阅读说明：本技术 具有抗微生物功能的单体组合物 (Monomer composition having antimicrobial function ) 是由 J·赫德里克 M·费夫尔 V·皮乌诺娃 N·帕克 M·S·张 陈邦钧 杨义燕 于 2018-12-04 设计创作，主要内容包括：本发明提供了关于具有抗微生物功能的阳离子聚合体组合物的技术。例如,一个或多个实施方案可包含单体,其可包含单一阳离子聚合体单元。该单一阳离子聚合体单元可以包含沿分子主链分布的阳离子。而且,疏水官能团可以共价键合到分子主链上,并且单一阳离子聚合体单元可以具有抗微生物功能。(The present invention provides a technology for a cationic polymer composition having an antimicrobial function. For example, one or more embodiments may comprise a monomer, which may comprise a single cationic polymeric unit. The single cationic polymeric unit may comprise cations distributed along the molecular backbone. Furthermore, hydrophobic functional groups may be covalently bonded to the molecular backbone, and a single cationic polymer unit may have antimicrobial functions.)

1. A monomer, comprising:

a single cationic polymer unit comprising a cation distributed along a molecular backbone and a hydrophobic functional group covalently bonded to the molecular backbone, wherein the single cationic polymer unit has an antibacterial function.

2. The monomer of claim 1, wherein the cation is selected from the group consisting of nitrogen cations and phosphorus cations.

3. The monomer of claim 2, wherein the cation is a nitrogen cation selected from the group consisting of protonated secondary amine cations, protonated tertiary amine cations, quaternary ammonium cations, and imidazolium cations.

4. The monomer of claim 3, wherein the hydrophobic functional group is derived from an alkyl halide.

5. The monomer of claim 4, wherein the hydrophobic functional group is covalently bonded to the cation.

6. A monomer, comprising:

a single cationic polymer unit comprising cations distributed along a degradable molecular backbone comprising a terephthalamide structure, wherein the single cationic polymer unit has an antibacterial function.

7. The monomer of claim 6, wherein the cation is selected from the group consisting of nitrogen cations and phosphorus cations.

8. The monomer of claim 7, wherein the cation is a nitrogen cation selected from the group consisting of protonated secondary amine cations, protonated tertiary amine cations, quaternary ammonium cations, and imidazolium cations.

9. The monomer according to claim 8, wherein the single cationic polymeric unit further comprises a hydrophobic functional group covalently bonded to the degradable molecular backbone.

10. The monomer of claim 9, wherein the single cationic polymeric unit has the structure of formula:

wherein R represents a hydrophobic functional group, wherein X represents a cation, and wherein Y represents a linking group selected from the group consisting of alkyl and aryl.

11. A method, comprising:

dissolving an amine monomer and an electrophilic reagent in a solvent, wherein the electrophilic reagent is alkyl halide; and

forming monomers from the amine monomer and the electrophile, the monomers comprising a single cationic polymer unit, and the single cationic polymer unit comprising a cation distributed along the molecular backbone, wherein the single cationic polymer unit has an antimicrobial function.

12. The method of claim 11, wherein said forming comprises a cation-forming process, and wherein said process is selected from the group consisting of alkylation and quaternization.

13. The method of claim 12, wherein the method further comprises:

the amine monomer, electrophile, and solvent are stirred at a temperature greater than or equal to 15 degrees celsius (° c) and less than or equal to 150 ℃ for a defined period of time greater than or equal to 12 hours and less than or equal to 24 hours.

14. The method of claim 13 wherein the single cationic polymeric unit further comprises a hydrophobic functional group covalently bonded to the molecular backbone.

15. The method of claim 14, wherein the cation is selected from the group consisting of protonated secondary amine cations, protonated tertiary amine cations, quaternary ammonium cations, and imidazolium cations.

16. A method, comprising:

dissolving an amine monomer and an electrophilic agent in a solvent, the amine monomer comprising a degradable molecular backbone comprising a terephthalamide structure; and

forming monomers from an amine monomer and an electrophilic reagent, the monomers comprising a single cationic polymer unit, and the single cationic polymer unit comprising cations distributed along the backbone of the degradable molecule, wherein the single cationic polymer unit has an antimicrobial function.

17. The method of claim 16, wherein said forming comprises a cation-forming process, and wherein said process is selected from the group consisting of alkylation and quaternization.

18. The method of claim 17, wherein the method further comprises:

the amine monomer, electrophile, and solvent are stirred at a temperature greater than or equal to 15 degrees celsius (° c) and less than or equal to 150 ℃ for a defined period of time greater than or equal to 12 hours and less than or equal to 24 hours.

19. The method of claim 18, wherein the single cationic polymer unit further comprises a hydrophobic functional group covalently bonded to the degradable molecular backbone, and wherein the electrophile is an alkyl halide.

20. The method of claim 19, wherein the cation is selected from the group consisting of protonated secondary amine cations, protonated tertiary amine cations, quaternary ammonium cations, and imidazolium cations.

21. A method of killing a pathogen, comprising:

contacting a pathogen with a monomer comprising a single cationic polymer unit comprising cations distributed along a molecular backbone and hydrophobic functional groups covalently bonded to the molecular backbone, wherein the single cationic polymer unit has antimicrobial functionality, and wherein said contacting electrostatically disrupts a membrane of the pathogen.

22. The method according to claim 21, wherein said pathogen is selected from the group consisting of gram-negative microorganisms, gram-positive microorganisms, fungi, and yeasts.

23. The method of claim 22, wherein the cation is selected from the group consisting of protonated secondary amine cations, protonated tertiary amine cations, quaternary ammonium cations, and imidazolium cations.

24. The method of claim 23, wherein the hydrophobic functional group is covalently bonded to the cation.

25. The method of claim 24, wherein the molecular backbone comprises a terephthalamide structure.

Background

The present disclosure relates to one or more monomers having antimicrobial functionality, and more particularly, to one or more monomers comprising one or more cationic and/or hydrophobic functional groups.

Summary of The Invention

The following presents a simplified summary in order to provide a basic understanding of one or more embodiments of the invention. This summary is not intended to identify key or critical elements or to delineate any scope of the particular embodiments or any scope of the claims. Its sole purpose is to present concepts in a simplified form as a prelude to the more detailed description that is presented later. In one or more embodiments described herein, methods and/or compositions are described with respect to cationic polymers (ionene) having antimicrobial functionality.

According to one embodiment, a monomer is provided. The monomer may comprise a single cationic polymer unit. The single cationic polymeric unit may comprise cations distributed along the molecular backbone. Furthermore, hydrophobic functional groups may be covalently bonded to the molecular backbone, and a single cationic polymer unit may have antimicrobial functions.

According to another embodiment, a monomer is provided. The monomer may comprise a single cationic polymer unit. The single cationic polymer unit may comprise cations distributed along the degradable molecular backbone, which may comprise a terephthalamide structure. In addition, a single cationic polymer unit may have an antimicrobial function.

According to another embodiment, a method is provided. The method may include dissolving an amine monomer and an electrophilic reagent in a solvent. The electrophile may be an alkyl halide. The method may further include forming monomers from the amine monomer and the electrophilic reagent. The monomer may comprise a single cationic polymer unit. The single cationic polymer unit may comprise cations distributed along the molecular backbone, and the single cationic polymer unit may have an antimicrobial function.

According to another embodiment, a method is provided. The method may include dissolving an amine monomer and an electrophilic reagent in a solvent. The amine monomer may comprise a degradable molecular backbone, which may comprise a terephthalamide structure. The method may further include forming monomers from the amine monomer and the electrophilic reagent. The monomer may comprise a single cationic polymer unit. The single cationic polymer unit may comprise cations distributed along the degradable molecular backbone and may have an antimicrobial function.

According to another embodiment, a method is provided. The method may include contacting the pathogen with the monomer. The monomer may comprise a single cationic polymeric unit, which may comprise cations distributed along the molecular backbone. In addition, hydrophobic functional groups may be covalently bonded to the molecular backbone. In addition, the single cationic polymer unit may have an antibacterial function. In addition, contact can electrostatically disrupt the membranes of pathogens.