阅读说明：本技术 一种儿童抑菌口香糖及其制备方法 (Antibacterial chewing gum for children and preparation method thereof ) 是由 刘皓 刘智明 郭周义 于 2020-05-11 设计创作，主要内容包括：本发明公开了一种儿童抑菌口香糖,包括胶基、抑菌成分和辅料,所述的胶基为明胶,所述的抑菌成分为单宁酸,所述的辅料中至少包含糖醇。该口香糖材料简单,制作方便,不仅具有很好的抑菌效果,且能在咀嚼过程中变得柔软,而离开口腔后变得硬度较大、黏性较弱,能减少儿童咀嚼后可能随处吐掉而对环境的影响。本发明还公开了所述儿童抑菌口香糖的制备方法。(The invention discloses bacteriostatic chewing gum for children, which comprises a gum base, bacteriostatic components and auxiliary materials, wherein the gum base is gelatin, the bacteriostatic components are tannic acid, and the auxiliary materials at least contain sugar alcohol. The chewing gum is simple in material and convenient to manufacture, has a good antibacterial effect, can become soft in the chewing process, becomes high in hardness and weak in viscosity after leaving the oral cavity, and can reduce the influence on the environment caused by the fact that children can spit away everywhere after chewing. The invention also discloses a preparation method of the children antibacterial chewing gum.)

1. The bacteriostatic chewing gum for children comprises a gum base, a bacteriostatic component and auxiliary materials, and is characterized in that the gum base is gelatin, the bacteriostatic component is tannic acid, and the auxiliary materials at least contain sugar alcohol.

2. The bacteriostatic chewing gum for children according to claim 1, wherein the bacteriostatic chewing gum for children comprises the following components in percentage by weight: 9-14 wt% of auxiliary materials; the mass ratio of the gelatin to the tannic acid is 1: 0.2-1: 0.3.

3. A bacteriostatic chewing gum for children according to claim 2, wherein the minimum addition amount of sugar alcohol is 2 wt%; the sugar alcohol is selected from one or more of maltitol, sorbitol, xylitol, lactitol, erythritol or mannitol.

4. A bacteriostatic chewing gum according to claim 3, wherein the auxiliary materials further comprise one or more of non-sugar sweetener, essence, lubricant, softener and thickener.

5. A child resistant chewing gum according to claim 4, wherein the non-sugar sweetener is selected from one or more of steviol glycosides, glycyrrhizin, mogrosides, acesulfame potassium, aspartame, sucralose and isomaltulose.

6. A child resistant chewing gum according to claim 4, wherein the lubricant is selected from one or more of triglycerides, glycerol, isopropanol, polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600; the softening agent is selected from pectin, alginic acid and alginate; the thickening agent is selected from one or more of hydroxyethyl cellulose, xanthan gum, carrageenan, carbomer and hydroxymethyl cellulose.

7. A preparation method of bacteriostatic chewing gum for children according to any one of claims 1 to 6, which comprises the following steps:

(1) preparing gelatin mother liquor, and stirring under heating condition until the gelatin mother liquor is completely dissolved;

(2) preparing a tannic acid mother solution, and stirring under a heating condition until the tannic acid mother solution is completely dissolved;

(3) preparing each auxiliary material into a solution respectively, and adding the solution into the tannic acid mother liquor obtained in the step (2) respectively to form a mixed mother liquor;

(4) mixing the gelatin mother liquor and the mixed mother liquor under the stirring state, and continuously stirring until a solid flocculent precipitate is formed;

(5) solid-liquid separation, namely taking solid precipitate, placing the solid precipitate in a mold for tabletting, and then placing the solid precipitate in a low-temperature environment for storage;

(6) and (4) drying the chewing gum stored at low temperature in a freeze dryer to obtain the antibacterial chewing gum for children.

8. A preparation method of a bacteriostatic chewing gum for children according to claim 7, wherein in the step (1), the concentration of the gelatin mother liquor is 0.5-7 mg/ml, the heating temperature is 40-60 ℃, the stirring speed of 200-400 rpm is adopted, and the stirring time is 20-40 min; in the step (2), the concentration of the tannic acid mother liquor is 1-10 mg/ml, the heating temperature is 25-40 ℃, the stirring speed of 200-400 rpm is adopted, and the stirring time is 20-40 min.

9. The preparation method of the bacteriostatic chewing gum for children according to claim 7, wherein in the step (3), different excipients are respectively prepared into solutions with the concentration of 0.2-5 mg/ml.

10. The preparation method of the bacteriostatic chewing gum for children according to claim 7, wherein the stirring speed of the tannic acid mother liquor in the step (4) is 200-400 rpm; the low-temperature environment in the step (5) is-80 to-20 ℃, and the storage time is 6 to 15 hours; in the step (6), the drying time is 10-15 h.

Technical Field

The invention belongs to the technical field of chewing gum manufacturing, and particularly relates to antibacterial chewing gum for children and a preparation method thereof.

Background

Chewing gum is already available everywhere as a snack food. The common chewing gum has the functions of refreshing breath, relieving pressure, cleaning oral cavity and the like. Chewing gum is based on ester gum matrix (or gum base for short), which is a solid having chewing property and is soft and will not break when chewing in mouth. Besides the ester gum matrix, the common chewing gum is also added with sweetening agents, spices and antibacterial component substances, so that the effects of fresh breath and clean oral cavity are brought after people chew the chewing gum.

Chinese patent application 201811607485.5 discloses a chewing gum and its preparation method, wherein the formula comprises 0.5-0.7 wt% of compound (I) with specific structure, 40-60 wt% of gum base, 0.09-0.15 wt% of citric acid, 0.1-0.5 wt% of lubricant, 0.15-0.45 wt% of softener and 8-15 wt% of water. The chewing gum can play a long-acting role in inhibiting the growth of bacteria in the oral cavity through the combined action of the compound (I) and the citric acid.

The current preparation method of the chewing gum is complicated, the auxiliary materials are used in a plurality of types, the functional chewing gum auxiliary materials are not common, and the raw material price is relatively high. These disadvantages have limited the development of functional chewing gums.

On the other hand, the chewing gum can bring fresh breath to people and bring a lot of benefits to social occasions. Chewing gum, however, also has a significant disadvantage: after chewing gum is chewed, the gum base becomes a very viscous substance. After chewing, if not wrapped with wrapping paper or the like, it sticks to other objects, such as the ground of a sidewalk, a stop board at a bus stop, or a wall; thereafter, the exposed chewing gum may be stained with dust and other contaminants, which may contaminate the environment and even affect the safe operation of the escalator or other machine.

Because chewing gum is very sticky, once it is sticky, it is very difficult to clean it completely. The singapore command therefore prohibits the sale of chewing gum, and carrying and eating chewing gum may even constitute an illegal act, which is seen in the fact that chewing gum is actually painful to the environment.

Children of small age are more reluctant to move and do not have environmental consciousness like adults, so that the situation of spitting everywhere is easy to occur after chewing the chewing gum, and a lot of hidden troubles are brought for environmental sanitation. The main focus of current chewing gum manufacturers is how to improve the taste, bacteriostatic and persistence of chewing gum without paying sufficient attention to the environmental problems associated with chewing gum, especially the problems caused by children.

Disclosure of Invention

The invention provides bacteriostatic chewing gum for children, which is simple in material and convenient to prepare, has a good bacteriostatic effect, can become soft in the chewing process, becomes high in hardness and weak in viscosity after leaving the oral cavity, and can reduce the influence on the environment caused by the fact that children can spit away everywhere after chewing.

The second purpose of the invention is to provide a preparation method of the bacteriostatic chewing gum for children.

The first purpose of the invention is realized by the following technical scheme:

the child bacteriostatic chewing gum comprises a gum base, a bacteriostatic component and an auxiliary material, wherein the gum base is gelatin, the bacteriostatic component is tannic acid, and the auxiliary material at least contains sugar alcohol.

Preferably, the antibacterial chewing gum for children comprises the following components in percentage by weight: 9-14 wt% of auxiliary materials; the mass ratio of the gelatin to the tannic acid is 1: 0.2-1: 0.3.

The invention adopts gelatin as the gum base of the chewing gum, and also contains tannic acid which can play a role of bacteriostasis due to higher content of phenolic hydroxyl and can generate certain crosslinking reaction with the gelatin, thereby changing the property of the gum base to a certain extent. Experiments and comparison show that when the mass ratio of the gelatin to the tannic acid is controlled within the range of 1: 0.2-1: 0.3, and the auxiliary material and the tannic acid are mixed firstly in the preparation process and then added into the gelatin, compared with the method of directly mixing the gelatin and the tannic acid to generate a crosslinking reaction, the gelatin-tannic acid crosslinking agent has the advantages that a better effect can be achieved:

it was found that after the preparation by the above method, a part of tannic acid was cross-linked with gelatin to form covalent bond, a part of tannic acid was not reacted with gelatin, and a certain electrostatic adsorption existed between tannic acid and gelatin, so that a part of tannic acid was attached to the surface of gum base after the chewing gum was prepared. When chewing gum is put into the oral cavity and chewed, the pH value changes, and the electrostatic adsorption capacity of tannic acid reduces for tannic acid on the chewing gum is slowly released in the oral cavity, thereby plays antibacterial effect in the oral cavity.

Further studies have found that such chewing gums exhibit different properties at different temperature conditions. In particular, such a chewing gum exhibits characteristics of greater hardness and less stickiness when the ambient temperature is at room temperature (around 25 ℃); and when the environment is at the temperature of human body temperature (37 ℃), the chewing gum becomes soft and chewy. Therefore, even if the chewing gum is discarded at will after being chewed by people, particularly children, the stickiness of the chewing gum is gradually reduced at room temperature, the hardness is increased, new dust and dirt are not easy to adhere, and the chewing gum is easy to clean.

The minimum addition amount of the sugar alcohol is 2 wt%. The sugar alcohol is selected from one or more of maltitol, sorbitol, xylitol, lactitol, erythritol or mannitol.

The adjuvants of the present invention may also include other common chewing gum additives including one or more of non-sugar sweeteners, flavors, lubricants, softeners, and thickeners.

The non-sugar sweetener is selected from one or more of stevioside, glycyrrhizin, mogroside, acesulfame potassium, aspartame, sucralose and isomaltulose.

The lubricant is selected from one or more of triglyceride, glycerol, isopropanol, polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600.

The softening agent is selected from pectin, alginic acid, alginate, etc.

The thickening agent is selected from one or more of hydroxyethyl cellulose, xanthan gum, carrageenan, carbomer and hydroxymethyl cellulose.

The second purpose of the invention is realized by the following technical scheme:

a preparation method of bacteriostatic chewing gum for children comprises the following steps:

(1) preparing gelatin mother liquor, and stirring under heating condition until the gelatin mother liquor is completely dissolved;

(2) preparing a tannic acid mother solution, and stirring under a heating condition until the tannic acid mother solution is completely dissolved;

(3) preparing each auxiliary material into a solution respectively, and adding the solution into the tannic acid mother liquor obtained in the step (2) respectively to form a mixed mother liquor;

(4) mixing the gelatin mother liquor and the mixed mother liquor under the stirring state, and continuously stirring until a solid flocculent precipitate is formed;

(5) solid-liquid separation, namely taking solid precipitate, placing the solid precipitate in a mold for tabletting, and then placing the solid precipitate in a low-temperature environment for storage;

(6) and (4) drying the chewing gum stored at low temperature in a freeze dryer to obtain the antibacterial chewing gum for children.

The children antibacterial chewing gum prepared by the method comprises granular chewing gum, sheet chewing gum, buccal tablets, chewing gum mask and chewing gum eye patches.

Experiments show that the gum base has many differences in the properties compared with the chewing gum prepared by mixing the tannic acid mother liquor and the gelatin mother liquor and then adding the auxiliary materials. The reason is that in the case where tannic acid is first mixed with an adjuvant, and then added to gelatin, sugar alcohol in the adjuvant provides a chemical reaction competitive effect.

As a result, in the case of directly mixing the tannin mother liquor and the gelatin mother liquor, the crosslinking reaction between tannin and gelatin is random, and it is easy to cause only a part of phenolic hydroxyl groups on a single tannin molecule to undergo crosslinking reaction with gelatin, so that in the crosslinked product, a part of unreacted phenolic hydroxyl groups remains in the tannin structure; the competitive action of the chemical reaction provided by the sugar alcohol can promote that in the process of the cross-linking reaction, the reaction tends to be that after all phenolic hydroxyl groups on a single tannin molecule are reacted, other tannin molecules can begin to be cross-linked, so that the phenolic hydroxyl groups on the single tannin molecule are reacted more thoroughly, the cross-linking degree is increased, the structure of a cross-linked product is changed, and then the chewing gum bases with different properties are obtained.

In the step (1), the concentration of the gelatin mother liquor is 0.5-7 mg/ml, the heating temperature is 40-60 ℃, the stirring speed of 200-400 rpm is adopted, and the stirring time is 20-40 min.

In the step (2), the concentration of the tannic acid mother liquor is 1-10 mg/ml, the heating temperature is 25-40 ℃, the stirring speed of 200-400 rpm is adopted, and the stirring time is 20-40 min.

In the step (3), different auxiliary materials are respectively prepared into solutions with the concentration of 0.2-5 mg/ml.

And (4) stirring speed of the tannic acid mother liquor in the step (4) is 200-400 rpm.

The low-temperature environment in the step (5) is-80 to-20 ℃, and the storage time is 6 to 15 hours.

In the step (6), the drying time is 10-15 h.

Compared with the prior art, the invention has the following beneficial effects:

1. the children antibacterial chewing gum contains tannic acid, and electrostatic adsorption can be generated between the tannic acid and a gum base based on gelatin, and the electrostatic adsorption is weakened when the pH value is changed, so that the adsorbed tannic acid is released into the oral cavity, gram-positive bacteria and gram-negative bacteria in the oral cavity can be effectively inhibited, and the pH environment in the oral cavity can be adjusted.

2. The bacteriostatic chewing gum for children provided by the invention shows different characteristics according to different environmental temperatures: the chewing gum shows good chewiness under the condition of the oral cavity temperature of 37 ℃; under the room temperature condition of 25 ℃, the hardness of the chewing gum is increased, the viscosity is reduced, and the chewing gum is easy to clean, so that the pollution of the chewing gum to the environment is reduced, and other problems caused by random discarding of children after chewing the chewing gum can be reduced.

3. The children antibacterial chewing gum provided by the invention has the advantages of easily available raw materials and simple preparation method, and is very suitable for being applied to actual production.

Drawings

The invention is further illustrated by the following figures.

Fig. 1 is a shape experiment effect diagram of bacteriostatic chewing gum for children in example 1.

Fig. 2 graph of pH change experiment of bacteriostatic chewing gum for children in example 1.

Fig. 3-4 histogram of bacteriostatic experiment results of bacteriostatic chewing gum for children in example 1.

Fig. 5 raman spectroscopy of bacteriostatic chewing gum for children in example 1.

Fig. 6 is one of the graphs of the temperature and hardness relationship experimental results of the bacteriostatic chewing gum for children in example 1.

Fig. 7 is a second graph of the temperature-hardness relationship experiment result of the bacteriostatic chewing gum for children in example 1.

Fig. 8 is a water absorption experimental result chart of the bacteriostatic chewing gum for children in example 1.

Detailed Description

The present invention will be further described with reference to the following specific examples.

Tannic acid (CAS No.: 1401-55-4), gelatin (CAS No.: 9000-70-8) described in the following examples were purchased from national drug group chemical Co., Ltd; the peptone, sodium chloride, yeast extract, etc. were purchased from Shanghai Aladdin Biotechnology, Inc.

The LB culture medium has the following formula:

10g of peptone, 10g of sodium chloride, 5g of yeast extract and water to a constant volume of 1L.