阅读说明：本技术 一种用于治疗乙型肝炎感染的中药组合物及其制备方法 (A Chinese medicinal composition for treating hepatitis B infection and preparation method thereof ) 是由 陈泽雄 孙保国 刘嘉辉 吕小州 陈淳 于 2020-07-16 设计创作，主要内容包括：本发明公开一种用于治疗乙型肝炎病毒感染的中药组合物及其制备方法。本发明用于治疗乙型肝炎病毒感染的中药组合物包含珍珠草、黄芪、紫草及白僵蚕；所述珍珠草、黄芪、紫草及白僵蚕的重量比为珍珠草：黄芪：紫草：白僵蚕＝4～10:2～5:1～5:1～4。其制备方法简单,通过两次煎煮取汁获得。本发明所述中药组合是基于平肝解毒法配伍组合,与多年临床经验总结而成的剂量固定比例,能够达到益气扶正、清热解毒、凉血散邪等药效,对乙型肝炎病毒感染者具有较好的抗病毒及抗原转阴效果。(The invention discloses a traditional Chinese medicine composition for treating hepatitis B virus infection and a preparation method thereof. The traditional Chinese medicine composition for treating hepatitis B virus infection comprises phyllanthus urinaria, astragalus membranaceus, lithospermum and white muscardine silkworm; the weight ratio of the pearl grass to the astragalus to the lithospermum to the white muscardine silkworm is as follows: astragalus root: lithospermum: the weight ratio of the white muscardine silkworm is 4-10: 2-5: 1-4. The preparation method is simple, and the Chinese medicinal composition is obtained by decocting twice and taking juice. The traditional Chinese medicine composition is prepared by compatibility based on a liver calming detoxification method and a fixed dose ratio summarized by years of clinical experience, can achieve the efficacies of tonifying qi, strengthening body resistance, clearing heat, detoxifying, cooling blood, eliminating pathogenic factors and the like, and has better antiviral and antigen-to-negative effects on hepatitis B virus infected patients.)

1. A Chinese medicinal composition for treating hepatitis B virus infection is characterized by comprising herba Phyllanthi Urinariae, radix astragali, radix Arnebiae and Bombyx Batryticatus; the weight ratio of the pearl grass to the astragalus to the lithospermum to the white muscardine silkworm is as follows: astragalus root: lithospermum: the weight ratio of the white muscardine silkworm is 4-10: 2-5: 1-4.

2. The Chinese medicinal composition according to claim 1, wherein the weight ratio of the phyllanthus urinaria, the astragalus root, the lithospermum and the white muscardine silkworm is phyllanthus urinaria: astragalus root: lithospermum: the weight ratio of the white muscardine silkworm is 5-8: 3-4: 2-4: 1-3.

3. The Chinese medicinal composition according to claim 1, wherein the weight ratio of the phyllanthus urinaria, the astragalus root, the lithospermum and the white muscardine silkworm is phyllanthus urinaria: astragalus root: lithospermum: white muscardine silkworm (Bombyx Batryticatus) 6:4:3: 2.

4. The preparation method of the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following steps:

(1) soaking the Chinese medicinal materials in water;

(2) adding water, heating and decocting the traditional Chinese medicine raw materials in the step (1) to obtain traditional Chinese medicine juice;

(3) adding water into the Chinese medicinal materials, decocting under heating, and collecting decoction;

(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.

5. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (1) is 400-500 mL.

6. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the soaking time in the step (1) is 15-20 min.

7. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (2) is 100-200 mL.

8. The method for preparing the Chinese medicinal composition according to claim 4, wherein the decocting method comprises the following steps: heating and boiling, and then continuously heating for 15-20 min.

9. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (3) is 80-120 mL.

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating hepatitis B virus infection and a preparation method thereof.

Background

HBV (hepatitis b virus) infection is the most common viral liver disease, has the characteristics of carrying state, chronicity and the like, and is the main cause of cirrhosis, hepatocellular carcinoma and liver failure. Vaccine and antiviral drug therapy are the main measures for preventing and treating HBV infection at present, and although various antiviral drugs are raised at present, the reality that the treatment time is too long, the drug resistance and the treatment compliance are poor, and part of adverse reactions are more still exists; since the last 80 century, research on the treatment of chronic hepatitis B by traditional Chinese medicines has achieved a plurality of achievements, the overall treatment effect is improved, and the research embodies that traditional Chinese medicines play an important role in diagnosis and treatment of chronic hepatitis B in China, and various classical ancient prescriptions and modern Chinese patent medicine preparations are important sections of comprehensive treatment at present.

The existing traditional Chinese medicine for treating HBV infection has the problems of inaccurate medicine compatibility and dosage, disordered formula, lack of clear safety and effectiveness evidence and the like, and causes the uneven traditional Chinese medicine treatment effect of hepatitis B infected patients.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a traditional Chinese medicine composition for treating hepatitis B infection and a preparation method thereof.

In order to achieve the purpose, the invention adopts the technical scheme that:

a traditional Chinese medicine composition for treating hepatitis B infection comprises the following components in parts by weight: astragalus root: lithospermum: the weight ratio of the white muscardine silkworm is 4-10: 2-5: 1-4.

The phyllanthus urinaria is sweet and bitter in taste and cold in nature, has the effects of calming the liver, clearing heat, inducing diuresis and removing toxicity, is sweet in raw astragalus root, is slightly warm in nature, can tonify qi and strengthen body resistance, is compatible with lithospermum for cooling blood and activating blood and removing toxicity, and white muscardine silkworm for removing obstruction in channels, detoxifying and eliminating evil, is cold and warm in formula, is slightly sweet and cold without damaging body resistance, can achieve the drug effects of tonifying qi and strengthening body resistance, clearing heat and removing toxicity, cooling blood and eliminating evil and the like, and has a good treatment effect on HBV infected patients.

Preferably, the weight ratio of the pearl grass, the astragalus root, the lithospermum and the white muscardine silkworm is that of the pearl grass: astragalus root: lithospermum: the weight ratio of the white muscardine silkworm is 5-8: 3-4: 2-4: 1-3.

More preferably, the weight ratio of the phyllanthus urinaria, the astragalus membranaceus, the lithospermum and the white muscardine silkworm is 6:4:3: 2.

The proportion of the traditional Chinese medicine composition is obtained by combining years of clinical experience with a liver calming detoxification method, and the traditional Chinese medicine composition has a good treatment effect on hepatitis B virus infection.

The preparation method of the traditional Chinese medicine composition is characterized by comprising the following steps:

(1) adding 400-500 mL of water to the medicinal materials, and soaking for 15-20 minutes;

(2) adding 100-200 mL of water into the traditional Chinese medicine raw materials in the step (1), decocting with strong fire until boiling, decocting with slow fire for 15-20 minutes after boiling, and taking traditional Chinese medicine decoction;

(3) adding 80-120 mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the materials are boiled, decocting with slow fire for 15-20 minutes after the materials are boiled, and taking traditional Chinese medicine decoction;

(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.

The method can fully obtain the effective components in the medicinal materials, so that the traditional Chinese medicine composition can better exert the effect.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition is a compatible combination based on a liver calming detoxification method, is fixed in dose proportion by years of clinical experience summarization, can achieve the drug effects of tonifying qi and strengthening body resistance, clearing heat and detoxifying, cooling blood and eliminating evil and the like, and has better antiviral and antigen-to-negative effects on HBV infected patients.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific embodiments.

The materials used in the examples of the present invention are commercially available unless otherwise specified.

The basic conditions of the main raw materials are described in the following according to the Chinese pharmacopoeia, the Chinese dictionary, the Chinese herbal medicine, and the like.

Pearl grass: bland taste and mild nature. Has effects of calming endogenous wind, relieving spasm, clearing heat, and promoting diuresis. Can be used for treating tetanus, jaundice, etc.

Astragalus root: sweet in flavor and warm in nature. Has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, removing toxic substance, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration, qi deficiency, edema, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and ulcer.

Lithospermum: sweet, salty and cold in nature. Has the effects of clearing heat, cooling blood, promoting blood circulation, removing toxic substances, promoting eruption and eliminating macula. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, scald due to hot water and fire, etc.

White muscardine silkworm: salty and pungent with mild natures. Has effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, relieving pain, eliminating phlegm, and resolving hard mass. Can be used for treating phlegm due to liver wind, convulsive epilepsy, convulsion, infantile convulsion, tetanus, apoplexy, wry mouth, wind-heat headache, conjunctival congestion, pharyngalgia, rubella pruritus, and parotitis.