,2H),1.71(s,2H),1.26(s,2H).

examples 2 to 3

In this example, when phenylacetonitrile was 1- (4-fluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (4-fluorophenyl) cyclopropane-1-carboxylic acid (5.176g) was obtained in 92.6% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 181.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.34–7.28(m,2H),6.99(t,J＝8.5Hz,2H),1.67(d,J＝2.7Hz,2H),1.23(d,J＝2.6Hz,2H).

examples 2 to 4

In the present example, when phenylacetonitrile was 1- (2, 4-difluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (2, 4-difluorophenyl) cyclopropane-1-carboxylic acid (7.18g) was obtained in a yield of 97% by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 199.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.24–7.17(m,1H),6.85–6.73(m,2H),1.71(d,J＝2.6Hz,2H),1.22(d,J＝2.6Hz,2H).

examples 2 to 5

In the present example, when phenylacetonitrile was 1- (2, 6-difluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (2, 6-difluorophenyl) cyclopropane-1-carboxylic acid (4.45g) was obtained in a yield of 93.4% by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 199.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.24–7.18(m,1H),6.85(t,J＝7.8Hz,2H),1.77(d,J＝20.1Hz,2H),1.30(s,2H).

examples 2 to 6

In this example, when phenylacetonitrile was 1- (3, 5-difluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (3, 5-difluorophenyl) cyclopropane-1-carboxylic acid (2.07g) was obtained in 97.8% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 199.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ6.92–6.82(m,2H),6.76–6.66(m,1H),1.69(q,J＝4.2Hz,2H),1.26(q,J＝4.2Hz,2H).

examples 2 to 7

In the present example, when phenylacetonitrile was 1- (3, 4-difluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (3, 4-difluorophenyl) cyclopropane-1-carboxylic acid (4.84g) was obtained in 100% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 199.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.20–7.10(m,1H),7.10–6.99(m,2H),1.68–1.61(m,2H),1.24–1.18(m,2H).

examples 2 to 8

The method of example 2-1 was used to obtain the compound 1- (2-chlorophenyl) cyclopropane-1-carboxylic acid (1.54g) in 92.7% yield, which is represented by the following structural formula:

LC-MS(ESI)m/z 197.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.39–7.36(m,1H),7.31(dt,J＝6.5,2.4Hz,1H),7.24–7.20(m,2H),1.82–1.75(m,2H),1.27(dd,J＝7.2,4.0Hz,2H).

examples 2 to 9

In this example, when phenylacetonitrile was 1- (4-chloro-2-fluorophenyl) cyclopropane-1-carbonitrile, the compound 1- (4-chloro-2-fluorophenyl) cyclopropane-1-carboxylic acid (2.065g) was obtained in 94.3% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 215.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.19(t,J＝8.1Hz,1H),7.07(d,J＝9.8Hz,2H),1.76–1.68(m,2H),1.23(q,J＝4.4Hz,2H).

examples 2 to 10

In this example, when phenylacetonitrile was 1- (3-fluoro-4-methoxyphenyl) cyclopropane-1-carbonitrile, the compound 1- (3-fluoro-4-methoxyphenyl) cyclopropane-1-carboxylic acid (4.472g) was obtained in 96.9% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 211.2(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.06(t,J＝10.2Hz,2H),6.88(t,J＝8.7Hz,1H),3.87(s,3H),1.70–1.58(m,2H),1.24(dd,J＝7.9,4.0Hz,2H).

examples 2 to 11

In this example, when phenylacetonitrile was 1- (3-bromophenyl) cyclopropane-1-carbonitrile, the compound 1- (3-bromophenyl) cyclopropane-1-carboxylic acid (2.275g) was obtained in 98% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 241.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.48(s,1H),7.39(d,J＝7.9Hz,1H),7.25(s,1H),7.17(t,J＝7.6Hz,1H),1.74–1.59(m,2H),1.28(d,J＝22.2Hz,2H).

examples 2 to 12

In this example, when phenylacetonitrile was 1- (4-bromophenyl) cyclopropane-1-carbonitrile, the compound 1- (4-bromophenyl) cyclopropane-1-carboxylic acid (3g) was obtained in 95.7% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 241.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.43(d,J＝8.2Hz,2H),7.22(d,J＝8.3Hz,2H),1.71–1.63(m,2H),1.27–1.19(m,2H).

examples 2 to 13

In this example, when phenylacetonitrile was 1- (3, 5-dimethylphenyl) cyclopropane-1-carbonitrile, the compound 1- (3, 5-dimethylphenyl) cyclopropane-1-carboxylic acid (5.335g) was obtained in 97.9% yield by the method of example 2-1, and the structural formula was as follows:

LC-MS(ESI)m/z 191.2(M+H)⁺

1H NMR(400MHz,CDCl3)δ6.96(s,2H),6.90(s,1H),2.29(s,6H),1.62(d,J＝2.7Hz,2H),1.24(d,J＝2.7Hz,2H).

example 3-1

The compound 1- (3-fluorophenyl) cyclopropane-1-carboxylic acid (5g,27.75mmol) and triethylamine (7.02g,69.375mmol) were dissolved in t-butanol (50ml), and diphenyl azide phosphate (9.55g,34.69mmol) was added thereto, followed by stirring at room temperature for 3 hours, heating to 80 ℃ and stirring for 24 hours. Cool, quench the reaction with water and extract with a solvent of ethyl acetate to 1:10 petroleum ether, combine the organic phases, concentrate and dissolve the concentrate in 6M hydrochloric acid (30 ml). Heating to 80 ℃ was continued and stirring was continued overnight. After the reaction is finished, the reaction product is cooled to room temperature and diluted by adding water, the reaction product is extracted by using a solvent of ethyl acetate and petroleum ether, the pH value of an aqueous phase is adjusted to 8-9, then the aqueous phase is extracted by using ethyl acetate, organic phases are combined and dried by using anhydrous sodium sulfate, a crude product obtained by concentration is dissolved in a 4M hydrochloric acid/1, 4-dioxane solution, the reaction product is stirred for 1 hour at room temperature, a reaction solution is concentrated, ethyl acetate is added, and the reaction product is filtered to obtain a compound 1- (3-fluorophenyl) cyclopropane-1-amine hydrochloride (1.38g), wherein the yield is 26.5 percent and the structural formula is as follows:

LC-MS(ESI)m/z 152.2(M+H)⁺

¹H NMR(400MHz,CD₃OD)δ7.46(dd,J＝14.6,7.3Hz,1H),7.29(d,J＝7.8Hz,1H),7.23(d,J＝9.9Hz,1H),7.13(t,J＝8.4Hz,1H),1.44–1.36(m,2H),1.35–1.28(m,2H).

examples 3 to 2

In this example, when phenylacetonitrile was 1- (2-fluorophenyl) cyclopropane-1-carboxylic acid, the procedure of example 3-1 was followed to give the compound 1- (2-fluorophenyl) cyclopropane-1-amine hydrochloride (0.59g) in a yield of 26%, and the structural formula was as follows:

LC-MS(ESI)m/z 152.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.51(d,J＝27.7Hz,2H),7.25(dd,J＝14.9,8.3Hz,2H),1.40(s,2H),1.28(d,J＝6.1Hz,2H).

example 4-1

At 0 deg.CUnder the protection. Lithium aluminum hydride (3.18g,83.76mmol) was dissolved in 32ml of tetrahydrofuran, and 1- (3-fluorophenyl) cyclopropane-1-carbonitrile (4.5g,27.92mmol) was dissolved in 45ml of tetrahydrofuran and slowly added dropwise thereto while controlling the temperature at 0 ℃ and naturally warming to room temperature, followed by stirring for 1.5 hours. After completion of the reaction, the reaction mixture was quenched with water (3.2ml), 10% sodium hydroxide solution (6.4ml) and water (9.6ml), and the mixture was filtered, washed with tetrahydrofuran and the filtrate was concentrated. Adding ethyl acetate for extraction, separating liquid and concentrating an organic phase. 2.45g of the crude product are concentrated in 15ml of 4M hydrochloric acid/1, 4-dioxane and stirred at room temperature for 1 hour. The reaction was concentrated, and ethyl acetate was added to the crude product, which was filtered to give the compound (1- (3-fluorophenyl) cyclopropyl) methylamine hydrochloride (1.54g) in 50.9% yield, structural formula:

LC-MS(ESI)m/z 166.2(M+H)+

1H NMR(400MHz,CD₃OD)δ7.38(dd,J＝14.6,7.3Hz,1H),7.24(d,J＝7.7Hz,1H),7.17(d,J＝10.1Hz,1H),7.02(t,J＝8.5Hz,1H),3.12(d,J＝28.0Hz,2H),1.02(d,J＝11.1Hz,4H).

example 4 to 2

In the present example, when phenylacetonitrile was 1- (2-fluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (2-fluorophenyl) cyclopropyl) methylamine hydrochloride (1.6g) was obtained in 51% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 166.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.39(dt,J＝13.8,7.3Hz,2H),7.26–7.06(m,2H),3.11(s,2H),1.04(d,J＝18.2Hz,4H).

examples 4 to 3

In this example, when phenylacetonitrile was 1- (4-fluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (4-fluorophenyl) cyclopropyl) methylamine hydrochloride (2.7g) was obtained in a yield of 74.75% by following method in example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 166.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.49–7.37(m,2H),7.10(t,J＝8.6Hz,2H),3.12(s,2H),1.00(s,4H).

examples 4 to 4

In the present example, when phenylacetonitrile was 1- (2, 4-difluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (2, 4-difluorophenyl) cyclopropyl) methylamine hydrochloride (1.7g) was obtained in 41.34% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 184.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.42(dd,J＝15.1,8.4Hz,1H),7.13–6.89(m,2H),3.10(d,J＝13.3Hz,2H),1.10–0.96(m,4H).

examples 4 to 5

In the present example, when the phenylacetonitrile was 1- (2, 6-difluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (2, 6-difluorophenyl) cyclopropyl) methylamine hydrochloride (1.3g) was obtained in the yield of 34% by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 184.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.38(t,J＝7.4Hz,1H),7.00(t,J＝8.2Hz,2H),3.07(s,2H),1.23–0.95(m,4H).

examples 4 to 6

In the present example, when phenylacetonitrile was 1- (3, 5-difluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (3, 5-difluorophenyl) cyclopropyl) methylamine hydrochloride (1.734g) was obtained in a yield of 43.5% by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 184.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.05(d,J＝8.1Hz,2H),6.88(s,1H),3.18(s,2H),1.06(s,4H).

examples 4 to 7

In the present example, when phenylacetonitrile was 1- (3, 4-difluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (3, 4-difluorophenyl) cyclopropyl) methylamine hydrochloride (2.154g) was obtained in 55% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 184.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.40–7.32(m,1H),7.30–7.20(m,2H),3.14(s,2H),1.03(s,4H).

examples 4 to 8

The method of example 4-1 was used to obtain the compound (1- (2-chlorophenyl) cyclopropyl) methylamine hydrochloride (1.5g) in 58% yield, structural formula:

LC-MS(ESI)m/z 182.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.38(dt,J＝13.5,7.4Hz,2H),7.28–7.07(m,2H),3.21(s,2H),1.08(d,J＝18.2Hz,4H).

examples 4 to 9

In this example, when phenylacetonitrile was 1- (4-chloro-2-fluorophenyl) cyclopropane-1-carbonitrile, the compound (1- (4-chloro-2-fluorophenyl) cyclopropyl) methylamine hydrochloride (1g) was obtained in 56.7% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 200.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.40(t,J＝7.7Hz,2H),7.19(dt,J＝19.9,10.6Hz,1H),3.18–3.04(m,2H),1.15–0.95(m,4H).

examples 4 to 10

In this example, when phenylacetonitrile was 1- (3-fluoro-4-methoxyphenyl) cyclopropane-1-carbonitrile, the compound (1- (3-fluoro-4-methoxyphenyl) cyclopropyl) methylamine hydrochloride (1.72g) was obtained in 43% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 196.2(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.17(d,J＝15.0Hz,2H),7.08(d,J＝8.4Hz,1H),3.85(s,3H),3.09(s,2H),0.97(s,4H).

examples 4 to 11

In this example, when phenylacetonitrile was 1- (3, 5-dimethylphenyl) cyclopropane-1-carbonitrile, the compound (1- (3, 5-dimethylphenyl) cyclopropyl) methylamine hydrochloride (0.93g) was obtained in 32% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 176.3(M+H)⁺

1H NMR(400MHz,CD₃OD)δ7.02(s,2H),6.93(s,1H),3.09(s,2H),2.29(s,6H),0.96(d,J＝6.3Hz,4H).

examples 4 to 12

In the present example, when phenylacetonitrile was 1- (3-bromophenyl) cyclopropane-1-carbonitrile, the compound (1- (3-bromophenyl) cyclopropyl) methylamine hydrochloride (1.6g) was obtained in a yield of 59% by following method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 221.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.41(s,1H),7.35(d,J＝7.7Hz,1H),7.24(s,1H),7.15(t,J＝7.6Hz,1H),1.76–1.59(m,2H),1.28(d,J＝22.2Hz,2H).

examples 4 to 13

In the present example, when phenylacetonitrile was 1- (4-bromophenyl) cyclopropane-1-carbonitrile, the compound (1- (4-bromophenyl) cyclopropyl) methylamine hydrochloride (1.4g) was obtained in 55% yield by the method of example 4-1, and the structural formula was as follows:

LC-MS(ESI)m/z 221.1(M+H)⁺

1H NMR(400MHz,CDCl₃)δ7.32(d,J＝8.6Hz,2H),7.22(d,J＝8.3Hz,2H),1.74–1.64(m,2H),1.24–1.17(m,2H).

the above embodiments are provided only for illustrating the present invention and not for limiting the present invention, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention, and therefore all equivalent technical solutions should also fall within the scope of the present invention, and should be defined by the claims.