阅读说明：本技术 用于治疗前蛋白转化酶枯草杆菌蛋白酶/Kexin 9型(PCSK9)相关的病症的组合物和方法 (Compositions and methods for treating proprotein convertase subtilisin/Kexin type 9 (PCSK9) -associated disorders ) 是由 A.S.伦德伯格 S.库尔卡尼 L.克莱因 Y.S.阿拉泰恩 R.L.博戈拉德 H.K.帕 于 2018-02-15 设计创作，主要内容包括：本申请提供了用于离体或体内治疗具有与PCSK9有关的一种或多种病况的患者的材料和方法。此外,本申请提供了通过基因组编辑来编辑和/或调节细胞中PCSK9基因的表达的材料和方法。(The present application provides materials and methods for ex vivo or in vivo treatment of patients having one or more conditions associated with PCSK 9. In addition, the present application provides materials and methods for editing and/or modulating the expression of the PCSK9 gene in a cell by genome editing.)