阅读说明：本技术 包含三硫代磷酸酯核苷间键的寡核苷酸 (Oligonucleotides comprising phosphorothioate internucleoside linkages ) 是由 K·布雷啻尔 T·科赫 A·朔伊布林 J·J·A·杜施梅尔 M·B·杜什马尔 李美玲 E 于 2019-07-30 设计创作，主要内容包括：本发明涉及一种寡核苷酸,其包含至少一个式(I)的三硫代磷酸酯核苷间键其中(A~1)、(A~2)和R如说明书和权利要求书中所定义。本发明所述的寡核苷酸可用作药物。(The present invention relates to an oligonucleotide comprising at least one phosphorothioate internucleoside linkage of formula (I) Wherein (A) 1 )、(A 2 ) And R is as defined in the description and claims. The oligonucleotides of the invention are useful as medicaments.)