阅读说明：本技术 一种应用于治疗乳腺炎的组合物 (Composition for treating mastitis ) 是由 苏小平 于 2019-09-09 设计创作，主要内容包括：一种应用于治疗乳腺炎的组合物,包括如下重量份的原料：蒲公英提取物0.5～2份、金银花提取物0.5～2份、夏枯草提取物0.5～2份、低聚半乳糖0.1～2份以及发酵乳杆菌CECT5716适量。本发明精选原料并科学配方,不含抗生素,安全无毒,适合产妇服用,服用后在预防和治疗乳腺炎上效果显著。(A composition for treating mastitis comprises the following raw materials in parts by weight: 0.5-2 parts of dandelion extract, 0.5-2 parts of honeysuckle extract, 0.5-2 parts of selfheal extract, 0.1-2 parts of galacto-oligosaccharide and a proper amount of lactobacillus fermentum CECT 5716. The invention selects raw materials and has scientific formula, does not contain antibiotics, is safe and nontoxic, is suitable for being taken by puerpera, and has obvious effect on preventing and treating mastitis after being taken.)

1. the composition for treating mastitis is characterized by comprising the following raw materials in parts by weight: 0.5-2 parts of dandelion extract, 0.5-2 parts of honeysuckle extract, 0.5-2 parts of selfheal extract, 0.1-2 parts of galacto-oligosaccharide and a proper amount of lactobacillus fermentum CECT 5716.

2. The composition for treating mastitis according to claim 1, wherein the weight ratio of the dandelion extract, the honeysuckle extract and the selfheal extract is 1:1: 1.

3. A composition for use in the treatment of mastitis according to claim 2, comprising the following raw materials in parts by weight: 1 part of dandelion extract, 1 part of honeysuckle extract, 1 part of selfheal extract, 1 part of galacto-oligosaccharide and a proper amount of lactobacillus fermentum CECT 5716.

4. The composition for use in treating mastitis according to claim 1, further comprising a suitable amount of a sweetener, wherein the sweetener is one or more of sorbitol, erythritol, or xylitol.

5. A composition for use in treating mastitis according to any one of claims 1 to 4, wherein the number of Lactobacillus fermentum CECT5716 per gram of galactooligosaccharide is from 15 to 100 hundred million strains.

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a composition for treating mastitis.

Background

Mastitis is an acute suppurative disease occurring in the breast, also known as acute mastitis. The problems of postpartum milk siltation, breast distending pain, mastitis and the like in the current society are more and more, many puerperae suffer from the damage, however, due to the fact that a reasonable conditioning method is not available, breast bacterial infection and repeated mastitis attack even symptoms such as breast abscess and breast cancer occur finally, acute mastitis frequently occurs in 3-4 weeks after delivery, high fever, chill, inflammation and pain and the like occur after illness occurs, and besides the pain of the puerperae, the problem of the breast of the puerperae directly affects the feeding and health of babies.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a composition which is safe, short in treatment course and good in treatment effect and is applied to treating mastitis.

the technical problem solved by the invention is realized by adopting the following technical scheme:

A composition for treating mastitis comprises the following raw materials in parts by weight: 0.5-2 parts of dandelion extract, 0.5-2 parts of honeysuckle extract, 0.5-2 parts of selfheal extract, 0.1-2 parts of galacto-oligosaccharide and a proper amount of lactobacillus fermentum CECT 5716.

Preferably, the mass ratio of the dandelion extract, the honeysuckle extract and the selfheal extract is 1:1: 1.

Preferably, the feed comprises the following raw materials in parts by weight: 1 part of dandelion extract, 1 part of honeysuckle extract, 1 part of galacto-oligosaccharide and a proper amount of lactobacillus fermentum CECT 5716.

Preferably, the sweetener also comprises a proper amount of sweetener, wherein the sweetener is one or more of sorbitol, erythritol or xylitol.

Preferably, the number of the lactobacillus fermentum CECT5716 is 15-100 hundred million strains per gram of galactooligosaccharide.

The composition can be tablets or dispersible tablets or buccal tablets or powder or granules.

In the invention, the preparation method of the dandelion extract comprises the following steps: the preparation method comprises the steps of crushing the dry dandelion, adding water according to the proportion of 1 (5-10) of the material-liquid ratio, keeping the water in a slightly boiling state, boiling for 40-60 min, separating an extracting solution, repeatedly extracting for three times, combining the extracting solutions, and performing spray drying.

In the invention, the preparation method of the honeysuckle extract comprises the following steps: the preparation method comprises the steps of crushing the dried honeysuckle, adding water according to the material-liquid ratio of 1 (5-10), keeping the water in a slightly boiling state, decocting for 40-60 min, separating an extracting solution, repeatedly extracting for three times under the same condition, combining the extracting solutions, and performing spray drying.

In the invention, the preparation method of the selfheal extract comprises the following steps: the preparation method comprises the steps of crushing dry selfheal, adding water according to the material-liquid ratio of 1 (5-10), keeping the water in a slightly boiling state, boiling for 40-60 min, separating an extracting solution, repeatedly extracting for three times under the same condition, combining the extracting solutions, and performing spray drying.

In particular, the dandelion extract, honeysuckle extract and honeysuckle extract are commercially available or prepared by other methods known in the art.

Dandelion is sweet in nature and taste, slightly bitter and cold. The dandelion extract contains various healthy nutritional ingredients such as dandelion alcohol, dandelion essence, choline, organic acid, inulin and the like, has the effects of promoting urination, relieving diarrhea, eliminating jaundice, benefiting gallbladder and the like, and can be used for treating heat toxin, carbuncle swelling, pyocutaneous disease, internal carbuncle, conjunctival congestion and swelling pain, damp-heat, jaundice, dribbling urination and painful urination, furuncle and pyogenic infections and the like.

prunellae Spica, recorded in Bencao Shinjian, has the effects of resolving hard mass, eliminating goiter and improving eyesight, is bitter and slightly cold in taste, and has the effects of relieving liver fire, relieving internal heat, dispersing pathogenic qi, etc.

Honeysuckle flower, listed as the top grade in Shen nong Ben Cao Jing and recorded as "getting light for a long time": the famous medical records describe that it has the function of treating summer heat and swollen body; li Shizhen is said in Ben Cao gang mu to treat all kinds of wind-damp-qi, swelling and toxin, scabies, red bayberry and malignant sores, dispel heat and remove toxicity. It is called as both a good medicine for treating wind, relieving swelling, relieving dysentery and expelling dead body and a good agent for relieving swelling, dispelling toxicity and treating sore, and the honeysuckle extract can be combined with other medicines, or has good effects of pills, wine soaking, oral administration or external application. The action and the effect are reflected in two aspects of diminishing inflammation and resisting bacteria. Modern medical research proves that the honeysuckle has stronger bacteriostatic power on streptococcus, staphylococcus, typhoid bacillus, dysentery bacillus, large intestine, pseudomonas aeruginosa, pneumococcus, pertussis bacillus, meningococcus and the like, and has certain curative effect on treating inflammation.

galacto-oligosaccharides (GOS): the dietary fiber is low-molecular-weight water-soluble dietary fiber, has fresh and cool taste and lower heat value, the sweetness of the dietary fiber is only 20-40 percent of that of cane sugar, the viscosity is low, the dietary fiber has stronger moisture retention, the GOS can enable probiotics such as lactobacillus fermentum and the like to be rapidly propagated, and harmful floras can not be utilized almost, so the dietary fiber plays a key role in shortening the treatment course of the medicine and avoiding toxic and side effects caused by taking the medicine.

Lactobacillus fermentum CECT5716, which is a probiotic purchased from Hereditum muricatum breast milk, has a WIPO patent number of WO/2004/003/003235, is a probiotic product that passes dual certification of the european food safety agency and the U.S. food and drug administration, and is listed in "list of strains available for food" in china in 2011, approved by the committee of chinese health in 2016, and listed in "list of strains available for infant food" in CECT 5716.

Is also the only probiotic in the list isolated from healthy breast milk, which can effectively promote intestinal digestion and absorption and protect gastrointestinal health; enhancing human immunity, etc.

The principle of the invention is that after mastitis occurs, harmful bacteria become dominant flora, microecological environment in breasts is destroyed, and a large amount of harmful bacteria are propagated to destroy mammary tissues and reduce immunity of human bodies, the invention combines the theory of traditional Chinese medicine, carefully selects raw materials, scientifically mixes dandelion extract, honeysuckle extract and selfheal extract to realize synergistic action, prevents obstruction of mammary glands caused by liver depression and stomach heat and irregular intestines and stomach, and then prevents pathogenic heat in vivo or pathogenic wind from being generated, on the basis, the lactobacillus fermentum CECT5716 is synergistically nourished by galactooligosaccharide and functional components in the dandelion extract, the honeysuckle extract and the selfheal extract to obtain continuous and rapid propagation, and simultaneously inhibits the generation of harmful flora, and the rapidly propagated lactobacillus fermentum CECT5716 continuously enters into human bodies and has stronger intestinal cell adhesion capacity, can be rapidly planted in the intestinal tract and transferred to the mammary gland to become dominant thalli, stimulates the expression of mucin genes, generates antibacterial substances to inhibit the growth and planting of harmful bacteria, regulates the microbial environment in the mammary gland to gradually tend to balance, completely eliminates the harmful bacteria, improves the immunity, avoids the continuous infection of the harmful bacteria, and thus achieves the aim of preventing or improving the mastitis.

Has the advantages that:

1) The invention selects raw materials and has scientific formula, does not contain antibiotics, is safe and nontoxic, is suitable for being taken by puerperae, has short treatment course and obvious effect on treating mastitis after being taken;

2) the raw material components of the invention are mutually promoted, and the composite plant extract can play a role in lactobacillus fermentum CECT5716 to ensure a proper human body microenvironment, thereby enhancing the effect, facilitating the rapid recovery of the human body and having positive effect on improving the human body immunity.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.