阅读说明：本技术 一种治疗高血压的药片的制备方法 (Preparation method of tablet for treating hypertension ) 是由 冯东东 于 2019-10-31 设计创作，主要内容包括：本发明公开了一种治疗高血压的药片的制备方法,依靠冷水浸提法提取中药材的有效成分,减压浓缩有效成分；具体步骤为取板蓝根、金钱草制备浸膏粉,再取夏枯草,茯苓,石决明制备提取膏粉,最后向提取膏粉与浸膏粉加入微晶纤维素混合均匀,直接粉末压片,得片剂,即治疗高血压的药片。本发明的一种治疗高血压的中药,成分简单,具有降血压效果,疗效显著、稳定、无副作用。(The invention discloses a preparation method of a tablet for treating hypertension, which extracts effective components of traditional Chinese medicinal materials by a cold water extraction method, and concentrates the effective components under reduced pressure; the specific steps are that isatis root and desmodium are taken to prepare extract powder, then selfheal, tuckahoe and abalone shell are taken to prepare extract powder, finally microcrystalline cellulose is added into the extract powder and the extract powder to be mixed evenly, and the powder is directly tabletted to obtain tablets, namely the tablets for treating hypertension. The traditional Chinese medicine for treating hypertension is simple in components, has the effect of reducing blood pressure, is remarkable and stable in curative effect, and has no side effect.)

1. The preparation method of the tablet for treating hypertension is characterized by comprising the following steps:

step 1, weighing 5-15% of radix isatidis, 5-15% of longhairy antenoron herb, 50-70% of selfheal, 10-15% of poria cocos and 5-20% of abalone shell according to mass percentage, wherein the sum of the mass percentages of the medicinal materials is 100%;

step 2, taking radix isatidis and desmodium, cleaning, adding water, decocting for three times respectively to obtain radix isatidis liquid medicine and desmodium liquid medicine, combining the liquid medicines, filtering, concentrating the filtrate under reduced pressure to obtain clear paste A, adding ethanol, standing overnight, taking supernatant, recovering ethanol under reduced pressure, concentrating to obtain clear paste B, and drying to obtain extract powder;

step 3, cleaning selfheal, poria cocos and abalone shell, adding water, decocting twice, combining extracting solutions obtained in the two times, and filtering dregs to obtain a traditional Chinese medicine extracting solution; concentrating under reduced pressure to obtain concentrated solution, centrifuging the concentrated solution to obtain clear solution, concentrating the clear solution to obtain Chinese medicinal extract, and drying the Chinese medicinal extract to obtain extract powder;

and 4, adding microcrystalline cellulose into the extract powder and the extract powder, uniformly mixing, and directly performing powder tabletting to obtain tablets, namely the tablets for treating hypertension.

2. The method for preparing a tablet for treating hypertension according to claim 1, wherein the amount of water added in step 2 for the first time is 6 times and the decoction is performed for 1.5 to 2 hours, and the amount of water added in the second and third times is 4 to 6 times and the decoction is performed for 1 to 2 hours.

3. The method for preparing a tablet for treating hypertension according to claim 1, wherein the relative density of the fluid extract A in the step 2 is 1.3 to 1.4(40 ℃), and the relative density of the fluid extract B in the step 2 is 1.35 to 1.45(40 ℃).

4. The method for preparing a tablet for treating hypertension according to claim 1, wherein ethanol is added in step 2 to make the ethanol content 70%.

5. The method for preparing a tablet for treating hypertension according to claim 1, wherein in the step 3, 8 to 10 times of water is added for the first time, and the decoction is carried out for 2 to 4 hours; adding 6-8 times of water for the second time, and decocting for 1-2 hours.

6. The method for preparing a tablet for treating hypertension according to claim 1, wherein the relative density of the concentrated solution in the step 3 is 1.12 to 1.16, and the relative density of the Chinese medicinal extract is 1.30 to 1.40.

7. The preparation method of a tablet for treating hypertension according to claim 1, wherein the weight ratio of the extract powder in the step 4 to the microcrystalline cellulose is 3: 7-8, wherein the weight ratio of the extract powder to the microcrystalline cellulose is 2: 7 to 9.

Technical Field

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of a tablet for treating hypertension.

Background

Hypertension (hypertension) is a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic pressure and/or diastolic pressure) (systolic pressure not less than 140 mm hg, diastolic pressure not less than 90 mm hg), which may be accompanied by functional or organic damage to organs such as heart, brain, kidney, etc. Hypertension is the most common chronic disease and also the most major risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range along with the changes of internal and external environments. In the whole population, the blood pressure level gradually increases with age, the systolic pressure is more obvious, but the diastolic pressure shows a descending trend after the age of 50, and the pulse pressure is increased. In recent years, people have increasingly deep knowledge on the effects of multiple risk factors of cardiovascular diseases and the protection of target organs of heart, brain and kidney, the diagnosis standard of hypertension is continuously adjusted, and at present, patients with the same blood pressure level are considered to have different cardiovascular disease risks, so that the concept of blood pressure stratification is provided, namely, the patients with different cardiovascular disease risks are different in proper blood pressure level. The evaluation of blood pressure value and risk factor is the main basis for diagnosing and formulating the treatment plan of hypertension, the aim of hypertension management of different patients is different, and doctors judge the most suitable blood pressure range of the patients according to the specific conditions of the patients on the basis of reference standard when facing the patients, and adopt the targeted treatment measures. On the basis of improving the life style, 24-hour long-acting antihypertensive drugs are recommended to control the blood pressure. In addition to assessing office blood pressure, patients should also be aware of home early morning blood pressure monitoring and management to control blood pressure and reduce the incidence of cardiovascular events.

Disclosure of Invention

The invention aims to provide a preparation method of a tablet for treating hypertension, which has the characteristics of simple components, obvious and stable curative effect and no side effect in the traditional Chinese medicine for treating hypertension.

The technical scheme adopted by the invention is that the preparation method of the tablet for treating hypertension is implemented according to the following steps:

step 1, weighing 5-15% of radix isatidis, 5-15% of longhairy antenoron herb, 50-70% of selfheal, 10-15% of poria cocos and 5-20% of abalone shell according to mass percentage, wherein the sum of the mass percentages of the medicinal materials is 100%;

step 2, taking radix isatidis and desmodium, cleaning, adding water, decocting for three times respectively to obtain radix isatidis liquid medicine and desmodium liquid medicine, combining the liquid medicines, filtering, concentrating the filtrate under reduced pressure to obtain clear paste A, adding ethanol, standing overnight, taking supernatant, recovering ethanol under reduced pressure, concentrating to obtain clear paste B, and drying to obtain extract powder;

step 3, cleaning selfheal, poria cocos and abalone shell, adding water, decocting twice, combining extracting solutions obtained in the two times, and filtering dregs to obtain a traditional Chinese medicine extracting solution; concentrating under reduced pressure to obtain concentrated solution, centrifuging the concentrated solution to obtain clear solution, concentrating the clear solution to obtain Chinese medicinal extract, and drying the Chinese medicinal extract to obtain extract powder; a

And 4, adding microcrystalline cellulose into the extract powder and the extract powder, uniformly mixing, and directly performing powder tabletting to obtain tablets, namely the tablets for treating hypertension.

The invention is also characterized in that:

in the step 2, the water adding amount for the first time is 6 times of that for decoction for 1.5-2 hours, and the water adding amount for the second time and the third time is 4-6 times of that for decoction for 1-2 hours.

The relative density of the clear paste A in the step 2 is 1.3-1.4 (40 ℃), and the relative density of the clear paste B in the step 2 is 1.35-1.45 (40 ℃).

In step 2, ethanol is added to make the ethanol content reach 70%.

Adding 8-10 times of water for the first time in the step 3, and decocting for 2-4 hours; adding 6-8 times of water for the second time, and decocting for 1-2 hours.

In the step 3, the relative density of the concentrated solution is 1.12-1.16, and the relative density of the Chinese medicinal extract is 1.30-1.40.

The weight ratio of the extract powder to the microcrystalline cellulose in the step 4 is 3: 7-8, wherein the weight ratio of the extract powder to the microcrystalline cellulose is 2: 7 to 9.

The invention has the beneficial effects that: the traditional Chinese medicine for treating hypertension is simple in components, has the effect of reducing blood pressure, is remarkable and stable in curative effect, and has no side effect.

Detailed Description

The present invention will be described in detail with reference to the following embodiments.