阅读说明：本技术 微囊包被颗粒类药物的热熔法制粒系统 (Hot-melting granulation system for microencapsulated granular drugs ) 是由 付崴 王克然 刘传辉 山涛 赵方方 姚志诚 于 2019-11-20 设计创作，主要内容包括：本发明公开了一种微囊包被颗粒类药物的热熔法制粒系统,旨在解决现有的热熔法制粒系统的流质混料输送管道内的流质混料易冷却的技术问题。包括原料混熔釜和制粒塔,所述原料混熔釜的出料口与所述制粒塔的进料口之间通过流质混料输送管道相连通,所述流质混料输送管道侧面并列设置有一暖管,所述暖管包括进水端和回水端,所述热泵包括两个出水口和一个进水口,所述进水端与热泵的一个出水口相连,所述回水端与热泵的进水口相连。本发明的优点在于,系统稳定,制粒效果好,在流质混料输送管道一侧并列设置有通循环热水的暖管,使得流质混料输送管道内的流质混料能够始终保持熔融态,以确保后续雾化喷出混料的均匀度。(The invention discloses a hot melting method granulating system of a microcapsule-coated granular drug, and aims to solve the technical problem that a fluid mixture in a fluid mixture conveying pipeline of the conventional hot melting method granulating system is easy to cool. Including raw materials mixing and melting cauldron and pelletization tower, the raw materials mixing and melting cauldron the discharge gate with be linked together through fluid matter compounding pipeline between the feed inlet of pelletization tower, fluid matter compounding pipeline side is provided with a warm pipe side by side, the warm pipe is including intaking end and return water end, the heat pump includes two delivery ports and a water inlet, it links to each other with a delivery port of heat pump to intake the end, the return water end links to each other with the water inlet of heat pump. The invention has the advantages that the system is stable, the granulating effect is good, and the heating pipes for circulating hot water are arranged on one side of the fluid mixed material conveying pipeline in parallel, so that the fluid mixed material in the fluid mixed material conveying pipeline can be always kept in a molten state, and the uniformity of the subsequently atomized and sprayed mixed material is ensured.)

1. The utility model provides a hot melt method pelletization system of microcapsule peridium granule class medicine, includes raw materials and mixes melting kettle and pelletization tower, the raw materials mix melting kettle's discharge gate with be linked together through fluid compounding pipeline between the feed inlet of pelletization tower, its characterized in that still includes the heat pump, fluid compounding pipeline side is provided with a warm tube side by side, the warm tube is including intaking end and return water end, the heat pump includes two delivery ports and a water inlet, it links to each other with a delivery port of heat pump to intake the end, the return water end links to each other with the water inlet of heat pump.

2. The system for granulating microencapsulated drugs in granule by hot melt method according to claim 1, wherein the bottom of the raw material mixing and melting kettle is provided with a heat-conducting oil injection port and an electric heater, and the top of the raw material mixing and melting kettle is provided with a stirring motor.

3. The system for hot-melt granulation of microencapsulated granules according to claim 1, wherein the bottom of the fluid mixture delivery conduit is provided with a pressure pump.

4. The system for hot-melt granulation of microencapsulated granules according to claim 1, wherein the discharge port of the fluid mixture delivery conduit is provided with an atomizing nozzle.

5. The system for hot-melt granulation of microencapsulated granular drugs according to claim 4, wherein the working surface of the atomizer is provided with uniformly distributed circular holes of the same diameter.

6. The system for hot-melt granulation of microencapsulated granules according to claim 1, wherein the feed inlet of the fluid mixture delivery conduit is provided at one end with a hot water nozzle communicating therewith.

7. The system according to claim 6, wherein the hot water inlet is connected to another water outlet of the heat pump.

8. The system for hot-melt granulation of microencapsulated granules according to claim 1, wherein the top of the granulation tower is further provided with a cold air duct, and a cold air outlet of the cold air duct is arranged at the top of the cavity of the granulation tower.

Technical Field

The invention relates to the technical field of pharmaceutical equipment, in particular to a hot-melting granulation system for microencapsulated granular medicines.

Background

Granulation is a common process in solid preparations, and can be used for improving the flowability and the formability of materials, improving the stability of the medicine, controlling the release speed of the medicine, covering the unpleasant taste of the medicine and selecting a proper prescription and a proper process; there are wet, dry and hot melt processes, which are classified according to the manufacturing method. Wet granulation requires volatilization of water or organic solvent at a higher temperature, which is more energy-consuming and may remain in the granules to affect the safety of the drug; the ideal particles can be obtained only by repeatedly granulating, sieving and extruding and granulating, and the efficiency is low.

The hot-melt granulation is to heat and melt the low-melting-point substance, add the medicine to be granulated to dissolve or disperse the medicine in the low-melting-point substance, and then extrude or spray the mixture at high temperature and cool the mixture to granulate; chinese patent application No. CN201820886343.6 discloses a spray condenser and a hot-melt granulation apparatus including the same, wherein the top of the condenser is communicated with a cold air supply device through a pipeline; the material inlet is connected with the melt pump through a pipeline; one end of the spray gun is communicated with the melt pump through a pipeline, the other end of the spray gun is communicated with the nozzle through a pipeline, and the nozzle extends into the condenser and is positioned above the condenser; the spray gun is also communicated with an atomizer through a pipeline, and the atomizer is used for controlling the flow velocity of heated high-pressure gas, atomizing the material in the spray gun and spraying the atomized material into the condenser through a nozzle; the material outlet is arranged at the bottom of the condenser; the side wall of the cyclone separator is communicated with a material outlet through a pipeline, the top of the cyclone separator is communicated with a draught fan through a pipeline, and the bottom of the cyclone separator is provided with a material collecting port; in a large-scale granulating device, a pipeline for connecting a spray gun and a melt pump is long, and the mixed and melted medicine is easy to cool, so that subsequent cooling, atomizing and granulating are uneven and the efficiency is low.

Disclosure of Invention

The invention aims to provide a hot-melting granulation system for micro-capsule coated granular drugs, which aims to solve the technical problem that a fluid mixture in a fluid mixture conveying pipeline of the existing hot-melting granulation system is easy to cool.

In order to solve the technical problems, the invention adopts the following technical scheme:

the design is a hot melting method pelletization system of microcapsule coated granular medicine, including raw materials mixing and melting kettle, pelletization tower and heat pump, the discharge gate of raw materials mixing and melting kettle with be linked together through fluid compounding pipeline between the feed inlet of pelletization tower, fluid compounding pipeline side is provided with a warm pipe side by side to the fluid compounding of molten state in maintaining fluid compounding pipeline avoids appearing because the partial cooling of the fluid compounding in the pipeline leads to the inhomogeneous condition of follow-up atomizing cooling pelletization. The heating pipe comprises a water inlet end and a water return end, the heat pump comprises two water outlets and a water inlet, the water inlet end is connected with one water outlet of the heat pump, and the water return end is connected with the water inlet of the heat pump.

Preferably, the bottom of the raw material mixing and melting kettle is provided with a heat-conducting oil injection port and an electric heater, and the top of the raw material mixing and melting kettle is provided with a stirring motor for providing power for a stirring mechanism in the raw material mixing and melting kettle.

Preferably, fluid compounding pipeline bottom is provided with the force (forcing) pump, for fluid compounding pipeline pressurization, makes the pressure of its feed inlet department be greater than the pressure of discharge gate department for fluid compounding can last the blowout.

Preferably, the discharge port of the fluid mixing material conveying pipeline is provided with an atomizing nozzle for uniformly dispersing the mixing material.

Preferably, the working surface of atomizer is provided with the round hole that diameter size is the same and evenly distributed for the fluid compounding can evenly spout liquid pearl form compounding.

Preferably, one end of the feeding hole of the fluid mixing material conveying pipeline is provided with a hot water injection port communicated with the feeding hole.

Preferably, the hot water injection port is connected with the other water outlet of the heat pump to provide continuous hot water for the fluid mixing pipeline.

Preferably, the top of the granulation tower is further provided with a cold air pipeline, and a cold air outlet of the cold air pipeline is arranged at the top of the cavity of the granulation tower. The temperature of the top of the cavity of the raw material hot melting kettle is reduced, so that atomized mixed material liquid beads sprayed from the atomizing nozzle are rapidly solidified in the presence of cold to form coated particles.

Compared with the prior art, the invention has the beneficial technical effects that:

the bottom of the raw material mixing and melting kettle is provided with a heat conduction oil inlet and an electric heater, the boiling point of the heat conduction oil is high, the thermal stability is good, the heat transfer performance is good, the low vapor pressure is nontoxic and odorless, and the equipment is not corroded; the warm pipes for circulating hot water are arranged on one side of the fluid mixing conveying pipeline in parallel, so that the fluid mixing in the fluid mixing conveying pipeline can be always kept in a molten state, and the uniformity of subsequent atomized and sprayed mixing is ensured.

Drawings

Fig. 1 is a schematic structural diagram of a hot-melt granulation system for microencapsulated drugs according to the present invention.

FIG. 2 is a second schematic diagram of the hot-melt granulation system of microencapsulated drug particles according to the present invention.

Fig. 3 is a schematic structural diagram of an atomizing nozzle of a hot-melt granulation system for microencapsulated drugs.

In the above figures, 1 is a raw material mixing and melting kettle, 2 is a granulation tower, 3 is a fluid material mixing and conveying pipeline, 4 is a warm pipe, 5 is a water inlet end, 6 is a water return end, 7 is a heat transfer oil injection port, 8 is an electric heater, 9 is a stirring motor, 10 is a hot water injection port, 11 is an atomizing nozzle, 12 is an air conditioning pipeline, 13 is an air conditioning outlet, and 14 is a pressure pump.

Detailed Description

The following examples are intended to illustrate the present invention in detail and should not be construed as limiting the scope of the present invention in any way.

The components and parts in the following examples are all conventional commercially available products unless otherwise specified.