阅读说明：本技术 用于制备取代多环吡啶酮衍生物及其晶体的方法 (Process for producing substituted polycyclic pyridone derivative and crystal thereof ) 是由 芝原摄也 福井伸明 牧利克 阿南浩辅 于 2017-06-19 设计创作，主要内容包括：提供了一种用于生产取代多环吡啶酮衍生物的方法。一种用于生产由式(II)表示的化合物的方法,其特征在于,在钠盐和/或镁盐的存在下使由式(I)表示的化合物与由式R～(2)-OH表示的化合物反应(其中R～(2)表示未取代烷基)。(在式(I)中,R～(1)表示氢原子或不同于未取代烷基的保护基团。)(在式(II)中,R～(2)是如上所定义的。)(A process for producing a substituted polycyclic pyridone derivative is provided. A process for producing a compound represented by the formula (II), characterized in that a compound represented by the formula (I) is reacted with a compound represented by the formula R in the presence of a sodium salt and/or a magnesium salt 2 Reaction of a compound represented by-OH (wherein R is 2 Represents an unsubstituted alkyl group). (in the formula (I), R 1 Represents a hydrogen atom or a protecting group other than an unsubstituted alkyl group. ) (in the formula (II), R 2 Is as defined above. ))