阅读说明：本技术 一种浓硫酸直接催化法生产牛磺酸的方法 (Method for producing taurine by concentrated sulfuric acid direct catalysis method ) 是由 陆昌元 陆剑平 温建华 王建峰 陈文如 任举 于 2020-12-25 设计创作，主要内容包括：本发明公开了一种浓硫酸直接催化法生产牛磺酸的方法,包括以下内容：首先,精确计量添加的无水乙醇胺和亚硫酸盐粉末,并高温共混搅拌；然后根据根据乙醇胺的总摩尔量添加浓硫酸作为催化剂进行反应,反应结束后向混合体系中加水至整个混合体系中的固体全部溶解,最后静置至常温,所述混合体系中反应生成的牛磺酸以颗粒状析出沉淀在反应釜底部；接着将沉淀从反应釜底部取出,通过离心分离的方式去除牛磺酸颗粒表面残留的反应溶液后使用冷水洗涤进一步去除牛磺酸颗粒表面附着的杂质得到牛磺酸晶体。通过上述方式,本发明能够减少中间体生成的工序,降低单次生产时间的同时提高最终产品的粗晶纯度。(The invention discloses a method for producing taurine by a concentrated sulfuric acid direct catalysis method, which comprises the following steps: firstly, accurately metering anhydrous ethanolamine and sulfite powder, and blending and stirring at high temperature; adding concentrated sulfuric acid serving as a catalyst according to the total molar weight of ethanolamine for reaction, adding water into a mixed system after the reaction is finished until all solids in the whole mixed system are dissolved, and finally standing to normal temperature, wherein taurine generated by the reaction in the mixed system is precipitated and precipitated at the bottom of a reaction kettle in a granular form; and taking the precipitate out of the bottom of the reaction kettle, removing the residual reaction solution on the surface of the taurine particles by a centrifugal separation mode, and washing with cold water to further remove impurities attached to the surface of the taurine particles to obtain the taurine crystals. Through the mode, the method can reduce the procedures of intermediate generation, reduce the single production time and improve the coarse crystal purity of the final product.)

1. A method for producing taurine by a direct catalysis method of concentrated sulfuric acid is characterized by comprising the following steps:

firstly, accurately measuring the molar weight of the added ethanolamine, putting liquid anhydrous ethanolamine into a reaction kettle, and heating and stirring;

secondly, adding sulfite powder into liquid anhydrous ethanolamine according to the molar weight of the ethanolamine, and stirring and blending;

according to the total molar weight of ethanolamine, slowly adding concentrated sulfuric acid into a blending system according to the proportion of adding 5-10 mL into 2 moles, continuously stirring for reaction for 2-3 hours, then adding water into the mixing system until all solids in the whole mixing system are dissolved, and finally standing to normal temperature, wherein taurine generated by reaction in the mixing system is precipitated and precipitated at the bottom of a reaction kettle in a granular form;

step four, discharging the taurine particles precipitated at the bottom of the reaction kettle from the reaction kettle, and then removing the residual reaction solution on the surfaces of the taurine particles in a centrifugal separation mode;

and step five, washing with cold water to further remove impurities attached to the surfaces of the taurine particles to obtain taurine crystals.

2. The method for producing taurine by direct catalysis of concentrated sulfuric acid according to claim 1, wherein the heating reaction temperature range in the first step is 140-160 ℃.

3. The method for producing taurine by direct catalytic concentrated sulfuric acid as claimed in claim 1, wherein the sulfite in the second step comprises ammonium sulfite, sodium sulfite, and sodium bisulfite.

4. The method for producing taurine by direct catalytic concentrated sulfuric acid as claimed in claim 1, wherein the particle size of the sulfite powder in the second step is not more than 50 mesh.

5. The method for producing taurine by direct catalysis of concentrated sulfuric acid according to claim 1, wherein the addition amount of the sulfite powder in the second step is 1 to 1.1 times of the molar amount of ethanolamine.

6. The method for producing taurine by direct catalysis of concentrated sulfuric acid according to claim 1, wherein the reaction solution separated in the fourth step is collected, added into the reaction kettle again, concentrated at high temperature until the water content is less than 3%, and used as mother liquor for the next reaction

The method for producing taurine by direct catalytic concentrated sulfuric acid as claimed in claim 1, wherein the cold water used in the fifth step is distilled water with a temperature not exceeding 10 ℃.

Technical Field

The invention relates to the field of taurine production, in particular to a method for producing taurine by a direct catalysis method of concentrated sulfuric acid.

Background

Taurine (Taurine), also known as taurocholic acid, is a sulfur-containing non-protein amino acid with a chemical name of 2-aminoethanesulfonic acid, is a sulfur-containing amino acid with multiple physiological functions existing in a human body, has the effects of promoting brain development, enhancing eyesight, resisting inflammation, relieving fever, reducing blood pressure, reducing blood sugar, strengthening liver, benefiting gallbladder and the like, and is one of the most important amino acids in the human body. Taurine has no toxic side effect, so developed countries pay attention to the research and application of taurine. In recent years, along with the intensive research on physiological action and nutritional value, the application of the taurine is very wide, and the taurine is widely used as a nutritional health product and a food additive in foreign countries;

taurine has been discovered, and synthetic pathways have been continuously explored. To date, there are not dozens of methods for synthesizing taurine. At present, the industrial production method of taurine in China mainly comprises an ethanolamine method and an ethylene oxide method, when the taurine is prepared by the ethanolamine method, the common method firstly uses sulfuric acid and ethanolamine for esterification reaction to generate a 2-aminoethanol sulfate intermediate, and then adds sulfite and 2-aminoethanol sulfate for sulfonation reaction to prepare the taurine, the preparation method needs intermediate transition, the reaction time is long, and the final product has more impurities.

Disclosure of Invention

The invention mainly solves the technical problem of providing a method for producing taurine, which can shorten the production time and improve the purity of coarse crystals.

In order to solve the technical problems, the invention adopts a technical scheme that: the method for producing the taurine by the direct catalysis of the concentrated sulfuric acid comprises the following steps:

firstly, accurately measuring the molar weight of the added ethanolamine, putting liquid anhydrous ethanolamine into a reaction kettle, and heating and stirring;

secondly, adding sulfite powder into liquid anhydrous ethanolamine according to the molar weight of the ethanolamine, and stirring and blending;

according to the total molar weight of ethanolamine, slowly adding concentrated sulfuric acid into a blending system according to the proportion of adding 5-10 mL into 2 moles, continuously stirring for reaction for 2-3 hours, then adding water into the mixing system until all solids in the whole mixing system are dissolved, and finally standing to normal temperature, wherein taurine generated by reaction in the mixing system is precipitated and precipitated at the bottom of a reaction kettle in a granular form;

step four, discharging the taurine particles precipitated at the bottom of the reaction kettle from the reaction kettle, and then removing the residual reaction solution on the surfaces of the taurine particles in a centrifugal separation mode;

and step five, washing with cold water to further remove impurities attached to the surfaces of the taurine particles to obtain taurine crystals.

In a preferred embodiment of the present invention, the heating reaction temperature in the first step is 140 to 160 ℃.

In a preferred embodiment of the present invention, the sulfite in the second step includes ammonium sulfite, sodium sulfite, and sodium bisulfite.

In a preferred embodiment of the present invention, the particle size of the sulfite powder in the second step is not more than 50 mesh.

In a preferred embodiment of the present invention, the amount of the sulfite powder added in the second step is 1 to 1.1 times of the molar amount of the ethanolamine.

In a preferred embodiment of the present invention, the reaction solution separated in the fourth step is collected and then added into the reaction kettle again to be concentrated at a high temperature until the water content is lower than 3%, and then the reaction solution is used as the mother solution for the next reaction.

In a preferred embodiment of the present invention, the cold water used in the fifth step is distilled water with a temperature not exceeding 10 ℃.

The invention has the beneficial effects that: the method takes concentrated sulfuric acid as a catalyst, directly promotes ethanolamine to react with sulfite to synthesize taurine under a high-temperature environment, omits the step of synthesizing a 2-aminoethanol sulfate intermediate, obviously reduces the time of single production of a reaction kettle and improves the production efficiency on the one hand, reduces the interference in the synthesis process and improves the purity of a crude product on the other hand, and the residual raw materials in the production can be recycled in a mother liquor recycling mode without waste.

Detailed Description

The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention, and to clearly and unequivocally define the scope of the present invention.

A preferred embodiment of the present invention comprises:

a method for producing taurine by a direct catalysis method of concentrated sulfuric acid comprises the following steps:

firstly, accurately measuring the molar weight of the added ethanolamine, putting liquid anhydrous ethanolamine into a reaction kettle, continuously stirring and heating the liquid anhydrous ethanolamine to 140-160 ℃;

secondly, adding the ground ammonium sulfite powder with the particle size smaller than 50 meshes into liquid anhydrous ethanolamine according to the molar weight of the ethanolamine, and mixing and stirring, wherein the addition amount of the ammonium sulfite powder is the same as the molar weight of the ethanolamine;

step three, according to the total molar weight of ethanolamine, slowly adding concentrated sulfuric acid into a blending system according to the proportion of adding 5mL per 2 moles, continuously stirring for reaction for 3 hours, then adding water into the mixing system until all solids in the whole mixing system are dissolved, and finally standing to normal temperature, wherein taurine generated by reaction in the mixing system is precipitated and precipitated at the bottom of a reaction kettle in a granular form;

discharging taurine particles precipitated at the bottom of the reaction kettle from the reaction kettle, removing the residual reaction solution on the surface of the taurine in a centrifugal separation mode, collecting the separated reaction solution, adding the collected reaction solution into the reaction kettle again, concentrating the reaction solution at a high temperature until the water content is lower than 3%, and using the concentrated reaction solution as a mother solution for next reaction;

and step five, washing the taurine particles by using distilled water with the temperature not more than 10 ℃ to further remove impurities attached to the surfaces of the taurine particles, thereby obtaining the taurine crystals.

Another preferred embodiment of the present invention comprises:

a method for producing taurine by a direct catalysis method of concentrated sulfuric acid comprises the following steps:

firstly, accurately metering the molar weight of the added ethanolamine, putting liquid anhydrous ethanolamine into a reaction kettle, continuously stirring and heating the liquid anhydrous ethanolamine to 140-160 ℃;

and step two, adding sodium sulfite powder with the particle size smaller than 50 meshes after grinding into liquid anhydrous ethanolamine according to the molar weight of the ethanolamine, and mixing and stirring, wherein the addition amount of the sodium sulfite powder is 1.05 times of the molar weight of the ethanolamine. (ii) a

Step three, according to the total molar weight of ethanolamine, slowly adding concentrated sulfuric acid into a blending system according to the proportion of adding 10mL per 2 moles, continuously stirring for reaction for 2 hours, then adding water into the mixing system until all solids in the whole mixing system are dissolved, and finally standing to normal temperature, wherein taurine generated by reaction in the mixing system is separated out in a granular form and is precipitated at the bottom of a reaction kettle;

discharging taurine particles precipitated at the bottom of the reaction kettle from the reaction kettle, removing the residual reaction solution on the surface of the taurine in a centrifugal separation mode, collecting the separated reaction solution, adding the collected reaction solution into the reaction kettle again, concentrating the reaction solution at a high temperature until the water content is lower than 3%, and using the concentrated reaction solution as a mother solution for next reaction;

and step five, washing the taurine particles by using distilled water with the temperature not more than 10 ℃ to further remove impurities attached to the surfaces of the taurine particles, thereby obtaining the taurine crystals.

Another preferred embodiment of the present invention comprises:

a method for producing taurine by a direct catalysis method of concentrated sulfuric acid comprises the following steps:

firstly, accurately metering the molar weight of the added ethanolamine, putting liquid anhydrous ethanolamine into a reaction kettle, continuously stirring and heating the liquid anhydrous ethanolamine to 140-160 ℃;

and step two, adding the ground sodium bisulfite powder with the particle size smaller than 50 meshes into liquid anhydrous ethanolamine according to the molar weight of ethanolamine, mixing and stirring, wherein the addition amount of the ammonium sulfite, the sodium sulfite and the sodium bisulfite powder is 1.1 times of the molar weight of ethanolamine. (ii) a

According to the total molar weight of ethanolamine, adding 8mL of concentrated sulfuric acid into the blending system according to the proportion of adding 2 mol per 2 mol, continuously stirring for reaction for 2.5h, then adding water into the mixing system until all solids in the whole mixing system are dissolved, and finally standing to normal temperature, wherein taurine generated by reaction in the mixing system is precipitated at the bottom of the reaction kettle in a granular form;

discharging taurine particles precipitated at the bottom of the reaction kettle from the reaction kettle, removing the residual reaction solution on the surface of the taurine in a centrifugal separation mode, collecting the separated reaction solution, adding the collected reaction solution into the reaction kettle again, concentrating the reaction solution at a high temperature until the water content is lower than 3%, and using the concentrated reaction solution as a mother solution for next reaction;

and step five, washing the taurine particles by using distilled water with the temperature not more than 10 ℃ to further remove impurities attached to the surfaces of the taurine particles, thereby obtaining the taurine crystals.

According to the mode of the 3 examples, the taurine is directly produced under the catalysis of concentrated sulfuric acid, and through practical measurement and calculation, the highest yield of the example 1 in a single time can reach about 37 percent, while the lowest yield of the example 2 is about 30 percent, and the yield is slightly lower than that of the conventional production.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.