阅读说明：本技术 一种缓解视疲劳的蓝莓叶黄素酯压片糖果及其制备方法 (Blueberry lutein ester tablet candy for relieving visual fatigue and preparation method thereof ) 是由 焦春伟 谢意珍 李洁仪 郑娇吉 陈家明 李舜贤 连晓东 吴宝森 于 2020-12-30 设计创作，主要内容包括：本发明公开了一种缓解视疲劳的蓝莓叶黄素酯压片糖果及其制备方法,按重量份数计,所述蓝莓叶黄素酯压片糖果包括以下组分：叶黄素酯5～30％、蓝莓粉10～60％、D-甘露糖醇10～70％、麦芽糊精5～30％、微晶纤维素0～10％、柠檬酸0～1.5％、硬脂酸镁0-1％；所述制备方法包括过筛、混合、制软材、制粒、总混、压片等步骤。本发明通过叶黄素酯、蓝莓粉等原料组分的协同配合作用,能够显著缓解视疲劳,采用所述制备方法制成当前接受度普遍较高的日常零食品之一的压片糖果,方便食用及携带,并具有良好的口感,且制备方法操作简单,流程简化,能够满足大规模工业化生产应用。(The invention discloses a blueberry lutein ester tablet candy for relieving visual fatigue and a preparation method thereof, wherein the blueberry lutein ester tablet candy comprises the following components in parts by weight: 5-30% of lutein ester, 10-60% of blueberry powder, 10-70% of D-mannitol, 5-30% of maltodextrin, 0-10% of microcrystalline cellulose, 0-1.5% of citric acid and 0-1% of magnesium stearate; the preparation method comprises the steps of sieving, mixing, preparing a soft material, granulating, totally mixing, tabletting and the like. The preparation method has the advantages that the visual fatigue can be remarkably relieved through the synergistic cooperation of the lutein ester, the blueberry powder and other raw material components, the tabletting candy which is one of daily zero foods with high general acceptance at present is prepared by the preparation method, the eating and carrying are convenient, the mouthfeel is good, the operation of the preparation method is simple, the flow is simplified, and the large-scale industrial production application can be met.)

1. The blueberry lutein ester tablet candy for relieving visual fatigue is characterized by comprising the following components: lutein ester, blueberry powder, D-mannitol, maltodextrin, microcrystalline cellulose, citric acid and magnesium stearate.

2. The blueberry lutein ester tabletted candy for relieving visual fatigue of claim 1, wherein the weight parts of the components are as follows: 5-30% of lutein ester, 10-60% of blueberry powder, 10-70% of D-mannitol, 5-30% of maltodextrin, 0-10% of microcrystalline cellulose, 0-1.5% of citric acid and 0-1% of magnesium stearate.

3. The blueberry lutein ester tabletted candy for relieving visual fatigue of claim 1, wherein the weight parts of the components are as follows: 5-25% of lutein ester, 10-50% of blueberry powder, 20-60% of D-mannitol, 5-28% of maltodextrin, 1-10% of microcrystalline cellulose, 0.2-1.3% of citric acid and 0.2-1% of magnesium stearate.

4. The blueberry lutein ester tabletted candy for relieving visual fatigue of claim 1, wherein the weight parts of the components are as follows: 5-20% of lutein ester, 10-40% of blueberry powder, 20-55% of D-mannitol, 5-25% of maltodextrin, 2-10% of microcrystalline cellulose, 0.2-1% of citric acid and 0.3-1% of magnesium stearate.

5. The blueberry lutein ester tableted candy for relieving asthenopia of claim 1, wherein the lutein ester is lutein ester or lutein ester microcapsule powder taken from marigold.

6. The blueberry lutein ester tableted candy for relieving visual fatigue of claim 1, wherein the lutein dipalmitate ester content in the lutein ester is more than 6% by mass.

7. A preparation method of the blueberry lutein ester tabletted candy for relieving asthenopia as claimed in any one of claims 1 to 6, comprising the following steps:

(1) sieving: sieving the raw material components except the citric acid by a sieve of 40-60 meshes, and sieving the citric acid by a sieve of 60-80 meshes for later use;

(2) mixing: adding the raw material components except for lutein ester, magnesium stearate, citric acid and maltodextrin according to parts by weight, diluting the citric acid with the maltodextrin for 3 times by equivalent gradient addition, adding the diluted citric acid, adding the rest maltodextrin, and fully and uniformly mixing;

(3) preparing a soft material: adding water or alcohol-water mixture to prepare soft material;

(4) and (3) granulating: sieving the soft material, granulating, drying, grading with a swing granulator, and drying again;

(5) adding lutein ester and magnesium stearate into the prepared granules, fully and uniformly mixing, and tabletting to obtain the blueberry lutein ester tabletting candy.

Technical Field

The invention relates to the technical field of health-care functional foods, in particular to a blueberry lutein ester tablet candy for relieving visual fatigue and a preparation method thereof.

Background

Asthenopia is also called asthenopia, is a disease caused by various reasons, such as the condition that eyes are not durable or the symptoms such as discomfort of eyes, visual disturbance, fatigue and the like appear after long-time use of eyes, and the subjective eye symptoms of patients are the main symptoms at present. Asthenopia has no organic pathological changes, is related to eye habits, social environment, constitution of the body, and the like, is clinically mainly manifested as ophthalmalgia, eye swelling, eye dryness, blurred vision, photophobia, foreign body sensation, unstable eyesight, and the like, and can also be combined with general and mental symptoms, such as headache, insomnia, waist and back soreness, memory decline, and the like.

Under the influence of life rhythm and working pressure, the eye use duration of people is generally prolonged, the strength is increased, and the occurrence of asthenopia is obviously increased in recent years. The research finds that factors causing the asthenopia comprise screen light exposure, poor eye habits, myopia correlation and the like. Long-term screen light exposure is a risk factor of visual fatigue, and may be related to visual fatigue caused by reduction of eye accommodation effect caused by screen exposure, and lutein intake and outdoor activities are protection factors of visual fatigue. Experiments by Yoshioka et al show that there is a clear correlation between visual fatigue and both computer screen exposure time and sleep quality, and that computer screen exposure appears as a significant linear correlation if greater than 6 hours per day. The bad eye habits such as overuse of eyes for a long time and eyes used in bad environment can increase the risk of asthenopia, and the use of eyes in bad environment can cause the reduction of tear secretion, the insufficient stability of tear film and the easy asthenopia.

Aiming at a series of problems caused by asthenopia, a plurality of related eye protection treatment instruments, medicines, health care products and the like are available on the market. Although the physical method relieves the asthenopia to a certain extent, the damage to eyes cannot be repaired, and the eye damage caused by factors such as light radiation and the like existing in most contemporary people cannot be safely and effectively solved; moreover, most drugs contain toxin or have side effects, such as naphazoline hydrochloride, oxymetazoline hydrochloride and tetrahydrozoline hydrochloride which are components in eye drops, which can cause mydriasis and even acute onset of angle-closure glaucoma, and cause larger blood vessels, more obvious relaxation and easy dependence. Neostigmine methylsulfate can reluctantly enable ciliary muscle to continue working, but fatigue is more difficult to relieve, and people with pseudomyopia abuse the drugs, possibly accelerating myopia development; in addition, the addition of the auxiliary materials of the related medicines or health care products is not scientific, and the problems that the addition of white granulated sugar and the like is not beneficial to the treatment of teenagers for preventing decayed teeth and senile diabetes patients, the taste is unpalatable and the like are solved.

Disclosure of Invention

In order to solve the technical problems, the invention aims to provide the blueberry lutein ester tablet candy for relieving the visual fatigue and the preparation method thereof, and the blueberry lutein ester tablet candy can improve the visual fatigue caused by screen light exposure, poor eye use habits, myopia and the like.

In order to achieve the purpose, the invention provides the following technical scheme:

a blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components: lutein ester, blueberry powder, D-mannitol, maltodextrin, microcrystalline cellulose, citric acid and magnesium stearate.

Lutein ester is an ester of lutein with various unsaturated fatty acids, and is abundantly present in plants, with the highest content in marigold. It is an important constituent and an antioxidant component of macular pigment, is the only carotenoid found in eyes, enters human bodies, is hydrolyzed into lutein by metabolism under the action of lipase, enters blood, and can effectively absorb blue light which damages human retinas. Lutein has the functions of preventing cataract and relieving asthenopia, is called as 'eye gold', is a filter of solar high-energy blue light, protects retina of eyes from being damaged, and is an antioxidant of retina; oxidative, photodamage is also a major cause of age-related macular degeneration (AMD) and cataracts. Many ophthalmic diseases are greatly related to the deficiency of lutein, but lutein and lutein esters cannot be synthesized in human bodies, so proper supplement of lutein and lutein esters can effectively protect the retina of eyes and prevent cataract.

Blueberry fruits contain a large amount of nutritional and physiologically active ingredients such as anthocyanin, procyanidine, flavonoid, superoxide dismutase (SOD), ursolic acid, vitamins, mineral elements and the like, have strong oxidation resistance, have various physiological effects of promoting resynthesis of rhodophyll, resisting inflammation, improving immunity, resisting cardiovascular diseases, resisting aging, resisting cancer and the like, and are one of hot spots and focuses in the fields of food, medicine, health products and the like. Matsumoto et al, research make internal disorder or usurp found that anthocyanins, especially cyanidin-3-O-glucoside, in berry extracts were effective in relieving asthenopia, effectively improving the adaptability of human eyes to strong light and dark light, and effectively improving the instantaneous adaptability of vision. Research on the influence of light on damage of human retinal pigment epithelial cells, such as Song snow and the like, reveals a protection mechanism of the blueberry anthocyanin on the damage of the human retinal pigment epithelial cells, and results show that the blueberry anthocyanin can obviously reduce the hREP cell damage caused by oxidation, and the higher the concentration of the anthocyanin is, the lower the damage degree of the blueberry anthocyanin on the hREP cells is. Researches such as Reineckia hole and the like find that the blueberry anthocyanin can reduce the oxidation of lens protein caused by excessive free radicals and remarkably reduce the incidence rate of cataract, crystal opacity and retinopathy. Anthocyanin in the blueberry extract can activate retinal enzyme, plays a role in activating and promoting synthesis of rhodophyll, improves the visual acuity of human eyes, and enables the human vision to adapt to the dark environment quickly, thereby enhancing the vision of people.

D-mannitol is a low calorie functional sweetener and can be used as a moisturizer, nutritional supplement and texture modifier. The product has good taste, and can improve bitter taste of food if the food has slight bitter taste.

The functional sweetener has the following characteristics: (1) the calorie is low and difficult to digest. The sweetener mainly comes from that the calorie value generated by metabolism of the sweetener after entering a human body is less, and the digestion path has no relation with insulin, so that the sweetener can be used by diabetics, hypertensive patients, obese patients and the like; (2) the functional sweetener can improve the intestinal function, mainly comes from that the functional sweetener can promote the proliferation of bifidobacteria in the intestinal tract, generate the bifidobacteria in the human intestinal tract, generate the chain-broken fatty acid and some antibiotic substances, have certain inhibiting effect on the growth and the reproduction of pathogenic bacteria and putrefying bacteria, increase the intestinal peristalsis and improve the constipation condition; (3) it also has dental caries preventing effect, and oligosaccharide and sugar alcohol in the functional sweetener can not nourish oral bacteria, and inhibit growth of mutant streptococcus, so that long-term consumption of sweetener food will not cause dental caries.

As a preferred technical scheme, the weight parts of the components are as follows: 5-30% of lutein ester, 10-60% of blueberry powder, 10-70% of D-mannitol, 5-30% of maltodextrin, 0-10% of microcrystalline cellulose, 0-1.5% of citric acid and 0-1% of magnesium stearate.

As a preferred technical scheme, the weight parts of the components are as follows: 5-25% of lutein ester, 10-50% of blueberry powder, 20-60% of D-mannitol, 5-28% of maltodextrin, 1-10% of microcrystalline cellulose, 0.2-1.3% of citric acid and 0.2-1% of magnesium stearate.

As a preferred technical scheme, the weight parts of the components are as follows: 5-20% of lutein ester, 10-40% of blueberry powder, 20-55% of D-mannitol, 5-25% of maltodextrin, 2-10% of microcrystalline cellulose, 0.2-1% of citric acid and 0.3-1% of magnesium stearate.

As a preferable technical scheme, the lutein ester is lutein ester or lutein ester microcapsule powder which is taken from marigold.

As a preferable technical scheme, the lutein dipalmitate content in the lutein ester is more than 6% by mass.

The second aspect of the invention provides a preparation method of the blueberry lutein ester tablet candy for relieving asthenopia, which comprises the following steps:

(1) sieving: sieving the raw material components except the citric acid by a sieve of 40-60 meshes, and sieving the citric acid by a sieve of 60-80 meshes for later use;

(2) mixing: adding the raw material components except for lutein ester, magnesium stearate, citric acid and maltodextrin according to parts by weight, diluting the citric acid with the maltodextrin for 3 times by equivalent gradient addition, adding the diluted citric acid, adding the rest maltodextrin, and fully and uniformly mixing;

(3) preparing a soft material: adding water or alcohol-water mixture to prepare soft material;

(4) and (3) granulating: sieving the soft material, granulating, drying, grading with a swing granulator, and drying again;

(5) adding lutein ester and magnesium stearate into the prepared granules, fully and uniformly mixing, and tabletting to obtain the blueberry lutein ester tabletting candy.

The weight of each tablet of the prepared blueberry lutein ester tablet candy is about 0.5g, and a user can take the blueberry lutein ester tablet candy in a chewing or swallowing way. The tablet candy adopts a daily zero-food mode with generally high current acceptance, is convenient to eat and carry, has good taste, and can remarkably relieve asthenopia through the synergistic cooperation of lutein ester microcapsule powder, blueberry powder and other raw material components.

The invention combines nutrition, adopts natural raw materials, such as lutein ester which can not be synthesized in human body, and blueberry powder to provide natural anthocyanin, etc., and the raw material components not only have good vision protection function respectively, but also have synergistic effect of the components after combined use, thereby promoting the effect of effectively relieving asthenopia among the raw materials, enhancing the anti-asthenopia capability of patients, and fundamentally solving the asthenopia problem. After the lutein ester and the blueberry powder are matched in a more scientific and reasonable proportion, the synergistic effect is stronger, and the visual fatigue can be improved and relieved more obviously. The functional sweetener D-mannitol and the citric acid are added in a proper proportion to prepare an excellent taste, and a small amount of other auxiliary materials such as processing aids are added to prepare the tabletted candy with high yield. The candy is natural in raw materials, safe to eat, free of side effects, good in taste, remarkable in effect and convenient to carry, and the number of the existing domestic pressed candy products with the eye protection function is small, so that the candy can effectively fill the defects of the market space, and has a good application prospect.

Detailed Description

The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. The reagents, equipment and methods adopted by the invention are all reagents, equipment and methods which are conventionally and commercially available in the technical field and are conventionally used in the technical field.

Example 1:

the blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components in parts by weight: lutein ester 10%, blueberry powder 40%, D-mannitol 27%, maltodextrin 20%, microcrystalline cellulose 2%, citric acid 0.5% and magnesium stearate 0.5%.

The preparation method comprises the following steps:

(1) sieving: sieving the raw material components except the citric acid by a 40-mesh sieve, and sieving the citric acid by a 60-mesh sieve for later use;

(2) mixing: adding the raw material components except for lutein ester, magnesium stearate, citric acid and maltodextrin according to parts by weight, diluting the citric acid with the maltodextrin for 3 times by equivalent gradient addition, adding the diluted citric acid, adding the rest maltodextrin, and fully and uniformly mixing;

(3) preparing a soft material: adding water or alcohol-water mixture to prepare soft material;

(4) and (3) granulating: sieving the soft material, granulating, drying, grading with a swing granulator, and drying again;

(5) adding lutein ester and magnesium stearate into the prepared granules, fully and uniformly mixing, and tabletting to obtain the blueberry lutein ester tabletting candy.

Example 2:

the blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components in parts by weight: 15% of lutein ester, 30% of blueberry powder, 35% of D-mannitol, 13.7% of maltodextrin, 5% of microcrystalline cellulose, 0.8% of citric acid and 0.5% of magnesium stearate.

The preparation method is the same as that of example 1 and is not repeated herein.

Example 3:

the blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components in parts by weight: 12% of lutein ester, 35% of blueberry powder, 36.7% of D-mannitol, 10% of maltodextrin, 5% of microcrystalline cellulose, 0.8% of citric acid and 0.5% of magnesium stearate.

The preparation method is the same as the embodiment and is not described herein.

Example 4:

the blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components in parts by weight: 15% of lutein ester, 40% of blueberry powder, 30% of D-mannitol, 11.5% of maltodextrin, 2% of microcrystalline cellulose, 0.9% of citric acid and 0.6% of magnesium stearate.

The preparation method is the same as that of example 1 and is not repeated herein.

Example 5:

the blueberry lutein ester tablet candy for relieving visual fatigue comprises the following components in parts by weight: 11.5% of lutein ester, 37% of blueberry powder, 30% of D-mannitol, 13.2% of maltodextrin, 7% of microcrystalline cellulose, 0.8% of citric acid and 0.5% of magnesium stearate.

The preparation method is the same as that of example 1 and is not repeated herein.

Effect example 1:

the blueberry lutein ester tabletted candy prepared in example 1 is used as a sample to perform a crowd eating test, and the actual effect of relieving visual fatigue of the product is evaluated.

1. Screening of test population

The requirements of the crowd are as follows: adults 18-65 years old are easy to fatigue in vision after long-term use.

Subject population exclusion criteria: patients suffering from infectious and traumatic eye diseases are excluded, patients suffering from eye surgery for less than 3 months, patients suffering from internal and external eye diseases such as cornea, lens, vitreous body and fundus oculi lesions, patients who take articles related to tested functions in a short term and influence judgment on results, and patients who take medicaments and health care products related to vision treatment for a long term or cannot stop using other treatment methods.

Subjects 45 were recruited, aged 20-63 years, 19 males and 26 females.

2. Dosage and method of use of samples

The administration method of the sample comprises orally taking two tablets per day for 30 consecutive days.

3. Efficacy determination criteria

The details are shown in the following table 1, 3 symptoms (the symptom score is reduced) of 8 symptoms of eye ache, eye swelling, photophobia, blurred vision, dry eye, foreign body sensation, lacrimation and general discomfort are improved, and the symptom is judged to be improved without deterioration of other symptoms. The effective rate (%) of symptom improvement was calculated as the number of symptom improvement cases/number of test food cases × 100%.

TABLE 1 determination of asthenopia symptoms

Note: "occasionally feel" means 1-2 times/2 days; sometimes "means 1-3 times per day; "often" means > 3 times per day.

4. Experimental results of human feeding trial

After the blueberry lutein ester tabletted candy is taken for 30 days continuously, statistics is carried out on the symptom improvement condition of a tested population, the number of symptom improvement cases is 37, the effective rate of symptom improvement reaches 82.2%, and the blueberry lutein ester tabletted candy has the obvious effect of improving visual fatigue.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and their concepts should be considered to be equivalent or modified within the technical scope of the present invention.