阅读说明：本技术 遗尿敷脐散及其制备方法 (Umbilicus dressing powder for enuresis and its preparation method ) 是由 宋虎杰 于 2020-06-23 设计创作，主要内容包括：本发明属于中药制剂技术领域,特别是涉及一种遗尿敷脐散及其制备方法。由以下重量份的原材料组成,甘草230-250份、白芍95-100份、白术100-105份、硫黄240-255份和白矾70-76份。经过临床试验,本产品对于遗尿有效率高达95％,与对照组相比,两组治疗后数据经过统计学处理,治疗组疗效明显优于对照组,P＜0.05,临床疗效显著,同时未见其它明显的不良反应。(The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a navel-applying powder for enuresis and a preparation method thereof. Comprises the following raw materials, by weight, 250 parts of licorice 230-. Clinical tests prove that the effective rate of the product on enuresis is up to 95%, compared with a control group, the curative effect of the treatment group is obviously superior to that of the control group by statistically processing the data after two groups of treatments, P is less than 0.05, the clinical curative effect is obvious, and other obvious adverse reactions are not seen.)

1. The umbilicus dressing powder for enuresis is characterized in that: comprises the following raw materials, by weight, 250 parts of licorice 230-.

2. The umbilicus dressing powder for enuresis according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 230 parts of liquorice, 95 parts of white paeony root, 100 parts of bighead atractylodes rhizome, 240 parts of sulfur and 70 parts of alum.

3. The umbilicus dressing powder for enuresis according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 250 parts of liquorice, 100 parts of white paeony root, 100 parts of bighead atractylodes rhizome, 250 parts of sulfur and 75 parts of alum.

4. The umbilicus dressing powder for enuresis according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises the following raw materials, by weight, 250 parts of liquorice, 100 parts of white paeony root, 105 parts of bighead atractylodes rhizome, 255 parts of sulfur and 76 parts of alum.

5. A preparation method of the umbilicus dressing powder for enuresis is characterized in that: the preparation method comprises the following steps of (1) mixing liquorice, white paeony root and bighead atractylodes rhizome, adding 10 times of water and 8 times of water, respectively soaking for 30 minutes, and then decocting for 2 hours; (2) filtering and combining the filtrates, and then concentrating the filtrate at-0.08-0.09 MPa and 60-70 ℃ until the relative density of the filtrate reaches 1.30-1.35 at 60 ℃ to obtain clear paste; (3) pulverizing Sulfur and Alumen, adding into the above fluid extract, stirring, drying, pulverizing, sieving, and packaging to obtain the final product.

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a navel-applying powder for enuresis and a preparation method thereof.

Background

Enuresis is a morbid state which is usually seen in children and can not control urination by oneself in sleep in 3 years old, and most patients are considered to be deficient in kidney qi in traditional Chinese medicine, and the kidney is the congenital base and can not help the bladder boat, so that qi can be gasified, the lower element can not be kept firmly, the urine can not be controlled automatically, and the urination can not be self-consciously in sleep. In nighttime sleep, the patients with mild symptoms and severe symptoms are treated for 1 time and several times, and the patients with severe symptoms can have lassitude, reduced appetite and yellow and thin face. The etiology of the disease is still complex in clinic, and the treatment is difficult to a certain extent. In the dialectical theory of traditional Chinese medicine, the symptoms can be mainly classified as liver and kidney weakness; kidney qi deficiency; it is also possible to urinate anywhere during the day; because of more traditional Chinese medicine treatment schemes in dreams and more traditional Chinese medicine treatment schemes, doctors of all generations record some prescription medicines, but the effects are not very obvious, and how to develop a medicine which can take effect quickly and has obvious treatment effects becomes urgent needs of patients.

Disclosure of Invention

The invention provides a navel-applying powder for enuresis and a preparation method thereof, which solve the technical problem that the traditional Chinese medicine in the prior art has poor treatment effect on enuresis.

In order to achieve the above object, an aspect of the embodiments of the present invention provides. The navel applying powder for treating enuresis consists of the following raw materials, by weight, 250 parts of licorice 230-.

Further, the enuresis navel-applying powder comprises, by weight, 230 parts of liquorice, 95 parts of white paeony root, 100 parts of bighead atractylodes rhizome, 240 parts of sulfur and 70 parts of alum.

Furthermore, the enuresis navel-applying powder comprises the following raw materials, by weight, 250 parts of liquorice, 100 parts of white paeony root, 100 parts of bighead atractylodes rhizome, 250 parts of sulfur and 75 parts of alum.

Furthermore, the enuresis navel-applying powder comprises the following raw materials, by weight, 250 parts of liquorice, 100 parts of white paeony root, 105 parts of bighead atractylodes rhizome, 255 parts of sulfur and 76 parts of alum.

Another aspect of the invention provides a preparation method of the navel-applying powder for enuresis, which comprises the following steps of (1) mixing liquorice, white paeony root and bighead atractylodes rhizome, adding 10 times of water and 8 times of water, respectively soaking for 30 minutes, and then decocting for 2 hours; (2) filtering and combining the filtrates, and then concentrating the filtrate at-0.08-0.09 MPa and 60-70 ℃ until the relative density of the filtrate reaches 1.30-1.35 at 60 ℃ to obtain clear paste; (3) pulverizing Sulfur and Alumen, adding into the above fluid extract, stirring, drying, pulverizing, sieving, and packaging to obtain the final product.

Compared with the prior art, the technical scheme of the invention has the beneficial effects that: according to the formula, bighead atractylodes rhizome, rhizoma atractylodis macrocephalae, capable of strengthening the spleen and tonifying qi, alum and sulfur, capable of eliminating dampness and inducing astringency, are used as monarch drugs, white paeony root, capable of nourishing blood and astringing yin, and liquorice, capable of tonifying the spleen and tonifying qi, are used as assistant drugs and conductant drugs. The combination of the medicines can strengthen the spleen and replenish qi to treat the root cause, and astringe to stop drowning to treat the secondary cause, so that both the symptoms and root causes can be treated, and the enuresis can be cured. Clinical tests prove that the effective rate of the preparation for treating enuresis is up to 95%, and the preparation passes related toxic and side effects tests, compared with a control group, the curative effect of the test group is obviously better than that of the control group, P is less than 0.05, and the preparation is externally used and has less side effect.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The terms "first" and "second," and the like, in the description and in the claims of embodiments of the present invention are used for distinguishing between different objects and not for describing a particular order of the objects. For example, the first parameter set and the second parameter set, etc. are used to distinguish different parameter sets, rather than to describe a particular order of parameter sets.

In the description of the embodiments of the present invention, the meaning of "a plurality" means two or more unless otherwise specified. For example, a plurality of elements refers to two elements or more.

The term "and/or" herein is an association relationship describing an associated object, and means that there may be three relationships, for example, a display panel and/or a backlight, which may mean: there are three cases of a display panel alone, a display panel and a backlight at the same time, and a backlight alone. The symbol "/" herein denotes a relationship in which the associated object is or, for example, input/output denotes input or output.

In the embodiments of the present invention, words such as "exemplary" or "for example" are used to mean serving as examples, illustrations or descriptions. Any embodiment or design described as "exemplary" or "e.g.," an embodiment of the present invention is not necessarily to be construed as preferred or advantageous over other embodiments or designs. Rather, use of the word "exemplary" or "such as" is intended to present concepts related in a concrete fashion.

Infantile enuresis occurs due to the failure of the bladder to regulate the function of the spleen and lung. The lung governs qi of the whole body and has the functions of regulating water passage and transporting bladder. The spleen belongs to the middle earth, and water can be produced by preference for dryness and aversion to dampness. The normal function of the spleen and lung can maintain the normal distribution and excretion of water. If lung qi is weak, it is unable to control the node and can not consolidate, it is determined that the lung qi is deficient. The bladder is not in the right place, and body fluids are not stored; if spleen qi is weak and water cannot be released from the lung, there is no water available, so when lung qi is deficient in spleen qi, the upper deficiency cannot be controlled and the lower deficiency cannot be supported, so there is no right to restrict water passage and self-enuresis occurs, or urine is discharged in sleep, so it is called enuresis. For enuresis, it is usually indicated for the pathological condition of bladder failure, and it is indicated for strengthening spleen, tonifying qi, inducing astringency to arrest drowning.

According to the embodiment of the invention, the bighead atractylodes rhizome, which is used for strengthening the spleen and tonifying qi, is taken as a monarch drug, the alum and the sulfur, which are used for eliminating dampness and inducing astringency, are taken as ministerial drugs, the white paeony root, which is used for nourishing the blood and astringing yin, and the liquorice, which is used for tonifying the spleen and tonifying qi. The combination of the medicines can strengthen the spleen and replenish qi to treat the root cause, and astringe to stop drowning to treat the secondary cause, so that both the symptoms and root causes can be treated, and the enuresis can be cured.

The navel applying powder for treating enuresis consists of the following raw materials, by weight, 250 parts of licorice 230-.

The efficacy and safety of the drug were tested as follows.

Test data:

of the 76 observed patients, 42 male patients and 34 female patients were aged 3-14 years, the disease course was 3 months to 10 years, no symptom of any symptom of the nervous system, no urinary system disease, normal urine volume and normal intelligence were observed.

The Western medicine diagnosis standard can be used for diagnosing children who have no symptoms and signs of a nervous system, no urinary system diseases, normal urine volume and normal intelligence and are over 3 years old and can control urination in the daytime but involuntarily urinate after falling asleep.

Traditional Chinese medicine diagnosis and syndrome differentiation: frequent enuresis in sleep often occurs several times a night, arouses the back, and causes lassitude, pale complexion, cold and intolerance of cold limbs, weakness of lower limbs, soreness and weakness of waist and legs, clear and long urine, white tongue coating, deep and slow pulse, and weakness.

The inclusion standard meets the Western diagnosis standard and Chinese medicine syndrome differentiation, and test cases can be included.

Case criteria (including maladaptive symptoms or rejection criteria) were excluded.

(1) The examination proves that the medicament is caused by spina bifida or other organic lesions.

(2) Those with age below 3 years or above 18 years are allergic to the medicine.

(3) Patients with serious primary diseases such as cardiovascular diseases, liver diseases, kidney diseases, hemopoietic system diseases and the like are combined.

(4) If the patient does not meet the inclusion criteria, the patient can not judge the curative effect or the data is incomplete, which affects the curative effect or the safety.

Test groups: the patient is observed, the other similar medicines are stopped, the enuresis navel applying powder is externally applied to the umbilical fossa, the umbilical fossa is filled with the medicine powder every time, the medicine powder is externally pasted with adhesive plaster for fixation, and the treatment course is 1 month. Three treatment courses were observed continuously.

Control group: imipramine hydrochloride is orally taken for 12.5mg each time under the age of 5, 1 time per night, 25mg each time over the age of 5 and 1 time per night, and three treatment courses are continuously observed.

The therapeutic effect judgment standard is as follows:

1. and (3) healing: the enuresis disappears within 3 treatment courses, and related symptoms and physical signs disappear.

2. The effect is shown: treat the patients with enuresis times reduced by more than 80 percent in 3 courses of treatment.

3. The method has the following advantages: the enuresis times are reduced by more than 50% after 3 courses of treatment.

4. And (4) invalidation: the treatment is performed for 3 courses of treatment, and the frequency of enuresis is reduced by less than 50% or the patients are not improved.

The experimental statistics are shown in the following table:

31 patients are cured in the test group, the effective rate is up to 95 percent, 21 patients are cured in the control group, the effective rate is 81.67 percent, the data after the two groups of treatment are statistically processed, the curative effect of the test group is obviously better than that of the control group, P is less than 0.05, and the clinical curative effect is obvious. Meanwhile, in the treatment process, 2 patients have navel itch and disappear after stopping taking the medicine, and other obvious adverse reactions are not seen.

Typical cases, Zhangyi, male 5 years old, patients often enuresis in sleep 3-4 times per week for more than 2 years, and patients have no abnormality in nervous system, good intelligence development, and no abnormality in urination routine. A deep red tongue with white coating and a deep and thready pulse. And (3) diagnosis: enuresis, syndrome differentiation of traditional Chinese medicine, kidney deficiency and cold syndrome, enuresis, the umbilicus applying powder for external application, Shenjue, 1 time per day, continuous medication for 1 month, disappearance of enuresis of children at night, and no bed wetting after follow-up for 3 months.