阅读说明：本技术 将3-(z)-不饱和羧酸异构化成3-(e)-异构体的方法 (Process for isomerizing 3- (Z) -unsaturated carboxylic acids to 3- (E) -isomers ) 是由 M·施尔维斯 W·塞格尔 R·帕切洛 A·凯勒 于 2019-02-13 设计创作，主要内容包括：本发明涉及使式I-Z的3-(Z)-不饱和羧酸或其盐异构化以得到式I-E的3-(E)-不饱和羧酸或其盐的方法,其中R<Sup>2</Sup>是C<Sub>1</Sub>-C<Sub>24</Sub>烷基,具有1、2、3或多于3个C-C双键的C<Sub>2</Sub>-C<Sub>24</Sub>链烯基,未取代或被取代的C<Sub>5</Sub>-C<Sub>12</Sub>环烷基,或者未取代或被取代的芳基；R<Sup>1</Sup>是氢或具有对于R<Sup>2</Sup>所述的含义之一；前提是R<Sup>2</Sup>具有根据IUPAC的高于R<Sup>1</Sup>的优先性；其中式I-Z化合物的异构化是在有机酸酐和碱的存在下进行,或在式CR<Sup>11</Sup>R<Sup>12</Sup>C(O)的烯酮和碱的存在下进行,其中R<Sup>11</Sup>和R<Sup>12</Sup>具有在权利要求和说明书中所述的含义。特别是,本发明涉及从包含(3Z,7E)-和(3E,7E)-高金合欢酸的组合物制备具有增加含量的(3E,7E)-高金合欢酸的组合物的方法。<Image he="507" wi="700" file="DDA0002628870930000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention relates to a method for isomerizing a 3- (Z) -unsaturated carboxylic acid of the formula I-Z or a salt thereof to give a 3- (E) -unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein R 2 Is C 1 ‑C 24 Alkyl, C having 1,2,3 or more than 3C-C double bonds 2 ‑C 24 Alkenyl, unsubstituted or substituted C 5 ‑C 12 Cycloalkyl, or unsubstituted or substituted aryl; r 1 Is hydrogen or aFor R to 2 One of the meanings mentioned; provided that R is 2 Having a value higher than R according to IUPAC 1 (iii) a priority of; wherein the isomerization of the compound of formula I-Z is carried out in the presence of an organic acid anhydride and a base, or in the presence of a compound of formula CR 11 R 12 In the presence of an alkenone and a base, wherein R 11 And R 12 Have the meaning stated in the claims and the description. In particular, the present invention relates to methods of preparing compositions having increased levels of (3E,7E) -homofarnesoic acid from compositions comprising (3Z,7E) -and (3E,7E) -homofarnesoic acid.)