阅读说明：本技术 一种化合物及其合成方法和驱蚊喷雾 (Compound, synthesis method thereof and mosquito-repellent spray ) 是由 杨春林 魏斌 于 2020-05-22 设计创作，主要内容包括：本发明公开了一种化合物,所述化合物为6-溴代-3,7-二甲基辛醇。其属于化学领域,该化合物采用香茅醛为原料,经过溴化后,由于其沸点提高15℃左右,其气味相对较小,且溴化后其气味更为醇厚,在抛射剂存在的条件下不会产生另人体不舒服的感觉,其停留皮肤后容易洗脱,在洗脱前其存留时间较长,本发明还提供了该化合物的制备方法和一种驱蚊喷雾。(The invention discloses a compound, which is 6-bromo-3, 7-dimethyl octanol. The compound is prepared by adopting citronellal as a raw material, and after bromination, the smell is relatively small because the boiling point of citronellal is increased by about 15 ℃, and the smell is more mellow after bromination, so that the citronellal does not generate uncomfortable feeling to a human body under the condition of the existence of a propellant, is easy to elute after staying on the skin, and has long retention time before eluting.)

1. A compound characterized in that said compound is 6-bromo-3, 7-dimethyloctanol.

2. A method of synthesizing the compound of claim 1, comprising the steps of:

step 1: under the protection of inert gas, mixing citronellol, solvent benzene and azo initiator and heating to 75-80 ℃;

step 2: slowly introducing HBr gas into the system in the step 1, and reacting for 1-2 h;

and step 3: the distillation residue obtained by reduced pressure distillation is 6-bromo-3, 7-dimethyl octanol;

the molar ratio of HBr to citronellol is 1.3-1.4: 1.

3. The method for synthesizing a compound according to claim 2, wherein the azo initiator is azobisisobutyronitrile; the dosage of the azo initiator is 0.5 to 1 percent of the weight of the citronellol.

4. The method for synthesizing the compound according to claim 2, wherein the weight of the solvent benzene is 6 to 10 times of the weight of the citronellol.

5. The method for synthesizing the compound according to claim 2, wherein the HBr gas is introduced for 0.5 to 1 hour.

6. The method for synthesizing the compound according to claim 2, wherein the reduced pressure distillation temperature in the step 3 is 40 to 50 ℃, and the reduced pressure distillation equipment is used for operation.

7. A mosquito repellent spray comprising the compound of claim 1.

8. The mosquito repellent spray according to claim 7, which comprises a propellant and an alcohol solution, wherein the ratio of the alcohol solution to the propellant is 6-7: 3-4; the content of 6-bromo-3, 7-dimethyl octanol in the alcohol solution is not less than 4 wt%.

9. The mosquito repellent spray of claim 8, wherein the alcoholic solution comprises the following components:

4-10 wt% of 6-bromo-3, 7-dimethyl octanol;

2-3 wt% of wormwood extract;

the balance of ethanol.

10. A mosquito repellent spray according to claim 7 wherein the propellant is propane butane.

Technical Field

The invention relates to the field of chemistry, and particularly relates to a compound, a synthesis method thereof and mosquito-repellent spray.

Background

In the field of mosquito repelling, the lemongrass extract and wormwood extract are very common extracts, and the following can be seen:

CN109125200A discloses a mosquito repellent liquid, which comprises the following raw material components in parts by weight: 2-5 parts of citronellal plant extract, 1-3 parts of geranium plant extract, 0.5-2 parts of peppermint oil, 0.3-0.8 part of wormwood extract, 1-2 parts of glabrous greenbrier rhizome, 1-3 parts of perilla leaf extract, 3-7 parts of deionized water and 0.1-0.4 part of borneol.

CN106719932A discloses a preparation method of a mosquito repellent liquid based on lemongrass, which comprises the following steps: (1) drying the lemongrass, cutting the roots and stems into 1cm, uniformly mixing the roots, stems and leaves, adding the mixture into an earthen pot, and adding 1: 20, decocting the mixture with purified water, concentrating the decoction to 1/20, and filtering the decoction to obtain filtrate for later use; (2) drying pyrethrum white flowers in the sun, grinding into powder, adding 1: 20, stirring uniformly, adding into a marmite, decocting, concentrating to 1/20, and filtering to obtain filtrate for later use; (3) concentrating the lemongrass and pyrethrum concentrated filtrate according to the proportion of 4:1, mixing the materials in a ratio, transferring the mixture into a sterilization room, and sterilizing the mixture; (4) after the inspection is qualified, the filtrate is bottled, and each bottle is 20 g.

The mosquito repellent liquid adopted in the method is sold as a product, and the smell is relatively strong after the mosquito repellent liquid is sprayed out, but the mosquito repellent effect is still good.

The company, after testing the above-mentioned extract, has found that the following problems occur when it is sprayed with a propane-butane propellant:

at higher concentrations, the odor of the essential oil in the spray is particularly great, to an unacceptable extent, in the presence of the volatile propellant.

If the concentration is small, although the smell is controlled, the mosquito repelling effect and the duration cannot be guaranteed.

Therefore, the scheme solves the problems that: how to balance the mosquito repelling time, the mosquito repelling effect and the smell in the aerosol type product.

Disclosure of Invention

The invention aims to provide a compound, which adopts citronellal as a raw material, has relatively small smell because the boiling point of the citronellal is increased by about 15 ℃ after bromination, has more mellow smell after bromination, does not generate uncomfortable feeling for a human body under the condition of the existence of a propellant, is easy to elute after staying on the skin, and has longer retention time before eluting.

Meanwhile, the invention also provides a preparation method of the compound and mosquito-repellent spray.

In order to achieve the purpose, the invention provides the technical scheme that: a compound which is 6-bromo-3, 7-dimethyloctanol.

The structure is as follows:

meanwhile, the invention also discloses a synthetic method of the compound, which is characterized by comprising the following steps:

step 1: under the protection of inert gas, mixing citronellol, solvent benzene and azo initiator and heating to 75-80 ℃;

step 2: slowly introducing HBr gas into the system in the step 1, and reacting for 1-2 h;

and step 3: the distillation residue obtained by reduced pressure distillation is 6-bromo-3, 7-dimethyl octanol;

the molar ratio of HBr to citronellol is 1.3-1.4: 1.

The compound is prepared based on a Ma's addition method, and the preparation process is simple and the reaction time is short.

In the synthesis method of the compound, the azo initiator is azobisisobutyronitrile; the dosage of the azo initiator is 0.5 to 1 percent of the weight of the citronellol.

In the synthesis method of the compound, the weight of the solvent benzene is 6-10 times of the weight of the citronellol.

In the synthesis method of the compound, the HBr gas is introduced for 0.5-1 h.

In the synthesis method of the compound, the reduced pressure distillation temperature in the step 3 is 40-50 ℃, and the reduced pressure distillation equipment is adopted for operation.

Meanwhile, the invention also discloses a mosquito-repellent spray which comprises the compound.

In the mosquito repellent spray, a propellant and an alcohol solution are included, and the proportion of the alcohol solution to the propellant is 6-7: 3-4; the content of 6-bromo-3, 7-dimethyl octanol in the alcohol solution is not less than 4 wt%.

In the mosquito-repellent spray, the alcohol solution contains the following components:

4-10 wt% of 6-bromo-3, 7-dimethyl octanol;

2-3 wt% of wormwood extract;

the balance of ethanol.

In the mosquito-repellent spray, the propellant is propane and butane.

The invention has the beneficial effects that:

the compound of the invention adopts citronellal as a raw material, after bromination, the smell is relatively small because the boiling point is increased by about 23 ℃, and the smell is more mellow after bromination, so that the compound does not generate uncomfortable feeling to human bodies under the condition of the existence of a propellant, is easy to elute after staying on the skin, and has long retention time before eluting.

The compound is prepared by adopting a Ma's addition method, and has the advantages of simple preparation process, proper reaction conditions and short reaction time.

The mosquito-repellent spray disclosed by the invention is low in effective component consumption, long in mosquito-repellent effect and low in odor.

Detailed Description

The invention will be described with reference to specific embodiments: it is to be understood that these specific embodiments are merely illustrative of the invention and are not to be construed as limiting the invention. While those skilled in the art can fully appreciate the improvements to the embodiments and features of the present invention that can be made without departing from the scope of the present invention, such improvements and modifications are intended to be included within the scope of the present invention.