阅读说明：本技术 一种结晶甘露醇干法造粒装置及工艺 (Dry granulation device and process for crystallized mannitol ) 是由 陈德水 罗家星 汪秀秀 毛宝兴 陈倩 毛晨建 于 2019-12-01 设计创作，主要内容包括：本发明涉及一种结晶甘露醇干法造粒装置,包括料仓、压片机、粉碎机、第一分离器、筛分机和成品仓,料仓与压片机之间设置有具有连续送料能力的输送器,料仓内的待造粒的结晶甘露醇物料经压片机压片后进入粉碎机粉碎,粉碎后的甘露醇晶体碎料经第一分离器分离后进入筛分机筛分后进入成品仓暂存。本发明还公开一种使用该装置进行结晶甘露醇干法造粒的工艺。本发明通过对待造粒的结晶甘露醇物料进行压片、粉碎、筛分制成甘露醇晶体颗粒成品,提高了生产效率,具有能耗低的优点。(The invention relates to a crystallized mannitol dry granulation device which comprises a storage bin, a tablet press, a crusher, a first separator, a screening machine and a finished product bin, wherein a conveyor with continuous feeding capacity is arranged between the storage bin and the tablet press, a crystallized mannitol material to be granulated in the storage bin is subjected to tabletting through the tablet press and then enters the crusher for crushing, and crushed mannitol crystal crushed materials are separated by the first separator, then enter the screening machine for screening and then enter the finished product bin for temporary storage. The invention also discloses a process for carrying out the dry granulation of the crystallized mannitol by using the device. The invention prepares the finished mannitol crystal particles by tabletting, crushing and screening the crystallized mannitol material to be granulated, improves the production efficiency and has the advantage of low energy consumption.)

1. The utility model provides a continuous prilling granulator of crystalline mannitol dry process, its characterized in that, including feed bin (1), tablet press (2), rubbing crusher (3), first separator (4), screening machine (5) and finished product storehouse, be provided with conveyer (6) that have continuous feeding ability between feed bin (1) and tablet press (2), treat the crystalline mannitol material of granulation and store in feed bin (1), tablet press (2) are treated the crystalline mannitol material of granulation and are carried out the preforming, obtain slice crystalline mannitol, rubbing crusher (3) are smashed slice crystalline mannitol, obtain mannitol crystal crushed aggregates, screening machine (5) are sieved mannitol crystal crushed aggregates after first separator (4) separation, the mannitol crystal granule that obtains after screening machine (5) sieves gets into the finished product storehouse and keeps in temporarily.

2. The dry continuous granulator according to claim 1, characterized in that the silo (1) is further provided with a second separator (9) and a first rotary valve (10), respectively, and the crystallized mannitol material to be granulated is conveyed to the second separator (9) after passing through the first rotary valve (10), and is separated by the second separator (9) and then enters the silo (1).

3. The dry continuous crystallized mannitol granulation apparatus according to claim 2, wherein the sieving machine (5) is provided with a single-layer sieve, the undersize material enters the first finished product bin (7) for temporary storage, the oversize material is conveyed back to the pulverizer (3) for pulverization and reuse, and the mannitol crystal particles temporarily stored in the first finished product bin (7) enter the next process after passing through the second rotary valve (11) arranged at the bottom of the first finished product bin (7).

4. The dry continuous crystallized mannitol granulation device according to claim 2, wherein the sieving machine (5) is provided with double-layer sieves, the oversize product of the large granules on the upper layer of the sieve is conveyed back to the crushing machine (3) to be crushed again for use, the undersize product on the lower layer of the sieve is temporarily stored in the first finished product bin (7), and the oversize product is temporarily stored in the second finished product bin (8); mannitol crystal particles temporarily stored in the first finished product bin (7) enter the next working procedure through a second rotary valve (11) arranged at the bottom of the first finished product bin (7), and mannitol crystal particles temporarily stored in the second finished product bin (8) enter the next working procedure through a third rotary valve (12) arranged at the bottom of the second finished product bin (8).

5. The dry continuous granulator according to claim 3 or 4, wherein a return line (13) is further provided beside the second rotary valve (11), and mannitol crystal particles temporarily stored in the first product bin (7) are transferred to the second separator (9) through the return line (13) for further treatment.

6. The dry continuous granulator of crystallized mannitol according to claim 3 or 4, wherein the screen mesh number of the screening machine (5) is 20-60 mesh.

7. A dry continuous granulation process of crystallized mannitol, which is characterized in that the dry continuous granulation process of crystallized mannitol is carried out by using the dry continuous granulation device of crystallized mannitol as claimed in any one of claims 1 to 5, and comprises the following steps: conveying the crystalline mannitol material to be granulated in the bin (1) to a tablet press (2) through a conveyor (6) for tabletting, then feeding the crystalline mannitol material into a crusher (3) for crushing, separating the crushed mannitol crystal material crushed by the crusher (3) through a first separator (4), then feeding the separated mannitol crystal material into a sieving machine (5) for sieving, and feeding the mannitol crystal particles obtained after sieving by the sieving machine (5) into a finished product bin for temporary storage.

8. The dry continuous granulation process of crystallized mannitol according to claim 7, wherein the feeding amount of the tablet press (2) is 0.5T/h to 1.5T/h, the pressure of the compression roller is controlled to be 2MPa to 6MPa, and the thickness of the discharged tablet of the tablet press is 1.5mm to 3.5 mm.

Technical Field

The invention belongs to the technical field of crystal granulation, and particularly relates to a crystallized mannitol dry granulation device and a process.

Background

Mannitol (D-mannitol) is colorless acicular or rhombic column crystals or white crystalline powder, has high solubility and melting point, has the sweetness of 50 percent of that of cane sugar, does not absorb moisture, has good thermal stability, is stable to dilute acid and dilute alkali, and has the chemical characteristics of polyhydric alcohol. The traditional industrial production method mainly comprises a kelp extraction and sucrose hydrolysis catalysis method, and mannitol particles obtained after refining and crystallization are fine, crisp and poor in fluidity, so that the further popularization and application of the mannitol particles in the industries of medicine, food, chemical industry and the like are limited.

At present, the method for improving the fluidity of the crystallized mannitol mainly adopts granulation, and a U.S. patent with publication number of US5160680A discloses a melt extrusion granulation method, wherein a 166 ℃ mannitol non-full molten liquid is extruded into a rod shape, and then is crushed and sieved, and the method needs to consume more heat for heating, and has high equipment requirement and high energy consumption. In addition, there are methods such as boiling granulation, mixing granulation, and spray granulation, in which mannitol or steam with a certain concentration is used as a binder, which results in high heat energy consumption, and if other substances are used as a binder, the mannitol purity is affected, and the material needs to be further dried after granulation, and if the temperature drops suddenly after granulation, the obtained powder product may be in a vitreous form and unstable in properties. The granulation method is a method commonly used in the food industry, and granulation is carried out by using a dry method in other industries. For example, chinese patent application publication No. CN103754872A discloses a dry granulation process for calcium carbide powder, which collects dust generated during the pulverization of calcium carbide, and performs extrusion, rolling, and granulation to obtain a granular material, and the method has the following disadvantages: (1) the materials are compressed in a ballast way, so that the pressure resistance requirement of the equipment is high; (2) the continuous property is influenced by normal pressure conveying and pressurization compression.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a device and a process for granulating crystallized mannitol by a dry method, wherein the crystallized mannitol is directly subjected to tabletting, crushing and screening to obtain granular mannitol, the whole process is continuous, efficient and low in energy consumption, melting or secondary drying is not required, and the granular mannitol with good fluidity and low friability is prepared.

The invention is realized in such a way, and provides a dry granulating device for crystallized mannitol, which comprises a storage bin, a tablet press, a crusher, a first separator, a sieving machine and a finished product bin, wherein a conveyor with continuous feeding capacity is arranged between the storage bin and the tablet press, the crystallized mannitol material to be granulated is stored in the storage bin, the tablet press is used for tabletting the crystallized mannitol material to be granulated to obtain flaky crystallized mannitol, the crusher is used for crushing the flaky crystallized mannitol to obtain crushed mannitol crystal material, the sieving machine is used for sieving the mannitol crushed crystal material separated by the first separator, and the mannitol crystal particles obtained after sieving by the sieving machine enter the finished product bin for temporary storage.

In this scheme, the crystallized mannitol material of treating the granulation in the feed bin enters rubbing crusher and smashes after the tablet press preforming, the mannitol crystal crushed aggregates after the rubbing crusher crushing gets into the screening machine screening after first separator separation, wherein, the mannitol crystal granule after the screening machine screening gets into the finished product storehouse, be provided with the conveyer that has continuous feeding ability between feed bin and tablet press, the conveyer carries the crystallized mannitol material of treating the granulation in the feed bin to the tablet press. Compared with the prior art, the scheme has the advantages that the mannitol crystal particles are prepared by tabletting, crushing and screening the crystallized mannitol material to be granulated, and the crystallized mannitol does not need to be melted or dried for the second time in the whole manufacturing process, so that the manufacturing efficiency of the mannitol crystal particles is improved, and the mannitol crystal particles have the advantage of low energy consumption. In addition, this scheme adopts the conveyer that has continuous feeding ability to carry the material in the feed bin to the tablet press, has the advantage that the continuity is good among the granulation process.

Further, still set up second separator and first rotary valve on the feed bin respectively, the crystallization mannitol material of treating the granulation is carried behind the first rotary valve and is got into the second separator, by get into the feed bin after the second separator separates.

Furthermore, the screening machine is provided with a single-layer screen, undersize materials enter the first finished product bin for temporary storage, oversize materials are conveyed back to the grinding machine for grinding and recycling, and mannitol crystal particles temporarily stored in the first finished product bin enter the next procedure after passing through a second rotary valve arranged at the bottom of the first finished product bin.

Furthermore, the screening machine is provided with double layers of screens, large-particle oversize products on the screen on the upper layer are conveyed back to the crusher to be crushed again for utilization, undersize products on the screen on the lower layer enter a first finished product bin for temporary storage, and oversize products enter a second finished product bin for temporary storage; and the mannitol crystal particles temporarily stored in the first finished product bin enter the next procedure through a second rotary valve arranged at the bottom of the first finished product bin, and the mannitol crystal particles temporarily stored in the second finished product bin enter the next procedure through a third rotary valve arranged at the bottom of the second finished product bin.

Furthermore, a return pipeline is arranged beside the second rotary valve, and mannitol crystal particles temporarily stored in the first finished product bin are conveyed to a second separator through the return pipeline for retreatment.

Furthermore, the screen mesh number of the screening machine is 20-60 meshes.

The invention is realized in such a way, and provides a crystallized mannitol dry continuous granulation process, which utilizes the crystallized mannitol dry continuous granulation device to carry out crystallized mannitol dry continuous granulation and comprises the following steps: conveying the crystalline mannitol material to be granulated in the storage bin to a tablet press through a conveyor for tabletting, then feeding the material into a crusher for crushing, separating the crushed mannitol crystal material by a first separator, then feeding the separated mannitol crystal material into a screening machine for screening, and feeding the mannitol crystal particles obtained after screening by the screening machine into a finished product bin for temporary storage.

Furthermore, the feeding amount of the tablet press is 0.5T/h-1.5T/h, the pressure of a compression roller is controlled to be 2 MPa-6 MPa, and the thickness of a discharged tablet of the tablet press is 1.5 mm-3.5 mm.

Compared with the prior art, the device and the process for granulating the crystalline mannitol by the dry method have the advantages that crystalline mannitol materials to be granulated in the storage bin are tableted by the tablet press and then enter the crusher to be crushed, mannitol crystal crushed materials crushed by the crusher are separated by the first separator and then enter the sieving machine to be sieved, the sieved mannitol crystal particles enter the finished product storage bin, the conveyer with continuous feeding capacity is arranged between the storage bin and the tablet press, and the conveyer conveys the crystalline mannitol to be granulated in the storage bin to the tablet press. The invention also has the following characteristics:

1) the needle-shaped or rod-shaped structure of the crystallized mannitol is destroyed in the tabletting and crushing processes, and then is subjected to pipeline conveying and friction, so that the product is macroscopically round, the flowability of the product is favorably improved, and the flowability of the finished product is less than 7s/100 g.

2) The crystallized mannitol material to be granulated is directly tabletted, and the crystallized mannitol is not required to be dissolved or melted in the production process, so that the energy consumption is reduced.

3) And no adhesive is adopted in the granulation process, so that the purity of the granulated mannitol crystal particles is not influenced.

4) And secondary drying is not needed in the granulation process, so that the production cost is reduced, and the moisture of the finished product is less than 0.15%.

5) And continuous operation can be realized under the condition of sufficient raw materials in the granulation production process.

6) The friability of the granulated mannitol crystal granule finished product is as low as 10-45%, and fine powder is not easy to generate in the transportation and use processes of the finished product.

Drawings

FIG. 1 is a schematic structural diagram of a preferred embodiment of a dry granulation apparatus for crystallized mannitol according to the present invention.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Referring to fig. 1, a preferred embodiment of a dry granulation apparatus for crystallized mannitol according to the present invention includes a storage bin 1, a tablet press 2, a pulverizer 3, a first separator 4, a sieving machine 5, and a finished product storage bin. A conveyor 6 with continuous feeding capacity is arranged between the bin 1 and the tablet press 2.

The mass of crystallized mannitol to be granulated is stored in the silo 1. And the tablet press 2 is used for pressing the crystalline mannitol material to be granulated to obtain the flaky crystalline mannitol. And the pulverizer 3 pulverizes the flaky crystalline mannitol to obtain mannitol crystal crushed aggregates. The screening machine 4 screens the mannitol crystal crushed aggregates separated by the first separator 4, and mannitol crystal particles obtained after screening by the screening machine 5 enter a finished product bin for temporary storage.

In the preferred embodiment, the storage bin 1 is used for storing raw materials, the raw materials in the storage bin 1 are continuously fed to the tablet press 2 through the conveyor 6, the tablet press 2 performs tabletting on the raw materials conveyed by the conveyor 6, then the raw materials tabletted by the tablet press 2 are crushed by the crusher 3, separated by the first separator 4, screened by the screening machine 5, and screened by the screening machine 5 to enter the finished product storage bin. Compared with the prior art, the scheme has simple process, and the finished product is prepared by directly tabletting the raw materials, then crushing and screening the crushed materials by a screening machine 5. The scheme improves the production efficiency of the crystal mannitol, reduces energy consumption, and has good continuity in the whole production process.

A second separator 9 and a first rotary valve 10 are also arranged on the silo 1, respectively. The crystallized mannitol material to be granulated is conveyed into the second separator 9 after passing through the first rotary valve 10, and is separated by the second separator 9 and then enters the storage bin 1.

As an embodiment, the sieving machine 5 is provided with a single-layer screen, undersize materials enter the first finished product bin 7 for temporary storage, oversize materials are conveyed back to the crushing machine 3 for crushing and recycling, and mannitol crystal particles temporarily stored in the first finished product bin 7 enter a next packaging process after passing through a second rotary valve 11 arranged at the bottom of the first finished product bin 7.

As another example, the sieving machine 5 is provided with two layers of screens, the oversize material of large particles on the upper layer of screen is conveyed back to the crusher 3 to be crushed again, the undersize material on the lower layer of screen enters the first finished product bin 7 for temporary storage, and the oversize material on the lower layer of screen enters the second finished product bin 8 for temporary storage. And the mannitol crystal particles temporarily stored in the first finished product bin 7 enter the next packaging procedure after passing through a second rotary valve 11 arranged at the bottom of the first finished product bin 7. The mannitol crystal particles temporarily stored in the second finished product bin 8 enter the next packaging process through a third rotary valve 12 arranged at the bottom of the second finished product bin 8.

In some preferred embodiments, the first finished goods silo 7 and the second finished goods silo 8 have automatic weighing capability. The finished product bin has the automatic weighing capacity, namely, the finished product bin can automatically acquire the weight of the materials in the finished product bin, so that the accurate measurement of the weight of the materials in the finished product bin is facilitated, and the monitoring of the weight of the finished products in the finished product bin is facilitated. The first finished product bin 7 and the second finished product bin 8 are independent from each other, so that the first finished product bin 7 and the second finished product bin 8 can contain mannitol crystal particles with different particle size specifications.

A return line 13 is also arranged next to the second rotary valve 11, and mannitol crystal particles temporarily stored in the first finished product bin 7 are conveyed to the second separator 9 through the return line 13 for further treatment.

The screen mesh number of the screening machine 5 is 20-60 meshes. In some preferred embodiments, the conveyor 6 is a screw conveyor (commonly known as a screw auger). The packing auger has good continuous feeding capacity, and the continuous feeding capacity of the conveyor 6 is optimized. The conveyor 6 may be replaced by other structures having continuous feed capability.

In some preferred embodiments, the first finished product bin 7, the second finished product bin 8 and the second separator 9 are connected with independent dust collectors for removing fine mannitol crystal dust. The first separator 4 is connected with the draught fan, and is convenient for convey the mannitol crystal crushed aggregates after the crusher 3 crushes and separate.

The invention also discloses a crystallized mannitol dry continuous granulation process, which utilizes the crystallized mannitol dry continuous granulation device to carry out crystallized mannitol dry continuous granulation and comprises the following steps: conveying the crystalline mannitol material to be granulated in the bin 1 to a tablet press 2 through a conveyor 6 for tabletting, then feeding the material into a crusher 3 for crushing, separating the crushed mannitol crystal material crushed by the crusher 3 through a first separator 4, then feeding the separated mannitol crystal material into a screening machine 5 for screening, and feeding the mannitol crystal particles obtained after screening by the screening machine 5 into a finished product bin for temporary storage.

The feeding amount of the tablet press 2 is 0.5T/h-1.5T/h, the pressure of a compression roller is controlled to be 2 MPa-6 MPa, and the thickness of a tablet-pressed discharging piece is 1.5 mm-3.5 mm.

In the process, air is used for conveying, the air temperature is 20-30 ℃, and the humidity is less than 45%. 16 grinding blocks of the crusher 3 have the working frequency of 15 Hz-35 Hz and the induced draft fan has the frequency of 75% -95%.

The process of the present invention is further described below in conjunction with the specific embodiments.