阅读说明：本技术 一种呋罗曲坦片及其制备方法 (Frovatriptan tablet and preparation method thereof ) 是由 陈阳生 孙桂玉 刘晓霞 刘薇 张怀征 牛建兴 王清亭 王婷婷 于 2020-03-27 设计创作，主要内容包括：本发明实施例公开了一种呋罗曲坦片及其制备方法,具体涉及夫罗曲坦药物技术领域,包括以下重量份数的原料：琥珀酸呋罗曲坦、普萘洛尔、阿米替林、羟丙甲纤维素、预胶化淀粉、润湿剂、野菊花、夜交藤、黄芩、莲子、食用明胶。本发明通过添加对偏头痛具有预防效果的普萘洛尔和阿米替林,在服用药片进行偏头痛治疗的同时,对偏头痛的再次复发进行预防,提供良好的治疗效果,本发明通过明胶裹住药芯,减轻服用药片时,药物对口腔的刺激,明胶混合野菊花、夜交藤、黄芩和莲子,通过静心安神的草药,方便患者服用药片的同时,提高患者的休息质量,缓解呕吐和恶心感觉,减轻药物的副作用。(The embodiment of the invention discloses a furotriptan tablet and a preparation method thereof, and particularly relates to the technical field of frovatriptan medicaments, which comprises the following raw materials in parts by weight: furotriptan succinate, propranolol, amitriptyline, hydroxypropyl methylcellulose, pregelatinized starch, a wetting agent, wild chrysanthemum flower, tuber fleeceflower stem, scutellaria baicalensis, lotus seed and edible gelatin. The tablet is coated with the drug core through the gelatin, so that the irritation of the medicine to the oral cavity is relieved when the tablet is taken, the wild chrysanthemum flower, the tuber fleeceflower stem, the scutellaria baicalensis and the lotus seed are mixed with the gelatin, the tablet is convenient for a patient to take the tablet through the herbal medicines for calming the heart and soothing the nerves, the rest quality of the patient is improved, the feeling of vomiting and nausea are relieved, and the side effect of the medicine is relieved.)

1. A furotriptan tablet, characterized in that: the used main materials comprise the following raw materials in parts by weight: 150-250 parts of furotriptan succinate, 50-80 parts of propranolol, 50-80 parts of amitriptyline, 2000 parts of hydroxypropyl methylcellulose, 1200 parts of pregelatinized starch, 100-150 parts of a wetting agent, 40-70 parts of wild chrysanthemum flower, 40-70 parts of tuber fleeceflower stem, 40-70 parts of scutellaria baicalensis, 40-70 parts of lotus seed and 800 parts of edible gelatin.

2. A furotriptan tablet according to claim 1, wherein: the wetting agent is selected to be a 95% ethanol solution.

3. A furotriptan tablet according to claim 1, wherein: the wild chrysanthemum flower, the tuber fleeceflower stem, the baical skullcap root and the lotus seed are ground into powder.

4. A furotriptan tablet according to claim 1, wherein: the used main materials comprise the following raw materials in parts by weight: 150 parts of furotriptan succinate, 50 parts of propranolol, 50 parts of amitriptyline, 1000 parts of hydroxypropyl methylcellulose, 800 parts of pregelatinized starch, 100 parts of wetting agent, 40 parts of wild chrysanthemum flower, 40 parts of tuber fleeceflower stem, 40 parts of scutellaria baicalensis, 40 parts of lotus seed and 500 parts of edible gelatin.

5. A furotriptan tablet according to claim 1, wherein: the used main materials comprise the following raw materials in parts by weight: 200 parts of furotriptan succinate, 65 parts of propranolol, 65 parts of amitriptyline, 1500 parts of hydroxypropyl methylcellulose, 1000 parts of pregelatinized starch, 125 parts of wetting agent, 55 parts of wild chrysanthemum flower, 55 parts of tuber fleeceflower stem, 55 parts of scutellaria baicalensis, 55 parts of lotus seed and 650 parts of edible gelatin.

6. A furotriptan tablet according to claim 1, wherein: the used main materials comprise the following raw materials in parts by weight: 250 parts of furotriptan succinate, 80 parts of propranolol, 80 parts of amitriptyline, 2000 parts of hydroxypropyl methylcellulose, 1200 parts of pregelatinized starch, 150 parts of wetting agent, 70 parts of wild chrysanthemum flower, 70 parts of tuber fleeceflower stem, 70 parts of scutellaria baicalensis, 70 parts of lotus seed and 800 parts of edible gelatin.

7. A furotriptan tablet according to claims 1-6, further comprising a furotriptan tablet preparation method, wherein:

the method comprises the following steps: according to the corresponding parts of the prescription, taking furotriptan succinate, propranolol, amitriptyline, hydroxypropyl methylcellulose and pregelatinized starch, screening, uniformly mixing, subsequently adding a wetting agent, uniformly stirring, and preparing soft medicine paste;

step two: granulating the soft medicinal mud prepared by stirring in the step one by using a granulator, subsequently drying the granules, screening and finishing to prepare tablet cores for later use;

step three: taking wild chrysanthemum flower, tuber fleeceflower stem, scutellaria baicalensis and lotus seed according to the corresponding parts of the prescription, grinding the wild chrysanthemum flower, tuber fleeceflower stem, scutellaria baicalensis and lotus seed into 1200-1500-mesh powder by using grinding equipment, firstly drying and screening the powder, and then uniformly mixing the powder to prepare mixed powder;

step four: selecting edible gelatin in corresponding parts, adding appropriate amount of distilled water, heating until the edible gelatin is completely melted, maintaining the temperature at 40-50 deg.C, subsequently adding the mixed medicinal powder prepared in step three, and stirring for 1-2 hr to obtain mixed colloid;

step five: and (4) taking the tablet core prepared in the step two and the mixed colloid prepared in the step four, wrapping the tablet core by the mixed colloid, putting the tablet core into a tablet machine for tabletting, and solidifying to obtain a finished product of the furotriptan tablet.

8. A method of preparing furotriptan tablets according to claim 7, wherein: and (4) the humidity of the tablet cores prepared in the second step is 8-12%, and the tablet cores are stored in a cool place for later use.

9. A method of preparing furotriptan tablets according to claim 7, wherein: in the fifth step, a tablet core is correspondingly pressed into a number of furotriptan tablets, and the mixed colloid completely covers the tablet core.

Technical Field

The embodiment of the invention relates to the technical field of frovatriptan medicaments, and particularly relates to a frovatriptan tablet and a preparation method thereof.

Background

Migraine is the most common clinical primary headache type, and the clinical symptoms are paroxysmal moderate and severe and pulsatile headache, most of the headache is deviated, generally lasts for 4-72 hours, can be accompanied by nausea and vomiting, and can be aggravated by light and sound stimulation or daily activities, and the headache can be relieved by resting in a quiet environment. Migraine is a common chronic neurovascular disease, which is mostly suffered from children and adolescence, the middle and young age reaches the peak of the disease, women are common, the proportion of male and female patients is about 1: 2-3, the morbidity of the crowd is 5% -10%, the genetic background is common, migraine can be orally taken by analgesic drugs to quickly relieve pain, ibuprofen sustained-release capsules can be orally taken when the migraine can attack, the analgesic drugs can relieve pain, the pain can be relieved by the analgesic drugs, because the migraine does not form a great threat to the health of the human body and can not have a great influence on the disease, the migraine can be treated firstly, whether the migraine is not migraine or not is determined, the typical symptom of the migraine attack is that eyes can see the east and west before each attack, some aura symptoms are unclear, for example, the eyes see things fuzzy, see the shape change of things, see things with water flow, and after the aura appears, the symptoms of headache on one side or two sides do not appear for a long time, some symptoms are accompanied by symptoms of nausea and vomiting, the headache can be completely recovered after the attack is relieved, the symptoms can be repeated, if the diagnosis is that the migraine is confirmed, pain can be relieved by taking an analgesic orally, the pain can be relieved quickly, people do not need to stay up all the night and do not need to be tired at ordinary times, the migraine attack can be induced by staying up all the night, in addition, some foods can induce the migraine, for example, the pickled salted pickles, the pickled foods, cheese products and red wine can induce the migraine, and the use is avoided as much as possible at ordinary times.

Frovatriptan, also known as frovatriptan, is a chemical. The chemical name is (+/-) -6-carbamoyl-3-methylamino-1, 2,3, 4-tetrahydrocarbazole, the molecular formula is C14H17N3O, and the molecular weight is 243.30400. Frovatriptan is an antimigraine drug and is mainly clinically used for treating acute attacks of migraine with or without aura in adults.

Disclosure of Invention

The invention provides furotriptan tablets and a preparation method thereof, and propranolol and amitriptyline with a migraine preventing effect are added, so that migraine treatment is carried out while the tablets are taken, and recurrence of migraine is prevented, and a good treatment effect is provided.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions: the furotriptan tablet comprises the following main materials in parts by weight: 150-250 parts of furotriptan succinate, 50-80 parts of propranolol, 50-80 parts of amitriptyline, 2000 parts of hydroxypropyl methylcellulose, 1200 parts of pregelatinized starch, 100-150 parts of a wetting agent, 40-70 parts of wild chrysanthemum flower, 40-70 parts of tuber fleeceflower stem, 40-70 parts of scutellaria baicalensis, 40-70 parts of lotus seed and 800 parts of edible gelatin.

Further, the wetting agent is selected to be a 95% ethanol solution.

Furthermore, the wild chrysanthemum flower, the tuber fleeceflower stem, the baical skullcap root and the lotus seed are ground into powder.

Further, the used main materials comprise the following raw materials in parts by weight: 150 parts of furotriptan succinate, 50 parts of propranolol, 50 parts of amitriptyline, 1000 parts of hydroxypropyl methylcellulose, 800 parts of pregelatinized starch, 100 parts of wetting agent, 40 parts of wild chrysanthemum flower, 40 parts of tuber fleeceflower stem, 40 parts of scutellaria baicalensis, 40 parts of lotus seed and 500 parts of edible gelatin.

Further, the used main materials comprise the following raw materials in parts by weight: 200 parts of furotriptan succinate, 65 parts of propranolol, 65 parts of amitriptyline, 1500 parts of hydroxypropyl methylcellulose, 1000 parts of pregelatinized starch, 125 parts of wetting agent, 55 parts of wild chrysanthemum flower, 55 parts of tuber fleeceflower stem, 55 parts of scutellaria baicalensis, 55 parts of lotus seed and 650 parts of edible gelatin.

Further, the used main materials comprise the following raw materials in parts by weight: 250 parts of furotriptan succinate, 80 parts of propranolol, 80 parts of amitriptyline, 2000 parts of hydroxypropyl methylcellulose, 1200 parts of pregelatinized starch, 150 parts of wetting agent, 70 parts of wild chrysanthemum flower, 70 parts of tuber fleeceflower stem, 70 parts of scutellaria baicalensis, 70 parts of lotus seed and 800 parts of edible gelatin.

A furotriptan tablet further comprises a preparation method of the furotriptan tablet, which comprises the following steps:

the method comprises the following steps: according to the corresponding parts of the prescription, taking furotriptan succinate, propranolol, amitriptyline, hydroxypropyl methylcellulose and pregelatinized starch, screening, uniformly mixing, subsequently adding a wetting agent, uniformly stirring, and preparing soft medicine paste;

step two: granulating the soft medicinal mud prepared by stirring in the step one by using a granulator, subsequently drying the granules, screening and finishing to prepare tablet cores for later use;

step three: taking wild chrysanthemum flower, tuber fleeceflower stem, scutellaria baicalensis and lotus seed according to the corresponding parts of the prescription, grinding the wild chrysanthemum flower, tuber fleeceflower stem, scutellaria baicalensis and lotus seed into 1200-1500-mesh powder by using grinding equipment, firstly drying and screening the powder, and then uniformly mixing the powder to prepare mixed powder;

step four: selecting edible gelatin in corresponding parts, adding appropriate amount of distilled water, heating until the edible gelatin is completely melted, maintaining the temperature at 40-50 deg.C, subsequently adding the mixed medicinal powder prepared in step three, and stirring for 1-2 hr to obtain mixed colloid;

step five: taking the tablet core prepared in the step two and the mixed colloid prepared in the step four, wrapping the tablet core with the mixed colloid, putting the tablet core into a tablet machine for tabletting, and solidifying to obtain a finished product of furotriptan tablets

Further, the humidity of the tablet cores prepared in the second step is 8-12%, and the tablet cores are stored in a cool place for later use.

Furthermore, in the fifth step, a tablet core is correspondingly pressed to form a quantity of furotriptan tablets, and the mixed colloid completely covers the tablet core.

The embodiment of the invention has the following advantages:

1. the tablet core is wrapped by the gelatin, so that the irritation of the medicine to the oral cavity is relieved when the tablet is taken, the wild chrysanthemum flower, the tuber fleeceflower stem, the scutellaria baicalensis and the lotus seed are mixed with the gelatin, the medicine tablet is convenient for a patient to take the tablet, the rest quality of the patient is improved, the feeling of vomiting and nausea are relieved, and the side effect of the medicine is relieved.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.