阅读说明：本技术 核酸单元及其聚合核酸与应用 (Nucleic acid unit, polymeric nucleic acid thereof and application ) 是由 张必良 杨秀群 丹米其·萨玛斯基 于 2018-07-20 设计创作，主要内容包括：本发明公开了新型的可用于构建聚合核酸的核酸单元及可用于干扰目的基因表达的聚合核酸。本发明通过设计和构建新型的核酸单元及其自组装聚合核酸,实现了多靶标干扰,可用于抑制疾病发生或发展的信号通路中的多个基因表达,或同时抑制多个疾病靶基因表达,在生物学、化学等多个学科领域具有广阔的应用前景。该聚合核酸可实现同时靶向多个序列,所述序列可在一个基因中,或位于多个基因中。本发明优势在于：1)RNAi效能高；2)稳定性好；3)降低脱靶率；4)导入细胞能力增强；5)可模块化设计。(The invention discloses a novel nucleic acid unit for constructing a polymeric nucleic acid and a polymeric nucleic acid for interfering the expression of a target gene. The invention realizes multi-target interference by designing and constructing novel nucleic acid units and self-assembled polymeric nucleic acid thereof, can be used for inhibiting the expression of a plurality of genes in a signal path for the occurrence or development of diseases or inhibiting the expression of a plurality of disease target genes simultaneously, and has wide application prospect in a plurality of subject fields such as biology, chemistry and the like. The polymeric nucleic acid can achieve simultaneous targeting of multiple sequences, which can be in one gene, or in multiple genes. The invention has the advantages that: 1) RNAi efficiency is high; 2) the stability is good; 3) the miss rate is reduced; 4) the capability of introducing cells is enhanced; 5) can be designed in a modularized way.)