阅读说明：本技术 一种苹果酸盐及其晶型 (Malate and crystal form thereof ) 是由 A·St·C·布朗 P·兰布 W·P·加拉赫尔 于 2010-01-15 设计创作，主要内容包括：本发明公开N-(4-{[6,7-双(甲基氧基)喹啉-4-基]氧基}苯基)-N’-(4-氟苯基)环丙烷-1,1-二甲酰胺的苹果酸盐,包括(L)-苹果酸盐、(D)-苹果酸盐、(DL)苹果酸盐和它们的混合物；以及这些苹果酸盐的结晶型和非晶型。本发明还公开含有N-(4-{[6,7-双(甲基氧基)喹啉-4-基]氧基}苯基)-N’-(4-氟苯基)环丙烷-1,1-二甲酰胺的至少一种苹果酸盐的药物组合物；和治疗癌症的方法,所述方法包括给予N-(4-{[6,7-双(甲基氧基)喹啉-4-基]氧基}苯基)-N’-(4-氟苯基)环丙烷-1,1-二甲酰胺的至少一种苹果酸盐。(The present invention discloses malic acid salts of N- (4- { [6, 7-bis (methyloxy) quinolin-4-yl ] oxy } phenyl) -N' - (4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, including (L) -malic acid salts, (D) -malic acid salts, (DL) malic acid salts, and mixtures thereof; and crystalline and amorphous forms of these malate salts. The invention also discloses pharmaceutical compositions containing at least one malate salt of N- (4- { [6, 7-bis (methyloxy) quinolin-4-yl ] oxy } phenyl) -N' - (4-fluorophenyl) cyclopropane-1, 1-dicarboxamide; and a method of treating cancer comprising administering at least one malate salt of N- (4- { [6, 7-bis (methyloxy) quinolin-4-yl ] oxy } phenyl) -N' - (4-fluorophenyl) cyclopropane-1, 1-dicarboxamide.)