阅读说明：本技术 一种用于防治2型糖尿病由食物制取的乳膏配方及制法 (Formula and preparation method of food-prepared emulsifiable paste for preventing and treating type 2 diabetes ) 是由 黄央喜 于 2019-05-04 设计创作，主要内容包括：本发明公开了一种用于防治2型糖尿病由食物制取的乳膏配方及制法。包含以下膏剂配方的原料质量比例：鳄梨油10-15份,桂花干燥粉2-6份,猪胰脏干燥粉8-12份,蜂王浆冻干粉5-10份。经多次浸泡、摇匀、密封等步骤制备。可穴位肚脐贴敷、皮肤黏膜涂搽、舌下含化等。与现有技术相比：提供一种应用在防治2型糖尿病及其并发症领域里,由纯天然食物提取制备,既秉承了中医的“以脏补脏”思想和辨治糖尿病的“君臣佐使”理论,又符合了现代药理学的有关胰岛素等皮肤黏膜给药的理论,无毒副作用、无添加防腐、色素、化学等物质,对皮肤黏膜无刺激,可内服外用使用灵活,经临床验证安全有效。(The invention discloses a formula of a food-prepared emulsifiable paste for preventing and treating type 2 diabetes and a preparation method thereof. Comprises the following raw materials in mass ratio: 10-15 parts of avocado oil, 2-6 parts of dried sweet osmanthus powder, 8-12 parts of dried porcine pancreas powder and 5-10 parts of lyophilized royal jelly powder. The preparation method comprises the steps of soaking for many times, shaking up, sealing and the like. Can be applied to navel, applied to skin mucosa, and absorbed in tongue. Compared with the prior art: the traditional Chinese medicine composition is applied to the field of prevention and treatment of type 2 diabetes and complications thereof, is prepared by extracting pure natural food, not only inherits the thought of 'tonifying viscera with viscera' of the traditional Chinese medicine and the 'monarch, minister, assistant and guide' theory of distinguishing and treating diabetes, but also conforms to the theory of modern pharmacology related to skin mucosa administration of insulin and the like, has no toxic or side effect, does not add antiseptic, pigment, chemical and other substances, has no stimulation to skin mucosa, can be taken orally and used externally flexibly, and is safe and effective through clinical verification.)

1. The formula of the raw materials of the emulsifiable paste prepared from food for preventing and treating type 2 diabetes is characterized in that:

the formula of the ointment comprises avocado oil, sweet osmanthus flower dry powder (Cinnamomum cassia or Cinnamomum cassia), porcine pancreas dry powder and royal jelly freeze-dried powder, and the mass ratio of the ointment formula is as follows: 10-15 parts of avocado oil, 2-6 parts of dried sweet osmanthus powder, 8-12 parts of dried porcine pancreas powder and 5-10 parts of lyophilized royal jelly powder.

2. A preparation method of a cream prepared from food for preventing and treating type 2 diabetes is characterized by comprising the following steps:

(1) soaking the dried powder of flos Osmanthi Fragrantis in avocado oil, shaking thoroughly, sealing and storing for 5-10 hr to obtain flos Osmanthi Fragrantis oil.

(2) Adding dried porcine pancreas powder into the above flos Osmanthi Fragrantis immersion oil, shaking thoroughly, sealing and storing for 1-4 hr to obtain flos Osmanthi Fragrantis pancreas powder extract.

(3) Adding the royal jelly freeze-dried powder into the spare sweet osmanthus pancreas powder extract, fully stirring and uniformly mixing to prepare the paste of the invention, bottling by using an opaque glass bottle with a cover, sealing in the shade and storing for 12-48 hours for use.

Technical Field

The invention relates to the field of traditional Chinese medicine food therapy conditioning and prevention and treatment of type 2 diabetes, in particular to a formula of a cream prepared from food for prevention and treatment of type 2 diabetes and a preparation method thereof.

Background

Diabetes mellitus, a chronic metabolic disease, is a complex disease that is not self-afraid and is afraid of chronic complications. The treatment should not only reduce blood sugar and blood pressure, but also focus on preventing and treating chronic complications. The pathological basis of chronic complications of diabetes is atherosclerosis. Most of type 2 diabetes mellitus have dyslipidemia before complications, and the dyslipidemia is manifested by atherosclerosis, dyslipidemia, increased total cholesterol, triglyceride and LDL-C, decreased LDL-C and the like. Therefore, comprehensive treatment of reducing blood sugar, blood pressure, blood fat and the like is required at the beginning of the prevention and treatment of type 2 diabetes. This will increase the burden on the patient and the toxic side effect of various drugs on the body. Diabetes is called diabetes in traditional Chinese medicine, the history of traditional Chinese medicine treatment of diabetes is long, good curative effect is favored by more and more patients, and especially, the food therapy of the traditional Chinese medicine ancient medicated diet tea for treating diabetes is favored by people. However, in traditional Chinese medicine diet tea food therapy, the classic traditional Chinese medicine theory is used as guidance to mainly solve the symptom of diabetes, or the research result of combining with a modern traditional Chinese medicine is also mainly used for reducing blood sugar, the use is limited to oral administration, and the curative effect is unstable. In the clinical practice of treating diabetes mellitus in traditional Chinese medicine, from the initial simple use of traditional medicated diet and tea diet therapy, the inventor slowly tries to combine different theories of traditional Chinese medicine and western medicine to match a plurality of types of materials for simultaneous use, develops diversified using methods, and continuously summarizes and perfects in the clinical practice, and gradually forms a formula and a preparation method of a cream prepared from food for preventing and treating type 2 diabetes mellitus, wherein the formula and the preparation method are as follows:

1. pig pancreas powder: the traditional Chinese medicine has the theory of 'organ nourishing' and health preservation from ancient times, and the diabetes is a disease of abnormal carbohydrate metabolism in vivo caused by absolute or relative insufficient insulin secretion, so that the extremely good curative effect of 'pig pancreas' for auxiliary treatment of diabetes (diabetes) is well recognized in the clinical traditional Chinese medicine. However, the pig pancreas is considered to be "in need of examination" in the western medicine world because the pig pancreas is extracted with insulin and is widely used for clinical treatment, but the insulin is digested and decomposed by oral administration, so that the modern medicine is not scientific for obtaining the contained insulin by oral administration of the pig pancreas to reduce the blood sugar. In fact, besides insulin, other elements such as Fe, Ca, Mg, Cu, Zn, Mn, Co and Ni are also very helpful for reducing blood sugar in pig pancreas. The porcine pancreas is taken orally to successfully reduce blood sugar in clinical traditional Chinese medicine, so that the frequent effect is frequently used in the traditional Chinese medicine treatment of diabetes for more than ten years, and the traditional Chinese medicine preparation is often added or added into dietotherapy medicinal diet medicinal tea for use, and the traditional Chinese medicine preparation is unprocessed, cooked or dried, ground and eaten. In recent years, there have been reports on the development of oral insulin and the non-injection route of administration of insulin. Therefore, the inventor also tries to explore the use of the pig pancreas in other non-oral administration ways in the traditional Chinese medicine, such as acupoint navel application, skin mucosa application, sublingual administration and the like, by combining the experience of clinically using the pig pancreas and related traditional Chinese medicines in the traditional Chinese medicine for treating diabetes for many years, and obtains more satisfactory effect on reducing blood sugar compared with the simple oral administration. In addition, the soap is also made into 'pig pancreas soap' in ancient times, which is used for cleaning, protecting skin, beautifying, treating skin diseases and the like, and the pig pancreas is very suitable for external treatment on skin mucosa. The selected porcine pancreas dry powder not only keeps the cell activity and the effective components of the porcine pancreas, but also avoids the defects of fat and lymph of the fresh porcine pancreas, and is more beneficial to oral administration and absorption of external skin mucosa. Improves and plays the role of pig pancreas in preventing and treating type 2 diabetes. The ointment of the invention is used as a monarch drug in the formula of the ointment and is called as natural animal insulin.

2. Lyophilized royal jelly powder: the royal jelly mainly comprises the following components for reducing blood sugar: insulin-like polypeptide, acetylcholine-like substance, and trace elements such as chromium, magnesium, and nickel. The royal jelly is neutral in nature and sweet and sour in taste, has the effects of nourishing and strengthening, strengthening the spleen and stomach, benefiting the liver and kidney and the like, and is beneficial to the recovery of the physique of chronic patients such as diabetes mellitus and the like. The royal jelly is convenient to store and use and is often prepared into royal jelly freeze-dried powder. The traditional Chinese medicine also is often matched with the pig pancreas powder for satisfying the curative effect in the treatment of the traditional Chinese medicine clinical diabetes, and the patients are advised to be singly or matched with the pig pancreas powder for sublingual administration because the taste is not good. The royal jelly freeze-dried powder has stable curative effect on the hypoglycemic component, is used as a ministerial drug in the formula of the paste, and is called as natural insect insulin. With porcine pancreas powder, it is called "Jiangtangxiong".

3. Avocado oil: avocado is a natural fruit which is generally recognized to have the best effects of reducing blood fat, blood pressure and blood sugar in recent years. The main components for reducing blood sugar of the health-care food mainly comprise unsaturated fatty acid components such as oleic acid, linoleic acid and the like, and also comprise a large amount of dietary fibers. The unsaturated fatty acid has good effects of reducing blood fat, blood pressure and blood sugar and protecting important organs such as the brain, the kidney and the like, and the dietary fiber is very helpful for reducing blood fat, blood pressure and blood sugar. Because of its high unsaturated fat, high fiber content, poor taste, difficult eating of fresh fruit, even avocado extract is also a bad eating of oily oil. However, avocado oil is well-liked by people as a healthy food oil, and is widely used for beauty treatment and skin treatment due to its excellent beauty, moisture, anti-inflammation and high permeability. The ointment of the invention is used as an adjuvant drug in the formula, can reduce blood sugar and can be used as a synergist for skin mucosa administration and acupoint application administration. The ointment of the invention has good curative effect on preventing and treating diabetes complicated with skin diseases.

4. Sweet osmanthus: the effective components of the osmanthus for diabetes are as follows: unsaturated fatty acid components of linoleic acid and linolenic acid and has effect of inhibiting a-glucosidase. The osmanthus tea is usually recommended to be soaked in osmanthus tea in clinical traditional Chinese medicine, has aromatic smell and good taste, is suitable for long-term use, and is beneficial to reducing blood fat, blood pressure and blood sugar. The sweet osmanthus is warm and fragrant in nature, and has the effects of promoting qi circulation, activating blood circulation, relieving pain, relieving cough, reducing phlegm and relieving asthma. Because of the aromatic smell, the cosmetic skin-care penetrant is often used for beauty and skin care. Therefore, the sugar-reducing oral liquid is selected and matched in the invention, and can be used as a synergist for skin mucosa administration and acupoint application administration. Selecting the cinnamomum japonicum or cinnamomum japonicum with high content of effective components, drying and grinding the cinnamomum japonicum or cinnamomum japonicum into fine powder, and soaking the fine powder into high-permeability avocado oil to extract the effective components, so that the effect of killing two birds with one stone is achieved. Therefore, the invention is selected as a 'messenger' for matching, can reduce blood sugar and can be used as a synergist for skin mucosa administration and acupoint application administration. Selecting the cinnamomum japonicum or cinnamomum japonicum with high content of effective components, drying and grinding the cinnamomum japonicum or cinnamomum japonicum into fine powder, and soaking the fine powder into high-permeability avocado oil to extract the effective components, so that the effect of killing two birds with one stone is achieved. The ointment of the invention has good curative effect on preventing and treating diabetes complicated with skin diseases.

The proportioning use of the four foods can be said to be 'fine selection', the theory of 'nourishing viscera with viscera' of the traditional Chinese medicine and the 'monarch, minister, assistant and guide' theory of distinguishing and treating diabetes mellitus are inherited, the innovative theory of skin mucosa administration related to insulin and the like of modern pharmacology is also met, and the ointment which is applied to the field of chronic blood sugar metabolic diseases and is formed by mixing dry powder extracted from a plurality of pure natural foods and vegetable oil has no toxic or side effect, is not externally added with antiseptic, pigment and chemical preparation, is soft and non-irritant to skin mucosa, can be taken orally and externally used, is flexible and has good effects on preventing and treating type 2 diabetes mellitus and complications thereof.

Disclosure of Invention

The invention aims to provide a formula and a preparation method of a cream prepared from food for preventing and treating type 2 diabetes, the cream is prepared from pure natural fresh foods such as pig pancreas, avocado, sweet osmanthus flower, royal jelly and the like through modern advanced technology processing into paste formula raw materials such as dried pig pancreas powder, avocado oil, dried sweet osmanthus flower powder, royal jelly freeze-dried powder and the like according to a certain proportion and a preparation method, the cream has no toxic or side effect, is not externally added with antiseptic, pigment and chemical preparations, is soft and non-irritant to skin mucosa, can be taken orally and externally used, is flexible and diverse in use, and has the effect of preventing and treating type 2 diabetes and complications thereof.To achieve the above object, the invention It is clear to provide the following technical scheme：

The formula of the raw materials of the ointment is as follows:

the formula of the ointment comprises avocado oil, sweet osmanthus flower dry powder (Cinnamomum cassia or Cinnamomum cassia), porcine pancreas dry powder and royal jelly freeze-dried powder, and the mass ratio of the ointment formula is as follows: 10-15 parts of avocado oil, 2-6 parts of dried sweet osmanthus powder, 8-12 parts of dried porcine pancreas powder and 5-10 parts of lyophilized royal jelly powder. The raw materials of the paste formula are from all natural fresh foods such as pig pancreas, avocado, sweet osmanthus, royal jelly and the like, and are processed by modern advanced technology, and the raw materials of the paste formula are selected to meet the following requirements:

1. fresh food raw materials are selected, and no external antiseptic, pigment or chemical agent is added in the process of processing the raw materials into the formula of the paste.

2. The preparation requirements of the pig pancreas dry powder are as follows: the preparation method comprises the steps of selecting fresh pig pancreas, using a modern supercritical extraction technology, adopting processes of vacuum freezing, drying, sterilizing and the like, keeping the cell activity of the fresh pig pancreas, and preparing the dried powder of the pig pancreas.

3. The preparation requirement of the avocado oil is as follows: fresh avocados are selected and extracted by adopting a cold pressing technology and an aqueous extraction method to obtain avocado oil.

4. The preparation requirement of the royal jelly freeze-dried powder is as follows: the royal jelly freeze-dried powder is prepared by selecting fresh royal jelly and using a vacuum low-temperature drying technology.

5. The preparation requirement of the dried powder of sweet osmanthus is as follows: selecting fresh flos Osmanthi Fragrantis (flos Osmanthi Fragrantis or fructus Ilicis Cornutae Immaturum), oven drying, pulverizing, sieving with 80-100 mesh sieve, and making into powder.

(II) a preparation method of the paste:

1. soaking the dried powder of flos Osmanthi Fragrantis in avocado oil, shaking thoroughly, sealing and storing for 5-10 hr to obtain flos Osmanthi Fragrantis oil.

2. Adding dried porcine pancreas powder into the above flos Osmanthi Fragrantis immersion oil, shaking thoroughly, sealing and storing for 1-4 hr to obtain flos Osmanthi Fragrantis pancreas powder extract.

3. Adding the royal jelly freeze-dried powder into the spare sweet osmanthus pancreas powder extract, fully stirring and uniformly mixing to prepare the paste of the invention, bottling by using an opaque glass bottle with a cover, sealing in the shade and storing for 12-48 hours for use.

(III) the paste using method:

1. taking 5-10 g of ointment once a day, placing the ointment at the Shenque acupoint of the navel after conventional disinfection, externally applying a disinfection gauze piece, a preservative film or a blank acupoint patch with proper size for 8-10 hours, then taking off the ointment, and cleaning the navel with clear water;

2. 3-5 g of the paste is taken each time, is dissolved in the tongue for 10 minutes and can be swallowed 3 times a day.

3. The ointment is taken 10-20 g once a day and is smeared on body mucous membrane tissues such as anus, vulva, nipple, lip, nasal cavity and the like after conventional disinfection or places with weak skin and rich capillary vessels such as armpits, earlobes, inner thighs and the like.

4. One or more of the methods may be used simultaneously.

As a further aspect of the present invention：

The formula of the raw materials of the ointment is as follows:

the formula of the ointment comprises avocado oil, sweet osmanthus flower dry powder (Cinnamomum cassia or Cinnamomum cassia), porcine pancreas dry powder and royal jelly freeze-dried powder, and the mass ratio of the ointment formula is as follows: 15 parts of avocado oil, 3 parts of dried sweet osmanthus powder, 12 parts of dried porcine pancreas powder and 5 parts of lyophilized royal jelly powder. The raw materials of the paste formula are from all natural fresh foods such as pig pancreas, avocado, sweet osmanthus, royal jelly and the like, and are processed by modern advanced technology, and the raw materials of the paste formula are selected to meet the following requirements:

1. fresh food raw materials are selected, and no external antiseptic, pigment or chemical agent is added in the process of processing the raw materials into the formula of the paste.

2. The preparation requirements of the pig pancreas dry powder are as follows: the preparation method comprises the steps of selecting fresh pig pancreas, using a modern supercritical extraction technology, adopting processes of vacuum freezing, drying, sterilizing and the like, keeping the cell activity of the fresh pig pancreas, and preparing the dried powder of the pig pancreas.

3. The preparation requirement of the avocado oil is as follows: fresh avocados are selected and extracted by adopting a cold pressing technology and an aqueous extraction method to obtain avocado oil.

4. The preparation requirement of the royal jelly freeze-dried powder is as follows: the royal jelly freeze-dried powder is prepared by selecting fresh royal jelly and using a vacuum low-temperature drying technology.

5. The preparation requirement of the dried powder of sweet osmanthus is as follows: selecting fresh flos Osmanthi Fragrantis (flos Osmanthi Fragrantis or fructus Ilicis Cornutae Immaturum), oven drying, pulverizing, sieving with 80-100 mesh sieve, and making into powder.

(II) a preparation method of the paste:

1. soaking the dried powder of sweet osmanthus into avocado oil, shaking thoroughly, sealing and storing for 8 hours to obtain sweet osmanthus oil for later use.

2. Adding dried porcine pancreas powder into the above flos Osmanthi Fragrantis immersion oil, shaking thoroughly, sealing and storing for 1 hr to obtain flos Osmanthi Fragrantis pancreas powder extract.

3. Adding the royal jelly freeze-dried powder into the spare sweet osmanthus pancreas powder extract, fully stirring and uniformly mixing to prepare the paste of the invention, and sealing the paste in an opaque glass bottle with a cover for 24 hours for use.

Compared with the prior art, the invention has the beneficial effects that:

on the aspect of treating type 2 diabetes and complications thereof, a formula of a cream prepared from food for preventing and treating type 2 diabetes and a preparation method thereof are formed, wherein the formula comprises the following steps:

1. pig pancreas powder: the extracted insulin is used for reducing blood sugar by injection, and the research on the non-injection administration route of the insulin is actively carried out. The auxiliary treatment of diabetes (diabetes) in the traditional Chinese medicine world has been recognized clinically in traditional Chinese medicine. The porcine pancreas is used in other non-oral administration ways in the traditional Chinese medicine, such as acupoint navel application, skin mucosa application, sublingual administration and the like, and achieves more satisfactory effect on reducing blood sugar than the porcine pancreas taken by a single oral administration way. In addition, the soap is also made into 'pig pancreas soap' in ancient times, which is used for cleaning, protecting skin, beautifying, treating skin diseases and the like, and the pig pancreas is very suitable for external treatment on skin mucosa. The selected porcine pancreas dry powder not only keeps the cell activity and the effective components of the porcine pancreas, but also avoids the defects of fat and lymph of the fresh porcine pancreas, and is more beneficial to oral administration and absorption of external skin mucosa. Improves and plays the role of pig pancreas in preventing and treating type 2 diabetes. The ointment of the invention is used as a monarch drug in the formula of the ointment and is called as natural animal insulin.

2. Lyophilized royal jelly powder: contains insulin-like polypeptide, acetylcholine-like substance and trace elements such as chromium, magnesium and nickel, and has good blood sugar lowering effect. The royal jelly is neutral in nature and sweet and sour in taste, has the effects of nourishing and strengthening, strengthening the spleen and stomach, benefiting the liver and kidney and the like, and is beneficial to the recovery of the physique of chronic patients such as diabetes mellitus and the like. The royal jelly freeze-dried powder has stable curative effect on the hypoglycemic component, is used as a ministerial drug in the formula of the paste, and is called as natural insect insulin. With porcine pancreas powder, it is called "Jiangtangxiong".

3. Avocado oil: mainly contains unsaturated fatty acid components such as oleic acid, linoleic acid, etc. The unsaturated fatty acid has good effects of reducing blood fat, blood pressure and blood sugar, and protecting important organs such as brain and kidney. In addition, the skin-care product has the functions of beautifying, moistening, diminishing inflammation and high permeability, and is widely applied to the treatment of beautifying skin. The ointment of the invention is used as an adjuvant drug in the formula, can reduce blood sugar and can be used as a synergist for skin mucosa administration and acupoint application administration. The ointment of the invention has good curative effect on preventing and treating diabetes complicated with skin diseases.

4. Sweet osmanthus: contains unsaturated fatty acid components of linoleic acid, linolenic acid and has inhibitory effect on alpha-glucosidase. Is helpful for reducing blood lipid, blood pressure, and blood sugar. The sweet osmanthus is warm and fragrant in nature, and has the effects of promoting qi circulation, activating blood circulation, relieving pain, relieving cough, reducing phlegm and relieving asthma. But also can be used as a synergist for skin mucosa administration and acupoint application administration. Selecting the cinnamomum japonicum or cinnamomum japonicum with high content of effective components, drying and grinding the cinnamomum japonicum or cinnamomum japonicum into fine powder, and soaking the fine powder into high-permeability avocado oil to extract the effective components, so that the effect of killing two birds with one stone is achieved. The ointment of the invention has good curative effect on preventing and treating diabetes complicated with skin diseases.

The proportioning use of the four foods can be said to be 'fine selection', the theory of 'nourishing viscera with viscera' of the traditional Chinese medicine and the 'monarch, minister, assistant and guide' theory of distinguishing and treating diabetes mellitus are inherited, the innovative theory of skin mucosa administration related to insulin and the like of modern pharmacology is also met, and the ointment which is applied to the field of chronic blood sugar metabolic diseases and is formed by mixing dry powder extracted from a plurality of pure natural foods and vegetable oil has no toxic or side effect, is not externally added with antiseptic, pigment and chemical preparation, is soft and non-irritant to skin mucosa, can be taken orally and externally used, is flexible and has good effects on preventing and treating type 2 diabetes mellitus and complications thereof.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the implementation of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by those skilled in the art without any creative work belong to the protection scope of the present invention.