阅读说明：本技术 一种含水溶性大麻二酚的压片糖果及其制备方法 (Tabletting candy containing water-soluble cannabidiol and preparation method thereof ) 是由 王钲霖 刘胜贵 薛红芬 李智高 孔令羽 于 2021-01-27 设计创作，主要内容包括：本发明公开了一种含水溶性大麻二酚的压片糖果及其制备方法,属于食品技术领域。本发明所述糖果添加了植物源活性成分―火麻仁蛋白和水溶性大麻二酚,二者同源于工业大麻,配合使用可充分发挥协同效应。该压片糖果为一种低糖型糖果,营养丰富,甜度适中,长期食用具有润肠通便、安神助眠、延缓衰老的保健功效,同时还可辅助调理精神情志,提高机体免疫力,适合广大消费人群。(The invention discloses a tabletting candy containing water-soluble cannabidiol and a preparation method thereof, belonging to the technical field of food. The candy of the invention is added with plant source active ingredients, namely hemp seed protein and water-soluble cannabidiol, which are homologous with industrial hemp and can fully exert synergistic effect when being matched with the industrial hemp. The tablet candy is a low-sugar candy, has rich nutrition and moderate sweetness, has the health-care effects of relaxing bowel, soothing nerves, helping sleep and delaying senility after being eaten for a long time, can assist in regulating spirits and emotion and improving the immunity of the organism, and is suitable for wide consumer groups.)

1. The invention discloses a tabletting candy containing water-soluble cannabidiol and a preparation method thereof, which are characterized in that the candy comprises the following components (by mass percent): 0.1-10% of water-soluble cannabidiol, 20-30% of fructus cannabis protein powder, 40-50% of isomalt, 10-15% of microcrystalline cellulose, 5-10% of maltodextrin, 0.1-0.3% of edible essence and 0.1-0.5% of magnesium stearate.

2. The sheeted candy containing water soluble cannabidiol according to claim 1 and the method of making the same, wherein the method of making the candy comprises the steps of:

s1, mixing materials: accurately weighing water-soluble cannabidiol, fructus cannabis protein powder, isomaltitol, microcrystalline cellulose, maltodextrin and edible essence according to the formula ratio, and uniformly mixing to obtain mixed powder;

s2, granulating: adding purified water into the mixed powder to prepare a soft material, and then granulating, drying, sieving and grading to obtain mixed granules;

s3, tabletting: and (3) uniformly mixing the mixed granules with magnesium stearate according to the formula ratio, and tabletting to obtain the tabletting candy.

3. The tabletted candy comprising cannabidiol in a water soluble content and the preparation method thereof as claimed in claim 2, wherein the drying temperature in the step S2 is 40-55 ℃, the drying time is 4-8h, and the particle size is 1 mm; the weight of the tablets tabletted in the step S3 was 0.5 g.

4. The tabletting candy containing water soluble cannabidiol as claimed in claims 1-2, wherein the fructus cannabis protein powder is obtained by physically shelling fructus cannabis, extracting oil with supercritical carbon dioxide extraction, and pulverizing.

5. The invention also provides a preparation method of the water-soluble cannabidiol, which comprises the following steps: firstly, dissolving high-purity CBD crystals by using 2-5 times of ethanol to form a solution; heating and dissolving cyclodextrin with 1-5 times of pure water or ethanol-water, adding the solution of step one after the cyclodextrin is completely dissolved, and stirring and mixing uniformly; clathrating, namely uniformly mixing the solution formed by the first step and the second step, carrying out cannabidiol clathration by using a high-pressure homogenization method, and after the clathration is finished, carrying out reduced pressure concentration by using a rotary evaporator to remove most of solvent and water; drying, and spray drying the material to obtain the water soluble cannabidiol.

6. The method of claim 5, wherein the cyclodextrin comprises α -cyclodextrin, β -cyclodextrin, γ -cyclodextrin, hydroxypropyl- β -cyclodextrin, hydroxyethyl- β -cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, carboxymethyl cyclodextrin, sulfobutyl ether- β -cyclodextrin; preferably any one or more of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

7. The method of claim 5, wherein the cannabidiol has a purity of greater than 99%.

8. The method of claim 5, wherein the amount of pure water is 1-5 times of the cyclodextrin by mass, and the temperature of heating and dissolving is 30-60 ℃; the step three is high-pressure homogenization, the homogenization treatment is carried out for 2 to 3 times, the pressure is 30 to 50MPa, and the temperature is 25 ℃; spray drying is carried out, the air inlet temperature is 100-.

Technical Field

The invention relates to the technical field of food, in particular to a tabletting candy containing water-soluble cannabidiol and a preparation method thereof.

Background

The tablet candy is a novel food form belonging to candy products. The traditional candy can only meet the requirement of human body for supplementing energy, and the health consciousness is more and more intense along with the improvement of the life quality of people, so that the development of functional candy food becomes a new trend of candy food development.

Hemp seed is an excellent source of dietary protein that is easily digestible and contains no gluten. Its total protein content of 34.6g/100g is comparable to that of soya, which is greater than that of nuts and other seeds, as well as milk products, meat, fish or poultry, and hemp is a very excellent source of protein. In addition, the fiber content of the hemp seed powder reaches 40 percent, and the hemp seed powder is the highest among all floured grains. The traditional Chinese medicine considers that the fructus cannabis has the main effects of tonifying spleen and deficiency, relaxing bowel, nourishing yin and moistening dryness, and has special curative effects on constipation, hypertension, high cholesterol and other diseases of the old.

Cannabidiol (CBD) is extracted from industrial cannabis, is the main active substance in cannabinoids, has no addiction and neurotoxicity, and is the first cannabinoids approved by the FDA for treating epilepsy. Research shows that CBD has a series of physiological activity functions of blocking breast cancer metastasis, resisting epilepsy, resisting anxiety, resisting insomnia, resisting depression and the like. In recent years, scientists also find that CBD is a powerful antioxidant, effectively removes free radicals in human bodies, and has the effects of resisting inflammation, delaying senescence, repairing lost cells and the like. However, since CBD is a fat-soluble compound, the water-insoluble nature limits the application area of cannabidiol, and its bioavailability is reduced by direct use. Therefore, improving the water solubility of CBD is a vital way to develop CBD series end products.

At present, functional tabletting candies are few in the market, and hemp seed protein powder and water-soluble cannabidiol serving as functional active substances are not added into tabletting candy foods, so that the market space is large.

Disclosure of Invention

In view of the above-mentioned problems and market prospects, the primary object of the present invention is to provide a tabletted confection comprising water-soluble cannabidiol.

The invention also aims to provide a preparation method of the tabletting candy.

The purpose of the invention is realized by the following technical scheme:

1. the tabletting candy containing water-soluble cannabidiol is prepared from the following components in percentage by mass:

0.1-10% of water-soluble cannabidiol, 20-30% of fructus cannabis protein powder, 40-50% of isomalt, 10-15% of microcrystalline cellulose, 5-10% of maltodextrin, 0.1-0.3% of edible essence and 0.1-0.5% of magnesium stearate.

The essence is conventional edible essence in the prior art, is added according to different flavor characteristics of products, and is not specifically limited in the invention.

2. The preparation method of the tabletting candy containing the water-soluble cannabidiol comprises the following steps:

s1, mixing materials: accurately weighing water-soluble cannabidiol, fructus cannabis protein powder, isomaltitol, microcrystalline cellulose, maltodextrin and edible essence according to the formula ratio, and uniformly mixing to obtain mixed powder.

S2, granulating: adding purified water into the mixed powder, making into soft material, granulating, drying, sieving, and grading to obtain mixed granule.

S3, tabletting: and (3) uniformly mixing the mixed granules with magnesium stearate according to the formula ratio, and tabletting to obtain the tabletting candy.

Further, in the step S2, the drying temperature is 40-55 ℃, and the drying time is 4-8 h; the particle size of the particles is 1 mm.

Further, the weight of the tablets tabletted in the step S3 was 0.5 g.

Furthermore, the fructus cannabis protein powder is prepared by physically shelling fructus cannabis, extracting oil by using a carbon dioxide supercritical extraction technology, obtaining the fructus cannabis protein, and crushing. 3. The invention also provides a preparation method of the water-soluble cannabidiol, which comprises the following steps: firstly, dissolving high-purity CBD crystals by using 2-5 times of ethanol to form a solution; heating and dissolving cyclodextrin with 1-5 times of pure water or ethanol-water, adding the solution of step one after the cyclodextrin is completely dissolved, and stirring and mixing uniformly; clathrating, namely uniformly mixing the solution formed by the first step and the second step, carrying out cannabidiol clathration by using a high-pressure homogenization method, and after the clathration is finished, carrying out reduced pressure concentration by using a rotary evaporator to remove most of solvent and water; drying, and spray drying the material to obtain the water soluble cannabidiol.

Further, the cyclodextrin comprises alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, carboxymethyl cyclodextrin and sulfobutyl ether-beta-cyclodextrin; preferably any one or more of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

Further, the consumption of pure water is 1-5 times of the mass of the cyclodextrin, and the heating and dissolving temperature is 30-60 ℃.

Further, the step III is high-pressure homogenizing, the homogenizing treatment is carried out for 2 to 3 times, the pressure is 30 to 50MPa, and the temperature is 25 ℃.

Further, the spray drying is carried out in the step (IV), the air inlet temperature is 100-.

The invention has the following advantages:

(1) the pressed candy is added with the plant source active ingredients of the hemp seed protein and the water-soluble cannabidiol, the hemp seed protein is rich in nutrition and has the effect of relaxing bowel, the cannabidiol is a main active substance of cannabinoids and has the physiological effects of calming, sleeping, resisting oxidation, resisting depression and the like, the cannabidiol and the cannabidiol are homologous to industrial hemp, and the synergistic effect can be fully exerted by matching.

(2) According to the invention, the water-insoluble cannabidiol is prepared into the water-soluble cannabidiol by a cyclodextrin inclusion method, so that the problem of solubility of the cannabidiol is solved, and the bioavailability of the cannabidiol is improved.

(3) The candy of the invention takes isomaltitol as a sweetener, has the advantages of high stability, low calorie, natural sweet taste, low hygroscopicity and the like, and is a low-sugar candy with moderate sweetness.

(4) The candy has the health-care effects of relaxing bowel, calming the nerves, helping sleep and delaying senility after being eaten for a long time, and can assist in conditioning spirits and improving the immunity of organisms.

Detailed Description

The present invention is further illustrated by, but is not limited to, the following examples.

Example 1

1. The preparation of water-soluble cannabidiol comprises the following steps:

accurately weighing 70g of cannabidiol solid powder and 350g of ethanol, and adding the powder and the ethanol into a 1L round-bottom flask with a single opening; mechanically stirring for 30min to dissolve cannabidiol solid completely; cooling to room temperature for later use after complete dissolution.

Accurately weighing 200g of alpha-cyclodextrin and 600g of first-grade purified water, adding the alpha-cyclodextrin and the first-grade purified water into a 2L single-mouth round-bottom flask, placing the flask into a water bath kettle at 40 ℃, and mechanically stirring for 30min to fully dissolve the alpha-cyclodextrin in the water to form a transparent solution; and (4) after the solution is completely dissolved, adding the solution in the step (i) into the solution at one time, and continuing stirring for 10 min.

Clathrating, pouring the mixed solution prepared in the step II into a high-pressure homogenizer, starting the high-pressure homogenizer, and homogenizing for 3 times at the pressure of 35MPa and the temperature of 25 ℃; after the high-pressure homogenization treatment is finished, a rotary evaporator is used for carrying out reduced pressure concentration, ethanol is removed, the vacuum degree is minus 0.1MPa, and the temperature is 70 ℃.

Spray drying, namely spray drying the reduced pressure concentrated solution, wherein the air inlet temperature is 180 ℃, the air outlet temperature is 70 ℃, and the feeding flow rate is 150 ml/h. To obtain water soluble cannabidiol powder.

2. A tabletting candy containing water-soluble cannabidiol comprises the following components in percentage by mass:

1.5% of water-soluble cannabidiol, 23% of fructus cannabis protein powder, 50% of isomalt, 15% of microcrystalline cellulose, 10% of maltodextrin, 0.2% of mint essence and 0.3% of magnesium stearate.

3. The preparation method of the tabletting candy containing the water-soluble cannabidiol comprises the following steps:

s1, mixing materials: accurately weighing water-soluble cannabidiol, fructus cannabis protein powder, isomaltitol, microcrystalline cellulose, maltodextrin and edible essence according to the formula ratio, and uniformly mixing to obtain mixed powder.

S2, granulating: adding purified water into the mixed powder, making into soft material, granulating, drying, sieving and grading to obtain mixed granule, wherein the drying temperature is 45 deg.C, the drying time is 6 hr, and the obtained granule diameter is 1 mm.

S3, tabletting: and (3) uniformly mixing the mixed granules with magnesium stearate according to the formula ratio, and tabletting to obtain the tabletting candy, wherein the weight of the tablets is 0.5 g.

Example 2

1. Water-soluble cannabidiol was prepared as in example 1.

2. A tabletting candy containing water-soluble cannabidiol comprises the following components in percentage by mass:

6.5% of water-soluble cannabidiol, 26% of fructus cannabis protein powder, 46% of isomalt, 13% of microcrystalline cellulose, 8% of maltodextrin, 0.2% of strawberry essence and 0.3% of magnesium stearate.

3. The preparation method of the tabletting candy containing water-soluble cannabidiol of the invention is the same as the example 1.

Example 3

1. Water-soluble cannabidiol was prepared as in example 1.

2. A tabletting candy containing water-soluble cannabidiol comprises the following components in percentage by mass:

10% of water-soluble cannabidiol, 30% of fructus cannabis protein powder, 40% of isomalt, 10% of microcrystalline cellulose, 9.5% of maltodextrin, 0.2% of rose essence and 0.3% of magnesium stearate.

3. The preparation method of the tabletting candy containing water-soluble cannabidiol of the invention is the same as the example 1.

The tabletted candy has the health-care effects of relaxing bowel, calming the nerves, helping sleep, delaying aging and the like through the synergistic effect of the fructus cannabis protein powder and the water-soluble cannabidiol contained in the tabletted candy, and can assist in conditioning spirit, delighting the body and mind and improving the immunity of the organism. The health-care effect of the present invention will be described below by specific examples.

Case one

Wangzhi, women, age 39, bank clerk, constipation, rough skin with fine lines, dark yellow skin. The tablet candy is taken 2 tablets in the morning and evening every day, after 3 months, constipation is obviously improved, defecation is normal every day, skin is improved regularly, fine wrinkles are reduced, and skin color is ruddy.

Case two

Old men, 14 years old, junior three students, poor sleep quality, dreaminess, frequent dizziness, weakness and poor resistance. The candy is taken 2 granules in the morning and evening every day, and after 3 months, the sleep is improved, the dream is poor, the mental state is good, and the body immunity is enhanced.

Case three

Li in Li Dynasty, female aged 67 years old, retired old, and had difficulty in falling asleep, frequent insomnia and perennial constipation. After eating 2 candies in the morning and at night every day and insisting for 3 months, the insomnia condition is obviously improved, the sleep is fast, the sleep quality is better, and the constipation condition is obviously improved.

Case four

Zhang, woman, 48 years old, high three main officers, often stay up all night, work and mental stress are great, insomnia and dreamful sleep are poor in sleep quality, and mood fluctuation is large. The candy is taken 2 granules in the morning and evening every day, and after 3 months, the sleep quality is obviously improved, no insomnia is caused, the mood is mild, and the mood is stable.

The above examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way. It will be apparent to those skilled in the art that equivalent embodiments or modifications without departing from the technical spirit of the present invention are within the scope of the present invention.