阅读说明：本技术 一种基于骨髓液代谢组学研究酒精性骨重构的方法 (Method for researching alcoholic bone remodeling based on marrow fluid metabonomics ) 是由 不公告发明人 于 2020-12-08 设计创作，主要内容包括：本发明涉及骨重构技术领域,尤其为一种基于骨髓液代谢组学研究酒精性骨重构的方法,骨重构的步骤包括：步骤一：对患者患有恶性肿瘤的腿部进行CT拍片,以此确定肿瘤附着在骨头上的范围；步骤二：使患者平躺在病床上,然后剖开患者腿部有肿瘤部分,接着通过切断设备切下有肿瘤部分的骨头；步骤三：通过钻孔设备在切断后的两节骨头外侧钻定位孔,本发明中,通过对切除的骨头进行浸泡灭瘤处理,然后将其重新复位,配合骨髓液的自主代谢和定位机构的辅助支撑挤压,不但保证了骨重构的效果,还缩短了骨重构的周期,因为不需要在重构部分内部增加额外的支撑机构,所以不会出现排斥的现象,很好的实现了骨重构的自主修复,大大提高了骨重构的可靠性。(The invention relates to the technical field of bone reconstruction, in particular to a method for researching alcoholic bone reconstruction based on marrow metabonomics, which comprises the following steps: the method comprises the following steps: CT shooting is carried out on the leg of the patient with the malignant tumor, so as to determine the range of the tumor attached to the bone; step two: the patient is laid on a bed, then the part with the tumor on the leg of the patient is dissected, and then the bone with the tumor part is cut off by a cutting device; step three: according to the bone reconstruction method, the cut bones are soaked for tumor removal treatment and then reset again, and the bone reconstruction effect is ensured and the bone reconstruction period is shortened by matching with the autonomous metabolism of bone marrow liquid and the auxiliary supporting extrusion of the positioning mechanism.)

1. A method for researching alcoholic bone remodeling based on marrow fluid metabonomics is characterized in that: the bone remodeling step comprises:

the method comprises the following steps: CT shooting is carried out on the leg of the patient with the malignant tumor, so as to determine the range of the tumor attached to the bone;

step two: the patient is laid on a bed, then the part with the tumor on the leg of the patient is dissected, and then the bone with the tumor part is cut off by a cutting device;

step three: drilling positioning holes on the outer sides of the two cut bones through drilling equipment, and fixing the two cut bones through two positioning devices;

step four: putting the cut bone with tumor in a glass bottle, injecting ethanol into the glass bottle, sealing the glass bottle after the injection of the ethanol is finished, and soaking the bone with tumor in the ethanol;

step five: taking out the soaked bone with the tumor, and wiping off ethanol on the surface;

step six: drilling holes on the outer sides of the two positioned bones by using drilling equipment, then drilling holes at the upper end and the lower end of the bone with the tumor, resetting the soaked bone with the tumor to a cut part, and positioning the bone through a connecting wire after resetting;

step seven: performing suture disinfection treatment on the leg operation part;

step eight: adjusting the positioning mechanism so as to adjust the strain and stress between bones, and stimulating the absorption and growth of bone tissues by matching with the metabolism of marrow fluid;

step nine: the leg repairing condition is regularly observed, and the positioning mechanism is removed after the repairing is finished.

2. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: in the process of bone extraction, the operation is performed in a sterile environment.

3. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: when a patient is subjected to a cutting operation for removing a bone, the cutting position is 2 to 3cm from the tumor.

4. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: when the bone with tumor is soaked, the concentration of the used ethanol is 94% -96%, and the glass bottle needs to be filled with the ethanol.

5. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: when the bone with tumor is soaked by using ethanol, the glass bottle needs to be placed on a rotating device for rotating treatment, so that the glass bottle is always in a slow rotating state, and the soaking time is controlled to be 20-30 minutes.

6. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: in the case of connection in the reduction of the bone after the soaking treatment, the main component of the connection wire used is polyimide or a methyl glycolate copolymer.

7. The method for studying alcoholic bone remodeling based on myeloid hydrometabolomics as claimed in claim 1, wherein: when stimulating bone resorption, the strain is controlled at 50-100 micro strain and the stress is controlled at 1-2MPa, and when stimulating bone growth, the strain is controlled at 1000-1500 micro strain and the stress is controlled at 20-30 MPa.

Technical Field

The invention relates to the technical field of bone remodeling, in particular to a method for researching alcoholic bone remodeling based on marrow fluid metabonomics.

Background

Bone remodeling refers to the physiological behavior that the shape and density of bone tissue change with the change of biomechanical environment, qualitatively speaking, in the area with higher load, the quality and density of bone increase, in the area with lower load, the quality and density of bone decrease, the characteristic that the bone tissue becomes stronger and weaker in waste reflects the adaptability to the biomechanical environment, thereby realizing the maximum bearing capacity with the minimum bone mass under specific mechanical environment, when the bone is in unfavorable external force environment, the shape and density of the bone can be abnormally changed, such as osteoporosis caused by weightlessness environment, stress shielding caused by implant, and the like, with the continuous development of society, some bone remodeling methods begin to appear continuously, but the traditional partial resection type remodeling method has poor bone remodeling effect and long period, and needs to add auxiliary support structure in the bone, the method is not beneficial to the autonomous repair of bones, is easy to cause infection and rejection phenomena, and has low reliability, so the method for researching alcoholic bone remodeling based on the marrow fluid metabonomics is provided for solving the problems.

Disclosure of Invention

The invention aims to provide a method for researching alcoholic bone remodeling based on marrow fluid metabonomics, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a method for researching alcoholic bone reconstruction based on marrow fluid metabonomics comprises the following steps:

the method comprises the following steps: CT shooting is carried out on the leg of the patient with the malignant tumor, so as to determine the range of the tumor attached to the bone;

step two: the patient is laid on a bed, then the part with the tumor on the leg of the patient is dissected, and then the bone with the tumor part is cut off by a cutting device;

step three: drilling positioning holes on the outer sides of the two cut bones through drilling equipment, and fixing the two cut bones through two positioning devices;

step four: putting the cut bone with tumor in a glass bottle, injecting ethanol into the glass bottle, sealing the glass bottle after the injection of the ethanol is finished, and soaking the bone with tumor in the ethanol;

step five: taking out the soaked bone with the tumor, and wiping off ethanol on the surface;

step six: drilling holes on the outer sides of the two positioned bones by using drilling equipment, then drilling holes at the upper end and the lower end of the bone with the tumor, resetting the soaked bone with the tumor to a cut part, and positioning the bone through a connecting wire after resetting;

step seven: performing suture disinfection treatment on the leg operation part;

step eight: adjusting the positioning mechanism so as to adjust the strain and stress between bones, and stimulating the absorption and growth of bone tissues by matching with the metabolism of marrow fluid;

step nine: the leg repairing condition is regularly observed, and the positioning mechanism is removed after the repairing is finished.

Preferably, the operation is performed in a sterile environment during the bone extraction procedure.

Preferably, when the patient is subjected to a cutting operation for removing a bone, the cutting position is 2 to 3cm from the tumor.

Preferably, when the bone with tumor is soaked, the concentration of the ethanol used is 94% -96%, and the glass bottle needs to be filled with the ethanol.

Preferably, when ethanol is used for soaking bones with tumors, the glass bottle is placed on a rotating device for rotating treatment, so that the glass bottle is always in a slowly rotating state, and the soaking time is controlled to be 20-30 minutes.

Preferably, when the bone after the soaking treatment is subjected to the connection at the time of restoration, the main component of the connection wire used is polyimide or a methyl glycolate copolymer.

Preferably, the strain is controlled to be 50-100 microstrain and the stress is controlled to be 1-2MPa when the bone resorption is stimulated, and the strain is controlled to be 1000-1500 microstrain and the stress is controlled to be 20-30MPa when the bone growth is stimulated.

Compared with the prior art, the invention has the beneficial effects that:

1. according to the bone reconstruction method, the excised bone is soaked for tumor removal treatment and then reset, and the bone is matched with autonomous metabolism of bone marrow fluid and auxiliary supporting extrusion of a positioning mechanism, so that the bone reconstruction effect is ensured, the bone reconstruction period is shortened, the rejection phenomenon is avoided because an additional supporting mechanism is not required to be added in the reconstruction part, the autonomous repair of the bone reconstruction is well realized, and the reliability of the bone reconstruction is greatly improved.

Detailed Description

Example 1:

the invention provides a technical scheme that:

a method for researching alcoholic bone reconstruction based on marrow fluid metabonomics comprises the following steps:

the method comprises the following steps: CT shooting is carried out on the leg of the patient with the malignant tumor, so as to determine the range of the tumor attached to the bone;

step two: the patient is laid on a bed, then the part with the tumor on the leg of the patient is dissected, and then the bone with the tumor part is cut off by a cutting device;

step three: drilling positioning holes on the outer sides of the two cut bones through drilling equipment, and fixing the two cut bones through two positioning devices;

step four: putting the cut bone with tumor in a glass bottle, injecting ethanol into the glass bottle, sealing the glass bottle after the injection of the ethanol is finished, and soaking the bone with tumor in the ethanol;

step five: taking out the soaked bone with the tumor, and wiping off ethanol on the surface;

step six: drilling holes on the outer sides of the two positioned bones by using drilling equipment, then drilling holes at the upper end and the lower end of the bone with the tumor, resetting the soaked bone with the tumor to a cut part, and positioning the bone through a connecting wire after resetting;

step seven: performing suture disinfection treatment on the leg operation part;

step eight: adjusting the positioning mechanism so as to adjust the strain and stress between bones, and stimulating the absorption and growth of bone tissues by matching with the metabolism of marrow fluid;

step nine: the leg repairing condition is regularly observed, and the positioning mechanism is removed after the repairing is finished.

When the bone with the tumor is soaked by using the ethanol, the glass bottle needs to be put on a rotating device for rotating treatment, the glass bottle is ensured to be in a slowly rotating state all the time, the soaking time is controlled to be 30 minutes, so that the tumor eliminating effect on the outer side of the bone is better, when the bone after soaking treatment is reset for connection, the main component of the used connecting wire is polyimide, and the wire can be absorbed by using the connecting wire, the step of removing stitches is omitted, the strain is controlled to be 50 micro-strain and the stress is controlled to be 1MPa when the bone resorption is stimulated, the strain is controlled to be 1000 micro-strain and the stress is controlled to be 20MPa when the bone growth is stimulated, and therefore the reconstruction recovery effect of the bone is better.

Example 2:

the invention provides a technical scheme that:

a method for researching alcoholic bone reconstruction based on marrow fluid metabonomics comprises the following steps:

the method comprises the following steps: CT shooting is carried out on the leg of the patient with the malignant tumor, so as to determine the range of the tumor attached to the bone;

step two: the patient is laid on a bed, then the part with the tumor on the leg of the patient is dissected, and then the bone with the tumor part is cut off by a cutting device;

step three: drilling positioning holes on the outer sides of the two cut bones through drilling equipment, and fixing the two cut bones through two positioning devices;

step four: putting the cut bone with tumor in a glass bottle, injecting ethanol into the glass bottle, sealing the glass bottle after the injection of the ethanol is finished, and soaking the bone with tumor in the ethanol;

step five: taking out the soaked bone with the tumor, and wiping off ethanol on the surface;

step six: drilling holes on the outer sides of the two positioned bones by using drilling equipment, then drilling holes at the upper end and the lower end of the bone with the tumor, resetting the soaked bone with the tumor to a cut part, and positioning the bone through a connecting wire after resetting;

step seven: performing suture disinfection treatment on the leg operation part;

step eight: adjusting the positioning mechanism so as to adjust the strain and stress between bones, and stimulating the absorption and growth of bone tissues by matching with the metabolism of marrow fluid;

step nine: the leg repairing condition is regularly observed, and the positioning mechanism is removed after the repairing is finished.

When the bone with the tumor is soaked by using the ethanol, the glass bottle needs to be put on a rotating device for rotating treatment, the glass bottle is ensured to be in a slowly rotating state all the time, the soaking time is controlled to be 20 minutes, so that the tumor eliminating effect on the outer side of the bone is better, when the bone after soaking treatment is reset for connection, the main component of the used connecting wire is methyl glycolate copolymer, and the absorbable wire can be absorbed by using the absorbable wire, the step of removing stitches is omitted, the strain is controlled to be 100 micro-strain and the stress is controlled to be 2MPa when the bone resorption is stimulated, the strain is controlled to be 1500 micro-strain and the stress is controlled to be 30MPa when the bone growth is stimulated, and therefore the reconstruction recovery effect of the bone is better.

The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present invention. The foregoing is only a preferred embodiment of the present invention, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present invention, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments.