阅读说明：本技术 通用淀粉样蛋白相互作用基序(gaim) (General amyloid-interacting motifs (GAIM) ) 是由 R.克里什南 E.艾斯普 M.普罗奇斯基 R.费希尔 于 2019-06-14 设计创作，主要内容包括：本发明涉及噬菌体基因3蛋白(g3p)的通用淀粉样蛋白相互作用基序(GAIM)的变体及其融合蛋白。本发明的GAIM变体和融合蛋白被部分或完全去免疫化,并显示出对多种多样的淀粉样蛋白的优异结合和特异性,以及表现出增强的淀粉样蛋白重构和对淀粉样蛋白聚集的抑制。本发明进一步涉及核酸、载体、宿主细胞以及制备GAIM变体及其融合蛋白的方法。本发明还涉及药物组合物和提高噬菌体感染性的方法,检测淀粉样蛋白聚集体的方法,以及诊断和/或治疗与错误折叠和/或聚集的淀粉样蛋白相关的疾病的方法。(The present invention relates to variants of the universal amyloid-interacting motif (GAIM) of the bacteriophage gene 3 protein (g3p) and fusion proteins thereof. The GAIM variants and fusion proteins of the invention are partially or fully deimmunized and exhibit excellent binding and specificity for a wide variety of amyloid proteins, as well as exhibit enhanced amyloid remodeling and inhibition of amyloid aggregation. The invention further relates to nucleic acids, vectors, host cells and methods for making GAIM variants and fusion proteins thereof. The invention also relates to pharmaceutical compositions and methods of increasing bacteriophage infectivity, methods of detecting amyloid aggregates, and methods of diagnosing and/or treating diseases associated with misfolded and/or aggregated amyloid proteins.)