阅读说明：本技术 定制的植入物创建 (The implantation material of customization creates ) 是由 G·福格特米尔 于 2018-03-23 设计创作，主要内容包括：本发明涉及定制植入物的创建。为了提供具有改进适应性的植入物,提供了一种用于定制植入物数据集创建的设备(10)。所述设备包括输入接口(12)和输出接口(14)；以及处理单元(16)。所述输入接口被配置为向处理单元提供要插入植入物的患者的肌肉骨骼系统数据集(18)。为了制造定制的植入物,所述处理单元被配置为基于所述肌肉骨骼系统数据集来生成定制的植入物数据集(19)。(The present invention relates to the creations of customized implants.There is the implantation material for improving adaptability in order to provide, provide a kind of equipment (10) for the creation of customized implants data set.The equipment includes input interface (12) and output interface (14)；And processing unit (16).The input interface is configured as providing the musculoskeletal system data set (18) that be inserted into the patient of implantation material to processing unit.In order to manufacture the implantation material of customization, the processing unit is configured as generating the implantation material data set (19) of customization based on the musculoskeletal system data set.)

1. a kind of equipment (10) for the creation of customized implants data set, the equipment include:

Input interface (12) and output interface (14)；And

Processing unit (16)；

Wherein, the input interface is configured as providing the muscle of the implantation material patient to be inserted to the processing unit Skeletal system data set；And

Wherein, in order to manufacture customized implants, the processing unit be configured as based on the musculoskeletal system data set come It generates customized implants data set (19)；And

Wherein, the musculoskeletal system data set is generated by different image modes, and the difference image mode includes with the following group At least one of:

Spectral computed tomography scanner；

Compose X-ray；And

Magnetic resonance tomography is merged with computer tomography device.

2. equipment according to claim 1, wherein the processing unit, which is additionally configured to also consider patient, specifically to be loaded Overview generates the customized implants data set；

Wherein, the specific loading profile of the patient describes the static state and dynamic motion scene of the patient；And

Wherein it is preferred to which the conduct for the proper motion process that the specific loading profile of patient lists the patient is mainly lived Dynamic, the proper motion process of the patient is at least one in the following group: sitting, stands, rides, runs and swims.

3. equipment according to one of the preceding claims, wherein the musculoskeletal system data set includes following The data of at least one in group:

Bone geometry；

Skeleton density；

Bone health；And

Surround the institutional framework of bone, the information including muscle, tendon and fascia.

4. equipment according to one of the preceding claims, wherein the customized implants data set includes with the following group In at least one of data:

The size and shape of implantation material；

The interface shape of the implantation material and the skeletal structure；

The position of the implantation material and the fixed point on the skeletal structure；

Fixed method；And

The use of material.

5. equipment according to one of the preceding claims, wherein the processing unit is configured as having using machinery Finite element analysis executes static simulation related with the specific loading profile of patient and dynamic analog.

6. a kind of system (20) for creating customized implants data set, the system comprises:

Spectral scanner (22)；And

Equipment (10) according to one of the preceding claims,

Wherein, the spectral scanner is configured as the spectroscopic data (24) of acquisition patient and generates musculoskeletal system data Collection；And the musculoskeletal system data set is provided to the equipment.

7. system according to claim 6, wherein the system also includes:

3D printer (26)；

Wherein, the output interface (14) of the equipment (10) is configured as sending the customized implants data set (19) generated to The 3D printer；And

Wherein, the 3D printer is configured as manufacturing implantation material (28) based on the customized implants data set.

8. system according to claim 6 or 7, wherein the system also includes:

The image data set of disposition guidance is provided based on the customized implants data set.

9. a kind of method (40) for creating customized implants data set, the described method comprises the following steps:

A) (42) implantation material musculoskeletal system data set to be inserted is provided；And

B) (44) customized implants data set is generated based on the musculoskeletal system data set；

Wherein, the musculoskeletal system data set is generated by different image modes, and the difference image mode includes with the following group At least one of:

Spectral computed tomography scanner；

Compose X-ray；And

Magnetic resonance tomography is merged with computer tomography device.

10. according to the method described in claim 9, wherein, the method also includes following steps:

A1) the specific loading profile of (46) patient is provided；And

Wherein, it in step b), generates (44) customized implants data set and also considers the specific loading profile of the patient；

Wherein, the specific loading profile of the patient describes the static state and dynamic motion scene of the patient；And

Wherein it is preferred to which the conduct for the proper motion process that the specific loading profile of patient lists the patient is mainly lived Dynamic, the proper motion process of the patient is at least one in the following group: sitting, stands, rides, runs and swims.

11. method according to claim 9 or 10, wherein the method also includes:

Static simulation and dynamic analog are executed based on the musculoskeletal system data set and the specific loading profile of the patient It is quasi-, to generate the customized implants data；Or

Static simulation and dynamic analog are executed based on the musculoskeletal system data set and the specific loading profile of the patient It is quasi-, to generate the customized implants data by modification standard implants data set.

12. according to method described in one in claim 9 to 11, further includes:

C) the customized implants data set is sent into (48) and arrives 3D printer；And

D) (50) described implantation material is printed based on the customized implants data set.

13. a kind of for controlling according to claim 1 to the computer program element of equipment described in one in 8, the meter Calculation machine program unit is adapted for carrying out the step of the method according to one in claim 9 to 12 when being run as processing unit Suddenly.

14. a kind of computer-readable medium for being stored with program unit according to claim 13.

Technical field

Equipment the present invention relates to creating for customized implants data set is related to the system with such equipment, relates to And the method for creating customized implants data set, it is related to the computer program element and storage for controlling such equipment There is the computer-readable medium of the program unit.

Background technique

Implantation material is used, for example, in order to replace the body structure of such as bone or joint.Implantation material may be provided as Adapt to the geometrical condition of patient.As an example, may be intended to make to plant in view of other criterion in addition to the geometrical property of patient Enter object and adapts to patient as much as possible.2013134584 A1 of WO describes one kind and customization is designed, generated and manufactured by following The method of implantation material: the 3D rendering that receive the position of implantation material is obtained, the volume change at the position is simulated, generates virtual 3D Implantation material, and manufacture true 3D implantation material.However, it has been shown that implantation material should have improved adaptability.

Summary of the invention

Therefore it may need to provide the implantation material with improved adaptability.

The purpose of the present invention is solved by subject matter of the independent claims；It is incorporated in the dependent claims other Embodiment.It should be noted that the equipment created for customized implants data set is also applied in terms of the following description of the present invention, Suitable for the system with this equipment, method suitable for creating customized implants data set, and it is suitable for control in this way Equipment computer program element and apply also for the computer-readable medium for being stored with described program unit.

According to the first aspect of the invention, a kind of equipment for the creation of customized implants data set is provided, it is described to set Standby includes input interface, output interface and processing unit.The input interface, which is configured as providing to processing unit, will be inserted into plant Enter the musculoskeletal system data set of the patient of object.The processing unit is configured as based on the musculoskeletal system data set To generate customized implants data set for manufacturing customized implants.Musculoskeletal system data set is by different image modes It generates, including spectral computed tomography (CT) scanner, spectrum X-ray scanning device, magnetic resonance tomography (MRT) and computer At least one of the fusion of tomography (CT) scanner.

Creation customized implants data set is to obtain the best match implantation for patient according to intracorporal position is inserted into Object.It, can be with best by using the benefit of enhancing data, such as from spectral scanner or other suitable data collection systems Mode constructs implantation material.Other than geological information, using such as spectral scanner equipment data acquisition provide about The additional information of the characteristic of bone is used to make the implantation material of customization to adapt to bone structure.This causes to have between bone structure and implantation material There is best match combination.

Musculoskeletal system is referred to as human motion system, mobile device, telecontrol equipment or skeletal structure.

By generating musculoskeletal system data set as described above, the soft tissue structure about surrounding bone can be obtained The information of (such as muscle, tendon and/or fascia).This is provided about (such as implantation material by be inserted) position of human body The information of the dynamic force at place.As a result, the soft tissue structure around bone information provides with skeleton density and being superimposed for geometry The functional information of musculoskeletal system.The information is for customizing implantation according to the specified conditions of the musculoskeletal system of patient Object.

CT scanner may include X-ray tube, and the X-ray tube emits ionising radiation, and the ionising radiation, which passes through, to be checked A part of region and object therein or object and detector array is irradiated, the detector array is arranged on test zone Domain opposite, it is opposite with the X-ray tube.The detector generates the data for projection for the radiation that instruction detects.Number can be rebuild The part of instruction object or object and the volumetric image data of geometry are generated accordingly.For example, for spectral CT, spectroscopic data Collection or data for projection include the signal corresponding to different photon energy ranges.In this example, signal can be by least one detection Device obtains simultaneously.In another example, two energy signals can pass through two layers of detector (such as photon counting detector) It is obtained and sequentially switching between at least two different peak kilovoltages (kVp) simultaneously.There is several methods that for executing light Compose CT scan.For example, CT scanner may include two or more sources and/or at least one is configured as at least two The source switched between different peak kilovoltages (kVps), and/or the detector array with energy-resolved detector.Show at another In example, spectroscopic data collection can be obtained by the different power spectrum filtering of application.Using double decker detector simultaneously (such as based on yttrium Scintillator), detector identifies the photon of high-energy and low energy simultaneously, to allow not only to check anatomical structure, but also looks into See the content of the material of key structure.Therefore, spectroscopic data collection is valuable and submits necessary information so that implantation material The detection material property of musculoskeletal system is adapted in the best way.

Musculoskeletal system data set can be generated by different image modes, such as MRT system and CT scanner Fusion, to obtain the imaging data of the enhancing of bone structure, i.e., as input data also for the more of soft tissue (muscle) etc. Material property.

According to example, processing unit is additionally configured to also consider the specific loading profile of patient to generate the customization implantation Object data set.

Using such additional information of the specific loading profile of patient, implantation material can also be made to adapt to the specific property of patient Matter.The specific loading profile of patient describes the static state and dynamic motion scene of patient.

The specific loading profile of patient can list patient's proper motion process and (such as sit, stands, riding, running, swimming Deng) expection main activities.

According to example, musculoskeletal system data set is by bone geometries, skeleton density, bone health and/or bone The institutional framework composition of surrounding.

It captures this information and shows the process values of spectral scan.In one example, it is also envisioned that by spectrum CT scan It is combined with standard DICOM (medical digital image and communication) CT geological information.

Bone geometries indicate size of the bone in three-dimensional system of coordinate, such as length, height.

Skeleton density indicates bone condition.Skeleton density may be different because of patient.For example, this may include the hole of bone structure The information of gap rate.

Whether bone health expression skeletal status, i.e. such as bone are worn or inflammation.

Institutional framework around bone include for example myoarchitecture, muscle-tendon structure, surrounding bone connective tissue or fascia Part etc..

By consider myoarchitecture, implantation material be adapted to such as muscle to the power of bone transmit, especially implantation material with Interface.This is different each patient and can be considered.

According to an example, the customized implants data set includes the size and shape of implantation material, implantation material and bone knot The interface shape of structure, the position of the fixed point on implantation material and bone structure, fixed method；And/or the use of material.

The size and shape of implantation material include the information of implantation material geometry.The interface shape of implantation material and bone structure is also Comprising the geological information at implantation material interface point, most preferably to match the interface point of bone.The position of fixed point provides implantation The information of the arrangement of fixed point on object.For example, the position of fixed point is related to arranging screw etc. with the position of fixation implant.It will plant Enter the method that object is fixed on bone structure and provides the information fixed using which kind of.For example, it can be threaded connection or gluing Connection.In addition, the data set can provide the information of the material used in implantation material.In one example, the plant Enter object to be made using homogenous material or multiple material.For example, providing the function for having the implantation material of multiple material to design implantation material Can part and implantation material interface portion using biocompatible materials (coating or porous print so that bone uptake to implantation material In).There is also additional chances in the design of implantation material to change the material property of private location to adapt to uniform dynamic The rigidity and/or flexibility of load matched design, to reduce the areas of overload of the interface between implantation material and bone and/or fixed point Risk.

In this example, the processing unit is configured as specifically loading generally based on musculoskeletal system data set and patient Condition executes static simulation and dynamic analog, to generate customization implant data.

In this example, the processing unit is configured as specifically loading generally based on musculoskeletal system data set and patient Condition executes static simulation and dynamic analog, to generate customized implants data by modification standard implants data set.

Term " standard implants " is related to the fixed use with size of standard.It may cause surgery using standard implants to cure Teacher always prepares bone in an identical manner, however, this may have the disadvantage, but at least surgeon gets used to process.It can be with The advantages of the two (i.e. standard implants and customized implants) is combined by modification standard implants data set.

Standard implants can be listed in the catalogue for listing standard implants, and the catalogue is based on implantation material in patient's body Destination, size etc..

Simulation can adjust geometry since some standard values but consider the specific loading profile of patient and muscle Automatic running in the iterative process of skeletal system data set.

Using the full geometry information from spectroscopic data collection so that the implantation material of Complete customization is accurately suitble to (residue ) geometry of bone structure, have the advantages that adapt to the individual geometry shape of patient.

Simulation of starting from scratch is additionally provided in one example, that is, is not had selection criteria implantation material, and is based on intermuscular bone Bone system data set and patient load's overview generate customized implants data set, without since standard implants.

By simulating musculoskeletal system data based on the individual attribute of skeletal structure and the specific loading profile of patient The perfect matching combination generated in customized implants data set can be generated in the various combination of collection and customization implant data.Example Such as, the interface between implantation material and bone with fixed point can configure in this way: so that in the natural fortune of patient The power applied on the interface of skeletal structure and customized implants during dynamic adjusts in the best way for the attribute of patient.

According to example, the processing unit is configured as being executed using mechanical finite element analysis and specifically be loaded with patient The relevant static simulation of overview and dynamic analog.Finite element analysis can simulate for example in the interface of implantation material and each region Locate the power of interaction, to have during designing the dynamic interaction between bone structure and implantation material based on patient load's overview There is the implantation material of best match characteristic.

According to the second aspect of the invention, a kind of system for creating customized implants data set is additionally provided.This is System includes spectral scanner and the equipment for the creation of customized implants data set.Spectral scanner is configured as acquisition patient's Spectroscopic data simultaneously generates musculoskeletal system data set and the musculoskeletal system data set is supplied to equipment.

It is disconnected that spectral scanner can be spectral computed tomography (CT) scanner, spectrum X-ray scanning device or magnetic resonance Layer photography (MRT) is merged with computer tomography (CT) scanner.

According to example, the system also includes 3D printer (three-dimensional printers).The output interface of the equipment is configured To send 3D printer for the customized implants data set of generation.3D printer is configured as based on customized implants data set To manufacture implantation material.

According to example, the system also includes the image data of disposition guidance is provided based on customized implants data set Collection.

Term " image data set " is related to the image information of virtual skeleton and customized implants.Based on the image data set, Disposition guidance is provided to surgeon, i.e. surgeon can prepare medicine intervention.Virtual graph can be provided with 2D or 3D data As data set.

According to the third aspect of the invention we, a kind of method for creating customized implants data set is additionally provided.It is described Method the following steps are included:

A) musculoskeletal system data set is provided；The musculoskeletal system data set is the implantation material bone to be inserted The spectral CT data set of structure；And

B) customized implants data set is generated based on the musculoskeletal system data set.

The musculoskeletal system data set is generated by different image modes, and the image mode includes in the following group At least one:

Spectral computed tomography scanner；

Compose X-ray；And

Magnetic resonance tomography is merged with computer tomography device.

According to example, the method also includes providing the specific loading profile of patient, and in step b), also The specific loading profile of the patient is considered to generate customized implants data set.

The step of providing patient's specific load distribution can operate after providing musculoskeletal system data set, but can also It operates simultaneously.

This is equally applicable to step b), that is, only considers musculoskeletal system data set or also considers patient load's overview To generate customized implants data set.

According to another example, the method also includes following steps: based on the musculoskeletal system data set and described The specific loading profile of patient executes static simulation and dynamic analog, to generate customization implant data；Or it is based on the flesh Meat bone bone system data set and the specific loading profile of the patient execute static simulation and dynamic analog, are planted by modification standard Enter object data set to generate the customization implant data.

These steps should not be considered as step a) and b) after additional step.These steps, which are shown, is generating customization plant The working method of processing unit when entering object data set.

According to an example, the described method comprises the following steps:

C) 3D printer is sent by customized implants data set；And

D) implantation material is printed based on customized implants data set.

In another exemplary embodiment of the invention, a kind of computer program or computer program element are provided, It is characterized in that, is suitable for executing the method and step according to one method in previous embodiment in suitable system.

Therefore computer program element can store on computing unit, be also possible to the portion of the embodiment of the present invention Point.The computing unit may be adapted to the step of executing the above method or execution the step of causing the above method.In addition, it can be with Suitable for operating the component of above-mentioned apparatus.The computing unit may be adapted to the order for automatically operating and/or executing user.It calculates Machine program can be loaded into the working storage of data processor.Therefore data processor can be equipped as implementing the present invention Method.

The exemplary embodiment of the invention is covered from most beginning to use computer program of the invention and by means of more Existing program is newly changed into the computer program using program of the invention.

Further, computer program element can be capable of providing the exemplary embodiment to realize method as described above Process all steps necessaries.

Another exemplary embodiment according to the present invention, proposes a kind of computer-readable medium, such as CD-ROM, In, the computer-readable medium has the computer program element being stored thereon, and the computer program element is by previous Described by part.Computer program be can store and/or be distributed on suitable medium, such as provided together with other hardware Either as part thereof of optical storage medium or solid state medium, but it can also distribute otherwise, such as via mutual Networking or other wired or wireless telecommunication systems.

However, computer program can also be by providing and can be by under the network from such as the network of WWW It is downloaded in the working storage of data processor.Other exemplary embodiment according to the present invention provides a kind of for making Computer program element medium available for download is obtained, the computer program element is arranged to execute previous description of the present invention Embodiment in one.

With reference to embodiment described below, these and other aspects of the invention will become obvious and will be explained It states.

Detailed description of the invention

Exemplary embodiment of the invention described below with reference to the accompanying drawings:

Fig. 1 shows the example of the equipment for creating customized implants data set；

Fig. 2 shows the examples of the system with this equipment；

Fig. 3 shows another example of the system；

Fig. 4 illustrates the example of the method for creating customized implants data set；And

Fig. 5 illustrates the example of the method for manufacturing implantation material based on customized implants data set.

Specific embodiment

Fig. 1 shows the equipment 10 for the creation of customized implants data set.The equipment includes input interface 12 and output Interface 14 and processing unit 16.Input interface is configured as providing the musculoskeletal system data set of patient to processing unit 18, wherein the musculoskeletal system data set is the spectroscopic data collection of the implantation material bone structure to be inserted.The place Reason unit is configured as generating customized implants data set based on musculoskeletal system data set for manufacturing customization implantation Object 19.

The spectroscopic data collection is by including that spectral computed tomography scanner and/or spectrum X-ray, and/or magnetic resonance are broken Layer is photographed with the different light sources of the fusion of computer tomography device and is generated.

In another also unshowned example, the processing unit, which is additionally configured to also consider patient, specifically to be loaded generally Condition generates customized implants data set.

In another also unshowned example, the musculoskeletal system data set includes bone geometries, bone The data of density, the institutional framework of bone health and surrounding bone.

In another unshowned example, customized implants data set includes the size and shape of implantation material, implantation material With the data of the position of the fixed point on the interface shape of bone structure, implantation material and bone structure, the method for fixation and/or material It uses.

In another example not being shown specifically, the processing unit is configured as executing using mechanical finite element analysis Static simulation relevant to the specific load distribution of patient and dynamic analog.

Fig. 2 shows for creating the system 20 of customized implants data set.System 20 includes spectral scanner 22 and sets Standby 10.Spectral scanner 22 is configured as the spectroscopic data 24 of acquisition patient and generates musculoskeletal system data set and by muscle Skeletal system data set 18 is supplied to the equipment.Spectral scanner can be spectrum CT scanner, spectrum X-ray scanning device and/ Or MRT scanner.

Fig. 3 shows another embodiment of system 20.System 20 further includes 3D printer 26, wherein equipment 10 it is defeated Outgoing interface 14 is configured as sending 3D printer 26 for customized implants data set 19.This can be directly or by hospital Service is transmitted to complete in network or outside.3D printer 26 is configured as manufacturing implantation material based on customized implants data set 28。

In example not shown further, the system also includes drawn based on customized implants data set to provide disposition The image data set led.

Fig. 4 shows the basic step of method 40, wherein the described method comprises the following steps: in first step 42, Referred to as step a) provides musculoskeletal system data set.The musculoskeletal system data set is that implantation material will be inserted The spectral CT data set of bone structure.In second step 44, also referred to as step b), based on the musculoskeletal system data set come Generate customized implants data set.

Fig. 5 shows the another exemplary embodiment of method 40.This method further includes providing 46 patients specifically to load generally The step of condition.In step b), generates 44 customized implants data sets and also consider the specific loading profile of the patient.

In this example, by processing unit by being changed based on musculoskeletal system data set and the specific loading profile of patient Generation ground (being shown by array) executes static simulation and dynamic analog to generate customized implants data set, to generate customization implantation number According to.

In another example, by processing unit by being based on musculoskeletal system data set and the specific loading profile of patient Static simulation and dynamic analog are executed to generate customized implants data set, to generate by modification standard implants data set Customize implant data.

In addition, once it is determined that customized implants data sets, in one example, the method also includes following steps: C) via in hospital direct interface or external delivery service customized implants data set sent 48 to 3D printer and d) 50 implantation materials are printed based on customized implants data set.

It must be noted that the embodiment of the present invention is described with reference to different themes.In particular, some embodiments are ginsengs Test method type claim describes, and other embodiments are reference device type claims to describe.However, this field Technical staff it is described above and below it can be concluded that, unless otherwise noted, in addition to belong to same type of theme spy appoint appoint Except what is combined, it is related to any combination between the feature of different themes and is recognized as to be disclosed by this application.However, all features It can be combined, the synergistic effect simply summed it up more than the feature is provided.

It is such to illustrate and retouch although illustrating and describing the present invention in detail in the drawings and the preceding description Stating should be considered as n-lustrative or exemplary, and not restrictive.The present invention is not limited to disclosed embodiments.This field skill Art personnel by research attached drawing, disclosure and dependent claims, when practicing the claimed present invention it will be appreciated that And realize other variants of the disclosed embodiments.

In the claims, one word of " comprising " is not excluded for other elements or step, and word "a" or "an" is not arranged Except multiple.The function for the several projects enumerated in claim may be implemented in single-processor or other units.Although specific arrange It applies and records in mutually different dependent claims, but this does not indicate that the collection that these measures cannot be used to advantage It closes.Any appended drawing reference in claims is not necessarily to be construed as the limitation to range.