阅读说明：本技术 用于治疗癌症的尿苷的二氧戊环类似物 (Dioxolane analogues of uridine for the treatment of cancer ) 是由 R·贝特尔 A·埃内罗特 B·克拉松 F·欧伯格 于 2015-08-24 设计创作，主要内容包括：本发明提供了式(I)的化合物,其中,R<Sup>1</Sup>是OR<Sup>11</Sup>或NR<Sup>5</Sup>R<Sup>5</Sup>’；R<Sup>2</Sup>是H或F；R<Sup>5</Sup>是H、C<Sub>1</Sub>-C<Sub>6</Sub>烷基、OH、C(＝O)R<Sup>6</Sup>、O(C＝O)R<Sup>6</Sup>或O(C＝O)OR<Sup>6</Sup>；R<Sup>5</Sup>’是H或C<Sub>1</Sub>-C<Sub>6</Sub>烷基；R<Sup>6</Sup>是C<Sub>1</Sub>-C<Sub>6</Sub>烷基或C<Sub>3</Sub>-C<Sub>7</Sub>环烷基；R<Sup>13</Sup>是H、苯基、吡啶基、苄基、吲哚基或萘基,其中,所述苯基、吡啶基、苄基、吲哚基和萘基任选被1、2或3个R<Sup>22</Sup>取代；其它变量如权利要求所定义,所述化合物用于治疗癌症和相关的方面。<Image he="224" wi="700" file="DDA0002283077450000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention provides compounds of formula (I) wherein R 1 Is OR 11 Or NR 5 R 5 '；R 2 Is H or F; r 5 Is H, C 1 ‑C 6 Alkyl, OH, C (═ O) R 6 、O(C＝O)R 6 OR O (C ═ O) OR 6 ；R 5 ' is H or C 1 ‑C 6 An alkyl group; r 6 Is C 1 ‑C 6 Alkyl or C 3 ‑C 7 A cycloalkyl group; r 13 Is H, phenyl, pyridyl, benzyl, indolyl or naphthyl, wherein said phenyl, pyridyl, benzyl, indolyl and naphthyl are optionally substituted by 1,2 or 3R 22 Substitution; the other variables are as defined in the claims, for use in the treatment of cancer and related aspects.)