阅读说明：本技术 2-噻唑甲醛-4-吡啶席夫碱的结构、制备和用途 (Structure, preparation and application of 2-thiazole formaldehyde-4-pyridine Schiff base ) 是由 谭学杰 刘帅 邢殿香 于 2019-09-30 设计创作，主要内容包括：本发明涉及有机合成、光学材料和药物化学等领域,具体是一种化合物晶体的结构、制备方法及部分性质；这种化合物外观呈黄色块状晶体,熔点为：145.5-146.0℃,分子式C<Sub>10</Sub>H<Sub>8</Sub>N<Sub>4</Sub>S,化学名为：2-((E)-(((E)-吡啶-4-基亚甲基)亚肼基)甲基)噻唑；该化合物结构详见说明书,具有一定的荧光性质以及抗癌活性。(The invention relates to the fields of organic synthesis, optical materials, pharmaceutical chemistry and the like, in particular to a structure, a preparation method and partial properties of a compound crystal; this compound appears as yellow blocky crystals with a melting point: 145.5-146.0 deg.C, molecular formula C 10 H 8 N 4 S, the chemical name is: 2- ((E) - (((E) -pyridin-4-ylmethylene) hydrazono) methyl) thiazole; the structure of the compound is detailed in the specification, and the compound has certain fluorescence property and anticancer activity.)

1. A compound which is yellow blocky crystal in appearance and has a melting point of: 145.5-146.0 deg.C, molecular formula C₁₀H₈N₄S, the chemical name is: 2- ((E) - (((E) -pyridin-4-ylmethylene) hydrazono) methyl) thiazole, having the structure:

the crystal belongs to monoclinic system, the space group is P21/n, β＝110.499(8)°，Z＝4。

2. a method of synthesizing a compound as claimed in claim 1, characterized in that: taking (E) -2- (hydrazono) thiazole and 4-pyridine-formaldehyde as raw materials, reacting at normal temperature or heating to reflux, and reacting in organic solvents such as methanol, ethanol, acetonitrile, dichloromethane, chloroform, tetrahydrofuran, acetone and the like, wherein the steps are as follows:

1) dissolving all (E) -2- (hydrazono) thiazole in an organic solvent, adding 4-pyridine-formaldehyde according to the mass ratio of 1:4 to 4:1, and stirring or grinding at a certain temperature for reaction for 1-10 h to complete the reaction; if a solid phase reaction is adopted, an organic solvent can be omitted;

2) filtering, and naturally volatilizing the filtrate to separate out orange blocky crystals which are target products; if solid phase reaction is adopted, the target product crystal can be obtained by recrystallization with organic solvents such as methanol, ethanol, acetonitrile, dichloromethane, chloroform, tetrahydrofuran, acetone and the like.

3. Use of the compound crystals as claimed in claim 1 in the fields of dyes, organic pigments, optical brighteners, photooxidizers, coatings, chemical and biochemical marking analysis, solar traps, security markings, drug tracing, fluorescent probes, fluorescence analysis, optoelectronic devices, photochemical sensors, laser dyes, organic electroluminescent devices, etc., based on their fluorescent properties.

4. Use of a crystal or other pharmaceutically acceptable salt of a compound as claimed in claim 1 for the manufacture of a medicament for the treatment of tumours, wherein: the tumor is lung cancer, malignant melanoma and cervical cancer.