阅读说明：本技术 将3-(z)-不饱和羧酸异构化成3-(e)-异构体的方法 (Process for isomerizing 3- (Z) -unsaturated carboxylic acids to 3- (E) -isomers ) 是由 M·施尔维斯 W·塞格尔 R·帕切洛 A·凯勒 于 2019-02-13 设计创作，主要内容包括：本发明涉及使式I-Z的3-(Z)-不饱和羧酸或其盐异构化以得到式I-E的3-(E)-不饱和羧酸或其盐的方法,其中R<Sup>2</Sup>是C<Sub>1</Sub>-C<Sub>24</Sub>烷基,具有1、2、3或多于3个C-C双键的C<Sub>2</Sub>-C<Sub>24</Sub>链烯基,未取代或被取代的C<Sub>5</Sub>-C<Sub>12</Sub>环烷基,或者未取代或被取代的芳基；R<Sup>1</Sup>是氢或具有对于R<Sup>2</Sup>所述的含义之一；前提是R<Sup>2</Sup>具有根据IUPAC的高于R<Sup>1</Sup>的优先性；其中式I-Z化合物的异构化是在有机酸酐和碱的存在下进行,或在式CR<Sup>11</Sup>R<Sup>12</Sup>C(O)的烯酮和碱的存在下进行,其中R<Sup>11</Sup>和R<Sup>12</Sup>具有在权利要求和说明书中所述的含义。特别是,本发明涉及从包含(3Z,7E)-和(3E,7E)-高金合欢酸的组合物制备具有增加含量的(3E,7E)-高金合欢酸的组合物的方法。<Image he="507" wi="700" file="DDA0002628870930000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention relates to a method for isomerizing a 3- (Z) -unsaturated carboxylic acid of the formula I-Z or a salt thereof to give a 3- (E) -unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein R 2 Is C 1 ‑C 24 Alkyl, C having 1,2,3 or more than 3C-C double bonds 2 ‑C 24 Alkenyl, unsubstituted or substituted C 5 ‑C 12 Cycloalkyl, or unsubstituted or substituted aryl; r 1 Is hydrogen or aFor R to 2 One of the meanings mentioned; provided that R is 2 Having a value higher than R according to IUPAC 1 (iii) a priority of; wherein the isomerization of the compound of formula I-Z is carried out in the presence of an organic acid anhydride and a base, or in the presence of a compound of formula CR 11 R 12 In the presence of an alkenone and a base, wherein R 11 And R 12 Have the meaning stated in the claims and the description. In particular, the present invention relates to methods of preparing compositions having increased levels of (3E,7E) -homofarnesoic acid from compositions comprising (3Z,7E) -and (3E,7E) -homofarnesoic acid.)

1. A process for isomerizing a 3- (Z) -unsaturated carboxylic acid of formula I-Z or a salt thereof to give a 3- (E) -unsaturated carboxylic acid of formula I-E or a salt thereof,

wherein

R¹Is hydrogen, straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group; and

R²is straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group;

provided that R is²Having a value higher than R according to IUPAC¹(iii) a priority of;

wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of an anhydride of an organic acid and a base; or

Wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of a base and a ketene of formula V:

wherein

R¹¹And R¹²Each independently selected from hydrogen, linear or branched C₁-C₂₄Alkyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₁₄And (4) an aryl group.

2. The process of claim 1, wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of an anhydride of an organic acid and a base.

3. The method according to claim 1 or 2, wherein a composition comprising a compound of formula I-Z or a salt thereof and a compound of formula I-E or a salt thereof is used and the compound of formula I-E or a salt thereof is isomerized to a compound of formula I-E or a salt thereof, wherein a composition is obtained in which the content of the compound of formula I-E in the composition is higher than the content of the compound I-E in the composition used.

4. The method according to claim 2 or 3, wherein the weight ratio between compound I-Z or a salt thereof and compound I-E or a salt thereof in the composition used is greater than 50:50, preferably greater than 85: 15.

5. The method according to claim 3 or 4, wherein the composition used comprises (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as compound of formula I-Z and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as compound of formula I-E.

6. The process of claim 5, wherein the composition resulting from the process comprising the steps of:

(a) providing a first composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid;

(b) subjecting the first composition from step (a) to an enzyme-catalyzed esterification reaction in the presence of an alcohol and a lipase, wherein a composition is obtained comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate, unreacted (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and unreacted (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid; and

(c) separating a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate from the composition obtained in step (b) and obtaining a second composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, wherein the content of (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid in the second composition is higher than in the first composition provided in step (a).

7. The method according to claim 5, wherein the composition used is obtained by a process comprising the steps of:

(d) providing a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate;

(e) subjecting the composition provided in step (d) to an enzyme-catalyzed ester cleavage reaction in the presence of a lipase, wherein a composition is obtained comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate, unreacted (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and unreacted (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid;

(f) separating a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid from the composition obtained in step (E) and obtaining a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester; and

(g) subjecting the composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate obtained in step (f) to an ester cleavage reaction to obtain a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof.

8. The process of any one of claims 5-7, wherein the composition for isomerization comprises (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof in a weight ratio of 1:99 to 50: 50.

9. The process according to any one of the preceding claims, wherein the process is carried out at a temperature of 60-175 ℃, preferably 70-160 ℃.

10. The process according to any one of the preceding claims, wherein the base is selected from alkali metal carbonates, alkaline earth metal carbonates, alkali metal bicarbonates, alkaline earth metal bicarbonates, alkali metal phosphates, alkaline earth metal phosphates, amines, basic N-heteroaromatic systems, basic ion exchangers, and mixtures thereof.

11. The method of claim 10, wherein the base is an amine selected from the group consisting of: trimethylamine, dimethylamine, monomethylamine, triethylamine, diethylamine, monoethylamine, tripropylamine, dipropylamine, tributylamine, dibutylamine, trihexylamine, dihexylamine, dicyclohexylamine, morpholine, piperidine, N-diisopropylethylamine, N-ethylpiperidine, or a mixture thereof.

12. The process of any one of the preceding claims, wherein 0.1-5 moles of base are used per mole of compound of formulae I-Z or salt thereof and formula I-E or salt thereof.

13. The process according to any of the preceding claims, wherein the anhydride is selected from aliphatic C' s₁-C₁₂Anhydrides of monocarboxylic acids, aliphatic C₄-C₂₀Anhydrides of dicarboxylic acids, cycloaliphatic C₇-C₂₀Anhydrides of dicarboxylic acids, aromatic C₈-C₂₀Anhydrides of dicarboxylic acids, anhydrides of aliphatic sulfonic acids, and anhydrides of aromatic sulfonic acids; the anhydride is preferably selected from acetic anhydride, maleic anhydride, p-toluenesulfonic anhydride or methanesulfonic anhydride.

14. The process according to any one of the preceding claims, wherein 0.05 to 0.8 mole of anhydride is used per mole of compound of formula I-Z or salt thereof and compound of formula I-E or salt thereof, preferably 0.1 to 0.5 mole of anhydride is used per mole of compound of formula I-Z or salt thereof and compound of formula I-E or salt thereof.

15. The method of any one of claims 1-12, wherein in the compound of formula V, R¹¹And R¹²Each independently selected from hydrogen, C₁-C₁₀Alkyl, or C having 1,2 or 3 double bonds₁₀-C₁₈An alkenyl group; preferably R¹¹And R¹²Are all hydrogen; or R¹¹Is hydrogen, and R¹²Is 2,6, 10-trimethylundec-1, 5, 9-trienyl.

Background

The present invention relates to a process for isomerizing 3- (Z) -unsaturated carboxylic acids to 3- (E) -unsaturated carboxylic acids in the presence of a base and an acylating agent such as an organic anhydride or an enone compound, and in particular to a process for preparing a composition having an increased content of (3E,7E) -homofarnesic acid from a composition comprising (3Z,7E) -and (3E,7E) -homofarnesic acid.

Summary of The Invention

The subject of the invention is a process for isomerizing 3- (Z) -unsaturated carboxylic acids of the formulae I to Z or salts thereof to give 3- (E) -unsaturated carboxylic acids of the formulae I to E or salts thereof,

wherein

R¹Is hydrogen, straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group; and

R²is straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group;

provided that R is²Having a value higher than R according to IUPAC¹(iii) a priority of;

wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of an anhydride of an organic acid and a base; or

Wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of a base and a ketene of formula V:

wherein

R¹¹And R¹²Each independently selected from hydrogen, linear or branched C₁-C₂₄Alkyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₁₄And (4) an aryl group.

In one embodiment, the subject of the invention is a process for isomerizing a 3- (Z) -unsaturated carboxylic acid of the formula I-Z or a salt thereof to give a 3- (E) -unsaturated carboxylic acid of the formula I-E or a salt thereof,

wherein

R¹Is hydrogen, straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group; and

R²is straight-chain or branched C₁-C₂₄Alkyl, straight-chain or branched C having 1,2,3 or more than 3C-C double bonds₂-C₂₄Alkenyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₂₀An aryl group;

provided that R is²Having a value higher than R according to IUPAC¹(iii) a priority of;

wherein the isomerization of the compound of formula I-Z or a salt thereof is carried out in the presence of an acid anhydride of an organic acid and a base.

Detailed Description

In the general formulae of the compounds I-Z and I-E,

it is obvious that only two different substituents R are present¹And R²E-and Z-isomers may be present when attached to the double bond. In the present invention, the substituent R²With priority according to IUPAC (International Union of Pure and applied chemistry). According to IUPAC, the substituents are prioritized in the order described by the Cahn-Ingold-Prelog rule (see E/Z notation, https:// en. wikipedia. org/wiki/E-Z _ node).

In the compounds of the general formulae (I), (II.2), (III.2) and (IV.2),

the wavy bond is used to indicate that it can be in each case in the form of the pure Z-isomer, the pure E-isomer or any desired E/Z-mixture.

The process of the present invention enables the at least partial isomerization of a 3- (Z) -unsaturated carboxylic acid of the formula I-Z or a salt thereof to a 3- (E) -unsaturated carboxylic acid or a salt thereof under mild reaction conditions.

In the present invention, the expression "aliphatic" includes hydrocarbon groups in which the carbon atoms are arranged in a straight chain or in a branched chain.

In the present invention, the expression "alicyclic" includes cyclic saturated or unsaturated carbon groups and does not include aromatic groups.

In the present invention, the expression "alkyl" and all alkyl moieties in alkoxy, alkylamino and dialkylamino includes straight-chain or branched saturated hydrocarbon groups having from 1 to 4 carbon atoms ("C₁-C₄Alkyl "), 1-6 carbon atoms (" C₁-C₆Alkyl "), 1-10 carbon atoms (" C₁-C₁₀Alkyl group "), 1-20 carbon atoms (" C₁-C₂₀Alkyl group ") or 1 to 24 carbon atoms (" C)₁-C₂₄Alkyl "). Straight-chain or branched C₁-C₄Examples of alkyl are methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methylpropyl, 1, 1-dimethylethyl. Straight-chain or branched C₁-C₆Examples of alkyl radicals other than those relating to C₁-C₄Alkyl includes, in addition to the definitions stated above, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2, 2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1, 1-dimethylpropyl, 1, 2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1, 1-dimethylbutyl, 1, 2-dimethylbutyl, 1, 3-dimethylbutyl, 2, 2-dimethylbutyl, 2, 3-dimethylbutyl, 3, 3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1, 2-trimethylpropyl, 1,2, 2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl. Straight-chain or branched C₁-C₁₀Examples of alkyl radicals other than those relating to C₁-C₆The definition of alkyl also includes heptyl, octyl, nonyl, decyl and positional isomers thereof. C₁-C₂₀Examples of alkyl radicals other than those relating to C₁-C₁₀In addition to the definitions of alkyl, there are also undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, pentacosyl, hexacosyl, heptacosyl, octacosyl, nonacosyl, triacontyl and positional isomers thereof.

In the present invention, the expression "alkenyl" includes straight-chain or branched unsaturated hydrocarbon groups having 2 to 4 (C)₂-C₄Alkenyl), to 6, to 8, to 10, to 16, to 20 or to 24 carbon atoms and 1,2,3 or more than 3 double bonds in any position. Straight-chain or branched C having one double bond₂-C₂₄Examples of alkenyl are vinyl, allyl (2-propen-1-yl), 1-methylprop-2-en-1-yl, 2-buten-1-yl, 3-buten-1-yl, n-pentenyl, n-hexenyl, n-heptenyl, n-octenyl, n-nonenyl, n-decenyl, n-undecenyl, n-dodecenyl, n-tridecenyl, n-tetradecenyl, n-pentadecenyl, n-hexadecenyl, n-heptadecenyl, n-octadecenyl, oleyl, n-nonadecenyl, n-eicosenyl, n-heneicosenyl, n-docosenyl, n-tricosenyl, n-tetracosenyl and structural isomers thereof. Straight-chain or branched C with 2 or 3 double bonds in any position₄-C₂₄Examples of alkenyl are n-butadienyl, n-pentadienyl, n-hexadienyl, n-octadienyl, n-nonadienyl, n-nonatrienyl, n-decadienyl, n-decatrienyl, n-undecabdienyl, n-undecabrienyl, n-dodecenyl, n-tridecadienylN-tridecenyl, n-tetradecenyl, n-pentadecenyl, n-hexadecenyl, n-heptadecenyl, n-octadecadienyl, n-octadecatrienyl, n-nonadecenyl, n-eicosadienyl, n-eicosatrienyl, n-heneicosanenyl, n-docosadienyl, n-docosatrienyl, n-tricosenyl, n-tricosanenyl, n-tetracosadienyl, n-tetracosatrienyl, linyl, and structural isomers thereof. At C₂-C₂₄Any double bonds in the alkenyl groups may each, independently of one another, be present in the E and Z configuration.

In the present invention, the expression "cycloalkyl" includes monocyclic saturated hydrocarbon groups having 3 to 8 ("C)₃-C₈Cycloalkyl "), preferably 5 to 7 carbon ring members (" C₅-C₇Cycloalkyl "). C₃-C₈Examples of cycloalkyl are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.

In the context of the present invention, the expression "heterocyclyl" (also referred to as heterocycloalkyl) includes monocyclic saturated cycloaliphatic radicals having generally 5 to 8 ring atoms, preferably 5 or 6 ring atoms, in which 1 or 2 ring carbon atoms have been replaced by a substituent selected from the group consisting of oxygen, nitrogen, NH and N (C)₁-C₄Alkyl) or a heteroatom-containing group. Examples of such heteroalicyclic groups are pyrrolidinyl, piperidinyl, tetrahydrofuranyl and tetrahydropyranyl.

In the present invention, the expression "aryl" includes mononuclear, dinuclear or trinuclear aromatic ring systems comprising 6 to 20 carbon ring members. Unsubstituted C₆-C₁₀Examples of aryl groups are phenyl and naphthyl. C₆-C₁₄Examples of aryl groups are phenyl, naphthyl, anthryl and phenanthryl. Substituted aryl groups generally carry 1,2,3, 4 or 5, preferably 1,2 or 3 identical or different substituents. Suitable substituents are in particular selected from alkyl, cycloalkyl, aryl, alkoxy, dialkylamino. With 1,2 or 3 members selected from C₁-C₆Examples of aryl groups as substituents of alkyl groups are tolyl, xylyl and trimethylphenyl.

In the context of the present invention, the expression "heteroaryl" includes 5-to 6-membered aromatic heteromonocyclic rings comprising 1,2,3 or 4 heteroatoms selected from oxygen, nitrogen or sulfur, and 9-or 10-membered aromatic heterocyclic rings, for example C-bonded 5-membered heteroaryl groups, containing 1 to 3 nitrogen atoms or one or two nitrogen atoms and one sulfur or oxygen atom as ring members, for example furyl, thienyl, pyrrolyl, isopyrrolyl

An azole group, an isothiazole group, a pyrazolyl group,azolyl, thiazolyl, imidazolyl, 4-imidazolyl, 1,2,4-Oxadiazolyl, 1,2, 4-thiadiazolyl, 1,2, 4-triazolyl, 1,3, 4-A diazolyl group; a 5-membered heteroaryl group bonded via nitrogen, which contains 1 to 3 nitrogen atoms as ring members, such as pyrrol-1-yl, pyrazol-1-yl, imidazol-1-yl, 1,2, 3-triazol-1-yl and 1,2, 4-triazol-1-yl; 6-membered heteroaryl groups which contain 1 to 3 nitrogen atoms as ring members, for example pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,3, 5-triazinyl and 1,2, 4-triazinyl.

Halogen is fluorine, chlorine, bromine or iodine. The halide is fluoride, chloride, bromide or iodide.

The alkali metal corresponds to an element of group 1 of the periodic table of the elements according to IUPAC, for example lithium, sodium, potassium, rubidium or caesium, preferably lithium, sodium or potassium, especially sodium or potassium.

The alkaline earth metal corresponds to an element of group 2 of the periodic table of the elements according to IUPAC, such as beryllium, magnesium, calcium, strontium or barium, preferably magnesium or calcium.

The elements of group 8 of the periodic Table of the elements according to IUPAC include, inter alia, iron, ruthenium and osmium. The elements of group 9 of the periodic table of the elements according to IUPAC include, inter alia, cobalt, rhodium, iridium. The group 10 elements of the periodic table of the elements according to IUPAC include, inter alia, nickel, palladium and platinum.

In the present invention, the expression "salt thereof" means a salt of a carboxyl group. Salts of carboxyl groups may be prepared in known manner, including inorganic salts such as sodium, potassium, calcium, ammonium, and the like; salts with organic bases, such as acid addition amines and salts; for example, salts with inorganic acids, such as hydrochloric acid or sulfuric acid, and salts with organic acids, such as acetic acid.

In the context of the present invention, the expression "ammonium salt" includes the salts derived from NH₄ ⁺Derivatized salts and mono-, di-, tri-, and tetraorganoammonium salts. The radicals bonded to the ammonium nitrogen atom are generally in each case independently selected from hydrogen and aliphatic, alicyclic and aromatic hydrocarbon radicals. Preferably, the groups bonded to the ammonium nitrogen atom are each independently selected from hydrogen and aliphatic groups, in particular from hydrogen and C₁-C₂₀An alkyl group.

In the present invention, the expression "acyl" includes alkanoyl or aroyl groups, which generally have 1 to 11, preferably 2 to 8, carbon atoms, such as formyl, acetyl, propionyl, butyryl, valeryl, benzoyl or naphthoyl.

"stereoisomers" are compounds having the same composition, but with different arrangements of atoms in three-dimensional space.

"enantiomers" are stereoisomers that have mirror images of each other. "enantiomerically pure" means that, in addition to the specifically mentioned enantiomer, no other enantiomeric forms of the compound having at least one asymmetric center are detectable in the analysis.

In the present invention, the term "terpene-like hydrocarbon group" includes hydrocarbon groups derived from 1,2,3 or more than 3 isoprene units. In this case, the terpene-like hydrocarbon group may still contain double bonds or be fully saturated. In this case, the double bond may be in any position, wherein cumulative double bonds are not included.

In the present invention, the term "farnesol (3,7, 11-trimethyl-2, 6, 10-dodecatrien-1-ol)" includes the (2E), (6E) -isomer, (2Z), (6Z) -isomer, (2Z), (6E) -isomer and the (2E), (6Z) -isomer, as well as mixtures of two, three or all isomers of said farnesol. Farnesol is commercially available.

Nerolidol has one chiral center and can exist as an E/Z mixture, so there are four stereoisomers. In the present invention, the term "nerolidol (3,7, 11-trimethyl-1, 6, 10-dodecatrien-3-ol)" includes (3S), (6Z) -isomer, (3R), (6Z) -isomer, (3S), (6E) -isomer, (3R), (6E) -isomer, and any desired mixture thereof. Nerolidol is commercially available. Neryl acetate (3,7, 11-trimethyl-1, 6, 10-octenylacetate) is the acetylation product of nerolidol. It is commercially available.

Another name for homofarnesoic acid is 4,8, 12-trimethyltridec-3, 7, 11-trienoic acid. Therefore, another name of (3Z,7E) -homofarnesic acid is (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid. Therefore, another name of (3E,7E) -homofarnesic acid is (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

Unless otherwise indicated, suitable and preferred conditions described hereinafter in connection with the process of the invention apply to the isomerization carried out in the presence of a base and an anhydride of an organic acid, and also in the presence of a base and an enone compound of formula V.

Unless otherwise indicated, the following embodiments apply to both the pure (Z) -isomer, to compositions comprising the (Z) -isomer, and to compositions comprising the (E) -isomer and the (Z) -isomer.

In the compounds of the formulae I-Z and I-E, R¹Preferably hydrogen, straight-chain or branched C₁-C₁₆Alkyl, or C, straight-chain or branched, with one or two non-conjugated double bonds₂-C₁₆An alkenyl group. R¹In particular hydrogen or C₁-C₄Alkyl, especially C₁-C₂An alkyl group. In the compounds of the formulae I-Z and I-E, R²Preferably straight-chain or branched C₁-C₁₆Alkyl, or straight-chain or branched having oneC of one or two non-conjugated double bonds₂-C₁₆Alkenyl groups, especially terpene-like hydrocarbon groups. R²In particular straight-chain or branched C₆-C₁₆Alkyl, or straight-chain or branched C having one or two non-conjugated double bonds₆-C₁₆An alkenyl group. R²Preferably having a ratio R¹One more carbon atom.

Suitable substances for use as 3- (Z) -unsaturated carboxylic acids of the formulae I-Z are pure 3- (Z) -unsaturated carboxylic acids; a composition comprising a 3- (Z) -unsaturated carboxylic acid; and compositions comprising 3- (Z) -unsaturated carboxylic acids and 3- (E) -unsaturated carboxylic acids. In a preferred embodiment, the proportion of 3- (Z) -unsaturated carboxylic acid in the composition is greater than the proportion of 3- (E) -unsaturated carboxylic acid.

According to a first embodiment of the invention, the pure isomers of formulae I-Z or salts thereof are used in the process of the invention.

According to another preferred embodiment of the invention, the composition used in the method of the invention comprises a compound of formula I-Z or a salt thereof and a compound of formula I-E or a salt thereof. The process according to the invention gives a composition in which the content of compounds of the formulae I to E is higher than the content of compounds I to E in the composition used.

Preferably, the weight ratio between compound I-Z or a salt thereof and compound I-E or a salt thereof in the composition used is greater than 50:50, preferably greater than 85: 15.

The process of the invention is particularly suitable for increasing the content of (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salts thereof in a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as compound of formula I-Z and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as compound I-E.

For example, a composition comprising an E/Z mixture of 3-unsaturated carboxylic acid or a salt thereof, especially (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof is obtained by the process described in WO 2018/153727. According to a first embodiment (variant 1) for preparing a composition comprising at least one E/Z mixture of unsaturated carboxylic acids of the general formula I or salts thereof,

wherein R is¹And R²As defined above, the above-mentioned,

allyl alcohol selected from compounds of the general formulae (II.1) and (II.2)

The carbonylation reaction is carried out by reacting with carbon monoxide in the presence of a transition metal catalyst comprising at least one metal of groups 8, 9 or 10 of the periodic Table of the elements, wherein the reaction is additionally carried out in the presence of at least one organophosphorus compound as ligand and in the presence of a substoichiometric amount, based on allyl alcohol, of a compound A) selected from aliphatic C₁-C₁₂Anhydrides of monocarboxylic acids, aliphatic C₄-C₂₀Anhydrides of dicarboxylic acids, cycloaliphatic C₇-C₂₀Anhydrides of dicarboxylic acids, aromatic C₈-C₂₀Anhydrides of dicarboxylic acids, and acylated allyl alcohols of the formulae (III.1) and (III.2):

wherein

R⁵Is C₁-C₅An alkyl group; and

R⁶and R⁷Having the above relation to R¹And R²One of said definitions; and

wherein the reaction is carried out at a temperature of at most 100 ℃.

According to a second embodiment (variant 2) for preparing a composition comprising at least one E/Z mixture of unsaturated carboxylic acids of general formula (I) or of salts thereof,

wherein R is¹And R²Is as defined above in that the process is carried out,

acylated alcohols selected from the group consisting of the compounds of the general formulae (IV.1) and (IV.2)

Wherein R is⁸Is C₁-C₅An alkyl group by carbonylation by reaction with carbon monoxide in the presence of a transition metal catalyst comprising at least one metal of groups 8, 9 or 10 of the periodic Table of the elements, wherein the reaction is additionally carried out in the presence of at least one organophosphorus compound as a ligand and in the presence of water, and wherein the reaction is carried out at a temperature of at most 100 ℃.

According to a third embodiment (variant 3) for the preparation of the composition, comprising at least one E/Z mixture of an unsaturated carboxylic acid of formula (I) or a salt thereof, an allyl alcohol chosen from the compounds of formulae (II.1) and (II.2)

Wherein R is¹And R²Is as defined above in that the process is carried out,

the carbonylation reaction is carried out by reaction with carbon monoxide in the presence of a transition metal catalyst comprising at least one metal of groups 8, 9 or 10 of the periodic Table of the elements, wherein the reaction is additionally carried out in the presence of at least one organophosphorus compound as ligand and in the presence of a substoichiometric amount, based on allyl alcohol, of a compound B),

wherein

R⁹And R¹⁰Each independently is C₁-C₆Alkyl radical, C₁-C₆-fluoroalkyl, or phenyl, unsubstituted or selected from bromine, nitro and C₁-C₄One substituent of alkyl;

and wherein the reaction is carried out at a temperature of at most 100 ℃.

The carbonylation reaction is carried out according to the three variants described above in the presence of a transition metal catalyst comprising at least one metal of groups 8, 9 or 10 of the periodic table of the elements. The transition metals used are preferably palladium, ruthenium, rhodium, iridium and iron, particularly preferably palladium. Both monodentate and bidentate phosphorus ligands are suitable as organophosphorus compounds. In principle, the type of organophosphorous compound used is not important, so that generally cost-effective monodentate tertiary phosphines can be used. In addition, the carbonylation catalyst used may have at least one other ligand.

The carbonylation reaction may suitably be carried out according to variants 1 and 3 above in the presence of a nucleophile. An example of a nucleophile is 4- (C)₁-C₄Alkyl) pyridines, 4- (1-pyrrolidinyl) pyridines, and 4- (di- (C)₁-C₄Alkyl) amino) pyridine. The carbonylation reaction can be carried out according to all the above variants in the presence or absence of a base which is different from the nucleophile, but the carbonylation reaction is preferably carried out in the presence of a base. Suitable bases are organic and inorganic bases. Suitable bases are, in particular, amines. It is also advantageous to carry out the carbonylation reaction with the exclusion of atmospheric oxygen or with a reduced amount of atmospheric oxygen. The carbonylation reaction may be carried out according to all the above variants at a wide range of pressures, for example from atmospheric pressure to at most 90 bar, preferably at most 30 bar, preferably at most 25 bar, more preferably at most 20 bar, especially at most 15 bar. Suitable pressure ranges are, for example, from 1.1 to 90 bar, from 1.1 to 30 bar, from 2 to 20 bar, from 5 to 15 bar. The reaction temperature according to the above-described variant can be chosen within a wide range from room temperature (20 ℃) to 100 ℃, but is preferably at most 80 ℃ and in particular not more than 75 ℃. The reaction output of the carbonylation reaction can be worked up by distillation. In thatAfter distillation a composition is obtained which comprises (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and small amounts of (2E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and possibly other compounds.

The above process enables the preparation of (3E,7E) -and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salts thereof in high yield under mild conditions starting from commercially available materials such as farnesol or nerolidol. In particular, the above process enables the preparation of a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof in a weight ratio of typically 80:20 to 50:50, preferably 70:30 to 50:50, from (E) -nerolidol. The proportion of (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid in the resulting isomer mixture is generally greater than the proportion of (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid. The resulting composition may be at least partially enriched in one isomer by an isomer separation operation as described below or by, for example, distillation.

WO 2018/154048 describes a possible isomer separation of the initially obtained mixture comprising 3- (Z) -unsaturated carboxylic acid and 3- (E) -unsaturated carboxylic acid. WO 2018/154048 describes, inter alia, the separation of isomers of a mixture comprising (3E,7E) -and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, resulting in a first stream enriched in (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and in a second stream enriched in (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

The enzymatic esterification reaction starting from a 3- (Z) -unsaturated carboxylic acid and a 3- (E) -unsaturated carboxylic acid enables the preparation of a composition comprising a 3- (Z) -unsaturated carboxylic acid and a 3- (E) -unsaturated carboxylic acid, wherein the proportion of 3- (Z) -unsaturated carboxylic acid is greater than the proportion of 3- (E) -unsaturated carboxylic acid. Such compositions are obtained, for example, in the process described in WO 2018/154048.

In the process of the present invention, it is preferred to use a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as I-Z compound and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as I-E compound, and the composition is obtained from a process comprising the steps of:

(a) providing a first composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid;

(b) subjecting the first composition from step (a) to an enzyme-catalyzed esterification reaction in the presence of an alcohol and a lipase, wherein a composition is obtained comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate, unreacted (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and unreacted (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid; and

(c) separating a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate from the composition obtained in step (b) and obtaining a second composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, wherein the content of (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid in the second composition is higher than in the first composition provided in step (a).

Suitable examples of lipases for use in step (b) are Candida Antarctica Lipase (CALB) and forms immobilized on a polymeric support, e.g.NovozymThe enzyme-catalyzed esterification reaction is preferably carried out in the presence of an aliphatic alcohol. Suitable aliphatic alcohols are C₁-C₂₀Alkanols, for example methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, n-pentanol, n-hexanol, n-heptanol and n-octanol. The enzyme-catalyzed esterification reaction may optionally be carried out in the presence of a diluent or solvent. Examples of suitable diluents or solvents are in particular aliphatic hydrocarbons, such as hexane, cyclohexane, heptane, octane; aromatic hydrocarbons such as toluene, xylene; dialkyl ethers, such as methyl tert-butyl ether and diisopropyl ether. Generally, in terms of (3E,7E) -1 to 5 equivalents of alcohol, based on 4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, are used. The esterification reaction is generally carried out at a temperature in the range of from 0 to 80 ℃.

The lipase esterification reaction of the 3E, 7E-isomer with an alcohol is significantly faster than the corresponding 3Z, 7E-isomer, which results in separable compositions comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate, (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

The composition obtained in step (b) may be isolated by extraction or distillation, wherein a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate is isolated and a second composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid is obtained, wherein the content of (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid in the second composition is higher than in the first composition provided in step (a).

Enzymatic saponification starting from a composition comprising a 3- (Z) -unsaturated carboxylic acid ester and a 3- (E) -unsaturated carboxylic acid ester can also produce a composition comprising a 3- (Z) -unsaturated carboxylic acid and a 3- (E) -unsaturated carboxylic acid, wherein the proportion of 3- (Z) -unsaturated carboxylic acid is greater than the proportion of 3- (E) -unsaturated carboxylic acid. Such compositions are obtained, for example, in the process described in WO 2018/154048.

Therefore, in the process of the present invention, it is also preferred to use a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as I-Z compound and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid as I-E compound, and the composition is obtained by a process comprising the steps of:

(d) providing a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate;

(e) subjecting the composition provided in step (d) to an enzyme-catalyzed ester cleavage reaction in the presence of a lipase, wherein a composition is obtained comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate, unreacted (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and unreacted (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid;

(f) separating a composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid from the composition obtained in step (E) and obtaining a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester; and

(g) subjecting the composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoate obtained in step (f) to an ester cleavage reaction to obtain a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or a salt thereof.

The composition provided in step (d) may be obtained by esterification of (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid with an alcohol.

The composition provided in step (d) is subjected to an enzyme-catalyzed ester cleavage in step (E) in the presence of a lipase, wherein a composition is obtained comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid, unreacted (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester and unreacted (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester. Suitable examples of lipases are Candida Antarctica Lipase (CALB) and forms immobilized on polymeric supports, e.g.NovozymThe enzyme-catalyzed ester cleavage reaction is usually carried out in the presence of water.

The composition obtained in step (e) may be isolated by distillation or extraction. Thus, the composition comprising (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid is separated in step (f) from the composition obtained in step (E) and a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid ester is obtained.

The ester cleavage reaction in step (g) may be catalyzed by an acid, base or enzyme, wherein a composition comprising (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof and (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof is obtained.

The composition used in the method of the invention preferably comprises (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salt thereof in a weight ratio of 1:99 to 50: 50. In particular, compositions are used in the process of the invention wherein the weight ratio between (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salts thereof and (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid or salts thereof is in the range of 15:85 to 50:50, preferably 15:85 to 50: 50.

According to the invention, the isomerization of the 3- (Z) -unsaturated carboxylic acids of the formulae I to Z is carried out in the presence of a base. Suitable bases are selected from alkali metal carbonates, alkaline earth metal carbonates, alkali metal bicarbonates, alkaline earth metal bicarbonates, alkali metal phosphates, alkaline earth metal phosphates, amines, basic N-heteroaromatic systems, basic ion exchangers, and mixtures thereof.

Suitable alkali metal carbonates are, for example, lithium, sodium or potassium carbonates. Suitable alkali metal bicarbonates are, for example, lithium, sodium or potassium bicarbonates. Suitable alkaline earth metal carbonates are for example calcium and magnesium carbonates. Suitable alkaline earth metal bicarbonates are, for example, the bicarbonates of calcium and magnesium. Suitable alkali metal phosphates are sodium and potassium phosphates. Suitable alkaline earth metal phosphates are magnesium and calcium phosphates. Suitable basic ion exchangers are, for example, basic anion exchangers having secondary or tertiary amino groups or quaternary ammonium groups or mixtures thereof. Alkali metal carbonates, such as sodium carbonate and potassium carbonate, are particularly preferred hereinafter.

Suitable amines are monoalkylamines, dialkylamines, trialkylamines; in particularIs mono- (C)₁-C₂₀Alkyl) amines, e.g. mono- (C)₁-C₁₅Alkyl) amines, di- (C)₁-C₂₀Alkyl) amines, e.g. di- (C)₁-C₁₅Alkyl) amines, tri- (C)₁-C₂₀Alkyl) amines, e.g. tri- (C)₁-C₁₅Alkyl) amines, such as monomethylamine, dimethylamine, trimethylamine, monoethylamine, diethylamine, triethylamine, monopropylamine, dipropylamine, tripropylamine, dibutylamine, tributylamine, trihexylamine, dihexylamine, trioctylamine, tridecylamine, N, N-dimethylethylamine, dimethylpropylamine, N, N-diisopropylethylamine (H ü nig's base) and cycloaliphatic amines, such as dicyclohexylamine, N, N-dimethylcyclohexylamine and N, N-dimethyldodecylamine other examples of suitable amines are 1, 4-diazabicyclo [2.2.2 ] amine]Octane (DABCO), 1, 8-diazabicyclo [5.4.0]Undec-7-ene (DBU), piperidine, N- (C)₁-C₆Alkyl) piperidines, e.g. N-methylpiperidine and N-ethylpiperidine, morpholine, N- (C)₁-C₆Alkyl) morpholines, such as N-ethyl morpholine and N-methyl morpholine. Further examples of suitable amines are piperazine and 1- (C)₁-C₄Alkyl) piperazine. Suitable basic N-heteroaromatic systems are unsubstituted basic N-heteroaromatic systems, e.g. pyridine, imidazole, N- (C)₁-C₆Alkyl) imidazoles such as N-methylimidazole and quinoline; and a basic N-heteroaromatic system with a carbon ring member selected from C₁-C₄Alkyl, di- (C)₁-C₄Alkyl) amino and pyrrolidinyl substituents, such as 4-methylpyridine, 4- (1-pyrrolidinyl) pyridine and 4-dimethylaminopyridine.

Amines are particularly preferred hereinafter. Particular preference is given to trimethylamine, dimethylamine, monomethylamine, triethylamine, diethylamine, monoethylamine, tripropylamine, dipropylamine, tributylamine, dibutylamine, trihexylamine, dihexylamine, dicyclohexylamine, morpholine, piperidine, N, N-diisopropylethylamine and N-ethylpiperidine, and mixtures thereof.

It is also obvious that mixtures of two or more of the above bases can be used.

In the case where the starting material is a composition comprising a compound of formula I-Z or a salt thereof and a compound of formula I-E or a salt thereof, the amount of base used is generally equal to or greater than 0.1 to 5 moles of base per mole of the total amount of the compound of formula I-Z or a salt thereof and the compound of formula I-E or a salt thereof. The amount of base used is preferably 0.2 to 3 moles of base per mole of the total amount of compounds of formulae I-Z and I-E. If the pure Z-isomer of formula I-Z or a salt thereof or a composition comprising a compound of formula I-Z or a salt thereof is used, the amount of base used is usually 0.1 to 5 moles of base per mole of the compound of formula I-Z or a salt thereof.

In one embodiment of the invention, the isomerization of the 3- (Z) -unsaturated carboxylic acid I-Z is carried out in the presence of a base and an anhydride of an organic acid. Suitable organic acids are, in particular, carboxylic acids and organic sulfonic acids. Preferably, the anhydrides are selected from aliphatic C₁-C₁₂Anhydrides of monocarboxylic acids, aliphatic C₄-C₂₀Anhydrides of dicarboxylic acids, cycloaliphatic C₇-C₂₀Anhydrides of dicarboxylic acids, aromatic C₈-C₂₀Anhydrides of dicarboxylic acids, anhydrides of aliphatic sulphonic acids, or anhydrides of aromatic sulphonic acids.

Suitable aliphatic C₁-C₁₂The anhydrides of monocarboxylic acids being linear or branched monocarboxylic acids C₁-C₁₂Anhydrides of alkane carboxylic acids. Examples are acetic anhydride, propionic anhydride, isopropyl anhydride, butyric anhydride, n-valeric anhydride, mixed anhydrides of formic acid and acetic acid, and the like. Among these, preferred are the symmetrical anhydrides of alkanemonocarboxylic acids having up to 5 carbon atoms. These also include straight-chain or branched monovalent C₃-C₁₂Anhydrides of alkene carboxylic acids. Examples thereof are (meth) acrylic anhydride, crotonic anhydride and isocrotonic anhydride. Aliphatic C₄-C₂₀Suitable examples of anhydrides of dicarboxylic acids are linear or branched dibasic C₄-C₂₀Anhydrides of alkanecarboxylic acids, for example the anhydrides of the following acids: succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, tridecanedioic acid, tetradecanedioic acid, pentadecanedioic acid, hexadecanedioic acid, heptadecanedioic acid, octadecanedioic acid. These also include linear or branched binary C₄-C₂₀Anhydrides of alkene carboxylic acids, e.g. maleic or itaconic anhydride. Alicyclic C₇-C₂₀Suitable examples of anhydrides of dicarboxylic acids are cyclopentane dicarboxylic acid anhydride and cyclohexane carboxylic acid anhydride. Also suitable are aromatic C₈-C₂₀Anhydrides of dicarboxylic acids, such as phthalic anhydride, 1, 8-naphthalic anhydride or 2, 3-naphthalic anhydride. Acetic anhydride, propionic anhydride, isopropyl anhydride, butyric anhydride, succinic anhydride, maleic anhydride and phthalic anhydride, especially acetic anhydride and maleic anhydride, are preferred hereinafter.

Also suitable are organic sulfonic anhydrides of formula III:

wherein

R³And R⁴Each independently is C₁-C₆Alkyl radical, C₁-C₆-a fluoroalkyl group; phenyl, unsubstituted or selected from bromo, nitro and C₁-C₄Alkyl substituents.

In the anhydrides of the formula III, R³And R⁴Preferably having the same definition. R³And R⁴Especially C₁-C₄Alkyl radical, C₁-C₄-a fluoroalkyl group; and phenyl, unsubstituted or selected from bromo, nitro and C₁-C₄Alkyl substituents. Preferred hereinafter are methanesulfonic anhydride, trifluoromethanesulfonic anhydride, benzenesulfonic anhydride, p-toluenesulfonic anhydride, 4-bromophenylsulfonic anhydride and 4-nitrophenylsulfonic anhydride; of these, methane sulfonic anhydride and p-toluene sulfonic anhydride are particularly preferable.

The anhydrides may advantageously be used in substoichiometric to stoichiometric amounts, based on the total amount of the compounds of the formulae I-Z and I-E or salts thereof. It is preferred to use 0.05 to 0.8 mole of anhydride per mole of total amount of compound of formulae I-Z or salt thereof and compound of formulae I-E or salt thereof. The anhydrides are used in particular in amounts of from 0.1 to 0.5mol of anhydride per mol of the total amount of compounds I to Z or salts thereof and compounds I to E or salts thereof. If the pure Z-isomer of formula I-Z or a salt thereof or a composition comprising a compound of formula I-Z or a salt thereof is used, the amount of anhydride used is generally 0.1 to 0.5 mole of anhydride per mole of compound of formula I-Z or a salt thereof.

In another embodiment of the invention, the isomerization of the 3- (Z) -unsaturated carboxylic acid I-Z is carried out in the presence of a base and an alkenone of the formula V:

wherein

R¹¹And R¹²Each independently selected from hydrogen, linear or branched C₁-C₂₄Alkyl, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₅-C₁₂Cycloalkyl radicals, unsubstituted or substituted by 1,2 or 3C₁-C₆Alkyl substituted C₆-C₁₄And (4) an aryl group.

Preference is given to alkenones of the formula V, in which R¹¹And R¹²Each independently selected from hydrogen, C₁-C₁₀Alkyl, and C having 1,2 or 3 double bonds₁₀-C₁₈An alkenyl group. In particular, R¹¹And R¹²Are all hydrogen. Also particularly preferred are homofarnesoic acid enones, i.e., compounds of formula V wherein R¹¹Is hydrogen, and R¹²Is 2,6, 10-trimethylundec-1, 5, 9-trienyl.

The simplest representative example of an enone compound of formula V is CH₂C ═ O (ketene). Ketene is preferably obtained by pyrolysis of acetone or acetic acid at temperatures generally above 650 ℃. The temperature for the production of ketene is preferably in the range of 650-1000 ℃ and particularly preferably 700-900 ℃.

In one embodiment, the ketene is prepared under reduced pressure. The pressure is preferably in the range of about 100-900 mbar, particularly preferably 300-500 mbar, especially 350-450 mbar. In another embodiment, the ketene is prepared at ambient pressure ("unpressurized"). In this case, the pressure is preferably in the range of about 950 and 1050 mbar.

Methods and apparatus for the preparation of ketene can be found, for example, in Organic Syntheses, col. Vol.1, 330Page (1941) and Vol.4, page 39 (1925), and Chemiker Zeitung [ The Chemists Journal]97, No.2, pages 67-73 (1979). If used in the process of the invention with CR¹¹R¹²A ═ C ═ O ketene compound of formula V, wherein R¹¹And R¹²In contrast to hydrogen, the preparation can in principle be carried out by known methods. These methods include, for example, elimination of hydrogen halide from carbonyl halides with adjacent hydrogen. These processes can be found, for example, in Organikum, VEB Deutscher Verlagder Wissenschaften, 16 th edition, Berlin 1986, chapter 3.1.5, in particular page 234. The ketene compounds can also be prepared by the Arndt-eisert synthesis by reacting carbonyl halides with diazomethane.

Since the ketene compounds of the formula V, in particular ketene, are compounds having a particular reactivity and have a strong tendency to dimerize to form dienones, the ketene compounds used in the process of the invention are preferably prepared only shortly before use. The process of the present invention is particularly advantageous when ketene prepared just before use is used, for example dehydrochlorination by thermal cleavage of acetone, acetic acid or acetic anhydride or by acetyl chloride using a base such as triethylamine.

The alkenone of formula V may be introduced via any suitable apparatus. Good distribution and rapid mixing are advantageous. Suitable devices are, for example, spray guns, or preferably nozzles, which can be fixed in position. The nozzle may be located at or near the bottom of the reactor. For this purpose, the nozzles can be designed as openings around the hollow chamber of the reactor. However, it is preferred to use a nozzle which is impregnated with a suitable feed line. The plurality of nozzles may be arranged, for example, in the form of a ring. These nozzles may be upward or downward. The nozzle is preferably inclined downwardly.

The amount of ketene of formula V can advantageously be from substoichiometric to stoichiometric, based on the total amount of compounds of formulae I-Z and I-E or salts thereof. Preference is given to using from 0.05 to 0.8 mol of ketene of the formula V per mole of the total amount of compounds of the formulae I to Z or salts thereof and compounds of the formulae I to E or salts thereof. The ketene of the formula V is used in particular in amounts of from 0.1 to 0.5mol per mole of the total amount of the compounds I to Z or their salts and of the compounds I to E or their salts.

In a preferred embodiment of the process of the invention, the isomerization reaction is carried out in the presence of a base as described above and an organic acid anhydride.

The process of the present invention can be carried out in the absence of a solvent or in an inert solvent or diluent. Examples of suitable diluents or solvents are in particular aliphatic hydrocarbons, such as hexane, cyclohexane, heptane, octane; aromatic hydrocarbons such as toluene, xylene; dialkyl ethers, such as methyl tert-butyl ether and diisopropyl ether. When the process is carried out in the absence of a solvent, the anhydride and/or base may act as a solvent or diluent.

The process of the invention is generally carried out at a reaction temperature of 20 ℃ or above. The process is preferably carried out at a temperature in the range from 60 to 175 ℃ and in particular from 70 to 160 ℃.

The process of the invention may be carried out at positive, negative or atmospheric pressure. When bases and/or anhydrides are used which have a boiling point below the reaction temperature at standard pressure, the process of the invention is carried out in a pressure reactor. When bases and organic anhydrides having a boiling point above the reaction temperature at standard pressure are used, the process of the invention is generally carried out in a glass reactor or glass vessel.

When a base and/or an alkenone having a boiling point below the reaction temperature at standard pressure is used, the process of the invention is carried out in a pressure reactor.

The process of the invention is preferably carried out at a pressure of from 1 to 25 bar, preferably from 1.1 to 25 bar.

In particular, the process of the invention is carried out at a temperature of from 60 to 175 ℃ and a pressure of from 1 to 25 bar, for example from 1.1 to 25 bar.

Suitable pressure-resistant reactions are known to the person skilled in the art, see for example Ullmann's encyclopedia of Industrial Chemistry, Vol.1, 3 rd edition, page 1951,769. An autoclave can advantageously be used in the process of the invention, which can be equipped with stirring equipment and an internal lining, if desired.

The reaction time at a temperature of 70-160 ℃ is usually 3-24 hours.

The process of the invention can be carried out in the presence of atmospheric oxygen or carbon monoxide or optionally under a protective gas atmosphere.

The process of the present invention can also advantageously be carried out by means of an allyl alcohol or an acylated alcohol in the presence of a transition metal catalyst and in the presence of an organic anhydride under the conditions used for preparing the 3-unsaturated carboxylic acids. WO 2018/153727 describes such a process.

The process of the present invention may be carried out as a batch or continuous process after at least partial separation of the above 3- (E) isomer.

The resulting reaction mixture may optionally be purified to remove by-products, for example by mixing with water, an acid, an aqueous acid solution or an aqueous base solution, separating the phases, and optionally purifying the crude product by chromatography or by distillation.

The present invention is explained in more detail below by working examples.

HPLC-analysis:

spectrometer Agilent Series 1100

Column Chiralpak AD-RH 5 μm 150 x 4.6mm from Daicel

Diluent A0.1% by volume H in water₃PO₄

B0.1% by volume of H in acetonitrile₃PO₄

Time [ min ]]	％B#	Flow rate [ mL/min]
			0.0	40	1.2
25.0	70	1.2
			30.0	100	1.2
40.0	100	1.2
			30.1	40	1.2

# is based on 100% for A + B

UV detector lambda 205nm, BW 5nm

Flow rate 1.2mL/min

Injection of 5 mul

The temperature is 40 DEG C

Time 45 minutes

Pressure of about 70 bar

The abbreviations used hereinafter have the following meanings:

high farnesic acid: 4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

3Z, 7E-homofarnesoic acid: (3Z,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

3E, 7E-homofarnesoic acid: (3E,7E) -4,8, 12-trimethyltridec-3, 7, 11-trienoic acid.

2E, 7E-homofarnesoic acid: (2E,7E) -4,8, 12-trimethyltridec-2, 7, 11-trienoic acid.

Ac₂And O is acetic anhydride.

eq is equivalent.

Example 1 compositions containing homofarnesoic acid

Palladium (II) acetate (46mg,0.2mmol), triphenylphosphine (120mg,0.46mmol) and 4-dimethylaminopyridine (DMAP,56mg,0.46mmol) were charged under argon in a steel autoclave. (E) -nerolidol (34g,152.6mmol), triethylamine (17g,167mmol) and acetic anhydride (3.6g,35mmol) were added under a counter-current flow of argon. Then 10 bar of CO was applied and the mixture was stirred at 1000rpm at 70 ℃ internal temperature for 24 hours at this pressure. After 24 hours, the mixture was cooled to room temperature and decompressed. GC analysis of the reaction effluent showed 95% conversion and 81% selectivity to the products (3E,7E) -homofarnesoic acid, (2E,7E) -homofarnesoic acid) and (3Z,7E) -homofarnesoic acid.

After the reaction was complete, the crude product was purified by Kugelf (Kugelrohr) distillation (1 mbar, up to 170 ℃). This gave 23g (61%) of E/Z-homofarnesic acid with a purity (GC) of 97% (3E, 7E-homofarnesic acid and 2E, 7E-homofarnesic acid): the isomer ratio of (3Z, 7E-homofarnesoic acid) is equal to 64:36 (GC).

The resulting mixture was dissolved in n-heptane (100g), and isopropanol (10g) and Novozym 435(0.5g) were added thereto, and the mixture was stirred at 60 ℃ for about 17 hours. Then, the enzyme was filtered off. Methanol and water were added at a temperature of 0 ℃ and the pH of the reaction mixture was adjusted to pH 12-13 by adding aqueous NaOH solution at a temperature below 10 ℃. The phases were separated to give an organic phase containing isopropyl (3E,7E) -homofarnesoate as the main component and an aqueous phase containing a composition comprising 3Z, 7E-homofarnesoate: 3E, 7E-homofarnesoate: 2E, 7E-homofarnesoate: other compounds in a ratio of 68% 14% to 17% to 1% (HPLC). This composition was used in the working examples below.