阅读说明：本技术 炎症性失调的基于纳米颗粒的疗法 (Nanoparticle-based therapy for inflammatory disorders ) 是由 M·麦卡特尔 T·库尔特 丁尧 J·波特 A·G·A·科里奥斯 O·博伊曼 A·奥兹坎 于 2019-12-13 设计创作，主要内容包括：本发明提供了纳米颗粒,其包括：包括金属和/或半导体的核；和多个共价连接至核的配体,其中所述配体包括：(i)至少一种稀释配体,其包括碳水化合物、谷胱甘肽或聚乙二醇部分；和(ii)式MTX-L-的配体,其中MTX-L-表示经连接体L耦合至所述核的甲氨蝶呤。还提供了纳米颗粒的药物组合物,包括凝胶制剂,以及纳米颗粒和药物组合物的医药用途,包括用于治疗炎症性或自身免疫失调,比如银屑病。(The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein the ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or polyethylene glycol moiety; and (ii) a ligand of formula MTX-L-, wherein MTX-L-represents methotrexate coupled to said core via a linker L. Also provided are pharmaceutical compositions of nanoparticles, including gel formulations, and medical uses of nanoparticles and pharmaceutical compositions, including for the treatment of inflammatory or autoimmune disorders, such as psoriasis.)