阅读说明：本技术 聚合物药物递送缀合物及其制备方法和使用方法 (Polymeric drug delivery conjugates and methods of making and using the same ) 是由 杨继源 李连 C·马修·彼得森 J·科佩塞克 于 2020-10-16 设计创作，主要内容包括：本文描述了用于向受试者有效地递送抗癌剂的可生物降解的药物递送缀合物和抗癌缀合物。缀合物包含与两个聚合物链段共价地连接的单个第一可裂解肽接头,其中至少一种PD-L1抑制剂与每个聚合物链段共价地键合(本文称为“PD-L1抑制剂聚合物缀合物”)。本文还描述了PD-L1抑制剂聚合物缀合物与抗癌剂组合用于治疗或预防癌症的用途。(Described herein are biodegradable drug delivery conjugates and anti-cancer conjugates for effectively delivering an anti-cancer agent to a subject. The conjugates comprise a single first cleavable peptide linker covalently linked to two polymer segments, wherein at least one PD-L1 inhibitor is covalently bonded to each polymer segment (referred to herein as "PD-L1 inhibitor polymer conjugate"). Also described herein is the use of a PD-L1 inhibitor polymer conjugate in combination with an anti-cancer agent for the treatment or prevention of cancer.)