阅读说明：本技术 一种i型胶原蛋白混悬药剂及其制备方法 (I-type collagen suspension medicament and preparation method thereof ) 是由 常慧楠 于 2021-08-04 设计创作，主要内容包括：本发明涉及一种I型胶原蛋白混悬药剂及其制备方法。所述I型胶原蛋白混悬药剂包括如下原料：I型胶原蛋白、维生素B-(12)、生理盐水和麻醉剂。所述I型胶原蛋白混悬药剂各组分间科学配伍,是一种不易栓塞且有效浓度足够的超微细结构混悬剂,尤其对于注射处周边因衰老而缺乏胶原蛋白的组织,具有良好的扩散效果。各层软组织接触胶原蛋白后会编织入网进入原有的胶原纤维网,恢复部分原有的组织结构位置和功能,最终使面部表现为年轻态。综合而言,能使皮下脂肪室复位,韧带恢复弹性；皮肤色泽提亮,弹性增强；面部深层脂肪垫弹性立体化,最终全面部呈现饱满年轻顺滑无沟壑的状态；所述制备工艺简单易控,有利于规模化产出。(The invention relates to a type I collagen suspension medicament and a preparation method thereof. The type I collagen suspension medicament comprises the following raw materials: type I collagen and vitamin B 12 Normal saline and anesthetic. The components of the type I collagen suspension medicament are scientifically compatible, and the type I collagen suspension medicament is an ultrafine structure suspension medicament which is not easy to embolism and has enough effective concentration, in particular toThe tissue which is lack of collagen due to aging around the injection site has good diffusion effect. After contacting collagen, each layer of soft tissue can be woven into the net and enter the original collagen fiber net, the position and the function of part of the original tissue structure are recovered, and finally the face is in a young state. In general, the subcutaneous fat compartment can be restored, and the ligament can recover elasticity; the skin color is bright, and the elasticity is enhanced; the deep fat pad on the face is elastic and three-dimensional, and finally the whole face is full, young, smooth and gully-free; the preparation process is simple and easy to control, and is beneficial to large-scale output.)

1. A type I collagen suspension medicament is characterized by comprising the following raw materials: type I collagen and vitamin B₁₂Normal saline and anesthetic.

2. The type I collagen suspension medicament according to claim 1, characterized by comprising the following raw materials in parts by volume: 1-2 parts of type I collagen and vitamin B₁₂0.5-1 part of normal saline, 1-2 parts of anesthetic and 0.5-1 part of water.

3. The type I collagen suspension medicament according to claim 2, characterized by comprising the following raw materials in parts by volume: 1 part of type I collagen and vitamin B₁₂0.5 part, 1 part of normal saline and 0.5 part of anesthetic.

4. The type I collagen suspension drug according to any one of claims 1 to 3, wherein said vitamin B₁₂The concentration was 0.25 mg/mL.

5. The type I collagen suspension agent according to any one of claims 1 to 3, wherein the type I collagen is double skin-beautifying soft skin; the type I collagen concentration is 30 mg/mL.

6. The type I collagen suspension preparation according to any one of claims 1 to 3, wherein said anesthetic is lidocaine; the concentration of the lidocaine is 0.02 g/mL.

7. The method for preparing the type I collagen suspension preparation according to any one of claims 1 to 6, wherein vitamin B is added to the type I collagen₁₂And normal saline and anesthetic are injected repeatedly to obtain the I type collagen suspension medicament.

8. The preparation method of the type I collagen suspension medicament according to claim 7, wherein the repeated bolus injection is a double-bolus repeated bolus injection 75-80 times.

Technical Field

The invention belongs to the technical field of collagen, and particularly relates to a type I collagen suspension medicament and a preparation method thereof.

Background

The concentration of the existing type I collagen in the market is generally 30-35 mg/mL, and the existing type I collagen has the function of slight filling capacity, but the type I collagen with a single component is not suitable for large-dose injection throughout the whole face, because the over-full condition occurs, and because the concentration is too high, the risk of embolism exists. In addition, the existing type I collagen does not contain anesthetic components, and the injection pain is very obvious.

There is another type of type III collagen available on the market, but at too low a concentration, the amount of collagen production is stimulated to be limited, and the preparation is a transparent preparation and cannot achieve the effect of whitening skin color.

Therefore, the technical scheme of the invention is provided.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a type I collagen suspension medicament and a preparation method thereof. The I type collagen suspension medicament is a medicament which is sterile, can reduce embolism risk, has proper concentration for stimulating regeneration and excellent diffusion capacity, is an ultrafine structure suspension medicament which is not easy to embolism and has sufficient effective concentration due to scientific compatibility of all components, and particularly has good diffusion effect on tissues which are lack of collagen due to aging at the periphery of an injection. After contacting collagen, each layer of soft tissue can be woven into the net and enter the original collagen fiber net, the position and the function of part of the original tissue structure are recovered, and finally the face is in a young state. In general, the subcutaneous fat compartment can be restored, and the ligament can recover elasticity; the skin color is bright, and the elasticity is enhanced; the deep fat pad on the face is elastic and three-dimensional, and finally the whole face is full, young, smooth and gully-free; the preparation process is simple and easy to control, and is beneficial to large-scale output.

The invention provides a type I collagen suspension medicament, which comprises the following raw materials: type I collagen and vitamin B₁₂Normal saline and anesthetic.

Preferably, the type I collagen suspension medicament comprises the following raw materials in parts by volume: 1-2 parts of type I collagen and vitamin B₁₂0.5-1 part of normal saline, 1-2 parts of anesthetic and 0.5-1 part of water.

Preferably, the type I collagen suspension medicament comprises the following bodyVolume portion of raw materials: 1 part of type I collagen and vitamin B₁₂0.5 part, 1 part of normal saline and 0.5 part of anesthetic.

Preferably, the vitamin B₁₂The concentration was 0.25 mg/mL.

Preferably, the type I collagen is double skin-beautifying; the type I collagen concentration is 30 mg/mL.

Preferably, the anesthetic is lidocaine; the concentration of the lidocaine is 0.02 g/mL.

Based on the same technical concept, another aspect of the present invention is to provide a method for preparing a type I collagen suspension medicament, comprising: adding vitamin B to type I collagen₁₂And normal saline and anesthetic are injected repeatedly to obtain the I type collagen suspension medicament.

Preferably, the repeated bolus injection is performed for 75-80 times in a double-pass repeated bolus injection mode.

Based on the same technical concept, the invention further provides a use method of various collagen type I suspension medicaments, which comprises the following steps:

(1) determining an object: for women between 30 and 50 years old, soft and drooping facial soft tissues, poor skin color, obvious ligament groove, facial fat layer fracture, poor continuous feeling and deep fat pad hernia to form the sheep cheek are mainly selected;

(2) cleaning the face: adopting a commercially available facial cleanser as a determined object to clean the face;

(3) skin detection: detecting skin condition of a determined object, aging condition of facial skin, etc.;

(4) disinfecting facial skin: wiping the face of the determined object with 75% medical alcohol for disinfection;

(5) injection of suspension medicament: nutrition is given in the important ligament area of the face, and periorbital ligament, zygomatic arch ligament, deep fat pad (buccal fat pad), subcutaneous superficial fat compartment are mainly injected.

Wherein, the injection is to inject the type I collagen suspension medicament into the corresponding part, and the mode is as follows: comprises 90-degree vertical column pulling and 45-degree inclined needle insertion administration. A blunt needle enters adipose tissues to inject a type I collagen suspension medicament as a main method, and a 30G sharp needle is matched for injection in a local ligament area and a cheek fat pad area.

The specific dosage of the type I collagen suspension medicament is as follows: 1.0mL of superficial fat chamber on temporal part and eyebrow, 0.5mL of deep fat pad on temporal part, 0.5mL of fat chamber in cheek and anterior labial sulcus, 1.0mL of fat chamber in cheek and external cheek, 0.7mL of superficial tissue under external canthus, 1.0mL of deep fat pad, 0.5mL of orbital ligament, 0.5mL of soof0.5mL of zygomatic ligament and 0.3mL of sulcus facialis.

The theoretical basis of the invention is as follows: the literature has proved that the collagen protein implanted into human body can stimulate the regeneration capacity of collagen blast cells to be enhanced, and finally, the result of collagen fiber regeneration is achieved. All facial tissues are aged closely related to collagen loss, and the stimulation of collagen regeneration can restore adipose tissues, restore the elasticity of facial supporting ligaments, tighten fascia, restore the color and elasticity of skin and the like. The combined effect is that the facial skin and other soft tissues can improve the aging signs and show the effect of state rejuvenation. Based on the above theory, the present invention provides a type I collagen suspension preparation which is sterile, can reduce the risk of embolism, has a concentration suitable for stimulating regeneration, and has excellent diffusion ability. The preparation method is simple and effective, and has wide application.

The invention has the beneficial effects that:

1. the I type collagen suspension medicament is scientifically compatible among the components, is an ultrafine structure suspension which is not easy to embolise and has enough effective concentration, and particularly has good diffusion effect on tissues which are lack of collagen at the periphery of an injection part due to aging. After contacting collagen, each layer of soft tissue can be woven into the net and enter the original collagen fiber net, the position and the function of part of the original tissue structure are recovered, and finally the face is in a young state. In general, the subcutaneous fat compartment can be restored, and the ligament can recover elasticity; the skin color is bright, and the elasticity is enhanced; the deep fat pad on the face is elastic and three-dimensional, and finally the whole face is full, young, smooth and has no gully.

2. The preparation method of the type I collagen suspension medicament has simple and easily controlled preparation process and is beneficial to large-scale production.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

The embodiment provides a preparation method of a type I collagen suspension medicament, which specifically comprises the following steps:

taking 1mL of double skin-beautifying soft skin (concentration is 30mg/mL), and respectively adding 0.5mL of vitamin B₁₂(the concentration is 0.25mg/mL), 1mL of physiological saline and 0.5mL of lidocaine (the concentration is 0.02g/mL), and the type I collagen suspension medicament is obtained by injecting 80 times repeatedly in a double-pass way.

Example 2

The embodiment provides a preparation method of a type I collagen suspension medicament, which specifically comprises the following steps:

2mL of type I collagen (30 mg/mL) was added with 0.5mL of vitamin B₁₂(the concentration is 0.25mg/mL), 2mL of physiological saline and 0.5mL of anesthetic, and the type I collagen suspension medicament is obtained by injecting the mixture twice and repeatedly for 75 times.

Example 3

The embodiment provides a preparation method of a type I collagen suspension medicament, which specifically comprises the following steps:

1mL of type I collagen (30 mg/mL) was added with 0.75mL of vitamin B₁₂(the concentration is 0.25mg/mL), 1mL of physiological saline and 0.75mL of anesthetic, and the type I collagen suspension medicament is obtained by injecting the mixture twice and repeatedly for 75 times.

Application example 1

The application example provides an application method of a type I collagen suspension medicament, which specifically comprises the following steps:

(1) selecting a 43 year old female with a sagging of the capsular bag of the mouth, the female having no other significant signs of aging on the face;

(2) 2mL of the prepared I-type collagen suspension medicament is taken, and the left 1mL and the right 1mL of the I-type collagen suspension medicament are injected into a cheek fat pad area respectively; after injection, the effects of fat pad replacement, mouth angle pocket shrinkage and lower face lifting can be seen.

Note: the prepared type I collagen suspension medicament is used within 15min at room temperature.

Application example 2

The application example provides an application method of a type I collagen suspension medicament, which specifically comprises the following steps:

(1) selecting a 47 year old female with photoaging skin, wherein the female has rough skin texture, dark skin, large pores and obvious fine lines;

(2) uniformly injecting the prepared I-type collagen suspension medicament into facial dermis of the female; through long-term observation, the female has the advantages that the facial skin elasticity is recovered, pores are fine and smooth, the photoaging condition is obviously improved, and the facial whitening effect is good.

Note: the prepared type I collagen suspension medicament is used within 15min at room temperature.

Application example 3

The application example provides an application method of a type I collagen suspension medicament, which specifically comprises the following steps:

(1) selecting a 45-year-old female with obvious periorbital comprehensive aging symptoms, wherein the female has lacrimal canals, pouch and loose skin;

(2) taking the prepared I-type collagen suspension medicament, and uniformly penetrating and injecting the I-type collagen suspension medicament into tissues of all layers around the female orbit; by long-term observation (within 6 months), the periorbital of the female has remarkable rejuvenation improvement, and the improvement is balanced from deep layer to superficial layer, specifically, the eye pouch is reduced, the lacrimal groove is smoothed, and the skin elasticity is recovered.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.