阅读说明：本技术 一种生物组织的联动切碎装置 (Linkage comminution device of biological tissue ) 是由 刘小艺 刘强 刘奕 张新凤 关伟 于 2020-06-22 设计创作，主要内容包括：本发明公开了一种生物组织的联动切碎装置,涉及医疗实验器械技术领域,包括机架,所述机架包括支撑台；转台,可转动地设置在所述支撑台上方；刀架部件,设置在所述转台的正上方；驱动部件,所述驱动部件包括驱动输出端,所述驱动输出端与所述刀架部件连接,所述驱动输出端被配置为能够伸缩运动以驱动所述刀架部件上下移动；联动机构,所述联动机构连接所述驱动部件和所述转台,所述联动机构被配置为能够利用所述驱动输出端的伸缩运动以驱动所述转台转动。本发明采用单一动力源完成切碎装置的各种动作,既可以降低组织破碎的外力对待分离组织细胞的破坏率,为切碎操作提供无菌、低温的环境,还具有装置结构简单、易于维护。(The invention discloses a linkage chopping device for biological tissues, which relates to the technical field of medical experimental instruments and comprises a rack, wherein the rack comprises a supporting table; the rotary table is rotatably arranged above the support table; a tool rest member provided directly above the turntable; a drive component comprising a drive output connected with the carriage component, the drive output configured to be telescopically movable to drive the carriage component up and down; a linkage mechanism connecting the driving part and the turntable, the linkage mechanism being configured to be able to drive the turntable to rotate by utilizing the telescopic motion of the driving output. The invention adopts a single power source to complete various actions of the mincing device, can reduce the damage rate of external force of tissue disruption to tissue cells to be separated, provides a sterile and low-temperature environment for the mincing operation, and has the advantages of simple structure and easy maintenance.)

1. A linkage morcellating device of biological tissue, comprising:

the device comprises a rack, a supporting platform and a control device, wherein the rack comprises the supporting platform which is arranged at the upper end of the rack;

a turntable rotatably provided above the support table, an upper surface of the turntable being configured to be horizontal, a rotation center axis of the turntable being configured to be vertical;

a tool rest member provided directly above the turntable, the tool rest member being configured to be vertically movable up and down;

the driving component is fixedly arranged on the rack and comprises a driving output end, the driving output end is connected with the tool rest component, and the driving output end is configured to be capable of moving telescopically so as to drive the tool rest component to move up and down;

the input end of the linkage mechanism is connected with the driving part, the output end of the linkage mechanism is connected with the rotary table, the linkage mechanism is configured to be capable of utilizing the telescopic motion of the driving output end to drive the rotary table to rotate, and the corresponding rotary angular displacement of the rotary table is equal when the tool rest part moves up and down once.

2. A linked morcellating device according to claim 1, wherein the drive member includes a first drive support, a second drive support, a drive cylinder, a displacement detection system;

a rectangular through hole is formed in the first driving support piece, the lower end of the first driving support piece is fixedly installed on the support table, the support table is provided with a first through hole, the first through hole is formed below the rectangular through hole of the first driving support piece, and a first sliding groove is formed in one side, close to the rotary table, of the upper end of the first driving support piece;

the second driving support piece comprises a sliding rod, a cantilever, a push head connector and a sliding rod connector, the cross section of the sliding rod is configured to be rectangular, the sliding rod is arranged in the rectangular through hole in a sliding mode, the cantilever is horizontally arranged, one end of the cantilever is fixedly arranged at the upper end of the sliding rod, the cantilever is arranged in the first sliding groove in a sliding mode, the upper end of the push head connector is fixedly arranged at the other end of the cantilever, the lower end of the push head connector is rotatably connected with the upper end of the tool rest component through a shaft, and the upper end of the sliding rod connector is fixedly arranged at the lower end of the sliding rod;

the driving cylinder is fixedly arranged below the supporting table, and a rod end connector of the driving cylinder penetrates through the first through hole to be rotatably connected with the lower end of the sliding rod connector through a shaft;

the displacement detection system is configured to be able to detect a position of the drive output.

3. A linked mincing device of biological tissue according to claim 2, wherein the linkage mechanism comprises a guide rod, a ratchet mechanism, a first transmission shaft, a second transmission shaft, a gear mechanism, a first mounting seat, a second mounting seat and a brake pad, the ratchet mechanism comprises a ratchet wheel and a pawl, the gear mechanism comprises a first gear and a second gear,

the guide rod is vertically arranged, the upper end of the guide rod is fixedly arranged on the lower end face of the slide rod, and the lower end of the guide rod penetrates through the first through hole and is arranged below the support table;

the first end of the pawl is arranged at the lower end of the guide rod in a swinging mode, the second end of the pawl and the ratchet form ratchet transmission, and the ratchet mechanism is configured to be capable of converting the upward or downward movement of the guide rod into the rotation of the ratchet;

the ratchet wheel is fixedly arranged at one end of the first transmission shaft, the first transmission shaft is sleeved in the first mounting seat, the first transmission shaft and the first mounting seat form a rotating pair, and the first gear is fixedly arranged at the other end of the first transmission shaft;

the second gear is fixedly arranged at one end of the second transmission shaft, the first gear and the second gear form gear transmission, the second transmission shaft is sleeved in the second mounting seat, the second transmission shaft and the second mounting seat form a revolute pair, and the other end of the second transmission shaft is fixedly connected with the rotary table; the central axis of the second transmission shaft is superposed with the central axis of the rotary table, and the central axis of the second transmission shaft is vertical to the upper end face of the rotary table;

the first mounting seat is fixedly mounted on the rack, and the second mounting seat is fixedly mounted on the rack;

the first through hole is further provided with a guide groove which is configured to guide the guide rod;

the brake pad is disposed between the first transmission shaft and the first mounting seat, and the brake pad is configured to increase rotational resistance of the first transmission shaft.

4. The linkage mincing device of claim 3, wherein the first gear is a first bevel gear, the second gear is a second bevel gear, the first bevel gear and the second bevel gear form a bevel gear transmission, and the central axis of the first bevel gear is perpendicular to the central axis of the second bevel gear.

5. The linkage mincing device of claim 4, wherein the pawl is a rod-shaped member, the second end of the pawl is an arc-shaped end surface, the center of the arc-shaped end surface coincides with the swing center of the pawl, and the ratchet wheel is a wheel-shaped member.

6. The linkage chopper of biological tissue of claim 5, further comprising a rotating shaft and a fastening device, wherein two ends of the rotating shaft are rotatably connected with the lower end of the guide rod, and the middle part of the rotating shaft is rotatably connected with the first end of the pawl; the fastening device is arranged at the lower end of the guide rod and is configured to fasten the rotating shaft.

7. The linkage mincing device of claim 6, wherein the rotating shaft is a crankshaft, the crankshaft comprises a crankshaft middle part, a crankshaft end part and a crankshaft rectangular end part, the crankshaft middle part and the crankshaft end part are both cylinders, the crankshaft end part is fixedly arranged at two sides of the crankshaft middle part, the crankshaft rectangular end part is a regular quadrangular prism, the crankshaft rectangular end part is fixedly arranged at the outer side of the crankshaft end part, the central axes of the crankshaft end parts are coincident, and the central axis of the crankshaft end part is not coincident with the central axis of the crankshaft middle part.

8. The linkage mincing device according to claim 7, further comprising a swing stopper, wherein the swing stopper comprises an upper stopper and a lower stopper;

the lower limiting block is arranged below the swinging center of the pawl, and the lower limiting block is configured to limit the downward swinging of the pawl not to exceed a lower limiting position;

the upper limiting block is arranged above the swinging center of the pawl, and the upper limiting block is configured to limit the upward swinging of the pawl not to exceed an upper limit position;

the pawl is configured such that a horizontal distance between the second end surface of the pawl and a swing center of the pawl is gradually reduced when the pawl swings from the lower limit position to the upper limit position.

9. The linkage chopper of claim 8, further comprising a buffer layer, wherein the buffer layer comprises a first buffer layer and a second buffer layer, the first buffer layer is annular, the first buffer layer is fixedly disposed on the outer peripheral surface of the ratchet wheel, the second buffer layer is fixedly disposed on the arc-shaped end surface of the pawl, and the pawl, the ratchet wheel and the buffer layer are in the following relationship:

R₁+R₂≤D＜R₁+R₂+h₁+h₂；

wherein，R₁Is the radius of the ratchet wheel, R₂When the pawl is positioned at the lower limit position, the horizontal distance between the arc end surface and the swing center of the pawl, D is the horizontal distance between the swing center of the pawl and the rotation center of the ratchet wheel, h₁Is the thickness of the first buffer layer, h₂Is the thickness of the second buffer layer.

10. The linkage mincing device of claim 9, further comprising a vessel, a temperature regulation system, a sealing cover, a controller;

the vessel is a container with an upward opening, the bottom surface of the vessel and the bottom surface of the inner cavity of the vessel are both flat and horizontally arranged, the vessel is arranged on the upper surface of the rotary table, and the horizontal section of the knife rest part is smaller than that of the inner cavity of the vessel;

the knife rest component comprises a plurality of blades, a knife holder and a pressing sheet, the blades are vertically and fixedly arranged on the lower surface of the knife holder, the pressing sheet is movably arranged below the blades, notches are formed in the pressing sheet, the blades can penetrate through the pressing sheet through the notches in the pressing sheet, and the pressing sheet is configured to press tissues to be cut;

the controller is configured to control the drive component;

the sealing cover is a container with a downward opening, the sealing cover is detachably and hermetically arranged on the upper surface of the supporting table, and the rotary table, the vessel and the tool rest component are arranged in an inner cavity of the sealing cover;

the temperature regulation system is configured to regulate a temperature of the containment cap interior cavity.

Technical Field

The invention relates to the technical field of medical experimental instruments, in particular to a linkage cutting device for biological tissues.

Background

The tissue disruption is an indispensable link in vitro tissue cell culture, is suitable for various animal cell separation culture methods, and the conventional tissue disruption methods mainly comprise manual shearing by using tissue scissors and disruption of tissues by using a mechanical breaker. The method for manually shearing and crushing the tissues by using the tissue scissors has the advantages of less damaged tissue cells, simple structure and convenient operation, has the defects of incapability of ensuring the uniformity of tissue crushing, time and labor waste, low efficiency, high dependence on the operation proficiency of experimenters, long operation time and influence on the experimental efficiency, and in addition, the long-term manual crushing action of the experimenters easily causes the strain of shoulders, arms and waist and back; the existing mechanical crusher adopts a turbine stirring and crushing method, which can damage cell membranes of tissue cells to be separated probably, cause a great amount of damage and death of the tissue cells, and finally obtain fewer living cells, thereby influencing the efficiency of subsequent cell culture experiments.

In addition, the existing partial tissue crusher does not consider the control of environmental conditions in the process of tissue crushing, such as temperature, aseptic conditions and the like, and is not beneficial to the culture of sensitive tissue cells; the main body part of the existing part of the tissue crusher is not easy to be cleaned and sterilized at high temperature.

The existing part of tissue crushers are provided with a plurality of power sources, action coordination devices are required to be configured among different power sources, the action coordination devices comprise a pose detection device and a motion control device, the structure is complex, and the reliability is low; and independent driving devices are required to be configured among different power sources, so that the cost is high.

Therefore, those skilled in the art are dedicated to develop a linkage mincing device for biological tissue, which uses one power source to complete various actions required for mincing biological tissue, can reduce the destruction rate of external force for tissue disruption to tissue cells to be separated, improves the uniformity and efficiency of tissue mincing, can provide a sterile and low-temperature environment for mincing operation, and has a simple structure and easy maintenance.

Disclosure of Invention

In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is that the existing tissue crusher using multiple power sources needs to be configured with a complex motion coordination device and multiple sets of independent driving devices, and has the disadvantages of complex structure, low reliability and high cost; when tissue is minced, there are problems of high tissue cell destruction rate and low tissue disruption uniformity.

To achieve the above object, the present invention provides a linkage morcellating device for biological tissue, comprising:

the device comprises a rack, a supporting platform and a control device, wherein the rack comprises the supporting platform which is arranged at the upper end of the rack;

a turntable rotatably provided above the support table, an upper surface of the turntable being configured to be horizontal, a rotation center axis of the turntable being configured to be vertical;

a tool rest member provided directly above the turntable, the tool rest member being configured to be vertically movable up and down;

the driving component is fixedly arranged on the rack and comprises a driving output end, the driving output end is connected with the tool rest component, and the driving output end is configured to be capable of moving telescopically so as to drive the tool rest component to move up and down;

the input end of the linkage mechanism is connected with the driving part, the output end of the linkage mechanism is connected with the rotary table, the linkage mechanism is configured to be capable of utilizing the telescopic motion of the driving output end to drive the rotary table to rotate, and the corresponding rotary angular displacement of the rotary table is equal when the tool rest part moves up and down once.

Further, the driving component comprises a first driving support, a second driving support, a driving cylinder and a displacement detection system;

a rectangular through hole is formed in the first driving support piece, the lower end of the first driving support piece is fixedly installed on the support table, the support table is provided with a first through hole, the first through hole is formed below the rectangular through hole of the first driving support piece, and a first sliding groove is formed in one side, close to the rotary table, of the upper end of the first driving support piece;

the second driving support piece comprises a sliding rod, a cantilever, a push head connector and a sliding rod connector, the cross section of the sliding rod is configured to be rectangular, the sliding rod is arranged in the rectangular through hole in a sliding mode, the cantilever is horizontally arranged, one end of the cantilever is fixedly arranged at the upper end of the sliding rod, the cantilever is arranged in the first sliding groove in a sliding mode, the upper end of the push head connector is fixedly arranged at the other end of the cantilever, the lower end of the push head connector is rotatably connected with the upper end of the tool rest component through a shaft, and the upper end of the sliding rod connector is fixedly arranged at the lower end of the sliding rod;

the driving cylinder is fixedly arranged below the supporting table, and a rod end connector of the driving cylinder penetrates through the first through hole to be rotatably connected with the lower end of the sliding rod connector through a shaft;

the displacement detection system is configured to be able to detect a position of the drive output.

In this technical scheme, the inside rectangle through-hole of first drive support piece plays for the guide effect of slide bar vertical direction, first spout is used for the direction cantilever for the second drive support piece for fixed setting first drive support piece only has one degree of freedom that slides.

Further, the driving cylinder is one of the following: hydraulic cylinder, electro-hydraulic cylinder, electronic jar.

In the technical scheme, the electric hydraulic cylinder is that a motor and a hydraulic cylinder are integrated together, and the hydraulic cylinder is driven to stretch by high-pressure oil generated by the rotation of the motor; the electric cylinder integrates a motor and a screw rod system, and the screw rod system is utilized to convert the rotation of the motor into the linear motion of an output component.

Further, the displacement detection system comprises one or more of the following: proximity switch, travel switch, magnetostrictive displacement sensor.

Further, the linkage mechanism comprises a guide rod, a ratchet mechanism, a first transmission shaft, a second transmission shaft, a gear mechanism, a first mounting seat and a second mounting seat, the ratchet mechanism comprises a ratchet wheel and a pawl, the gear mechanism comprises a first gear and a second gear,

the guide rod is vertically arranged, the upper end of the guide rod is fixedly arranged on the lower end face of the slide rod, and the lower end of the guide rod penetrates through the first through hole and is arranged below the support table;

the first end of the pawl is arranged at the lower end of the guide rod in a swinging mode, the second end of the pawl and the ratchet form ratchet transmission, and the ratchet mechanism is configured to be capable of converting the upward or downward movement of the guide rod into the rotation of the ratchet;

the ratchet wheel is fixedly arranged at one end of the first transmission shaft, the first transmission shaft is sleeved in the first mounting seat, the first transmission shaft and the first mounting seat form a rotating pair, and the first gear is fixedly arranged at the other end of the first transmission shaft;

the second gear is fixedly arranged at one end of the second transmission shaft, the first gear and the second gear form gear transmission, the second transmission shaft is sleeved in the second mounting seat, the second transmission shaft and the second mounting seat form a revolute pair, and the other end of the second transmission shaft is fixedly connected with the rotary table; the central axis of the second transmission shaft is superposed with the central axis of the rotary table, and the central axis of the second transmission shaft is vertical to the upper end face of the rotary table;

the first mounting seat is fixedly mounted on the rack, and the second mounting seat is fixedly mounted on the rack.

Further, the first gear is a first bevel gear, the second gear is a second bevel gear, and the first bevel gear and the second bevel gear form bevel gear transmission.

Further, the first bevel gear is perpendicular to the central axis of the second bevel gear.

Optionally, the first gear is a worm, the second gear is a worm wheel, and the first gear and the second gear form a worm-gear drive.

Furthermore, the pawl is a rod-shaped member, the second end of the pawl is an arc-shaped end surface, the circle center of the arc-shaped end surface is coincided with the swing center of the pawl, and the ratchet wheel is a wheel-shaped member.

Further, the first through hole is further provided with a guide groove configured to be capable of guiding the guide bar.

Furthermore, the device also comprises a rotating shaft, two ends of the rotating shaft are rotatably connected with the lower end of the guide rod, and the middle part of the rotating shaft is rotatably connected with the first end of the pawl.

The rotating shaft is rotatably connected with the guide rod and the pawl, so that the pawl can swing more flexibly, and the probability of unsmooth swinging of the pawl caused by mechanism deformation, aging, corrosion and the like is reduced.

Further, the device also comprises a fastening device which is arranged at the lower end of the guide rod and is configured to fasten the rotating shaft.

Optionally, the fastening device includes a first bolt and a first nut, a first threaded hole is provided on the guide rod, the first bolt and the first threaded hole form a threaded connection, a screw end surface of the first bolt passes through the first threaded hole to contact with the rotating shaft, the first nut is provided between a nut side of the first bolt and the guide rod, and the first nut is configured to prevent the first bolt from loosening.

Further, the rotating shaft is a crankshaft, the crankshaft comprises a crankshaft middle part, crankshaft end parts and crankshaft rectangular end parts, the crankshaft middle part and the crankshaft end parts are both cylinders, the crankshaft end parts are fixedly arranged on two sides of the crankshaft middle part, the crankshaft rectangular end parts are regular quadrangular prisms, the crankshaft rectangular end parts are fixedly arranged on the outer sides of the crankshaft end parts,

the central axis of the end part of the crankshaft is overlapped, and the central axis of the end part of the crankshaft is not overlapped with the central axis of the middle part of the crankshaft.

In the technical scheme, the distance between the swing center of the pawl and the rotation center of the ratchet wheel can be finely adjusted by adopting the scheme of the eccentric shaft, and the end part of the rectangular section is favorable for rotating the rotating shaft.

Furthermore, the swing limiting block comprises an upper limiting block and a lower limiting block;

the lower limiting block is arranged below the swinging center of the pawl, and the lower limiting block is configured to limit the downward swinging of the pawl not to exceed a lower limiting position;

the upper limiting block is arranged above the swinging center of the pawl, and the upper limiting block is configured to limit the upward swinging of the pawl not to exceed an upper limit position;

the pawl is configured such that a horizontal distance between the second end surface of the pawl and a swing center of the pawl is gradually reduced when the pawl swings from the lower limit position to the upper limit position.

Further, still include the buffer layer, the buffer layer includes first buffer layer, second buffer layer, first buffer layer is the ring shape, first buffer layer is fixed to be set up the ratchet peripheral face, the second buffer layer is fixed to be set up the arc terminal surface of pawl, ratchet and the buffer layer has following relation:

R₁+R₂≤D＜R₁+R₂+h₁+h₂；

wherein R is₁Is the radius of the ratchet wheel, R₂When the pawl is positioned at the lower limit position, the horizontal distance between the arc end surface and the swing center of the pawl, D is the horizontal distance between the swing center of the pawl and the rotation center of the ratchet wheel, h₁Is the thickness of the first buffer layer, h₂Is the second slowThickness of strike layer.

Further, still include the brake pad, the brake pad sets up between first transmission shaft and the first mount pad, the brake pad is configured to can increase the rotational resistance of first transmission shaft.

The invention also comprises a vessel, a temperature adjusting system, a sealing cover and a controller;

the vessel is a container with an upward opening, the bottom surface of the vessel and the bottom surface of the inner cavity of the vessel are both flat and horizontally arranged, the vessel is arranged on the upper surface of the rotary table, and the horizontal section of the knife rest part is smaller than that of the inner cavity of the vessel;

the knife rest component comprises a plurality of blades, a knife holder and a pressing sheet, the blades are vertically and fixedly arranged on the lower surface of the knife holder, the pressing sheet is movably arranged below the blades, notches are formed in the pressing sheet, the blades can penetrate through the pressing sheet through the notches in the pressing sheet, and the pressing sheet is configured to press tissues to be cut;

the controller is configured to control the drive component;

the sealing cover is a container with a downward opening, the sealing cover is detachably and hermetically arranged on the upper surface of the supporting table, and the rotary table, the vessel and the tool rest component are arranged in an inner cavity of the sealing cover;

the temperature regulation system is configured to regulate a temperature of the containment cap interior cavity.

Compared with the prior art, the invention has at least the following beneficial technical effects:

(1) the method for vertically cutting and breaking the tissue is adopted, so that cell death or injury caused by cell membrane damage caused by shearing force of the worm is avoided, and the damage rate of external force to tissue cells to be separated is reduced.

(2) The invention is provided with a temperature adjusting system, which can ensure the temperature condition in the process of tissue cutting and improve the survival rate of separated tissue cells.

(3) The invention is provided with the sealing cover, is beneficial to temperature control, provides relatively independent sterile environment, and has simple structure and low cost.

(4) The vessel and the knife rest part of the invention can be conveniently disassembled, and are convenient for high-temperature and high-pressure disinfection.

(5) The knife rest component is provided with the pressing sheet, so that the tissue to be separated can be conveniently cut, and the tissue to be separated can be prevented from moving and being bonded with the blade in the cutting process.

(6) The rotating table is provided with the limiting block and the buffer cushion, the buffer cushion can reduce the impact of the blade on the device in the chopping process, the limiting block can position and fix a utensil, the utensil is prevented from tilting in the chopping process, and the central axis of the utensil is kept to be coincident with the rotating central axis of the rotating table.

(7) The invention adopts a set of driving system to drive the movement of the tool rest component and the turntable, and has simple structure, low cost and maintained performance.

(8) The linkage mechanism is provided with the buffer layer and the brake pad, so that the linkage mechanism has the functions of buffering and absorbing vibration, and the transmission is more reliable.

The conception, the specific structure and the technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, the features and the effects of the present invention.

Drawings

FIG. 1 is a cross-sectional view of a preferred embodiment of the present invention;

FIG. 2 is an enlarged partial schematic view of FIG. 1 in accordance with an embodiment II of the present invention;

FIG. 3 is an enlarged partial view of FIG. 1 showing embodiment I of the present invention;

FIG. 4 is a schematic illustration of the linkage mechanism of the embodiment of FIG. 1 of the present invention;

FIG. 5 is a schematic cross-sectional view E-E of the embodiment of FIG. 1 of the present invention;

FIG. 6 is a schematic cross-sectional view B-B of the embodiment of FIG. 4 of the present invention;

FIG. 7 is a K-way schematic view of the embodiment of the present invention shown in FIG. 4;

FIG. 8 is a schematic front view of a crankshaft of the embodiment of FIG. 7 of the present invention;

FIG. 9 is a schematic side view of the crankshaft of the FIG. 8 embodiment of the present invention.

Wherein, 1-a machine frame, 2-a support table, 21-a first through hole, 211-a guide groove, 3-a driving cylinder, 31-a rod end connector, 4-a first driving support, 5-a second driving support, 51-a sliding rod connector, 52-a sliding rod, 53-a cantilever, 54-a push head connector, 6-a linkage mechanism, 61-a second mounting seat, 611-a thrust ball bearing, 612-a third spacer ring, 613-a second self-aligning roller bearing, 614-a second spacer ring, 615-a second shoulder sleeve, 616-a protective cover, 617-an oil cup, 62-a second transmission shaft, 63-a second bevel gear, 64-a first bevel gear, 65-a first mounting seat, 651-a first shoulder sleeve, 652-a first end cover and 653-a first self-aligning roller bearing, 654-first spacer ring, 655-second end cap, 66-first transmission shaft, 67-brake pad, 68-ratchet mechanism, 681-ratchet, 682-pawl, 683-crankshaft, 6831-crankshaft middle, 6832-crankshaft end, 6833-crankshaft rectangular end, 684-first buffer layer, 685-second buffer layer, 686-fastening device, 687-lower limit block, 688-upper limit block, 69-guide rod, 7-knife rest component, 8-vessel, 9-turntable, 91-limit end block, 92-buffer pad, 10-seal cover, 11-ice box, 12-seal, 13-temperature sensor.

Detailed Description

The technical contents of the preferred embodiments of the present invention will be more clearly and easily understood by referring to the drawings attached to the specification. The present invention may be embodied in many different forms of embodiments and the scope of the invention is not limited to the embodiments set forth herein.

In the drawings, structurally identical elements are represented by like reference numerals, and structurally or functionally similar elements are represented by like reference numerals throughout the several views. The size and thickness of each component shown in the drawings are arbitrarily illustrated, and the present invention is not limited to the size and thickness of each component. The thickness of the components may be exaggerated where appropriate in the figures to improve clarity.

In the description of the embodiments of the present application, it should be clear that the terms "center", "upper", "lower", "left", "right", "inner", "outer", "top", "bottom", "side", "vertical", "horizontal", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the embodiments of the present application and simplifying the description, but do not indicate or imply that the described devices or elements must have specific orientations or positional relationships, i.e., cannot be construed as limiting the embodiments of the present application; furthermore, the terms "first," "second," "third," "fourth," and the like are used merely to facilitate description or to simplify description, and do not indicate or imply importance.

As shown in fig. 1, the present embodiment provides a linkage chopper for biological tissue, which includes:

the device comprises a rack 1, a rotary table 9, a tool rest part 7, a driving part, a displacement detection system, a linkage mechanism 6, a vessel 8, a temperature regulation system, a sealing cover 10, a controller, a limiting end block 91 and a cushion pad 92;

the frame 1 comprises a support table 2, and the support table 2 is arranged at the upper end of the frame 1;

a turntable 9 is rotatably provided above the support table 2, an upper surface of the turntable 9 is configured to be horizontal, and a rotation center axis of the turntable 9 is configured to be vertical;

the tool rest member 7 is provided directly above the turntable 9, and the tool rest member 7 is configured to be vertically movable up and down;

the driving part is fixedly arranged on the machine frame 1 and comprises a driving output end, the driving output end is connected with the tool rest part 7, and the driving output end is configured to be capable of performing telescopic motion so as to drive the tool rest part 7 to move up and down; the driving part comprises a first driving support 4, a second driving support 5, a driving cylinder 3 and a displacement detection system; a rectangular through hole is formed in the first driving support piece 4, the lower end of the first driving support piece 4 is fixedly arranged on the support table 2, the support table 2 is provided with a first through hole 21, the first through hole 21 is arranged below the rectangular through hole of the first driving support piece 4, and a first sliding groove is formed in one side, close to the rotary table 9, of the upper end of the first driving support piece 4; the second driving support member 5 includes a sliding rod 52, a cantilever 53, a pushing head connector 54, and a sliding rod connector 51, in this embodiment, the driving output end is the pushing head connector 54, as shown in fig. 5, the cross-sectional shape of the sliding rod 52 is configured as a rectangle, the sliding rod 52 is slidably disposed in the rectangular through hole, the cantilever 53 is horizontally disposed, one end of the cantilever 53 is fixedly installed at the upper end of the sliding rod 52, the cantilever 53 is slidably disposed at the first sliding groove, the upper end of the pushing head connector 54 is fixedly installed at the other end of the cantilever 53, the lower end of the pushing head connector 54 is rotatably connected with the upper end of the knife rest part 7 through a shaft, and the upper end of the sliding rod connector 51; the driving cylinder 3 is fixedly arranged below the supporting platform 2, and a rod end connector 31 of the driving cylinder 3 passes through the first through hole 21 and is rotatably connected with the lower end of the sliding rod connector 51 through a shaft; the driving cylinder 3 is one of the following: a hydraulic cylinder, an air cylinder, an electro-hydraulic cylinder, and an electric cylinder, preferably an electro-hydraulic cylinder in this embodiment, as shown in fig. 1;

the displacement detection system is configured to be able to detect the position of the push-head adaptor 54; the displacement detection system comprises one or more of the following: the device comprises a proximity switch, a travel switch and a magnetostrictive displacement sensor, wherein the proximity switch is preferably arranged on the outer side of a driving cylinder 3 and is divided into an upper limit and a lower limit;

the input end of the linkage mechanism 6 is connected with the driving part, the output end of the linkage mechanism 6 is connected with the rotary table 9, the linkage mechanism 6 is configured to be capable of driving the rotary table 9 to rotate by utilizing the telescopic motion of the driving output end, and the corresponding rotary angular displacement of the rotary table 9 is equal when the tool rest part 7 moves up and down once;

the vessel 8 is a container with an upward opening, the bottom surface of the vessel 8 and the bottom surface of the inner cavity of the vessel 8 are both flat and horizontally arranged, the vessel 8 is arranged on the upper surface of the rotary table 9, and the horizontal section of the knife rest component 7 is smaller than that of the inner cavity of the vessel 8;

the knife rest component 7 comprises a plurality of blades, a knife holder and a pressing sheet, the blades are vertically and fixedly arranged on the lower surface of the knife holder, the pressing sheet is movably arranged below the blades, notches are formed in the pressing sheet, the blades can penetrate through the pressing sheet through the notches in the pressing sheet, and the pressing sheet is configured to press tissues to be cut;

the controller is configured to control the driving part;

the sealing cover 10 is a container with a downward opening, the sealing cover 10 is detachably and hermetically arranged on the upper surface of the support platform 2, the rotary table 9, the vessel 8 and the tool rest component 7 are arranged in an inner cavity of the sealing cover 10, and the sealing element 12 is arranged between the sealing cover 10 and the support platform 2;

the temperature regulation system is configured to adjust the temperature of the inner cavity of the sealed cover 10, and the temperature regulation system comprises a temperature sensor 13 and a cold source, wherein the temperature sensor 13 is arranged on the first driving support 4, the cold source is fixedly arranged on the support table 2 in the sealed cover 10, the temperature sensor 13 is configured to detect the temperature of the inner cavity of the sealed cover 10, and the cold source is configured to reduce the temperature of the inner cavity of the sealed cover 10. The cold source in this embodiment is an ice box 11, and ice cubes are arranged in the ice box 11;

the buffer pad 92 is fixedly arranged between the vessel 8 and the turntable 9, the buffer pad 92 can be made of rubber or soft plastic, and the buffer pad 92 is used for relieving impact on other equipment caused by vertical cutting force;

the limiting end block 91 is arranged on the upper surface of the rotary table 9 by taking the rotary central axis of the rotary table 9 as a circle center, when the vessel 8 is arranged on the upper surface of the rotary table 9, the inner side surface of the limiting end block 91 is contacted with the peripheral side surface of the vessel 8, before tissue cutting, the limiting end block 91 plays a positioning role, so that the central line of the vessel 8 placed on the rotary table 9 is superposed with the rotary central line of the rotary table 9, and the limiting end block 91 limits the vessel 8 from tipping and moving in the tissue cutting process; the limiting end blocks 91 can be arranged in a whole circle or independently, when the limiting end blocks 91 are in an independent form, the number of the limiting end blocks is not less than 3, in another preferred mode of the embodiment, independent slide ways are arranged on the rotary table 9, the independent limiting end blocks 91 can slide in the slide ways to adapt to vessels 8 with different sizes and shapes, and when the position of the limiting end blocks 91 is adjusted, the limiting end blocks are fastened through screws or bolts.

As shown in fig. 4, the linkage mechanism 6 includes a guide rod 69, a ratchet mechanism 68, a first transmission shaft 66, a second transmission shaft 62, a gear mechanism, a first mounting seat 65, a second mounting seat 61, and a brake pad 67, the ratchet mechanism 68 includes a ratchet 681, a pawl 682, and a buffer layer, the gear mechanism includes a first gear and a second gear, the first gear and the second gear form a gear transmission to transmit the rotation of the first transmission shaft 66 to the second transmission shaft 62, the first gear and the second gear may form a worm gear transmission or a bevel gear transmission, the embodiment is preferably a bevel gear transmission, the first gear is a first bevel gear 64, the second gear is a second bevel gear 63, the first bevel gear 64 and the second bevel gear 63 form a bevel gear transmission, and the embodiment is preferably that the first bevel gear 64 is perpendicular to the central axis of the second bevel gear 63;

the guide rod 69 is vertically arranged, the upper end of the guide rod 69 is fixedly arranged on the lower end surface of the slide rod 52, and the lower end of the guide rod 69 passes through the first through hole 21 and is arranged below the support table 2; the first through hole 21 is further provided with a guide groove 211, as shown in fig. 6, the guide groove 211 being configured to be able to guide the guide bar 69;

ratchet mechanism 68 may be one of a toothed ratchet mechanism or a friction ratchet mechanism, preferably a friction ratchet mechanism in the present embodiment, as shown in figure 4,

the pawl 682 is a rod-shaped member, a first end of the pawl 682 is swingably mounted at the lower end of the guide rod 69, a second end of the pawl 682 is an arc-shaped end face, the center of the arc-shaped end face coincides with the swing center of the pawl 682, the ratchet 681 is a wheel-shaped member, the ratchet 681 is fixedly mounted at one end of the first transmission shaft 66 through a key and a shaft end baffle, the arc-shaped end face of the pawl 682 and the ratchet 681 form ratchet transmission, and the ratchet mechanism 68 is configured to convert the upward or downward movement of the guide rod 69 into the rotation of the ratchet 681;

the buffer layer includes first buffer layer 684, second buffer layer 685, and first buffer layer 684 is the ring shape, and first buffer layer 684 is fixed to be set up in the ratchet 681 outer peripheral face, and second buffer layer 685 is fixed to be set up in the arc terminal surface of pawl 682, and pawl 682, ratchet 681 and buffer layer have the following relation:

R₁+R₂≤D＜R₁+R₂+h₁+h₂；

wherein R is₁Radius of ratchet 681, R₂The horizontal distance between the arcuate end surface and the center of oscillation of the pawl 682 for the pawl 682 in the lower limit position, D the horizontal distance between the center of oscillation of the pawl 682 and the center of rotation of the ratchet 681, h₁Is the thickness of the first buffer layer 684, h₂Is the thickness of second buffer layer 685;

as shown in fig. 3, the first mounting seat 65 is fixedly mounted on the frame 1, the first transmission shaft 66 is sleeved in the first mounting seat 65, two first self-aligning roller bearings 653 are arranged between the first transmission shaft 66 and the first mounting seat 65, a first spacer ring 654 is arranged between outer rings of the two first self-aligning roller bearings 653, the outer ring of the first self-aligning roller bearing 653 and the first mounting seat 65 are in transition fit or interference fit, a first end cap 652 is arranged at the other side of the first mounting seat 65 and is matched with an inner hole step of the first mounting seat 65 to fix the outer ring of the first self-aligning roller bearing 653, the first transmission shaft 66 passes through the first self-aligning roller bearing 653, the first transmission shaft 66 and the inner ring of the first self-aligning roller bearing 653 are in transition fit or interference fit, a shaft shoulder is arranged at the other end of the first transmission shaft 66, the first bevel gear 64 is fixedly mounted at the other end of the first transmission, the first shaft shoulder sleeve 651 is arranged between the first bevel gear 64 and the inner ring of the first self-aligning roller bearing 653; the brake pad 67 is provided between the first transmission shaft 66 and the first mounting seat 65, and the brake pad 67 is configured to be able to increase the rotational resistance of the first transmission shaft 66.

As shown in fig. 2, the second mounting base 61 is fixedly mounted on the frame 1, the second transmission shaft 62 is sleeved in the second mounting base 61, and the upper end of the second transmission shaft 62 is fixedly connected with the turntable 9; the central axis of the second transmission shaft 62 is coincident with the central axis of the turntable 9, and the central axis of the second transmission shaft 62 is perpendicular to the upper end face of the turntable 9; two second self-aligning roller bearings 613 are arranged between the second transmission shaft 62 and the second mounting seat 61, a third spacer ring 612 is arranged between the lower surface of the rotary table 9 and the inner ring of the second self-aligning roller bearings 613, a thrust ball bearing 611 is arranged between the lower surface of the rotary table 9 and the upper surface of the second mounting seat 61, and the periphery of the third spacer ring 612 is in contact with the upper ring of the thrust ball bearing 611; the second spacer ring 614 is arranged between outer rings of the two second self-aligning roller bearings 613, the outer rings of the second self-aligning roller bearings 613 and the second mounting seat 61 are in transition fit or interference fit, the second transmission shaft 62 passes through the second self-aligning roller bearings 613, the second transmission shaft 62 and the inner rings of the second self-aligning roller bearings 613 are in transition fit or interference fit, a shaft shoulder is arranged at the lower end of the second transmission shaft 62, the second bevel gear 63 is fixedly arranged at the lower end of the second transmission shaft 62 through a key and a shaft end baffle, and the second shaft shoulder sleeve 615 is arranged between the second bevel gear 63 and the inner rings of the second self-aligning roller bearings 613; the outer periphery of the thrust ball bearing 611 is provided with a protective cover 616, the protective cover 616 is fixedly mounted on the turntable 9, an oil cup 617 is mounted on the protective cover 616, the oil cup 617 is used for adding grease to the second self-aligning roller bearing 613 and the thrust ball bearing 611, and the protective cover 616 is used for preventing impurities from entering the second self-aligning roller bearing 613 and the thrust ball bearing 611.

In another technical scheme of the embodiment, the first gear is a worm, the second gear is a worm wheel, and the first gear and the second gear form worm and gear transmission.

As shown in fig. 7, the linkage mechanism 6 further includes a rotating shaft, a fastening device 686 and a swing limiting block, the swing limiting block includes a lower limiting block 687 and an upper limiting block 688, two ends of the rotating shaft are rotatably connected with the lower end of the guide rod 69, and the middle part of the rotating shaft is rotatably connected with the first end of the pawl 682;

a lower limit block 687 is disposed below the center of oscillation of the pawl 682, the lower limit block 687 being configured to limit downward oscillation of the pawl 682 beyond a lower limit, which is when the pawl 682 is in a horizontal position;

an upper limit block 688 is disposed above the center of oscillation of the pawl 682, the upper limit block 688 being configured to limit upward oscillation of the pawl 682 beyond an upper limit, the upper limit being an oscillation position of the pawl 682 that does not allow contact between the first and second cushioning layers 684, 685;

the pawl 682 is configured such that the horizontal distance between the second end face of the pawl 682 and the center of oscillation of the pawl 682 decreases progressively as the pawl oscillates from the lower limit to the upper limit.

The rotating shaft is rotatably connected with the guide rod 69 and the pawl 682, so that the pawl 682 can swing more flexibly, and the probability of unsmooth swinging of the pawl 682 caused by mechanism deformation, aging, corrosion and the like is reduced; a fastening means 686 is provided at the lower end of the guide rod 69, the fastening means 686 being configured to fasten the rotating shaft.

In this embodiment, the fastening device 686 includes a first bolt and a first nut, a first threaded hole is provided on the guide rod 69, the first bolt and the first threaded hole form a threaded connection, a screw end surface of the first bolt passes through the first threaded hole to contact with the rotating shaft, the first nut is disposed between a nut side of the first bolt and the guide rod 69, and the first nut is configured to prevent the first bolt from loosening.

As shown in fig. 8 and 9, the rotating shaft is preferably a crankshaft 683 in the present embodiment, the crankshaft 683 includes a crankshaft middle portion 6831, crankshaft end portions 6832, and crankshaft rectangular end portions 6833, both the crankshaft middle portion 6831 and the crankshaft end portions 6832 are cylinders, the crankshaft end portions 6832 are fixedly disposed on both sides of the crankshaft middle portion 6831, the crankshaft rectangular end portions 6833 are regular quadrangular prisms, the crankshaft rectangular end portions 6833 are fixedly disposed outside the crankshaft end portions 6832,

the central axes of the crankshaft ends 6832 coincide, and the central axis of the crankshaft ends 6832 does not coincide with the central axis of the crankshaft middle 6831.

The crankshaft 683 allows fine tuning of the distance between the center of oscillation of the pawl 682 and the center of rotation of the ratchet 681, with the ends of the rectangular cross-section facilitating rotation of the crankshaft 683.

In this embodiment, the guide rod 69 moves downward during the downward movement of the driving cylinder 3 to move the pawl 682 downward, when the pawl 682 contacts the ratchet 681, the pawl 682 cannot be pushed to rotate due to the presence of the brake pad 67, the pawl 682 swings upward, when the guide rod 69 moves downward to the lower limit, the pawl 682 moves over the ratchet 681, the pawl 682 swings downward under the action of gravity until the pawl 682 swings to the lower limit block 687, the pawl 682 is in the horizontal state, when the driving cylinder 3 moves upward, the pawl 682 is moved upward due to the presence of the lower limit block 687, when the pawl 682 passes over the ratchet 681, the first buffer layers 684 and 685-the second buffer layer 685 are pressed, the rotation moment applied to the ratchet 681 is greater than the resistance of the rotation of the first transmission shaft 66, so that the first transmission shaft 66 rotates to bring the turntable 9 into rotation until the pawl 682 passes over the ratchet 681, the first drive shaft 66 is held against rotational displacement by a brake pad 67.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.