阅读说明：本技术 一种治疗小叶增生的中药喷剂及制备方法 (Traditional Chinese medicine spray for treating lobular hyperplasia and preparation method ) 是由 张天亮 于 2018-05-30 设计创作，主要内容包括：本发明提供一种治疗小叶增生的中药喷剂,包括以下重量的中药原料：艾叶5-15克、丝瓜160-230克、丝瓜络75-130克、丝瓜子30-55克、红花0.1-0.6克和夏枯草5-15克。其制备方法是将艾叶和夏枯草在夏季放入盛有500克白酒的密闭玻璃容器中,置于阴凉干燥处,泡制到秋季,浸泡满240天；再将丝瓜,丝瓜络,丝瓜子和红花依次放入泡制的药酒中,浸泡八个月后方可取出；从获得的固液混合物中分离出滤液,并装入带有喷头的喷壶中。本发明的中药喷剂针对小叶增生具有疏通,镇疼,活血化瘀的功效,药剂喷上患处立马缓解疼痛,短时间内得到改善,起到立杆见影的效果。(the invention provides a traditional Chinese medicine spray for treating lobular hyperplasia, which comprises the following traditional Chinese medicine raw materials by weight: 5-15 g of folium artemisiae argyi, 230 g of luffa 160-plus, 75-130 g of luffa vegetable sponge, 30-55 g of luffa seed, 0.1-0.6 g of safflower and 5-15 g of selfheal. The preparation method comprises placing folium Artemisiae Argyi and Prunellae Spica in summer in a sealed glass container containing 500 g Chinese liquor, placing in a cool and dry place, soaking in autumn for 240 days; sequentially putting the loofah, the loofah sponge, the loofah seeds and the safflower into the soaked medicinal liquor, and taking out after soaking for eight months; the filtrate was separated from the obtained solid-liquid mixture and charged into a watering can with a shower head. The traditional Chinese medicine spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia, is sprayed on the affected part immediately to relieve pain, is improved in a short time, and has the effect of showing the upright pole.)

1. A traditional Chinese medicine spray for treating lobular hyperplasia is characterized by comprising the following traditional Chinese medicine raw materials by weight: 5-15 g of folium artemisiae argyi, 230 g of luffa 160-plus, 75-130 g of luffa vegetable sponge, 30-55 g of luffa seed, 0.1-0.6 g of safflower and 5-15 g of selfheal.

2. The traditional Chinese medicine spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 8-13 g of folium artemisiae argyi, 215 g of luffa 180-.

3. The traditional Chinese medicine spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 10 g of folium artemisiae argyi, 200 g of towel gourd, 100 g of towel gourd vegetable sponge, 40 g of towel gourd seeds, 0.3 g of safflower and 10 g of selfheal.

4. the Chinese medicinal spray for treating lobular hyperplasia according to any one of claims 1 to 3, wherein the loofah sponge or the loofah seeds comprise old and tender components, and one component comprises the following components by weight: three parts are old and seven parts are tender; the old appearance is brownish yellow, and the tender one is obtained by picking in the dark brown junction period.

5. a preparation method of a traditional Chinese medicine spray for treating lobular hyperplasia is characterized by comprising the following steps:

(1) Putting folium Artemisiae Argyi and Prunellae Spica in summer in a sealed glass container filled with 500 g Chinese liquor, placing in a cool and dry place, and soaking in autumn for 240 days;

(2) after the soaking days are met, sequentially putting the loofah, the loofah sponge, the loofah seeds and the safflower into the soaked medicinal liquor, and taking out after soaking for eight months;

(3) The filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head.

6. The preparation method of the traditional Chinese medicine spray for treating lobular hyperplasia according to claim 5, wherein in the step (1), the folium artemisiae argyi and the selfheal are respectively ground and sieved by a 40-80 mesh sieve, preferably a 60-mesh sieve.

7. The method for preparing a Chinese medicinal spray for treating lobular hyperplasia according to claim 5, wherein in step (2), the ground luffa, luffa seeds and safflower are sieved by a sieve of 80-120 meshes, preferably 100 meshes.

8. the preparation method of the traditional Chinese medicine spray for treating lobular hyperplasia according to claim 5, wherein the solid-liquid mixture is separated in the step (3), ultrasonic extraction is adopted, extraction is performed for 5 times, and the extraction time is set to be 10-15 min each time.

9. The preparation method of the traditional Chinese medicine spray for treating lobular hyperplasia according to claim 5, wherein the solid-liquid mixture is separated in the step (3), a centrifuge is adopted, the first centrifugation is carried out for 10-20 min at the rotation speed of 1800-3000 r/min, and supernatant of the first centrifugation is collected; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

10. The preparation method of the traditional Chinese medicine spray for treating lobular hyperplasia according to claim 5, wherein the outer wall of the spray can used in the step (3) is provided with scales so as to control the usage amount.

Technical Field

The invention relates to the field of medicine formulas, in particular to a traditional Chinese medicine composition spray for treating lobular hyperplasia and a preparation method thereof.

Background

Lobular hyperplasia belongs to the category of hyperplasia of mammary glands, and is a benign proliferative disease of mammary tissue. Is neither inflammatory nor neoplastic, and is caused by hormonal cycling in women. Hyperplasia of mammary duct epithelial cells and fibrous tissue in the breast can be caused by excessive ovarian estrogen levels, insufficient luteal progestagen, or an dysregulated secretion of both. Normally, the acinus, ducts and fibrous tissue of each breast of a woman who enters puberty undergoes a process of tissue change of proliferation and recovery during each menstrual cycle. Due to the change, before each menstruation, each woman may have a slight or heavy distending pain in one or both breasts, and the distending pain naturally disappears after menstruation, which is a normal physiological phenomenon without hindering life, learning and work. However, when the body is under the action of some stress factors (such as over-tension in work, over-excited mood, old age without marriage, no lactation after delivery and some chronic diseases), the hyperplasia of mammary glands which should be restored by the breasts can not be restored or can not be restored completely, and hyperplasia of mammary glands is formed after a long time, which is manifested by three symptoms and signs of thickened mammary lobe and nodular granules, breast swelling pain, nipple galactorrhea and the like.

Mammary lobular hyperplasia (stage I mammary gland hyperplasia): for medical diagnosis, the disease is the initial hyperplasia of mammary glands, which mostly occurs in 25-35 years old, and the symptom is less, belonging to the hyperplasia of mammary glands stage I. The prevalence rate of hyperplasia of mammary glands is more than 70%, which is not paid attention to and is not treated actively. If the treatment is not carried out in time, the mammary gland is easy to become cancerous, part of mammary gland hyperplasia is lingering for a long time, and benign tumor or malignant lesion of the mammary gland can be generated.

At present, the treatment of the disease is mainly based on drug therapy, western medicines take hormone as a preferred medicine, symptoms are relieved by regulating endocrine, and medicines for symptomatic treatment are supplemented according to the symptoms. According to the traditional Chinese medicine, the Chong and ren meridians are the sea of qi and blood, the ascending meridians are the breast, the descending meridians are the channels, once worry damages the spleen and worry damages the liver, the qi stagnation of the channels and the disorder of the Chong and ren meridians can occur as a result, and the breast diseases can occur.

Chinese patent (No. CN 102225123B) discloses a Chinese medicament for treating hyperplasia of mammary glands, which is prepared by decocting the following raw material medicaments in part by weight in water into decoction: 9-12 parts of muskroot-like semiaquilegia root, 10-20 parts of coltsfoot-flower, 9-12 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 20-40 parts of dandelion, 9-12 parts of orange leaf and 6-10 parts of green plum blossom. Chinese patent (No. CN 101564483B) discloses a liver soothing granule for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 200-250 parts of angelica, 133-150 parts of white peony root, 133-150 parts of bighead atractylodes rhizome, 67-100 parts of vinegar-processed rhizoma cyperi, 93-140 parts of radix bupleuri, 133-150 parts of poria cocos, 67-100 parts of mint, 40-60 parts of cape jasmine, 40-60 parts of moutan bark and 94-120 parts of liquorice. Therefore, the traditional Chinese medicine has a good curative effect on treating the lobular hyperplasia of mammary glands, but the existing traditional Chinese medicine is an oral medicine, has a poor effect on treating the lobular hyperplasia of mammary glands as compared with a spray, and causes additional burden on the body of a patient.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine spray for treating the lobular hyperplasia, which has the advantages of convenience in carrying and obvious effect. The invention also aims to provide a preparation method of the spray.

In order to achieve the purpose, the technical scheme of the invention is as follows:

A traditional Chinese medicine spray for treating lobular hyperplasia comprises the following traditional Chinese medicine raw materials by weight: 5-15 g of folium artemisiae argyi, 230 g of luffa 160-plus, 75-130 g of luffa vegetable sponge, 30-55 g of luffa seed, 0.1-0.6 g of safflower and 5-15 g of selfheal.

The preferred scheme of the traditional Chinese medicine spray is as follows: comprises the following Chinese medicinal raw materials by weight: 8-13 g of folium artemisiae argyi, 215 g of luffa 180-.

The better preferable scheme of the traditional Chinese medicine spray is as follows: comprises the following Chinese medicinal raw materials by weight: 10 g of folium artemisiae argyi, 200 g of towel gourd, 100 g of towel gourd vegetable sponge, 40 g of towel gourd seeds, 0.3 g of safflower and 10 g of selfheal.

Furthermore, the loofah sponge or the loofah seeds are old and tender in weight, and one part of the loofah sponge or the loofah seeds comprises the following components in parts by weight: three parts are old and seven parts are tender; the old appearance is brownish yellow, and the tender one is picked up in the dark brown junction period.

The preparation method of any traditional Chinese medicine spray preferably comprises the following steps:

(1) Putting folium Artemisiae Argyi and Prunellae Spica in summer in a sealed glass container filled with 500 g Chinese liquor, placing in a cool and dry place, and soaking in autumn for 240 days;

(2) After the soaking days are met, sequentially putting the loofah, the loofah sponge, the loofah seeds and the safflower into the soaked medicinal liquor, and taking out after soaking for eight months;

(3) The filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head.

The preferred scheme is as follows: in the step (1), the folium artemisiae argyi and the prunella vulgaris are ground respectively and sieved by a 40-80 mesh sieve, preferably a 60 mesh sieve.

The preferred scheme is as follows: in the step (2), the loofah sponge, the loofah seeds and the safflower are respectively ground and sieved by a sieve with 80-120 meshes, preferably 100 meshes.

The preferred scheme is as follows: and (4) separating the solid-liquid mixture in the step (3), extracting for 5 times by adopting ultrasonic extraction, wherein the extraction time is set to be 10-15 min each time.

Another preferred solution is: separating the solid-liquid mixture in the step (3), performing primary centrifugation for 10-20 min by adopting a centrifuge at the rotating speed of 1800-3000 r/min, and collecting supernatant of the primary centrifugation; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

The preferred scheme is as follows: scales are arranged on the outer wall of the sprinkling can used in the step (3), so that the using amount is convenient to control.

the using method comprises the following steps: in order to achieve the best treatment effect, when the traditional Chinese medicine spray is used, hands and breasts are cleaned by warm water, the traditional Chinese medicine spray is sprayed on the breasts, the hands are used for kneading for 5 circles, the spraying is carried out for several times a day, more than 2 grams of the traditional Chinese medicine spray is required to be sprayed every day, and 7 days are a treatment course.

the pharmacological effects of the raw materials are respectively as follows:

(1) Folium artemisiae argyi: bitter and pungent, warm. Enter spleen, liver and kidney meridians. Regulating qi and blood, dispelling cold and dampness; warm meridians, stop bleeding, prevent abortion. It can be used for treating psychroalgia of heart and abdomen, diarrhea, spasm of tendons, chronic dysentery, hematemesis, hemorrhage, menoxenia, metrorrhagia, leukorrhagia, threatened abortion, carbuncle, ulcer, and scabies.

(2) Loofah (melon): also known as Tianluo. Sweet, mild and nontoxic. Mainly treats the symptoms of chronic acne, unhealing carbuncle and cellulitis, wind-heat costal swelling, sore of sitting plate, cold sore of hands and feet, anal fistula and rectocele, intestinal wind and bleeding, metrorrhagia, galactostasis, small intestine pain, umbilical rush, oval swelling and falling, lumbago, sore throat, phlegm reducing and cough stopping, wind-qi toothache, knife sore and chronic ulcer.

(3) Loofah sponge (strands): cool in nature and sweet in taste. Dredge collaterals, activate blood and dispel wind. Mainly treats chest and hypochondriac pain; rheumatic arthralgia, spasm of meridians, obstruction of breast milk, cough with lung-qi, sore before carbuncle, and carbuncle of the other organs.

(4) luffa seeds (seeds): slightly sweet and mild. Clear heat and resolve phlegm, moisten dryness and expel parasites. It can be used for treating cough with excessive phlegm, ascariasis, and constipation.

(5) Safflower: warm in nature and pungent in flavor. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. It can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, and swelling and pain of pyocutaneous disease.

(6) Selfheal: bitter, pungent and cold. Enter gallbladder and liver meridians. Clearing liver and improving vision; dispersing accumulation of pathogen and removing toxic substance. Mainly treats photophobia of eyes; pain in the eyeball; headache and dizziness; tinnitus; scrofula; goiter and tumor; acute mastitis; mumps; carbuncle and furuncle; acute and chronic hepatitis; hypertension disease

(7) White spirit: pungent, sweet and bitter. Promoting blood circulation; the efficacy of the medicine is exerted. Is mainly used for treating wind-cold arthralgia; spasm and urgency of tendons and vessels; chest stuffiness; heartburn; abdominal cold pain.

Has the advantages that: the traditional Chinese medicine spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia, is sprayed on the affected part to relieve pain immediately, is improved in a short time, and has the effect of showing the upright pole. The preparation method of the invention can better exert the drug effect of the traditional Chinese medicine.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.