阅读说明：本技术 一种包括珊瑚钙的保健药品及其制备方法 (A health product comprising coral calcium, and its preparation method ) 是由 曹小霞 于 2021-08-03 设计创作，主要内容包括：本发明公开了一种包括珊瑚钙的保健药品,原料包括碳酸钙、氢化珊瑚钙、山梨醇、淀粉、麦芽糊精、崩解剂和润滑剂,且将以上原料制成为片剂、胶囊剂或颗粒剂,还有其制备方法。本发明巧妙地利用了氢化珊瑚钙作为药品的原料,作为补剂不但可以补钙,还利用氢化带来的氢气以起到特有的保健作用,效果良好。(The invention discloses a health-care medicine containing coral calcium, which is prepared from calcium carbonate, calcium hydride, sorbitol, starch, maltodextrin, disintegrating agent and lubricant through preparing tablets, capsules or granules and preparing method. The invention skillfully utilizes the calcium hydride coral as the raw material of the medicine, can supplement calcium as a supplement, and also utilizes hydrogen brought by hydrogenation to play a special health-care role, and has good effect.)

1. A health medicine containing coral calcium is characterized in that: the raw materials comprise calcium carbonate, calcium coralline hydride, sorbitol, starch, maltodextrin, disintegrating agent and lubricant, and the raw materials are prepared into tablets, capsules or granules.

2. A nutraceutical composition comprising coral calcium as in claim 1 wherein: 3-5 parts of calcium carbonate, 1-4 parts of calcium hydride coral, 4-8 parts of sorbitol, 10-15 parts of starch, 10-15 parts of diluent, 0.7-1.5 parts of disintegrating agent and 1-2 parts of lubricant.

3. A nutraceutical product comprising coral calcium as in claim 2 wherein: 3.5-4.5 parts of calcium carbonate, 1-4 parts of calcium hydride coral, 5-6.5 parts of sorbitol, 10-15 parts of starch, 10-15 parts of diluent, 0.9-1.5 parts of disintegrating agent and 1-2 parts of lubricant.

4. A nutraceutical product comprising coral calcium as in claim 3 wherein: the diluent is maltodextrin.

5. A nutraceutical product comprising coral calcium as in claim 4, wherein: the lubricant is magnesium stearate.

6. A nutraceutical product comprising coral calcium as in claim 5, wherein: the disintegrant is citric acid.

7. The process for preparing a health-care medicine as claimed in claim 6, which comprises the steps of:

s100, selecting calcium hydride as a raw material, grinding the calcium hydride coral into powder, and screening out calcium hydride coral powder through a 100-mesh sieve for later use;

s200, adding the calcium carbonate powder, the citric acid and the maltodextrin into the hydrogenated coral calcium powder obtained in the previous step, stirring and mixing by a stirrer at the rotating speed of 50-80 revolutions per minute for 30-40 minutes, and stirring to obtain a first mixture;

s300, adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing the mixture by a stirrer in a heating state, wherein the heating temperature is 40-45 ℃, the rotating speed of the stirrer is 40-60 revolutions per minute, the stirring time is 20-30 minutes, stirring is completed to obtain a second mixture, and then the second mixture is cooled for 20-30 minutes within the temperature range of-6 ℃ to-7 ℃;

s400, adding a wetting agent into the second mixture subjected to cold storage in the previous step, and pressing into tablets, or preparing into granules, or preparing into capsules.

8. The method for preparing a health care medicine according to claim 7, wherein the step S100 comprises the following substeps:

s110, selecting calcium carbonate as a raw material, and grinding the calcium carbonate into powder;

s120, screening the calcium carbonate powder obtained in the previous step through a 200-mesh sieve;

s130, taking the calcium carbonate powder screened in the previous step as the calcium carbonate powder in the step S200 for standby.

9. The process for preparing a health-care medicine as claimed in claim 7, wherein: the citric acid particle size in the step S200 is 400 meshes.

10. The process for preparing a health-care medicine as claimed in claim 7, wherein: in the step S300, the sorbitol particle size is 400 mesh.

Technical Field

The invention relates to the technical field of calcium supplement tablets, in particular to a health-care medicine containing coral calcium and a preparation method thereof.

Background

Coral calcium is a daily nutritional supplement, and is coral sand prepared by weathering and naturally decomposing live coral. It contains very high concentrations of calcareous, major minerals and trace minerals, also known as marine diamonds because of their abundant mineral content. The mineral-rich coral sand is produced by the natural coral reef continuously and then collected by people. Coral calcium is 24% calcium, 12% magnesium, and more than 70 other sea minerals such as zinc, iron, potassium, manganese, and selenium. The minerals exist in an ion form, can be highly absorbed by a human body immediately, are most suitable for the nutrition balance metabolism of the human body, and are alkalescent health foods; the abundant trace minerals in coral are important factors for its great efficacy. Since it is easily absorbed and does not cause constipation.

The japanese government has taken hydrogen inhalation as an advanced medical means in 2016, and related people research and discover that hydrogen inhalation can improve visceral lesion, and is anti-aging and anti-oxidation, namely widely known as "hydrogen health".

Research shows that the coral calcium can be used as calcium-rich calcium hydrogen, i.e. a great amount of hydrogen stored in a great amount of micropores in the coral calcium is used as a hydrogen source, and the coral calcium is ingested to achieve the health-care effect. Therefore, based on coral calcium, can be fully utilized as a health supplement.

Disclosure of Invention

In view of the above circumstances, an object of the present invention is to provide a health medicine comprising coral calcium, which satisfies a better effect of use, and the following:

a health medicine comprises coral calcium, calcium carbonate, calcium hydride, sorbitol, starch, maltodextrin, disintegrating agent and lubricant, and is made into tablet, capsule or granule.

Further, 3-5 parts of calcium carbonate, 1-4 parts of calcium hydride coral, 4-8 parts of sorbitol, 10-15 parts of starch, 10-15 parts of diluent, 0.7-1.5 parts of disintegrating agent and 1-2 parts of lubricant.

Further, 3.5-4.5 parts of calcium carbonate, 1-4 parts of calcium hydride coral, 5-6.5 parts of sorbitol, 10-15 parts of starch, 10-15 parts of diluent, 0.9-1.5 parts of disintegrant and 1-2 parts of lubricant.

Further, the diluent is maltodextrin.

Further, the lubricant is magnesium stearate.

Further, the disintegrant is citric acid.

Another object of the present invention is to provide a method for preparing the above mentioned health care medicine, comprising the following steps:

s100, selecting calcium hydride as a raw material, grinding the calcium hydride coral into powder, and screening out calcium hydride coral powder through a 100-mesh sieve for later use;

s200, adding the calcium carbonate powder, the citric acid and the maltodextrin into the hydrogenated coral calcium powder obtained in the previous step, stirring and mixing by a stirrer at the rotating speed of 50-80 revolutions per minute for 30-40 minutes, and stirring to obtain a first mixture;

s300, adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing the mixture by a stirrer in a heating state, wherein the heating temperature is 40-45 ℃, the rotating speed of the stirrer is 40-60 revolutions per minute, the stirring time is 20-30 minutes, stirring is completed to obtain a second mixture, and then the second mixture is cooled for 20-30 minutes within the temperature range of-6 ℃ to-7 ℃;

s400, adding a wetting agent into the second mixture subjected to cold storage in the previous step, and pressing into tablets, or preparing into granules, or preparing into capsules.

Further, the step S100 includes the following sub-steps:

s110, selecting calcium carbonate as a raw material, and grinding the calcium carbonate into powder;

s120, screening the calcium carbonate powder obtained in the previous step through a 200-mesh sieve;

s130, taking the calcium carbonate powder screened in the previous step as the calcium carbonate powder in the step S200 for standby.

Further, the citric acid particle size in step S200 is 400 mesh.

Further, the sorbitol particle size in step S300 is 400 mesh.

Has the advantages that: the invention has novel concept, reasonable design and convenient use, skillfully utilizes the calcium hydride coral as the raw material of the medicine, can supplement calcium as a supplement, also utilizes hydrogen brought by hydrogenation to play a special health-care role, and has good effect.

Detailed Description

The following examples illustrate the invention in further preference during its practice:

a health medicine comprises coral calcium, calcium carbonate, calcium hydride, sorbitol, starch, maltodextrin, disintegrating agent and lubricant, and is made into tablet, capsule or granule.

In some embodiments, the calcium carbonate is 3-5 parts, the calcium hydride coral is 1-4 parts, the sorbitol is 4-8 parts, the starch is 10-15 parts, the diluent is 10-15 parts, the disintegrant is 0.7-1.5 parts, and the lubricant is 1-2 parts.

Preferably, in one embodiment, the calcium carbonate is 3 parts, the calcium hydride coral is 1 part, the sorbitol is 4 parts, the starch is 10 parts, the diluent is 10 parts, the disintegrating agent is 0.7 part, and the lubricant is 1 part.

Preferably, in one embodiment, the calcium carbonate is 5 parts, the calcium hydride coral is 4 parts, the sorbitol is 8 parts, the starch is 15 parts, the diluent is 15 parts, the disintegrating agent is 1.5 parts, and the lubricant is 2 parts.

Preferably, in one embodiment, the calcium carbonate is 4 parts, the calcium hydride coral is 2 parts, the sorbitol is 6 parts, the starch is 12 parts, the diluent is 12 parts, the disintegrating agent is 1 part, and the lubricant is 1.5 parts.

In some embodiments, the calcium carbonate is 3.5-4.5 parts, the calcium hydride coral is 1-4 parts, the sorbitol is 5-6.5 parts, the starch is 10-15 parts, the diluent is 10-15 parts, the disintegrant is 0.9-1.5 parts, and the lubricant is 1-2 parts.

Preferably, in one embodiment, the calcium carbonate is 3.5 parts, the calcium hydride coral is 1 part, the sorbitol is 5 parts, the starch is 10 parts, the diluent is 10 parts, the disintegrating agent is 0.9 part, and the lubricant is 1 part.

Preferably, in one embodiment, the calcium carbonate is 4.5 parts, the calcium hydride coral is 4 parts, the sorbitol is 6.5 parts, the starch is 15 parts, the diluent is 15 parts, the disintegrating agent is 1.5 parts, and the lubricant is 2 parts.

Preferably, in one embodiment, the calcium carbonate is 4 parts, the calcium hydride coral is 2 parts, the sorbitol is 5.5 parts, the starch is 12 parts, the diluent is 12 parts, the disintegrating agent is 1 part, and the lubricant is 1.5 parts.

Preferably, in one embodiment, the diluent is maltodextrin.

Preferably, in one embodiment, the lubricant is magnesium stearate.

Preferably, in one embodiment, the disintegrant is citric acid.

With the content of the above embodiment, a preparation method of a corresponding health care medicine is further provided, which comprises the following steps:

s100, selecting calcium hydride as a raw material, grinding the calcium hydride coral into powder, and screening out calcium hydride coral powder through a 100-mesh sieve for later use;

s200, adding the calcium carbonate powder, the citric acid and the maltodextrin into the hydrogenated coral calcium powder obtained in the previous step, stirring and mixing by a stirrer at the rotating speed of 50-80 revolutions per minute for 30-40 minutes, and stirring to obtain a first mixture;

s300, adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing the mixture by a stirrer in a heating state, wherein the heating temperature is 40-45 ℃, the rotating speed of the stirrer is 40-60 revolutions per minute, the stirring time is 20-30 minutes, stirring is completed to obtain a second mixture, and then the second mixture is cooled for 20-30 minutes within the temperature range of-6 ℃ to-7 ℃;

s400, adding a wetting agent into the second mixture subjected to cold storage in the previous step, and pressing into tablets, or preparing into granules, or preparing into capsules.

In some embodiments, the step S100 includes the following sub-steps:

s110, selecting calcium carbonate as a raw material, and grinding the calcium carbonate into powder;

s120, screening the calcium carbonate powder obtained in the previous step through a 200-mesh sieve;

s130, taking the calcium carbonate powder screened in the previous step as the calcium carbonate powder in the step S200 for standby.

Preferably, the citric acid particle size in step S200 is 400 mesh.

Preferably, the sorbitol particle size in step S300 is 400 mesh.

In some embodiments, the step S300 is preferably:

adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing with a stirrer under heating condition at 40 deg.C and 40 rpm for 20 min, stirring to obtain a second mixture, and cooling the second mixture at-6 deg.C for 20 min.

In some embodiments, the step S300 is preferably:

adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing with a stirrer under heating condition at 45 deg.C and rotation speed of 60 rpm for 30 min to obtain a second mixture, and cooling the second mixture at-6.5 deg.C for 25 min.

In some embodiments, the step S300 is preferably:

adding starch, sorbitol, magnesium stearate and maltodextrin into the first mixture, stirring and mixing with a stirrer under heating at 42 deg.C and 50 rpm for 25 min to obtain a second mixture, and cooling at-7 deg.C for 30 min.

The health medicine containing calcium hydride coral with different specific gravity is prepared by the above method, and has antiaging effect as shown in Table 1 below.

	Calcium salt of coral	Time of administration	Anti-aging test effect
				Control group	0	2 weeks	Without significant improvement
Formulation I	1 part of	2 weeks	Good taste
				Formulation II	2 portions of	2 weeks	Good wine
Formulation III	3 portions of	2 weeks	Superior food
				Formulation IV	4 portions of	2 weeks	Superior food

The health medicine containing calcium hydride Corallium japonicum Kishinouye (different specific gravity) is prepared by the above method, and has the effects of improving viscera sequelae as shown in Table 1 below.

	Calcium salt of coral	Time of administration	Improving effect on visceral organs
				Control group	0	4 weeks	Without significant improvement
Formulation I	1 part of	4 weeks	Good taste
				Formulation II	2 portions of	4 weeks	Good wine
Formulation III	3 portions of	4 weeks	Superior food
				Formulation IV	4 portions of	4 weeks	Superior food

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.