阅读说明：本技术 杀微生物的噻唑衍生物 (Microbiocidal thiazole derivatives ) 是由 D·斯狄尔利 M·R·摩纳科 S·伦丁 于 2020-03-25 设计创作，主要内容包括：披露了具有式(I)的化合物,其中取代基是如权利要求1中所定义的,所述化合物可用作杀有害生物剂,并且尤其可用作杀真菌剂。(Compounds of formula (I) wherein the substituents are as defined in claim 1 are disclosed which are useful as pesticides, and in particular as fungicides.)

1. A compound having the formula (I):

wherein

R¹Is hydrogen, cyano, formyl, C₁-C₆Alkylcarbonyl group, C₁-C₆Alkoxy radical C₁-C₆Alkylcarbonyl group, C₁-C₆Halogenoalkylcarbonyl group, C₁-C₆Alkoxycarbonyl radical C₁-C₄Alkylcarbonyl group, C₃-C₆Cycloalkyl carbonyl group, C₁-C₆Alkoxycarbonyl group, C₁-C₆Alkoxycarbonyl carbonyl group, C₁-C₆Alkoxy radical C₁-C₄Alkoxycarbonyl group, C₂-C₆Alkenyloxycarbonyl radical, C₂-C₆Alkynyloxycarbonyl group, C₁-C₆Alkylsulfanyl carbonyl, phenylcarbonyl, phenoxycarbonyl, or heteroarylcarbonyl, wherein the heteroaryl is 1 or 2 comprising independently selected nitrogen, oxygen, and sulfurA 5-or 6-membered aromatic monocyclic ring of heteroatoms;

R²is hydrogen, halogen, cyano, C₁-C₄Alkyl radical, C₁-C₄Alkoxy radical, C₁-C₄Haloalkyl, or HC (O) NH-;

R³is hydrogen, C₁-C₄Alkyl radical, C₁-C₄Alkoxy radical, C₁-C₄Haloalkyl, or C₃-C₄A cycloalkyl group;

R⁴is C₁-C₈An alkyl group; c₁-C₈A haloalkyl group; c₁-C₈An alkoxy group; c₃-C₈A cycloalkyl group; c₃-C₈Cycloalkyl radical C₁-C₂An alkyl group; a phenyl group; phenyl radical C₁-C₂An alkyl group; heteroaryl or heteroaryl C₁-C₂An alkyl group, wherein the heteroaryl group is a 5-or 6-membered aromatic monocyclic ring containing 1,2,3, or 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; heterocyclyl or heterocyclyl C₁-C₂Alkyl, wherein the heterocyclyl is a 4-, 5-or 6-membered non-aromatic monocyclic ring comprising 1,2 or 3 heteroatoms independently selected from nitrogen, oxygen and sulfur; or optionally comprising 1,2,3, 4 or 5 heteroatoms independently selected from nitrogen, oxygen and sulfur, optionally through C₁-C₂An alkylene linker is bonded to the 5-to 10-membered non-aromatic spirocyclic carbobicyclic or carbotricyclic ring system of the remainder of the molecule, and wherein each cycloalkyl, phenyl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents R⁵Substituted with the group represented; and is

R⁵Is halogen, C₁-C₄Alkyl radical, C₁-C₄Alkoxy, or C₁-C₄A haloalkyl group;

or a salt or N-oxide thereof.

2. The compound of claim 1, wherein R¹Is hydrogen, cyano, formyl, acetyl, propionyl, methoxycarbonyl, ethoxycarbonyl, fluoromethylcarbonyl, 2,2, 2-trifluoroethylcarbonyl, cyclopropylCarbonyl, methoxyethoxycarbonyl, 2-methoxy-2-oxo-ethylcarbonyl, 2-methoxy-oxo-propylcarbonyl, propargyloxycarbonyl, isopropylsulfanylcarbonyl, phenylcarbonyl, phenoxycarbonyl, 2-furanylcarbonyl, or 2-thiophenylcarbonyl.

3. A compound according to claim 1 or claim 2, wherein R¹Is hydrogen, cyano, methoxymethylcarbonyl, or acetyl.

4. A compound according to any one of claims 1 to 3, wherein R²Is halogen, methyl, ethyl, methoxy, ethoxy, or HC (O) NH-.

5. A compound according to any one of claims 1 to 4, wherein R²Is methyl.

6. A compound according to any one of claims 1 to 5, wherein R⁴Is C₁-C₅An alkyl group; c₁-C₃An alkoxy group; c₃-C₆A cycloalkyl group; c₃-C₆Cycloalkyl radical C₁-C₂An alkyl group; a phenyl group; phenyl radical C₁-C₂An alkyl group; heteroaryl, wherein the heteroaryl is a 5-or 6-membered aromatic monocyclic ring comprising 1,2 or 3 heteroatoms independently selected from nitrogen, oxygen and sulfur; heterocyclyl, wherein the heterocyclyl is a 4-, 5-or 6-membered non-aromatic monocyclic ring comprising 1,2 or 3 heteroatoms independently selected from nitrogen, oxygen and sulfur; or a 5-to 10-membered non-aromatic spirocyclic carbocyclic or tricyclic carbocyclic system optionally comprising a single heteroatom selected from nitrogen, oxygen and sulfur; and wherein each cycloalkyl group is optionally substituted with 1 to 3 groups R⁵The groups represented are substituted.

7. A compound according to any one of claims 1 to 6, wherein R⁴Is C₄-C₅Alkyl radical, C₃-C₆Cycloalkyl, phenyl C₁-C₂Alkyl, or a 6-to 10-membered non-aromatic spirocarbocyclic bicyclic ring system; and wherein said cycloalkyl is optionally substituted by 1 or 2R⁵The groups represented are substituted.

8. A compound according to any one of claims 1 to 7, wherein R⁴Is n-butyl, 2-dimethylpropyl, 3-methylbutyl, 2-dimethylcyclobutyl, 1-phenylethyl or spiro [3.4]]An octyl group.

9. A compound according to any one of claims 1 to 7, wherein R⁵Is C₁-C₃An alkyl group.

10. The compound of any one of claims 1 to 9, wherein R³Is hydrogen, methyl, ethyl, methoxy or ethoxy.

11. The compound of any one of claims 1 to 10, wherein R³Is hydrogen.

12. An agrochemical composition comprising a fungicidally effective amount of a compound of formula (I) according to any one of claims 1 to 11.

13. The composition according to claim 12, further comprising at least one additional active ingredient and/or an agrochemically acceptable diluent or carrier.

14. A method for controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a fungicidally effective amount of a compound of formula (I) according to any one of claims 1 to 11 or a composition comprising said compound as active ingredient is applied to the plants, parts thereof or the locus thereof.

15. Use of a compound of formula (I) according to any one of claims 1 to 11 as a fungicide.