阅读说明：本技术 降血脂抗氧化压片糖果 (Blood fat reducing antioxidant tabletting candy ) 是由 白鹤松 于 2020-07-08 设计创作，主要内容包括：本发明公开一种降血脂抗氧化压片糖果,由下述重量份的原料组成：地龙蛋白粉100-200份、山楂提取物100-200份、荷叶提取物100-200份、白萝卜提取物100-200份和/或姜黄提取物100-200份、水蜜桃果粉400-600份、水蜜桃香精5-10份、异麦芽酮糖醇100-150份、微晶纤维素50-70份、羟丙基甲基纤维素10-20份、硬脂酸镁10-15份。本发明降血脂抗氧化压片糖果以山楂提取物、荷叶提取物、白萝卜提取物和姜黄提取物为主要功效成分,长期食用,具有良好的降血脂抗氧化作用。(The invention discloses a blood fat reducing antioxidant tabletting candy which is prepared from the following raw materials in parts by weight: 200 portions of earthworm protein powder, 200 portions of hawthorn extract, 200 portions of lotus leaf extract, 200 portions of white radish extract and/or 200 portions of turmeric extract, 400 portions of honey peach powder, 600 portions of honey peach essence, 150 portions of isomalt, 50-70 portions of microcrystalline cellulose, 10-20 portions of hydroxypropyl methyl cellulose and 10-15 portions of magnesium stearate. The blood fat reducing and oxidation resisting tablet candy takes the hawthorn extract, the lotus leaf extract, the white radish extract and the turmeric extract as main functional components, and has good blood fat reducing and oxidation resisting effects after being eaten for a long time.)

1. A blood fat reducing antioxidant tabletting candy is composed of the following raw materials: earthworm protein powder, hawthorn extract, lotus leaf extract, white radish extract and/or turmeric extract, honey peach fruit powder, honey peach essence, isomalt, microcrystalline cellulose, hydroxypropyl methyl cellulose and magnesium stearate.

2. The blood fat reducing and antioxidant tabletting candy is characterized by comprising the following raw materials in parts by weight: 200 portions of earthworm protein powder, 200 portions of hawthorn extract, 200 portions of lotus leaf extract, 200 portions of white radish extract and/or 200 portions of turmeric extract, 400 portions of honey peach powder, 600 portions of honey peach essence, 150 portions of isomalt, 50-70 portions of microcrystalline cellulose, 10-20 portions of hydroxypropyl methyl cellulose and 10-15 portions of magnesium stearate.

3. The blood lipid-lowering antioxidant tabletted candy as claimed in claim 1 or 2, wherein the preparation method of the white radish extract comprises the steps of:

s1 weighing 1-3kg of fresh white radish, and removing juice with a juicer to obtain white radish residues;

s2, putting the white radish slag into a drying oven at 60-70 ℃ for drying for 3-5 h;

s3, drying the white radish residues, and mixing the dried white radish residues according to the solid-to-liquid ratio (1-3): (1-3) adding the mixture into petroleum ether in a ratio of g/mL, and adding cyclodextrin; adding cyclodextrin 0.1-0.2 times of white radish residue, soaking at 25-30 deg.C for 18-24 hr, performing ultrasonic treatment for 1-3 hr with ultrasonic power of 1000-; obtaining a white radish extracting solution;

s4 distilling the radix Raphani extractive solution under reduced pressure to remove solvent to obtain radix Raphani extract.

4. The blood lipid-lowering antioxidant tabletted candy as claimed in claim 1 or 2, wherein the preparation method of the turmeric extract comprises the steps of:

s1 slicing turmeric, drying in a vacuum drying oven at 30-50 ℃, crushing, and sieving with a 150-mesh sieve of 100 meshes to obtain turmeric powder;

s2, adding 1-3g of turmeric powder into 20-40mL of 75-95% ethanol solution by mass fraction, adding 0.1-0.2g of ionic liquid and 0.2-0.4g of cyclodextrin, then performing microwave extraction for 20-40min, performing microwave power of 300-;

s3 distilling the supernatant under reduced pressure to remove solvent to obtain Curcuma rhizome extract.

5. The blood lipid-lowering antioxidant tabletted candy as claimed in claims 3 and 4, wherein the cyclodextrin is one or a mixture of two or more of α -cyclodextrin, β -cyclodextrin and γ -cyclodextrin.

6. The blood lipid-lowering antioxidant tabletted candy as claimed in claim 4, wherein the ionic liquid is one or a mixture of two or more of 1-methyl-3-ethylimidazole bromide, 1-methyl-3-n-butylimidazole bromide, 1-methyl-3-n-hexylimidazole bromide, 1-methyl-3-n-decylimidazole bromide and 1-methyl-3-n-dodecylimidazole bromide.

7. The method for preparing a blood fat reducing antioxidant tableting candy as claimed in any one of claims 1 to 6, which comprises the steps of:

(1) stirring earthworm protein powder, hawthorn extract, lotus leaf extract, white radish extract and/or turmeric extract, honey peach fruit powder, honey peach essence, isomaltitol and microcrystalline cellulose at the rotation speed of 300-; adding hydroxypropyl methyl cellulose, stirring at the rotation speed of 300 and 500 revolutions per minute for 10-20 minutes, uniformly mixing, and granulating by using a 10-20-mesh sieve to obtain wet granules;

(2) drying the wet granules in a drying oven at 40-60 deg.C for 8-15 hr, and grading with 10-30 mesh sieve to obtain dry granules;

(3) adding magnesium stearate into the dry granules, fully and uniformly mixing, and tabletting to prepare the candy tablets, wherein each tablet is 500 mg and 600mg to obtain the blood fat reducing and oxidation resisting tabletting candy.

Technical Field

The invention relates to the technical field of health-care food, in particular to a blood fat-reducing antioxidant tabletting candy.

Background

Turmeric, a dried rhizome of turmeric, a genus of curcuma of the family zingiberaceae, has been used for thousands of years and is widely used in the flavor, color, and pharmaceutical industries. The curcumin compounds are main active ingredients in turmeric, are diaryl heptane compounds derived from plants of Zingiberaceae, and are mainly present in rhizome of medicinal plants such as turmeric, tulip and zedoary. More than 40 curcumin compounds are separated from curcuma, wherein curcumin) is a main active substance, and since the curcumin compounds are firstly separated from plants in 1970 and the molecular structure is determined in 1910, the curcumin compounds have various biological activities such as blood fat regulation, antitumor, antiviral, anti-inflammatory and Alzheimer disease prevention through years of research, and partial pharmacological activities of the curcumin compounds are closely related to antioxidant effects.

However, curcumin has a significant disadvantage of low water solubility, instability under physiological conditions, low intestinal absorption, rapid metabolism in vivo, low bioavailability, and difficult absorption by human body, only a trace amount of curcumin molecules on the surface of the agglomerate are absorbed, and most curcumin is excreted out of the body.

Radix Raphani is also called Raphani, radix Pseudostellariae, and vegetable head, and is a one or two year old herb of Raphanus of Brassicaceae. The white radish and the extract thereof are used as food-borne plants, and the medicinal value and the clinical application prospect of the white radish are increasingly paid attention and paid attention by people. In recent years, radish extracts have been gaining attention because of their important regulatory effects in terms of antibacterial, antioxidant, antiviral, repairing intestinal wall damage, inhibiting cancer cell proliferation, and the like.

4-methylthio-3-butenyl isothiocyanate is an irritating bioactive ingredient found in radish. Research shows that the polypeptide has good effects on inhibiting cancer cell growth, resisting mutation, resisting oxidation, regulating blood lipid metabolism and the like. But it is unstable in nature and is easily hydrolyzed to 3-hydroxy-methylene-2-thiopyrrolidine, resulting in a failure of the functional action.

Disclosure of Invention

Aiming at the defects in the prior art, the technical problems to be solved by the invention are as follows: provides a tablet candy with good hypolipidemic and antioxidant effects.

The inventor aims at the defects that curcumin in the turmeric extract has low water solubility, is unstable under physiological conditions, is less absorbed by intestinal tracts, is rapidly metabolized in vivo, has low bioavailability and is difficult to be absorbed by human bodies. Cyclodextrin is added in the curcumin extraction process, wherein the cyclodextrin has a ring-shaped three-dimensional structure, amphiphilic molecules with a hydrophobic inner cavity and a hydrophilic outer cavity form a cone-shaped hydrophobic cavity, and weak interaction force between molecules of curcumin and cyclodextrin exists, so that the curcumin and the cyclodextrin enter the cavity and are wrapped by the cyclodextrin. Whereas the hydrophilic shell is compatible with aqueous systems. The hydrophobic curcumin forms a hydrophilic shell, can form molecular emulsion which is easier to be absorbed by human body in water, and is wrapped by cyclodextrin to form molecular dispersion, so that more curcumin molecules are transported to the upper intestinal tract, and absorbed into the body.

Aiming at the problem that 4-methylthio-3-butenyl isothiocyanate in the white radish extract is unstable in property and easy to hydrolyze and deteriorate. The cyclodextrin is added in the extraction process of the 4-methylthio-3-butenyl isothiocyanate, and the characteristics of the 4-methylthio-3-butenyl isothiocyanate are coated by the cyclodextrin, so that the 4-methylthio-3-butenyl isothiocyanate can be stabilized, and more 4-methylthio-3-butenyl isothiocyanate can be transported to the upper intestinal tract, and absorbed into the body at the upper intestinal tract.

The raw materials of the tablet candy simultaneously comprise the turmeric extract and the white radish extract, and the blood fat reducing and antioxidation effects of the tablet candy can be remarkably improved.

The technical scheme of the invention is as follows:

in order to achieve the purpose, the technical solution adopted by the invention is as follows:

a blood fat reducing antioxidant tabletting candy is composed of the following raw materials: earthworm protein powder, hawthorn extract, lotus leaf extract, white radish extract and/or turmeric extract, honey peach fruit powder, honey peach essence, isomalt, microcrystalline cellulose, hydroxypropyl methyl cellulose and magnesium stearate.

Preferably, the blood fat reducing and antioxidant tabletting candy is prepared from the following raw materials in parts by weight: 200 portions of earthworm protein powder, 200 portions of hawthorn extract, 200 portions of lotus leaf extract, 200 portions of white radish extract and/or 200 portions of turmeric extract, 400 portions of honey peach powder, 600 portions of honey peach essence, 150 portions of isomalt, 50-70 portions of microcrystalline cellulose, 10-20 portions of hydroxypropyl methyl cellulose and 10-15 portions of magnesium stearate.

Most preferably, the blood fat reducing and oxidation resisting tablet candy is composed of the following raw materials in parts by weight: 200 portions of earthworm protein powder, 200 portions of hawthorn extract, 100 portions of lotus leaf extract, 200 portions of white radish extract, 200 portions of turmeric extract, 400 portions of honey peach powder, 600 portions of honey peach essence, 5-10 portions of isomalt, 150 portions of microcrystalline cellulose, 10-20 portions of hydroxypropyl methylcellulose and 10-15 portions of magnesium stearate.

Preferably, the preparation method of the white radish extract comprises the following steps:

s1 weighing 1-3kg of fresh white radish, and removing juice with a juicer to obtain white radish residues;

s2, putting the white radish slag into a drying oven at 60-70 ℃ for drying for 3-5 h;

s3, drying the white radish residues, and mixing the dried white radish residues according to the solid-to-liquid ratio (1-3): (1-3) adding the mixture into petroleum ether in a ratio of g/mL, and adding cyclodextrin; adding cyclodextrin 0.1-0.2 times of white radish residue, soaking at 25-30 deg.C for 18-24 hr, performing ultrasonic treatment for 1-3 hr with ultrasonic power of 1000-; obtaining a white radish extracting solution;

s4 distilling the radix Raphani extractive solution under reduced pressure to remove solvent to obtain radix Raphani extract.

The preparation method of the turmeric extract comprises the following steps:

s1 slicing turmeric, drying in a vacuum drying oven at 30-50 ℃, crushing, and sieving with a 150-mesh sieve of 100 meshes to obtain turmeric powder;

s2, adding 1-3g of turmeric powder into 20-40mL of 75-95% ethanol solution by mass fraction, adding 0.1-0.2g of ionic liquid and 0.2-0.4g of cyclodextrin, then performing microwave extraction for 20-40min, performing microwave power of 300-;

s3 distilling the supernatant under reduced pressure to remove solvent to obtain Curcuma rhizome extract.

The ionic liquid is one or a mixture of two or more of 1-methyl-3-ethylimidazole bromide, 1-methyl-3-n-butylimidazole bromide, 1-methyl-3-n-hexylimidazole bromide, 1-methyl-3-n-decylimidazole bromide and 1-methyl-3-n-dodecylimidazole bromide.

The cyclodextrin is one or a mixture of two or more of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.

Cyclodextrins are cyclic oligosaccharides composed of D-glucose linked by alpha-l, 4-glycosidic bonds. The most common cyclodextrins are alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin, containing 6, 7, 8 alpha-D-glucose, respectively. Cyclodextrins are considered to be typical host molecules, the interaction of guest molecules with the hydrophobic cavity of the host facilitates the inclusion process, and the geometrical compatibility of the host and guest, the structure, charge and polarity of the guest, the reaction medium and temperature have a significant influence on the formation of inclusion compounds.

Further, in the above-mentioned case,

compared with the cyclodextrin with different structures, the inventor shows that in the preparation process of the white radish extract, when the cyclodextrin is preferably alpha-cyclodextrin, the tablet candy prepared by the white radish extract has better blood fat reducing and oxidation resisting effects, and the obtained effect is more clearly proved in specific embodiments.

The alpha-cyclodextrin is a host with the smallest cavity in the cyclodextrin and can be matched and combined with small-size object molecules, and the effective component 4-methylthio-3-butenyl isothiocyanate in the white radish extract is a linear structure molecule with small molecular geometric size. Therefore, the alpha-cyclodextrin and the 4-methylthio-3-butenyl isothiocyanate form relatively strong intermolecular acting force, so that object molecules exist in the cavity more stably, and the blood fat reducing and oxidation resisting effects of the 4-methylthio-3-butenyl isothiocyanate are further improved.

The results show that when the cyclodextrin is preferably beta-cyclodextrin in the preparation process of the turmeric extract, the tablet candy prepared by adopting the turmeric extract has better blood fat reducing and oxidation resisting effects, and the obtained effect is more clearly demonstrated in specific examples.

Curcumin has benzene ring in the molecular structure, has medium molecular size, and the cavity of alpha-cyclodextrin is too small, so that curcumin molecules cannot enter the cavity. The cavity size of the beta-cyclodextrin is larger than that of the alpha-cyclodextrin, the beta-cyclodextrin can be matched with the molecular size of curcumin, a host-guest encapsulated structure can be well formed, the water solubility of the curcumin is increased, and the blood fat reducing and oxidation resisting effects of the curcumin are further improved.

The invention also provides a preparation method of the blood fat reducing antioxidant tabletting candy, which is prepared by adopting the raw materials.

The preparation method of the blood fat reducing and oxidation resisting tabletting candy comprises the following steps:

(1) stirring earthworm protein powder, hawthorn extract, lotus leaf extract, white radish extract and/or turmeric extract, honey peach fruit powder, honey peach essence, isomaltitol and microcrystalline cellulose at the rotation speed of 300-; adding hydroxypropyl methyl cellulose, stirring at the rotation speed of 300 and 500 revolutions per minute for 10-20 minutes, uniformly mixing, and granulating by using a 10-20-mesh sieve to obtain wet granules;

(2) drying the wet granules in a drying oven at 40-60 deg.C for 8-15 hr, and grading with 10-30 mesh sieve to obtain dry granules;

(3) adding magnesium stearate into the dry granules, mixing well, tabletting to obtain candy tablets, wherein each tablet contains 500 mg of magnesium stearate and 600mg of magnesium stearate. The blood fat reducing and oxidation resisting tablet candy is obtained.

Advantageous effects

(1) The tablet candy prepared by the invention has good blood fat reducing and anti-oxidation effects after being eaten for a long time.

(2) According to the invention, a certain amount of cyclodextrin is added in the process of preparing the white radish extract which is one of the raw materials of the blood fat reducing and oxidation resisting tablet candy, and the characteristic that the cyclodextrin wraps 4-methylthio-3-butenyl isothiocyanate is utilized, so that not only can the 4-methylthio-3-butenyl isothiocyanate be stabilized, but also more 4-methylthio-3-butenyl isothiocyanate can be transported to the upper intestinal tract, and absorbed into the body at the upper intestinal tract, and further the blood fat reducing and oxidation resisting effects of the tablet candy are improved.

(3) According to the invention, a certain amount of cyclodextrin is also added in the process of preparing the white radish extract which is one of the raw materials of the blood fat reducing and antioxidant tabletting candy, and weak intermolecular interaction force exists between curcumin molecules and the cyclodextrin, so that the curcumin molecules and the cyclodextrin enter a cavity and are wrapped by the cyclodextrin. Whereas the hydrophilic shell is compatible with aqueous systems. The hydrophobic curcumin forms a hydrophilic shell, can form molecular emulsion which is easier to be absorbed by human body in water, and is wrapped by cyclodextrin to form molecular dispersion, so that more curcumin molecules are transported to the upper intestinal tract, and absorbed into the body. The defects that curcumin in the turmeric extract is low in water solubility, unstable under physiological conditions, less in intestinal absorption and rapid in vivo metabolism, so that the curcumin is low in bioavailability and difficult to be absorbed by a human body are overcome, and the blood fat reducing and antioxidant effects of the tablet candy are further improved.

Detailed Description