Y肽在制备降血压药物或保健品中的应用

文档序号:1408822 发布日期:2020-03-06 浏览:28次 >En<

阅读说明:本技术 Y肽在制备降血压药物或保健品中的应用 (Application of Y peptide in preparation of antihypertensive drug or health-care product ) 是由 潘武广 朱威 于 2018-02-11 设计创作,主要内容包括:本发明公开了二肽YY在制备降血压药物或保健品中的应用。本发明根据已经确定的ACE酶晶体结构,采用分子对接法,利用自研软件对二肽的ACE抑制作用进行虚拟筛选,并对虚拟筛选得到的二肽的ACE抑制活性进行实验验证,发现二肽YY具有较好的ACE抑制活性。多个Y组成的肽或蛋白质,在体内可以水解成活性YY肽,从而发挥相同或类似的效果。(The invention discloses an application of dipeptide YY in preparing a blood pressure lowering medicine or a health care product. The invention adopts a molecular docking method according to the determined ACE enzyme crystal structure, utilizes self-research software to virtually screen the ACE inhibitory effect of the dipeptide, and carries out experimental verification on the ACE inhibitory activity of the dipeptide obtained by virtual screening, and finds that the dipeptide YY has better ACE inhibitory activity. Peptides or proteins composed of a plurality of Y can be hydrolyzed in vivo into active YY peptides, thereby exerting the same or similar effects.)

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