阅读说明：本技术 一种软胶囊装量差异检查装置及其检查方法 (Soft capsule loading difference inspection device and inspection method thereof ) 是由 周飞飞 朱振羽 潘卫平 于 2021-06-29 设计创作，主要内容包括：本发明公开了一种软胶囊装量差异检查装置及其检查方法,该量差异检查装置包括箱体和设置于箱体顶部的箱盖,其中：箱盖的中部垂直设置有转轴,转轴中部装配位上套设有可上下移动的装载板,装载板的底部均布有若干用于装载软胶囊的镂空腔体,且箱体的底部设置有若干与镂空腔体相配合的切割刀片。本发明的软胶囊装量差异检查装置及其检查方法可同时将多粒软胶囊进行固定、剪切及甩干,实验条件趋于一致；软胶囊在剪切过程中不用手接触,不易造成切割伤害,安全性高；且升起后旋转甩干过程中可以短时间吹干胶皮,保证了胶皮具有较高的清洁度。(The invention discloses a soft capsule loading difference checking device and a checking method thereof, wherein the soft capsule loading difference checking device comprises a box body and a box cover arranged at the top of the box body, wherein: the middle part of the box cover is vertically provided with a rotating shaft, a loading plate capable of moving up and down is sleeved on an assembling position in the middle of the rotating shaft, a plurality of hollow cavities for loading soft capsules are uniformly distributed at the bottom of the loading plate, and a plurality of cutting blades matched with the hollow cavities are arranged at the bottom of the box body. The soft capsule loading difference inspection device and the inspection method thereof can fix, shear and spin-dry a plurality of soft capsules at the same time, and the experimental conditions tend to be consistent; the soft capsule is not contacted with hands in the shearing process, so that the cutting injury is not easy to cause, and the safety is high; and the rubber can be dried in a short time in the rotary drying process after being lifted, so that the rubber is ensured to have higher cleanliness.)

1. The soft capsule loading difference inspection device is characterized by comprising a box body (1) and a box cover (2) arranged at the top of the box body (1), wherein: the middle part of case lid (2) is provided with pivot (3) perpendicularly, the cover is equipped with loading plate (5) that can reciprocate on pivot (3) middle part assembly position (7), the bottom equipartition of loading plate (5) has a plurality of hollow cavity bodies (6) that are used for loading the softgel, just the bottom of box (1) be provided with a plurality of with hollow cavity body (6) matched with cutting blade (11).

2. The soft capsule loading difference inspection apparatus according to claim 1, wherein the upper end of the rotary shaft (3) is connected to a servo motor (4) shaft provided at the top of the case cover (2).

3. The soft capsule loading difference inspection apparatus according to claim 1, wherein a return spring (8) is fitted around the middle of the rotary shaft (3), and the upper end of the return spring (8) abuts against the loading plate (5) and the lower end abuts against the bottom of the loading block (7).

4. The device for checking the difference in the amount of soft capsules according to claim 1, wherein the fitting site (7) is provided with a guide strip (12) along its length, the guide strip (12) being fitted with a guide groove of the inner hole of the loading plate (5).

5. The soft capsule loading difference inspection apparatus according to claim 1, wherein the loading site (7) is provided with an external thread in a longitudinal direction thereof, the external thread being engaged with an internal thread of an inner hole of the loading plate (5).

6. The soft capsule loading difference inspection device according to claim 1, wherein a support column (9) is vertically provided at the bottom of the case (1), and the upper end of the support column (9) is connected to the lower end of the rotary shaft (3) in an embedded manner.

7. The soft capsule loading difference inspection device according to claim 6, wherein a fixing plate (10) is provided at a middle portion of the support column (9), and the fixing plate (10) is provided with a plurality of the cutting blades (11) arranged vertically.

8. The soft capsule loading difference inspection device according to claim 1, wherein a drain line (14) is provided at the bottom of the case (1), and an electromagnetic valve is provided in the drain line (14).

9. A method for checking the difference of soft capsule filling amount is characterized by comprising the following steps:

(1) providing the soft capsule loading difference inspection apparatus according to any one of claims 1 to 8, and charging a cleaning solvent into the case (1);

(2) soft capsules are filled in a plurality of hollow cavities (6) at the bottom of the loading plate (5), and then the box cover (2) is integrally assembled on the box body (1);

(3) controlling the loading plate (5) to move downwards and sink into the cleaning solvent, and shearing the soft capsules in the corresponding hollow cavity body (6) through the cutting blade (11) to release the content in the soft capsules to be dissolved in the cleaning solution;

(4) controlling the loading plate (5) to move upwards to be above the liquid level of the solvent, rotating the loading plate (5) through the rotating shaft (3), and drying rubber in the hollow cavity (6) in a drying way;

(5) calculation of the amount of difference: the loading difference limit is (net weight-average value of each capsule)/average value × 100%.

10. The soft capsule loading difference inspection method according to claim 9, wherein the loading plate (5) is moved downward in step (3) by manual pressing or is driven by a servo motor (4), and the loading plate (5) is rotated in step (4) by the servo motor (4).

Technical Field

The invention relates to the technical field of capsule quality inspection, in particular to a soft capsule loading difference inspection device and an inspection method thereof.

Background

The soft capsule belongs to a packaging mode of capsules, and is commonly used in medicines or health-care foods. It is a capsule prepared by processing liquid medicine or liquid solid medicine and sealing the liquid medicine or the liquid solid medicine in a soft capsule material. The soft capsule wall material is prepared by encapsulating a certain amount of liquid medicine directly or dissolving or dispersing solid medicine in a proper excipient to prepare solution, suspension, emulsion or semisolid, and sealing in a spherical or elliptic soft capsule wall material, wherein the gelatin, the glycerol or other proper pharmaceutical excipients are used for independent or mixed preparation of the capsule.

At present, according to the standard of Chinese pharmacopoeia, the soft capsules with content uniformity which are not checked are checked according to the regulations. The existing industry has no specific specified equipment, a differential weighing method is generally adopted in the industry, in the process, a capsule needs to be manually cut off, the content is cleaned by using a volatile solvent such as diethyl ether and the like, and the volatile solvent is placed in a ventilation position to volatilize the solvent completely. In the actual operation process, because one particle needs to be cut off separately, the experiment period is prolonged, and the error of the experiment data is easily caused.

Disclosure of Invention

The invention provides a soft capsule loading difference inspection device and an inspection method thereof, which can be used for operations such as soft capsule shearing, flushing, spin-drying and the like, and aims to solve the problems in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme:

the first aspect of the present invention provides a soft capsule loading difference inspection device, comprising a box body and a box cover arranged on the top of the box body, wherein: the soft capsule loading device is characterized in that a rotating shaft is vertically arranged in the middle of the box cover, a loading plate capable of moving up and down is sleeved on an assembly position in the middle of the rotating shaft, a plurality of hollow cavities for loading soft capsules are uniformly distributed at the bottom of the loading plate, and a plurality of cutting blades matched with the hollow cavities are arranged at the bottom of the box body.

Further, on the soft capsule loading difference inspection device, the upper end of the rotating shaft is connected with a servo motor shaft arranged on the top of the box cover.

Furthermore, on the soft capsule loading difference inspection device, a return spring is sleeved in the middle of the rotating shaft, the upper end of the return spring is abutted against the loading plate, and the lower end of the return spring is abutted against the bottom of the loading position.

Furthermore, on the soft capsule loading quantity difference checking device, a guide strip is arranged on the loading position along the length direction of the loading position, and the guide strip is matched with a guide groove of an inner hole of the loading plate.

Furthermore, on the soft capsule loading quantity difference checking device, an external thread is arranged on the loading position in the length direction, and the external thread is matched with the internal thread of the inner hole of the loading plate.

Furthermore, on the soft capsule loading difference inspection device, a support column is vertically arranged at the bottom of the box body, and the upper end of the support column is connected with the lower end of the rotating shaft in an embedded manner.

Furthermore, on the soft capsule loading difference inspection device, an embedded block is arranged at the lower end of the rotating shaft and is matched with an embedded groove at the top of the supporting column.

Further preferably, on the soft capsule loading difference inspection device, a fixing plate is arranged in the middle of the supporting column, and a plurality of cutting blades which are vertically arranged are arranged on the fixing plate.

Further preferably, in the soft capsule loading difference inspection device, the fixing plate is fixedly connected with the middle part of the supporting column, and the bottom of the supporting column is connected with the lifting cylinder.

Further preferably, in the soft capsule loading difference inspection device, the fixing plate is in threaded connection with the middle of the supporting column, and the bottom shaft of the supporting column is connected with a lifting motor.

Further preferably, in the soft capsule loading difference inspection device, the outer edge of the fixed plate is provided with a guide block, and the guide block is embedded in a guide groove formed in the inner side wall of the box body.

Furthermore, on the soft capsule loading difference inspection device, a liquid discharge pipeline is arranged at the bottom of the box body, and an electromagnetic valve is arranged on the liquid discharge pipeline.

Further, in the soft capsule loading difference inspection device, the box body and the box cover are made of insulating materials.

Further, on the soft capsule loading difference inspection device, the rotating shaft, the loading plate, the fixing plate and the cutting blade are made of stainless steel.

The second aspect of the present invention provides a method for checking a difference in soft capsule filling amount, comprising the steps of:

(1) providing a soft capsule loading quantity difference checking device according to any one of the above, and filling a cleaning solvent into a box body;

(2) soft capsules are filled into the hollow cavities at the bottom of the loading plate, and then the box cover is integrally assembled on the box body;

(3) controlling the loading plate to move downwards and sink into the cleaning solvent, cutting the soft capsules in the corresponding hollow cavities by a cutting blade, and releasing the content in the soft capsules to be dissolved in the cleaning solution;

(4) controlling the loading plate to move upwards to a position above the liquid level of the solvent, and rotating the loading plate through a rotating shaft to spin-dry the rubber in the hollow cavity;

(5) calculation of the amount of difference: the loading difference limit is (net weight-average value of each capsule)/average value × 100%.

Further, the downward movement of the loading plate in the step (3) is driven by a manual press or a servo motor, and the rotation of the loading plate in the step (4) is driven by a loading plate.

By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:

(1) the stability is good: the equipment simultaneously fixes a plurality of soft capsules independently, and the heights and relative positions of the soft capsules are good in uniformity, so that the experimental conditions tend to be consistent; the soft capsule is not easy to be broken by shearing and is thoroughly cleaned in a solvent; the lower weight and the upper weight of the water flow system are more stable in a counterweight mode;

(2) the cleanliness is high: because the cut soft capsule can be directly contacted with the solvent, the dissolution of the content is accelerated; the equipment does not need to be heated, and the requirement on temperature is extremely low; the air flow in the rotary drying process after the lifting is favorable for the volatilization of the solvent, and the rubber can be dried in a short time;

(3) the observation is convenient: the inspection device fixes each soft capsule independently through the hollow cavities distributed on the loading plate, so that disorder is not easy to occur, and personnel can observe the rupture condition of the soft capsule conveniently;

(4) the safety is high: the inspection device automatically cuts the soft capsules by using the cutting blade, does not need to be contacted by hands when cutting the soft capsules with certain hardness, and is not easy to cause cutting injury;

(5) the application range is wide: the box body is made of stainless steel, so that the box body is not easy to react with most organic solvents, equipment is not easy to corrode, and the box body is easy to clean.

Drawings

FIG. 1 is a schematic view of the overall structure of an automatic shearing and washing device for detecting soft capsule loading of the present invention;

FIG. 2 is a schematic view of a front view assembly structure of a rotary shaft and a loading plate in the automatic soft capsule loading detection shearing and washing device of the present invention;

FIG. 3 is a schematic view of a three-dimensional assembly structure of a rotating shaft and a loading plate in the automatic soft capsule loading detection shearing and washing device of the present invention;

FIG. 4 is a schematic view of a three-dimensional assembly structure of the loading plate of the automatic soft capsule loading detection shearing and washing device of the present invention with an elastic latch on the top;

wherein the reference symbols are:

1-box body, 2-box cover, 3-rotating shaft, 4-servo motor, 5-loading plate, 6-hollowed cavity, 7-assembly position, 8-reset spring, 9-support column, 10-fixing plate, 11-cutting blade, 12-guide bar, 13-embedded block, 14-drainage pipeline, 15-elastic pressing sheet, 16-lock catch seat and 17-lock catch convex rib.

Detailed Description

The present invention will be described in detail and specifically with reference to the following examples to facilitate better understanding of the present invention, but the following examples do not limit the scope of the present invention.

Example 1

As shown in figure 1, the device for checking the soft capsule filling quantity difference can be used for operations of shearing, washing, spin-drying and the like of soft capsules. The loading difference checking device mainly comprises a box body 1, a box cover 2 arranged at the top of the box body 1, a cutting blade 11 arranged in the box body 1, a rotating shaft 3 arranged on the box cover 2 and a loading plate 5. Specifically, the middle part of the box cover 2 is vertically provided with a rotating shaft 3, a loading plate 5 capable of moving up and down is sleeved on an assembling position 7 in the middle part of the rotating shaft 3, and the loading plate 5 is limited in the assembling position 7 to move up and down or rotate.

In order to realize the shearing of the soft capsules in the up-and-down moving process of the loading plate 5 and simultaneously realize the spin-drying of the rubber sheet along with the rotation of the rotating shaft 3 in the subsequent process, a guide strip 12 is arranged on the assembly position 7 along the length direction of the assembly position, and the guide strip 12 is matched with a guide groove of an inner hole of the loading plate 5. On one hand, the loading plate 5 can move up and down along the length direction of the guide strip 12, so that the loading plate 5 can descend or ascend under the action of external force pressing; on the other hand, the loading plate 5 is buckled on the guide strip 12 through the guide groove on the inner hole, so that the loading plate 5 can synchronously rotate along with the rotating shaft 3, and the rubber sheet on the loading plate 5 after the content is released is dried.

In addition, for improving work efficiency, still through the middle part cover at pivot 3 being equipped with reset spring 8, reset spring 8's upper end and loading plate 5 butt, the lower extreme is with the bottom butt of assembly position 7, loading plate 5 is located above the liquid level all the time under the effect of not receiving the external force through reset spring 8, when receiving external force to press down, reset spring 8 receives compression loading plate 5 and sinks and immerses in the washing liquid, after the softgel is cuted and is accomplished, cancel and press down, loading plate 5 upwards rises to the liquid level top automatically under reset spring 8's effect, then the action of spin-drying next step, need not manual lifting loading plate 5, and guaranteed that loading plate 5 can not immerse the washing liquid once more at the rotation in-process.

In the present embodiment, as shown in fig. 1, the loading plates 5 are arranged in one-to-one correspondence with the cutting blades 11 up and down during the cutting process. Specifically, the bottom equipartition of loading plate 5 has a plurality of hollow cavity bodies 6 that are used for loading the soft capsule, and hollow cavity body 6 is similar oval structure, and its size and soft capsule shape phase-match, the bottom opening of hollow cavity body 6 are greater than the open-top, are convenient for fill in the hollow cavity body 6 with soft capsule from the bottom opening. And the bottom of box 1 is provided with a plurality of cutting blade 11 with hollow cavity body 6 matched with, and cutting blade 11 can make fixed setting also can the oscilaltion setting, and through cutting blade 11 and loading plate 5's relative movement, the one-to-one aims at the interior softgel of hollow cavity body 6 and cuts to the content of release softgel is in the washing liquid.

In this embodiment, as shown in fig. 1, the rotation of the rotating shaft 3 can be achieved manually or electrically, for example, a hand crank connected to the top end of the rotating shaft 3 is provided on the box cover 2, and the rotating shaft 3 is controlled to rotate manually. If the upper end of the rotating shaft 3 is connected with a servo motor 4 shaft arranged at the top of the box cover 2, the rotating shaft 3 is electrically controlled to rotate through the servo motor 4, power is provided for the whole equipment, and the rotating time and the rotating speed of the whole equipment can be operated according to preset parameters.

In this embodiment, as shown in fig. 1, a fixing plate 10 is disposed in the middle of the supporting column 9, a plurality of cutting blades 11 vertically disposed are mounted on the fixing plate 10, and the cutting blades 11 correspond to the hollow cavities 6 on the loading plate 5 one to one.

In this embodiment, as shown in fig. 1, a liquid discharge pipe 14 is provided at the bottom of the tank 1, and an electromagnetic valve is provided on the liquid discharge pipe 14 for discharging the solvent of the tank 1, and the tank can be cleaned to discharge the waste liquid.

In this embodiment, the box body 1 and the box cover 2 are made of insulating materials, the box body 1 and the box cover 2 are used for containing a solvent, and are isolated from the outside to prevent static electricity, and the contained solvent is used for cleaning a rubber sheet after the soft capsules are cut.

The rotating shaft 3, the loading plate 5, the fixing plate 10 and the cutting blade 11 are made of stainless steel, such as 304 stainless steel, which is not easy to react with most organic solvents, so that the equipment is not easy to corrode and is easy to clean.

Example 2

The present embodiment provides a device for checking the loading difference of soft capsules for cutting, washing, spin-drying, etc. operations of soft capsules, which also mainly comprises a box body 1, a box cover 2 arranged on the top of the box body 1, a cutting blade 11 arranged in the box body 1, and a rotating shaft 3 and a loading plate 5 arranged on the box cover 2.

Different from the embodiment 1, the assembly position 7 is provided with an external thread in the length direction, the external thread is matched with the internal thread of the inner hole of the loading plate 5, the middle part of the rotating shaft 3 is sleeved with a return spring 8, the upper end of the return spring 8 is abutted to the loading plate 5, and the lower end of the return spring is abutted to the bottom of the assembly position 7. The screw rod adjusting mechanism is composed of a rotating shaft 3 and a loading plate 5, and when the rotating shaft 3 rotates at a certain speed, the loading plate 5 can overcome the acting force of a position spring 8 under the action of the self gravity and centrifugal force and move up and down along threads on the rotating shaft 3 along with the rotation of the rotating shaft 3.

Specifically, the rotating shaft 3 is controlled by the servo motor 4 to rotate counterclockwise at a certain speed, so as to drive the loading plate 5 to move downwards to sink into the cleaning solution against the upward force of the return spring 8, thereby completing the soft capsule shearing action in cooperation with the cutting blade 11. When the servo motor 4 stops moving, the loading plate 5 moves upward along the screw thread by the upward force of the return spring 8 to disengage the loading plate 5 from the liquid surface. In addition, in the process, when the upward acting force of the return spring 8 is not enough to push the loading plate 5 to be separated from the liquid surface, the servo motor 4 can be started to operate clockwise, the loading plate 5 is separated from the liquid surface under the comprehensive action of the gravity of the loading plate 5 and the like driven by the rotating shaft 3, then the rotating speed of the rotating shaft 3 is increased, the loading plate 5 is enabled to rise to the top of the assembling position 7 and to be in contact with the rotating shaft 3 to increase the friction force between the loading plate and the rotating shaft, the loading plate 5 can rotate at a high speed along with the rotating shaft 3, and the spin-drying of the rubber is achieved.

Different from the embodiment 1 in which two driving manners, namely manual driving and electric driving, are adopted, in this embodiment, only the electric driving manner is adopted, and the lead screw transmission mechanism is matched to realize not only the up-and-down lifting of the loading plate 5 to complete the shearing action, but also the rotation of the loading plate 5 to complete the spin-drying action, and the rotation speed and time of the servo motor 4 can be calculated according to the requirements of the descending, ascending and rotating of the loading plate 5. This dress volume difference inspection device of modified need not the manual work and presses the shearing, and degree of automation is high, has improved inspection efficiency greatly, and labour saving and time saving.

Example 3

Different from the above embodiments 1 and 2, a support column 9 is vertically arranged at the bottom of the box body 1, and the upper end of the support column 9 is connected with the lower end of the rotating shaft 3 in a fitting manner. Specifically, the lower end of the rotating shaft 3 is provided with an insert 13, and the insert 13 is arranged in a matching way with an insert groove at the top of the supporting column 9. After the whole box cover 2 is loaded with soft capsules on the loading plate 5, the whole box cover is integrally placed on the box body 1, and the embedded block 13 at the lower end of the rotating shaft 3 is aligned to the embedded groove at the top of the supporting column 9, so that the stability of the rotating shaft 3 in the rotating process is ensured.

In one embodiment, the fixing plate 10 is fixedly connected to the middle of the supporting column 9, and the bottom of the supporting column 9 is connected to the lifting cylinder. The cutting blade on the fixed plate 10 is controlled by the lifting cylinder to move upwards to puncture the soft capsules. Through the design of the lifting cylinder, the shearing efficiency can be improved by matching with the loading plate 5 to perform relative movement.

In another embodiment, the fixing plate 10 is in threaded connection with the middle of the supporting column 9, and the bottom shaft of the supporting column 9 is connected with a lifting motor. And the edge of the outer side of the fixed plate 10 is provided with a guide block which is embedded in a guide groove arranged on the inner side wall of the box body 1. The fixed plate 10 is controlled by the lifting motor to move up and down on the supporting columns 9, and the relative movement with the loading plate 5 can also be realized.

Example 4

Different from the above embodiments 1, 2 and 3, as shown in fig. 4, a plurality of hollow cavities 6 for loading soft capsules are uniformly distributed at the bottom of the loading plate 5, the hollow cavities 6 are in an ellipse-like structure, the size of the hollow cavities 6 is matched with the shape of the soft capsules, the bottom opening of the hollow cavities 6 is smaller than the top opening, and the soft capsules are loaded from the top opening. And an elastic lock catch is arranged at the hollow cavity body 6 and comprises an elastic pressing sheet 15 and a lock catch seat 16 matched with the elastic pressing sheet, and a lock catch convex rib 17 matched with a movable pressing sheet of the elastic pressing sheet 15 is arranged on the inner side wall of the lock catch seat 16. When in use, the movable pressing sheet of the elastic pressing sheet 15 is pressed into the locking seat 16, so that the soft capsule can be fixed in the hollow cavity body 6 to prevent the soft capsule from moving out.

Example 5

As shown in fig. 1, the present embodiment provides a method for checking a difference in soft capsule loading, including the following steps:

(1) providing a soft capsule loading amount difference inspection device as in example 1, example 2 or example 3, and loading a cleaning solvent into a case 1;

(2) soft capsules with the weight of m1 are filled in the hollow cavities 6 at the bottom of the loading plate 5, and then the box cover 2 is integrally assembled on the box body 1;

(3) controlling the loading plate 5 to move downwards to sink into the cleaning solvent, cutting the soft capsules in the corresponding hollow cavity 6 through the cutting blade 11, and releasing the content in the soft capsules to be dissolved in the cleaning solution;

(4) controlling the loading plate 5 to move upwards to be above the liquid level of the solvent, rotating the loading plate 5 through the rotating shaft 3, spin-drying the rubber in the hollow cavity 6, and respectively calculating the weight m2 of the rubber;

(5) calculation of the amount of difference: the loading difference limit is (net weight-average value of each capsule)/average value multiplied by 100%, wherein the net weight of each capsule is m 1-weight of each soft capsule m2, and the average value refers to the average value of the net weight (content) of a plurality of capsules.

As in the above embodiments 1 and 2, the loading plate 5 is moved downwards in step (3) by manual pressing or by the servo motor 4, and the loading plate 5 is rotated in step (4) by the servo motor 4, which is selected according to the requirement.

The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.